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Protective effect of gastrodin on myocardial ischemia‑reperfusion injury and the expression of Bax and Bcl‑2

  • Authors:
    • Xiao Han
    • Hai Shi
    • Kun Liu
    • Lou Zhong
    • Fei Wang
    • Qingsheng You
  • View Affiliations / Copyright

    Affiliations: Department of Cardiothoracic Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Cardiothoracic Surgery, The Third People's Hospital of Nantong, Nantong, Jiangsu 226001, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4389-4394
    |
    Published online on: April 19, 2019
       https://doi.org/10.3892/etm.2019.7512
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Abstract

The protective effects of gastrodin on myocardial ischemia‑reperfusion injury in rats and the underlying mechanism were investigated. Sprague Dawley (SD) rats were randomly divided into three groups, of which the gastrodin group was treated with gastrodin, and the other two groups were treated with normal saline. In the myocardial ischemia-reperfusion model group, myocardial ischemia was induced by ligation of the left anterior descending coronary artery, and myocardial reperfusion was performed by ligature removal. Only thread without ligation for the sham operation group was conducted. The rats were euthanized 8 days after surgery. Heart tissues were harvested and used for measurement of apoptotic rate and expression levels of apoptosis‑related proteins. Serum levels of cytokines were measured also using blood samples. Compared with the myocardial ischemia‑reperfusion model group, significant reduction of cardiomyocyte apoptosis was observed in the gastrodin group (P<0.05). In the gastrodin group, the protein and mRNA expression levels for Bax and activated caspase‑3 decreased, while for Bcl‑2 increased (P<0.05). Gastrodin can downregulate inflammatory cytokines (P<0.05) and upregulate anti‑inflammatory cytokines such as IL‑10 (P<0.05) in serum of SD rats. Therefore, gastrodin played a protective role in myocardial ischemia‑reperfusion injury by regulating the expression levels of apoptosis‑related signaling proteins and inflammatory cytokines.
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1 

Steg PG, Greenlaw N, Tendera M, Tardif JC, Ferrari R, Al Zaibag M, Dorian P, Hu D, Shalnova S, Sokn FJ, et al Prospective Observational Longitudinal Registry of Patients with Stable Coronary Artery Disease (CLARIFY) Investigators, : Prevalence of anginal symptoms and myocardial ischemia and their effect on clinical outcomes in outpatients with stable coronary artery disease: data from the international observational CLARIFY registry. JAMA Intern Med. 174:1651–1659. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Cheng D, Zhu C, Cao J and Jiang W: The protective effects of polyphenols from jujube peel (Ziziphus Jujube Mill) on isoproterenol-induced myocardial ischemia and aluminum-induced oxidative damage in rats. Food Chem Toxicol. 50:1302–1308. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Misumida N, Kobayashi A, Saeed M, Fox JT and Kanei Y: Electrocardiographic left ventricular hypertrophy as a predictor for nonsignificant coronary artery disease in patients with non ST segment elevation myocardial infarction. Angiology. 67:27–33. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Sung HK, Chan YK, Han M, Jahng JWS, Song E, Danielson E, Berger T, Mak TW and Sweeney G: Lipocalin-2 (NGAL) attenuates autophagy to exacerbate cardiac apoptosis induced by myocardial ischemia. J Cell Physiol. 232:2125–2134. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Panza JA, Holly TA, Asch FM, She L, Pellikka PA, Velazquez EJ, Lee KL, Borges-Neto S, Farsky PS, Jones RH, et al: Inducible myocardial ischemia and outcomes in patients with coronary artery disease and left ventricular dysfunction. J Am Coll Cardiol. 61:1860–1870. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Patel RD and Saver JL: Evolution of reperfusion therapies for acute brain and acute myocardial ischemia: a systematic, comparative analysis. Stroke. 44:94–98. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Zhang J, Yu XH, Yan YG, Wang C and Wang WJ: PI3K/Akt signaling in osteosarcoma. Clin Chim Acta. 444:182–192. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Kim HJ, Moon KD, Lee DS and Lee SH: Ethyl ether fraction of Gastrodia elata Blume protects amyloid beta peptide-induced cell death. J Ethnopharmacol. 84:95–98. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Kim HJ, Moon KD, Oh SY, Kim SP and Lee SR: Ether fraction of methanol extracts of Gastrodia elata, a traditional medicinal herb, protects against kainic acid-induced neuronal damage in the mouse hip-pocampus. Neurosci Lett. 314:65–68. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Park S, da Kim S and Kang S: Gastrodia elata Blume water extracts improve insulin resistance by decreasing body fat in dietinduced obese rats: vanillin and 4-hydroxybenzaldehyde are the bioactive candidates. Eur J Nutr. 50:107–118. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Xu X, Lu Y and Bie X: Protective effects of gastrodin on hypoxia-induced toxicity in primary cultures of rat cortical neurons. Planta Med. 73:650–654. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Dai JN, Zong Y, Zhong LM, Li YM, Zhang W, Bian LG, Ai QL, Liu YD, Sun J and Lu D: Gastrodin inhibits expression of inducible NO synthase, cyclooxygenase-2 and proinflammatory cytokines in cultured LPS-stimulated microglia via MAPK pathways. PLoS One. 6:e218912011. View Article : Google Scholar : PubMed/NCBI

13 

Shu C, Chen C, Zhang DP, Guo H, Zhou H, Zong J, Bian Z, Dong X, Dai J, Zhang Y and Tang Q: Gastrodin protects against cardiac hypertrophy and fibrosis. Mol Cell Biochem. 359:9–16. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Zhao X, Zou Y, Xu H, Fan L, Guo H, Li X, Li G, Zhang X and Dong M: Gastrodin protect primary cultured rat hippocampal neurons against amyloid-beta peptide-induced neurotoxicity via ERK1/2-Nrf2 pathway. Brain Res. 1482:13–21. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Abbate A, Salloum FN, Van Tassell BW, Vecile E, Toldo S, Seropian I, Mezzaroma E and Dobrina A: Alterations in the interleukin-1/interleukin-1 receptor antagonist balance modulate cardiac remodeling following myocardial infarction in the mouse. PLoS One. 6:e279232011. View Article : Google Scholar : PubMed/NCBI

17 

Ke Z, Wang G, Yang L, Qiu H, Wu H, Du M, Chen J, Song J, Jia X and Feng L: Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway. J Ethnopharmacol. 206:160–169. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Cui G, Shan L, Hung M, Lei S, Choi I, Zhang Z, Yu P, Hoi P, Wang Y and Lee SM: A novel Danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways. Int J Cardiol. 168:1349–1359. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Ouyang ZH, Wang WJ, Yan YG, Wang B and Lv GH: The PI3K/Akt pathway: A critical player in intervertebral disc degeneration. Oncotarget. 8:57870–57881. 2017. View Article : Google Scholar : PubMed/NCBI

20 

De Los Santos S, García-Pérez V, Hernández-Reséndiz S, Palma-Flores C, González-Gutiérrez CJ, Zazueta C, Canto P and Coral-Vázquez RM: (−)-Epicatechin induces physiological cardiac growth by activation of the PI3K/Akt pathway in mice. Mol Nutr Food Res. 61:612017. View Article : Google Scholar

21 

Correa F, Buelna-Chontal M, Chagoya V, García-Rivas G, Vigueras RM, Pedraza-Chaverri J, García-Niño WR, Hernández-Pando R, León-Contreras JC and Zazueta C: Inhibition of the nitric oxide/cyclic guanosine monophosphate pathway limited the cardioprotective effect of post-conditioning in hearts with apical myocardial infarction. Eur J Pharmacol. 765:472–481. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Kambara T, Shibata R, Ohashi K, Matsuo K, Hiramatsu-Ito M, Enomoto T, Yuasa D, Ito M, Hayakawa S, Ogawa H, et al: C1q/tumor necrosis factor-related protein 9 protects against acute myocardial injury through an adiponectin receptor I-AMPK-dependent mechanism. Mol Cell Biol. 35:2173–2185. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Broughton BR, Reutens DC and Sobey CG: Apoptotic mechanisms after cerebral ischemia. Stroke. 40:e331–e339. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Pape M, Engelhard K, Eberspächer E, Hollweck R, Kellermann K, Zintner S, Hutzler P and Werner C: The long-term effect of sevoflurane on neuronal cell damage and expression of apoptotic factors after cerebral ischemia and reperfusion in rats. Anesth Analg. 103:173–179. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Smith IC, Vigna C, Levy AS, Denniss SG, Rush JW and Tupling AR: The effects of buthionine sulfoximine treatment on diaphragm contractility and SERCA pump function in adult and middle aged rats. Physiol Rep. 3:e125472015. View Article : Google Scholar : PubMed/NCBI

26 

Komin N, Moein M, Ellisman MH and Skupin A: Multiscale modeling indicates that temperature dependent [Ca2+]i spiking in astrocytes is quantitatively consistent with modulated SERCA activity. Neural Plast. 2015:6834902015. View Article : Google Scholar : PubMed/NCBI

27 

Yan J, Schmid E, Hosseinzadeh Z, Honisch S, Shumilina E, Fuchs J and Lang F: Impact of Janus kinase 3 on cellular Ca release, store operated Ca(2+) entry and Na(+)/Ca(2+) exchanger activity in dendritic cells. Cell Physiol Biochem. 36:2287–2298. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Wiernicki B, Rozwadowska N, Malcher A, Kolanowski T, Zimna A, Rugowska A and Kurpisz M: Human myoblast transplantation in mice infarcted heart alters the expression profile of cardiac genes associated with left ventricle remodeling. Int J Cardiol. 202:710–721. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Han X, Shi H, Liu K, Zhong L, Wang F and You Q: Protective effect of gastrodin on myocardial ischemia‑reperfusion injury and the expression of Bax and Bcl‑2 . Exp Ther Med 17: 4389-4394, 2019.
APA
Han, X., Shi, H., Liu, K., Zhong, L., Wang, F., & You, Q. (2019). Protective effect of gastrodin on myocardial ischemia‑reperfusion injury and the expression of Bax and Bcl‑2 . Experimental and Therapeutic Medicine, 17, 4389-4394. https://doi.org/10.3892/etm.2019.7512
MLA
Han, X., Shi, H., Liu, K., Zhong, L., Wang, F., You, Q."Protective effect of gastrodin on myocardial ischemia‑reperfusion injury and the expression of Bax and Bcl‑2 ". Experimental and Therapeutic Medicine 17.6 (2019): 4389-4394.
Chicago
Han, X., Shi, H., Liu, K., Zhong, L., Wang, F., You, Q."Protective effect of gastrodin on myocardial ischemia‑reperfusion injury and the expression of Bax and Bcl‑2 ". Experimental and Therapeutic Medicine 17, no. 6 (2019): 4389-4394. https://doi.org/10.3892/etm.2019.7512
Copy and paste a formatted citation
x
Spandidos Publications style
Han X, Shi H, Liu K, Zhong L, Wang F and You Q: Protective effect of gastrodin on myocardial ischemia‑reperfusion injury and the expression of Bax and Bcl‑2 . Exp Ther Med 17: 4389-4394, 2019.
APA
Han, X., Shi, H., Liu, K., Zhong, L., Wang, F., & You, Q. (2019). Protective effect of gastrodin on myocardial ischemia‑reperfusion injury and the expression of Bax and Bcl‑2 . Experimental and Therapeutic Medicine, 17, 4389-4394. https://doi.org/10.3892/etm.2019.7512
MLA
Han, X., Shi, H., Liu, K., Zhong, L., Wang, F., You, Q."Protective effect of gastrodin on myocardial ischemia‑reperfusion injury and the expression of Bax and Bcl‑2 ". Experimental and Therapeutic Medicine 17.6 (2019): 4389-4394.
Chicago
Han, X., Shi, H., Liu, K., Zhong, L., Wang, F., You, Q."Protective effect of gastrodin on myocardial ischemia‑reperfusion injury and the expression of Bax and Bcl‑2 ". Experimental and Therapeutic Medicine 17, no. 6 (2019): 4389-4394. https://doi.org/10.3892/etm.2019.7512
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