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Case Report

Therapeutic management with biological anti-TNF-α agent in severe psoriasis associated with chronic hepatitis B: A case report

  • Authors:
    • Anca Raducan
    • Stefana Bucur
    • Constantin Caruntu
    • Traian Constantin
    • Iuliana Elena Nita
    • Nicuta Manolache
    • Maria-Magdalena Constantin
  • View Affiliations / Copyright

    Affiliations: Dr. Anca Răducan Anti-Aging Dermatology Clinic, 900705 Constanta, Romania, The Second Department of Dermatology, Colentina Clinical Hospital, 020125 Bucharest, Romania, Department of Dermatology, Prof. ‘N. Paulescu’ National Institute of Diabetes, Nutrition and Metabolic Diseases, 021106 Bucharest, Romania , Department of Urology, ‘Prof. Dr. Th. Burghele’ Hospital, 050659 Bucharest, Romania, Department of Dermatology, Faculty of Pharmacological Sciences, ‘Dunarea de Jos’ University of Medicine and Pharmacy, 800201 Galati, Romania
  • Pages: 895-899
    |
    Published online on: May 9, 2019
       https://doi.org/10.3892/etm.2019.7567
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Abstract

Systemic therapy in patients with concurrent psoriasis and chronic hepatitis B is a challenging task for both dermatologists and gastroenterologists since there is a high risk for hepatitis B virus (HBV) reactivation and hepatic toxicity under biological therapy. The therapeutic management of a patient with psoriasis and infection with the HBV is a challenge as the classical systemic treatment (methotrexate, acitretin, cyclosporine) shows a high risk of immunosuppression and/or hepatic toxicity and the biological therapy is endangered by the possibility of HBV reactivation. We present the case of a patient with moderate-severe psoriasis and chronic hepatitis B for whom we assessed the risk-benefit relation and considered useful to initiate the anti-TNF therapy concomitantly with the antiviral therapy with entecavir. The therapeutic algorithm included initiation of anti-TNF therapy with etanercept 2x50 mg/week combined with entecavir, an antiviral treatment administered continuously since the diagnosis of the HBV hepatitis, with hepatic function and viral load monitoring. After 3 months of therapy with etanercept the patient was given a dose of etanercept of 50 mg/week combined with entecavir 0.5 mg/day which he continued until week 36 when psoriatic lesions had cleared (PASI=0.6; DLQI=0). No adverse effects were registered and there was no evidence of HBV viral replication or changes in viral markers. We wish to emphasize that the use of etanercept in a patient with psoriasis and hepatitis B is a successful therapeutic alternative which may be safely used concomitantly with entecavir, with regular monitoring of viral load and hepatic function tests.
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1 

Boda D, Negrei C, Nicolescu F and Balalau C: Assessment of some oxidative stress parameters in methotrexate treated psoriasis patients. Farmacia. 62:704–710. 2014.

2 

Căruntu C, Boda D, Căruntu A, Rotaru M, Baderca F and Zurac S: In vivo imaging techniques for psoriatic lesions. Rom J Morphol Embryol. 55 (Suppl):1191–1196. 2014.PubMed/NCBI

3 

Batani A, Brănișteanu DE, Ilie MA, Boda D, Ianosi S, Ianosi G and Caruntu C: Assessment of dermal papillary and microvascular parameters in psoriasis vulgaris using in vivo reflectance confocal microscopy. Exp Ther Med. 15:1241–1246. 2018.PubMed/NCBI

4 

Nosotti L, Francesconi F, Izzi S, Berardesca E, Morrone A and Bonifati C: Safety of antitumour necrosis factor-α therapy in psoriatic patients with hepatitis B virus infection. Br J Dermatol. 162:1408–1410. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Fotiadou C, Lazaridou E and Ioannides D: Safety of anti-tumour necrosis factor-α agents in psoriasis patients who were chronic hepatitis B carriers: A retrospective report of seven patients and brief review of the literature. J Eur Acad Dermatol Venereol. 25:471–474. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Cassano N, Mastrandrea V, Principi M, Loconsole F, De Tullio N, Di Leo A and Vena GA: Anti-tumor necrosis factor treatment in occult hepatitis B virus infection: A retrospective analysis of 62 patients with psoriatic disease. J Biol Regul Homeost Agents. 25:285–289. 2011.PubMed/NCBI

7 

Prignano F, Ricceri F, Pescitelli L, Zanieri F and Lotti T: Tumour necrosis factor-α antagonists in patients with concurrent psoriasis and hepatitis B or hepatitis C: A retrospective analysis of 17 patients. Br J Dermatol. 164:645–647. 2011.PubMed/NCBI

8 

Romanian Therapeutic Guidelines: Chronic Hepatitis. http://www.ms.ro/wp-content/uploads/2018/08/Anexa_Ordin_protocoale_29_august_2018.pdf

9 

Zoulim F and Durantel D: Antiviral therapies and prospects for a cure of chronic hepatitis B. Cold Spring Harb Perspect Med. 5(a021501)2015.doi: 10.1101/cshperspect.a021501. PubMed/NCBI

10 

Seto WK: Hepatitis B virus reactivation during immunosuppressive therapy: Appropriate risk stratification. World J Hepatol. 7:825–830. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Domm S, Cinatl J and Mrowietz U: The impact of treatment with tumour necrosis factor-alpha antagonists on the course of chronic viral infections: A review of the literature. Br J Dermatol. 159:1217–1228. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Girolomoni G, Altomare G, Ayala F, Berardesca E, Calzavara-Pinton P, Chimenti S, Peserico A, Puglisi Guerra A and Vena GA: Safety of anti-TNFα agents in the treatment of psoriasis and psoriatic arthritis. Immunopharmacol Immunotoxicol. 34:548–560. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Olteanu R, Zota A and Constantin MM: Biosimilars: An update on clinical trials (review of published and ongoing studies). Acta Dermatovenerol Croat. 25:57–66. 2017.PubMed/NCBI

14 

Sanz-Bueno J, Vanaclocha F, García-Doval I, Torrado R, Carretero G, Daudén E, Patricia Ruiz-Genao D, Alsina-Gibert MM, Pérez-Zafrilla B, Pérez-Rial G, et al members of the BIOBADADERM group, : Risk of reactivation of hepatitis B virus infection in psoriasis patients treated with biologics: A retrospective analysis of 20 cases from the BIOBADADERM Database. Actas Dermosifiliogr. 106:477–482. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Lee YH, Bae SC and Song GG: Hepatitis B virus (HBV) reactivation in rheumatic patients with hepatitis core antigen (HBV occult carriers) undergoing anti-tumor necrosis factor therapy. Clin Exp Rheumatol. 31:118–121. 2013.PubMed/NCBI

16 

Kuroda T, Wada Y, Kobayashi D, Sato H, Murakami S, Nakano M and Narita I: Effect of etanercept and entecavil in a patient with rheumatoid arthritis who is a hepatitis B carrier: A review of the literature. Rheumatol Int. 32:1059–1063. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Chung SJ, Kim JK, Park MC, Park YB and Lee SK: Reactivation of hepatitis B viral infection in inactive HBsAg carriers following anti-tumor necrosis factor-alpha therapy. J Rheumatol. 36:2416–2420. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Strohal R, Chimenti S, Vena GA and Girolomoni G: Etanercept provides an effective, safe and flexible short- and long-term treatment regimen for moderate-to-severe psoriasis: A systematic review of current evidence. J Dermatolog Treat. 24:199–208. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Strohal R, Puig L, Chouela E, Tsai TF, Melin J, Freundlich B, Molta CT, Fuiman J, Pedersen R and Robertson D: The efficacy and safety of etanercept when used with as-needed adjunctive topical therapy in a randomised, double-blind study in subjects with moderate-to-severe psoriasis (the PRISTINE trial). J Dermatolog Treat. 24:169–178. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Esposito M, Gisondi P, Cassano N, Babino G, Cannizzaro MV, Ferrucci G, Chimenti S and Giunta A: Treatment adherence to different etanercept regimens, continuous vs. intermittent, in patients affected by plaque-type psoriasis. Drug Dev Res. 75 (Suppl 1):S31–S34. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Babino G, Esposito M, Mazzotta A, Chimenti S and Giunta A: Entecavir and intermittent etanercept therapy in a patient with concurrent hepatitis B virus infection and psoriasis. Acta Derm Venereol. 93:373–374. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Olteanu R, Constantin MM, Zota A, Dorobantu DM, Constantin T, Șerban ED, Bălănescu P, Mihele D and Gheucă Solovăstru L: Original clinical experience and approach to treatment study with interleukin 12/23 inhibitor in moderate-to-severe psoriasis patients. Farmacia. 64:918–921. 2016.

23 

Căruntu C, Boda D, Musat S, Căruntu A and Mandache E: Stress-induced mast cell activation in glabrous and hairy skin. Mediators Inflamm. 2014:1059502014. View Article : Google Scholar : PubMed/NCBI

24 

Negrei C, Arsene AL, Toderescu CD, Boda D and Ilie M: Acitretin treatment in psoriasis may influence the cell membrane fluidity. Farmacia. 60:767–771. 2012.

25 

Caruntu C, Boda D, Dumitrascu G, Constantin C and Neagu M: Proteomics focusing on immune markers in psoriatic arthritis. Biomarkers Med. 9:513–528. 2015. View Article : Google Scholar

26 

Motaparthi K, Stanisic V, Van Voorhees AS, Lebwohl MG and Hsu S; Medical Board of the National Psoriasis Foundation, : From the Medical Board of the National Psoriasis Foundation: Recommendations for screening for hepatitis B infection prior to initiating anti-tumor necrosis factor-alfa inhibitors or other immunosuppressive agents in patients with psoriasis. J Am Acad Dermatol. 70:178–186. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Raducan A, Bucur S, Caruntu C, Constantin T, Nita IE, Manolache N and Constantin M: Therapeutic management with biological anti-TNF-α agent in severe psoriasis associated with chronic hepatitis B: A case report. Exp Ther Med 18: 895-899, 2019.
APA
Raducan, A., Bucur, S., Caruntu, C., Constantin, T., Nita, I.E., Manolache, N., & Constantin, M. (2019). Therapeutic management with biological anti-TNF-α agent in severe psoriasis associated with chronic hepatitis B: A case report. Experimental and Therapeutic Medicine, 18, 895-899. https://doi.org/10.3892/etm.2019.7567
MLA
Raducan, A., Bucur, S., Caruntu, C., Constantin, T., Nita, I. E., Manolache, N., Constantin, M."Therapeutic management with biological anti-TNF-α agent in severe psoriasis associated with chronic hepatitis B: A case report". Experimental and Therapeutic Medicine 18.2 (2019): 895-899.
Chicago
Raducan, A., Bucur, S., Caruntu, C., Constantin, T., Nita, I. E., Manolache, N., Constantin, M."Therapeutic management with biological anti-TNF-α agent in severe psoriasis associated with chronic hepatitis B: A case report". Experimental and Therapeutic Medicine 18, no. 2 (2019): 895-899. https://doi.org/10.3892/etm.2019.7567
Copy and paste a formatted citation
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Spandidos Publications style
Raducan A, Bucur S, Caruntu C, Constantin T, Nita IE, Manolache N and Constantin M: Therapeutic management with biological anti-TNF-α agent in severe psoriasis associated with chronic hepatitis B: A case report. Exp Ther Med 18: 895-899, 2019.
APA
Raducan, A., Bucur, S., Caruntu, C., Constantin, T., Nita, I.E., Manolache, N., & Constantin, M. (2019). Therapeutic management with biological anti-TNF-α agent in severe psoriasis associated with chronic hepatitis B: A case report. Experimental and Therapeutic Medicine, 18, 895-899. https://doi.org/10.3892/etm.2019.7567
MLA
Raducan, A., Bucur, S., Caruntu, C., Constantin, T., Nita, I. E., Manolache, N., Constantin, M."Therapeutic management with biological anti-TNF-α agent in severe psoriasis associated with chronic hepatitis B: A case report". Experimental and Therapeutic Medicine 18.2 (2019): 895-899.
Chicago
Raducan, A., Bucur, S., Caruntu, C., Constantin, T., Nita, I. E., Manolache, N., Constantin, M."Therapeutic management with biological anti-TNF-α agent in severe psoriasis associated with chronic hepatitis B: A case report". Experimental and Therapeutic Medicine 18, no. 2 (2019): 895-899. https://doi.org/10.3892/etm.2019.7567
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