Insulin therapy is not associated with improved clinical outcomes in critically ill infants with stress hyperglycemia

  • Authors:
    • Fang Wen
    • Yi Zhang
    • Chunwang Lin
    • Minghong Deng
    • Jinfeng Zhang
    • Jianping Zhang
  • View Affiliations

  • Published online on: April 30, 2019     https://doi.org/10.3892/etm.2019.7537
  • Pages: 397-403
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Abstract

The aim of the present study was to examine the benefits of insulin use and non‑use in critically ill infants with stress‑induced hyperglycemia. The present retrospective study used clinical data from 302 critically ill infants with stress hyperglycemia admitted to pediatric intensive care units (PICUs). The patients were recruited randomly and divided into three groups: The tight glycemic control, conventional insulin therapy and control groups. Correlations between insulin therapy and improved clinical outcomes were assessed according to key parameters (length of PICU stay, total length of stay, occurrence of organ dysfunction and mortality). Correlations between blood glucose level and these parameters in the three groups were also examined. Blood glucose levels following insulin therapy were not correlated with the length of PICU stay, total length of stay, mortality, secondary coma, or secondary hepatic or renal dysfunction in the three groups. At 96 h following PICU admission, blood glucose levels were statistically similar (5.0±1.2, 4.9±1.3 and 5.1±0.9 mmol/l, respectively; P>0.05). Insulin therapy was revealed to have no benefit on the length of hospitalization, the occurrence of organ dysfunction or mortality in critically ill pediatric patients with stress hyperglycemia. Even with no insulin use, the blood glucose level could spontaneously return to normal, with no associated risk of organ dysfunction or fatality.
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July-2019
Volume 18 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wen F, Zhang Y, Lin C, Deng M, Zhang J and Zhang J: Insulin therapy is not associated with improved clinical outcomes in critically ill infants with stress hyperglycemia. Exp Ther Med 18: 397-403, 2019
APA
Wen, F., Zhang, Y., Lin, C., Deng, M., Zhang, J., & Zhang, J. (2019). Insulin therapy is not associated with improved clinical outcomes in critically ill infants with stress hyperglycemia. Experimental and Therapeutic Medicine, 18, 397-403. https://doi.org/10.3892/etm.2019.7537
MLA
Wen, F., Zhang, Y., Lin, C., Deng, M., Zhang, J., Zhang, J."Insulin therapy is not associated with improved clinical outcomes in critically ill infants with stress hyperglycemia". Experimental and Therapeutic Medicine 18.1 (2019): 397-403.
Chicago
Wen, F., Zhang, Y., Lin, C., Deng, M., Zhang, J., Zhang, J."Insulin therapy is not associated with improved clinical outcomes in critically ill infants with stress hyperglycemia". Experimental and Therapeutic Medicine 18, no. 1 (2019): 397-403. https://doi.org/10.3892/etm.2019.7537