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Emerging Gram‑positive bacteria and drug resistance in cirrhosis patients with spontaneous bacterial peritonitis: A retrospective study

  • Authors:
    • Jingjing Guo
    • Jingren Shi
    • Huizhu Wang
    • Hui Chen
    • Shunai Liu
    • Junnan Li
    • Yajie Wang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, P.R. China, School of Biomedical Engineering, Capital Medical University, Beijing 100069, P.R. China, Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, P.R. China, Department of Research and Education, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4568-4576
    |
    Published online on: April 18, 2019
       https://doi.org/10.3892/etm.2019.7502
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Abstract

Spontaneous bacterial peritonitis (SBP) is one of the most severe complications in liver cirrhosis (LC) patients with ascites. The aim of the present study was to retrospectively analyze the bacterial spectrum and drug resistance in ascites culture of patients with SBP. A total of 3, 189 patients with ascites were enrolled in the present study, including 912 LC patients, of which 247 had SBP. It was revealed that in the 3, 189 patients, the ratio of SBP exhibited annual increases, especially in 2015, and this trend remained when cases were divided into two groups: Group A (admission, 2011‑2013) and Group B (admission, 2014‑2016). The 247 SBP patients were then stratified into two groups: Group 1 (admission, 2011‑2013) and Group 2 (admission, 2014‑2016). The rate of infection with gram‑positive bacteria (GPB) was markedly higher in Group 2 compared with Group 1. Over time, GPB and gram‑negative bacteria (GNB) were increased, while the increase of GPB was greater than that of GNB. Direct bilirubin and C‑reactive protein levels, and the positive rate of ascites culture in Group 2 were greater than in Group 1. Furthermore, marked differences in serological and ascitic indexes or pathogeny, as well as complications between the patients with GPB and GNB infection were observed. The results regarding drug sensitivity revealed that the resistance rate of GPB and GNB to penicillin (ampicillin) was 100%, while the resistance rate to amikacin, imipenem, meropenem and piperacillin/tazobactam was 0% for GNB, and similarly, the resistance rate to vancomycin, teicoplanin, amikacin and linezolid was 0% for GPB. The results suggested that combined use of ampicillin/sulbactam or piperacillin/tazobactam should be selected forempirical therapy. In cases of nosocomial infection, these drugs should be combined with vancomycin, linezolid or teicoplanin when required.
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View References

1 

Tsochatzis EA, Bosch J and Burroughs AK: Liver cirrhosis. Lancet. 383:1749–1761. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Fiore M, Maraolo AE, Gentile I, Borgia G, Leone S, Sansone P, Passavanti MB, Aurilio C and Pace MC: Current concepts and future strategies in the antimicrobial therapy of emerging Gram-positive spontaneous bacterial peritonitis. World J Hepatol. 9:1166–1175. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Cui Y and Jia J: Update on epidemiology of hepatitis B and C in China. J Gastroenterol Hepatol. 28 (Suppl 1):S7–S10. 2013. View Article : Google Scholar

4 

Enomoto H, Inoue S, Matsuhisa A and Nishiguchi S: Diagnosis of spontaneous bacterial peritonitis and an in situ hybridization approach to detect an ‘unidentified’ pathogen. Int J Hepatol. 2014:6346172014. View Article : Google Scholar : PubMed/NCBI

5 

Kim JH, Jeon YD, Jung IY, Ahn MY, Ahn HW, Ahn JY, Ku NS, Han SH, Choi JY, Ahn SH, et al: Predictive factors of spontaneous bacterial peritonitis caused by gram-positive bacteria in patients with cirrhosis. Medicine (Baltimore). 95:e34892016. View Article : Google Scholar : PubMed/NCBI

6 

Paul K, Kaur J and Kazal HL: To study the incidence, predictive factors and clinical outcome of spontaneous bacterial peritonitis in patients of cirrhosis with ascites. J Clin Diagn Res. 9:OC09–OC12. 2015.PubMed/NCBI

7 

Yan K and Garcia-Tsao G: Novel prevention strategies for bacterial infections in cirrhosis. Expert Opin Pharmacother. 17:689–701. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Fukui H: Gut Microbiome-based therapeutics in liver cirrhosis: Basic consideration for the next step. J Clin Transl Hepatol. 5:249–260. 2017.PubMed/NCBI

9 

Runyon BA: Management of adult patients with ascites due to cirrhosis: Update 2012. American Association for the Study of Liver Diseases. 2012, https://www.aasld.org/sites/default/files/guideline_documents/adultascitesenhanced.pdfMay 6–2012

10 

European Association for the Study of the Liver, . EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis. J Hepatol. 53:397–417. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Clinical and Laboratory Standards Institute (CLSI), . Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts. 4th. CLSI standard M27. CLSI; Wayne, PA: 2017

12 

Bal CK, Daman R and Bhatia V: Predictors of fifty days in-hospital mortality in decompensated cirrhosis patients with spontaneous bacterial peritonitis. World J Hepatol. 8:566–572. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Wong F: Acute kidney injury in liver cirrhosis: New definition and application. Clin Mol Hepatol. 22:415–422. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Cholongitas E, Papatheodoridis GV, Lahanas A, Xanthaki A, Kontou-Kastellanou C and Archimandritis AJ: Increasing frequency of Gram-positive bacteria in spontaneous bacterial peritonitis. Liver Int. 25:57–61. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Yang Y, Li L, Qu C, Zeng B, Liang S, Luo Z, Wang X and Zhong C: Diagnostic accuracy of serum procalcitonin for spontaneous bacterial peritonitis due to end-stage liver disease: A Meta-analysis. Medicine (Baltimore). 94:e20772015. View Article : Google Scholar : PubMed/NCBI

16 

de Mattos AA, Costabeber AM, Lionco LC and Tovo CV: Multi-resistant bacteria in spontaneous bacterial peritonitis: A new step in management? World J Gastroenterol. 20:14079–14086. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Hatami B, Ashtari S, Sharifian A, Rahmani Seraji H, Khalili E, Hatami Y and Zali MR: Changing the cause of liver cirrhosis from hepatitis B virus to fatty liver in Iranian patients. Gastroenterol Hepatol Bed Bench. 10 (Suppl):S20–S26. 2017.PubMed/NCBI

18 

Li YT, Yu CB, Huang JR, Qin ZJ and Li LJ: Pathogen profile and drug resistance analysis of spontaneous peritonitis in cirrhotic patients. World J Gastroenterol. 21:10409–10417. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Xie Y, Tu B, Zhang X, Bi J, Shi L, Zhao P, Chen W, Liu S, Xu D and Qin E: Investigation on outcomes and bacterial distributions of liver cirrhosis patients with gram-negative bacterial bloodstream infection. Oncotarget. 9:3980–3995. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Kim T, Hong SI, Park SY, Jung J, Chong YP, Kim SH, Lee SO, Kim YS, Woo JH, Lim YS, et al: Clinical features and outcomes of spontaneous bacterial peritonitis caused by streptococcus pneumoniae: A matched Case-control study. Medicine (Baltimore). 95:e37962016. View Article : Google Scholar : PubMed/NCBI

21 

Acevedo J: Multiresistant bacterial infections in liver cirrhosis: Clinical impact and new empirical antibiotic treatment policies. World J Hepatol. 7:916–921. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Karkmann K, Piecha F, Runzi AC, Schulz L, von Wulffen M, Benten D, Kluwe J and Wege H: Management of compensated liver cirrhosis 2018-Evidence based prophylactic measures. Z Gastroenterol. 56:55–69. 2018.(In German). PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Guo J, Shi J, Wang H, Chen H, Liu S, Li J and Wang Y: Emerging Gram‑positive bacteria and drug resistance in cirrhosis patients with spontaneous bacterial peritonitis: A retrospective study. Exp Ther Med 17: 4568-4576, 2019.
APA
Guo, J., Shi, J., Wang, H., Chen, H., Liu, S., Li, J., & Wang, Y. (2019). Emerging Gram‑positive bacteria and drug resistance in cirrhosis patients with spontaneous bacterial peritonitis: A retrospective study. Experimental and Therapeutic Medicine, 17, 4568-4576. https://doi.org/10.3892/etm.2019.7502
MLA
Guo, J., Shi, J., Wang, H., Chen, H., Liu, S., Li, J., Wang, Y."Emerging Gram‑positive bacteria and drug resistance in cirrhosis patients with spontaneous bacterial peritonitis: A retrospective study". Experimental and Therapeutic Medicine 17.6 (2019): 4568-4576.
Chicago
Guo, J., Shi, J., Wang, H., Chen, H., Liu, S., Li, J., Wang, Y."Emerging Gram‑positive bacteria and drug resistance in cirrhosis patients with spontaneous bacterial peritonitis: A retrospective study". Experimental and Therapeutic Medicine 17, no. 6 (2019): 4568-4576. https://doi.org/10.3892/etm.2019.7502
Copy and paste a formatted citation
x
Spandidos Publications style
Guo J, Shi J, Wang H, Chen H, Liu S, Li J and Wang Y: Emerging Gram‑positive bacteria and drug resistance in cirrhosis patients with spontaneous bacterial peritonitis: A retrospective study. Exp Ther Med 17: 4568-4576, 2019.
APA
Guo, J., Shi, J., Wang, H., Chen, H., Liu, S., Li, J., & Wang, Y. (2019). Emerging Gram‑positive bacteria and drug resistance in cirrhosis patients with spontaneous bacterial peritonitis: A retrospective study. Experimental and Therapeutic Medicine, 17, 4568-4576. https://doi.org/10.3892/etm.2019.7502
MLA
Guo, J., Shi, J., Wang, H., Chen, H., Liu, S., Li, J., Wang, Y."Emerging Gram‑positive bacteria and drug resistance in cirrhosis patients with spontaneous bacterial peritonitis: A retrospective study". Experimental and Therapeutic Medicine 17.6 (2019): 4568-4576.
Chicago
Guo, J., Shi, J., Wang, H., Chen, H., Liu, S., Li, J., Wang, Y."Emerging Gram‑positive bacteria and drug resistance in cirrhosis patients with spontaneous bacterial peritonitis: A retrospective study". Experimental and Therapeutic Medicine 17, no. 6 (2019): 4568-4576. https://doi.org/10.3892/etm.2019.7502
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