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Article

Altered spontaneous brain activity patterns in patients with corneal ulcer using amplitude of low‑frequency fluctuation: An fMRI study

  • Authors:
    • Wen‑Qing Shi
    • Wei Wu
    • Lei Ye
    • Nan Jiang
    • Wen‑Feng Liu
    • Yong‑Qiang Shu
    • Ting Su
    • Qi Lin
    • You‑Lan Min
    • Biao Li
    • Pei‑Wen Zhu
    • Yi Shao
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center, Nanchang, Jiangxi 330006, P.R. China, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute of Xiamen University, Xiamen, Fujian 361102, P.R. China, Department of Radiology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Medical Imaging Research Institute, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 125-132
    |
    Published online on: May 7, 2019
       https://doi.org/10.3892/etm.2019.7550
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Abstract

The aim of the present study was to investigate the altered spontaneous brain activity in patients with corneal ulcer (CU) through the amplitude of low‑frequency fluctuation (ALFF) technique and the association with their visual performance. A total of 40 patients with CU and 40 healthy controls (HCs) matched for sex, age and educational level were enrolled. Resting‑state functional magnetic resonance imaging (rs‑fMRI) was performed to examine the probands. Spontaneous cerebral activity variations were investigated using the ALFF technique. The average ALFF values of the CU patients and the HCs were classified by utilizing receiver operating characteristic (ROC) curves. Contrary to HCs, the CU patients had significantly lower ALFF values in the left cerebellar anterior lobe, right middle frontal gyrus and left middle frontal gyrus, but higher ALFF values in the right cerebellar inferior lobe, left cerebellar inferior lobe, left inferior temporal gyrus, right fusiform gyrus, left superior frontal gyrus, right angular gyrus and bilateral superior frontal gyrus. ROC curve analysis of each brain region indicated that the accuracy of ALFF value specificity between the CU and HCs of the area under the curve was perfect. In conclusion, abnormal spontaneous activities were detected in numerous brain regions of CU patients, which may provide useful information for understanding the dysfunction of CU. These activity changes in brain regions may be used as effective clinical indicators for CU.
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Copy and paste a formatted citation
Spandidos Publications style
Shi WQ, Wu W, Ye L, Jiang N, Liu WF, Shu YQ, Su T, Lin Q, Min YL, Li B, Li B, et al: Altered spontaneous brain activity patterns in patients with corneal ulcer using amplitude of low‑frequency fluctuation: An fMRI study. Exp Ther Med 18: 125-132, 2019.
APA
Shi, W., Wu, W., Ye, L., Jiang, N., Liu, W., Shu, Y. ... Shao, Y. (2019). Altered spontaneous brain activity patterns in patients with corneal ulcer using amplitude of low‑frequency fluctuation: An fMRI study. Experimental and Therapeutic Medicine, 18, 125-132. https://doi.org/10.3892/etm.2019.7550
MLA
Shi, W., Wu, W., Ye, L., Jiang, N., Liu, W., Shu, Y., Su, T., Lin, Q., Min, Y., Li, B., Zhu, P., Shao, Y."Altered spontaneous brain activity patterns in patients with corneal ulcer using amplitude of low‑frequency fluctuation: An fMRI study". Experimental and Therapeutic Medicine 18.1 (2019): 125-132.
Chicago
Shi, W., Wu, W., Ye, L., Jiang, N., Liu, W., Shu, Y., Su, T., Lin, Q., Min, Y., Li, B., Zhu, P., Shao, Y."Altered spontaneous brain activity patterns in patients with corneal ulcer using amplitude of low‑frequency fluctuation: An fMRI study". Experimental and Therapeutic Medicine 18, no. 1 (2019): 125-132. https://doi.org/10.3892/etm.2019.7550
Copy and paste a formatted citation
x
Spandidos Publications style
Shi WQ, Wu W, Ye L, Jiang N, Liu WF, Shu YQ, Su T, Lin Q, Min YL, Li B, Li B, et al: Altered spontaneous brain activity patterns in patients with corneal ulcer using amplitude of low‑frequency fluctuation: An fMRI study. Exp Ther Med 18: 125-132, 2019.
APA
Shi, W., Wu, W., Ye, L., Jiang, N., Liu, W., Shu, Y. ... Shao, Y. (2019). Altered spontaneous brain activity patterns in patients with corneal ulcer using amplitude of low‑frequency fluctuation: An fMRI study. Experimental and Therapeutic Medicine, 18, 125-132. https://doi.org/10.3892/etm.2019.7550
MLA
Shi, W., Wu, W., Ye, L., Jiang, N., Liu, W., Shu, Y., Su, T., Lin, Q., Min, Y., Li, B., Zhu, P., Shao, Y."Altered spontaneous brain activity patterns in patients with corneal ulcer using amplitude of low‑frequency fluctuation: An fMRI study". Experimental and Therapeutic Medicine 18.1 (2019): 125-132.
Chicago
Shi, W., Wu, W., Ye, L., Jiang, N., Liu, W., Shu, Y., Su, T., Lin, Q., Min, Y., Li, B., Zhu, P., Shao, Y."Altered spontaneous brain activity patterns in patients with corneal ulcer using amplitude of low‑frequency fluctuation: An fMRI study". Experimental and Therapeutic Medicine 18, no. 1 (2019): 125-132. https://doi.org/10.3892/etm.2019.7550
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