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Efficacy and safety of N‑acetylcysteine therapy for idiopathic pulmonary fibrosis: An updated systematic review and meta‑analysis

  • Authors:
    • Fanchao Fen
    • Jiarui Zhang
    • Zhichao Wang
    • Qi Wu
    • Xianmei Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China, State Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Medicine and Life Science, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China
    Copyright: © Fen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 802-816
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    Published online on: May 15, 2019
       https://doi.org/10.3892/etm.2019.7579
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Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal lung disease with poor prognosis and limited treatment options. N‑acetylcysteine (NAC), an anti‑oxidant drug, has promising potential in the treatment of IPF. In the present systematic review and meta‑analysis, the efficacy and safety of NAC for IPF were investigated. The following databases were comprehensively searched for relevant studies published until August 2018: Pubmed, Embase, Cochrane library, Chinese National Knowledge Infrastructure, Wangfang Database, VIP and the Chinese Biology Medical Database. A total of 21 controlled trials assessing the efficacy and safety of NAC therapy for IPF were identified and primary outcomes [forced vital capacity (FVC), adverse side effects] and secondary outcomes [diffusing capacity for carbon monoxide (DLCO) and its percentage predicted value (DLCO%), vital capacity (VC), partial arterial oxygen pressure (PaO2), 6‑min walking distance test and mortality] were extracted for the meta‑analysis. The risk ratio and mean difference or standardized mean difference with 95% confidence interval were calculated using RevMan 5.3 software. Analysis of the pooled data revealed that, compared with control treatments (routine treatment or drugs other than anti‑oxidants), NAC therapy reduced the decline in lung function, as indicated by the FVC and DLCO, and slowed the progression of the disease, as indicated by the PaO2, while complications and mortality were similar. These results suggest good efficacy, tolerability and safety of the treatment. Furthermore, subgroup analysis revealed that combined therapy including NAC for IPF might be more effective than NAC monotherapy, while oral administration of NAC was safer than inhalation. In conclusion, the results of the present review and meta‑analysis provide important information that may serve as a guide regarding NAC therapy for IPF in clinical practice.
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View References

1 

Lederer DJ and Martinez FJ: Idiopathic pulmonary fibrosis. N Engl J Med. 378:1811–1823. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA, et al: An official ATS/ERS/JRS/ALAT statement: Idiopathic pulmonary fibrosis: Evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 183:788–824. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Richeldi L, Collard HR and Jones MG: Idiopathic pulmonary fibrosis. Lancet. 389:1941–1952. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Hutchinson J, Fogarty A, Hubbard R and McKeever T: Global incidence and mortality of idiopathic pulmonary fibrosis: A systematic review. Eur Respir J. 46:795–806. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Strand MJ, Sprunger D, Cosgrove GP, Fernandez-Perez ER, Frankel SK, Huie TJ, Olson AL, Solomon J, Brown KK and Swigris JJ: Pulmonary function and survival in idiopathic vs secondary usual interstitial pneumonia. Chest. 146:775–785. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Wynn TA: Integrating mechanisms of pulmonary fibrosis. J Exp Med. 208:1339–1350. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Liu YM, Nepali K and Liou JP: Idiopathic pulmonary fibrosis: Current status, recent progress, and emerging targets. J Med Chem. 60:527–553. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Kliment CR and Oury TD: Oxidative stress, extracellular matrix targets, and idiopathic pulmonary fibrosis. Free Radic Biol Med. 49:707–717. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Kinnula VL, Fattman CL, Tan RJ and Oury TD: Oxidative stress in pulmonary fibrosis: A possible role for redox modulatory therapy. Am J Respir Crit Care Med. 172:417–422. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Paliogiannis P, Fois AG, Collu C, Bandinu A, Zinellu E, Carru C, Pirina P, Mangoni AA and Zinellu A: Oxidative stress-linked biomarkers in idiopathic pulmonary fibrosis: A systematic review and meta-analysis. Biomark Med. 12:1175–1184. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Borok Z, Buhl R, Grimes GJ, Bokser AD, Hubbard RC, Holroyd KJ, Roum JH, Czerski DB, Cantin AM and Crystal RG: Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis. Lancet. 338:215–216. 1991. View Article : Google Scholar : PubMed/NCBI

12 

Hagiwara SI, Ishii Y and Kitamura S: Aerosolized administration of N-acetylcysteine attenuates lung fibrosis induced by bleomycin in mice. Am J Respir Crit Care Med. 162:225–231. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Demedts M, Behr J, Buhl R, Costabel U, Dekhuijzen R, Jansen HM, MacNee W, Thomeer M, Wallaert B, Laurent F, et al: High-dose acetylcysteine in idiopathic pulmonary fibrosis. N Engl J Med. 353:2229–2242. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Homma S, Azuma A, Taniguchi H, Ogura T, Mochiduki Y, Sugiyama Y, Nakata K, Yoshimura K, Takeuchi M and Kudoh S; Japan NAC Clinical Study Group, : Efficacy of inhaled N-acetylcysteine monotherapy in patients with early stage idiopathic pulmonary fibrosis. Respirology. 17:467–477. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Sakamoto S, Itoh T, Muramatsu Y, Satoh K, Ishida F, Sugino K, Isobe K and Homma S: Efficacy of pirfenidone in patients with advanced-stage idiopathic pulmonary fibrosis. Intern Med. 52:2495–2501. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Sakamoto S, Muramatsu Y, Satoh K, Ishida F, Kikuchi N, Sano G, Sugino K, Isobe K, Takai Y and Homma S: Effectiveness of combined therapy with pirfenidone and inhaled N-acetylcysteine for advanced idiopathic pulmonary fibrosis: A case-control study. Respirology. 20:445–452. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Tomioka H, Kuwata Y, Imanaka K, Hashimoto K, Ohnishi H, Tada K, Sakamoto H and Iwasaki H: A pilot study of aerosolized N-acetylcysteine for idiopathic pulmonary fibrosis. Respirology. 10:449–455. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Bando M, Hosono T, Mato N, Nakaya T, Yamasawa H, Ohno S and Sugiyama Y: Long-term efficacy of inhaled N-acetylcysteine in patients with idiopathic pulmonary fibrosis. Intern Med. 49:2289–2296. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Behr J, Bendstrup E, Crestani B, Günther A, Olschewski H, Sköld CM, Wells A, Wuyts W, Koschel D, Kreuter M, et al: Safety and tolerability of acetylcysteine and pirfenidone combination therapy in idiopathic pulmonary fibrosis: A randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Respir Med. 4:445–453. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Martinez FJ, de Andrade JA, Anstrom KJ, King TE Jr and Raghu G: Randomized trial of acetylcysteine in idiopathic pulmonary fibrosis. N Engl J Med. 370:2093–2101. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Sun T, Liu J and Zhao de W: Efficacy of N-Acetylcysteine in idiopathic pulmonary fibrosis: A systematic review and meta-analysis. Medicine (Baltimore). 95:e36292016. View Article : Google Scholar : PubMed/NCBI

22 

Kandhare AD, Mukherjee A, Ghosh P and Bodhankar SL: Efficacy of antioxidant in idiopathic pulmonary fibrosis: A systematic review and meta-analysis. EXCLI J. 15:636–651. 2016.PubMed/NCBI

23 

Birmingham CL: Total parenteral nutrition in the critically ill patient. Lancet. 353:1116–1117. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Langlois PL, Manzanares W, Adhikari NKJ, Lamontagne F, Stoppe C, Hill A and Heyland DK: Vitamin C administration in the critically ill: A systematic review and meta-analysis. JPEN J Parenter Enteral Nutr. 43:335–346. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Manzanares W, Lemieux M, Elke G, Langlois PL, Bloos F and Heyland DK: High-dose intravenous selenium does not improve clinical outcomes in the critically ill: A systematic review and meta-analysis. Crit Care. 20:3562016. View Article : Google Scholar : PubMed/NCBI

26 

Fu SQ, Wang J, Yan YN and Fu SB: Effects of acetylcysteine plus prednisone for idiopathic pulmonary fibrosis patients. Clin Focus. 30:38–40. 2015.(In Chinese).

27 

Huang QY: Therapeutic effect of N-acetylcysteine combined with glucocorticoid for idiopathic pulmonary fibrosis. Chin J Clin Ration Drug Use. 8:52–53. 2015.(In Chinese).

28 

Jiang AG, Lu HY and Duan DJ: Therapeutic effect of N-acetylcysteine combined with glucocorticoid for idiopathic pulmonary fibrosis. J Clin Med Pract. 13:69–70. 2009.(In Chinese).

29 

Jiang YQ and Jiang H: Therapeutic effect of N-acetylcysteine 20 idiopathic pulmonary fibrosis patients. Chinese Community Doctors. 10:43–44. 2008.(In Chinese).

30 

Liu XJ: Glucocorticoid combined with acetylcysteine for treating idiopathic pulmonary fibrosis in 58 cases. China Pharmaceuticals. 25:99–101. 2016.(In Chinese).

31 

Liu Y: Clinical effect of budesonide atomization inhalation combined with N-Acetylcysteine on idiopathic pulmonary fibrosis. Pract J Cardiac Cereb Pneumal Vasc Dis. 23:74–77. 2015.(In Chinese).

32 

Long QZ, Du J, Zhang XM, Ma W and Hui K: Curative effect of combination of interferon-γ, n-acetylcysteine and low dose prednisone on idiopathic pulmonary interstitial fibrosis. J Guiyang Med Coll. 36:465–469. 2011.(In Chinese).

33 

Lu JH and Gao JZ: Therapeutic effect of N-acetylcysteine combined glucocorticoid on nitric oxide in idiopathic pulmonary fibrosis patients. Chin J Lab Diagn. 17:1692–1693. 2013.(In Chinese).

34 

Luo HJ: Effect of N-acetylcysteine on pulmonary function of idiopathic pulmonary fibrosis patients. Chin J Clin Pract Med. 7:60–61. 2006.(In Chinese).

35 

Nan QQ: Influence of N-acetylcysteine on serum interlukin-13 for idiopathic pulmonary fibrosis patients. Chin J Prim Med Pharm. 14:1513–1514. 2007.(In Chinese).

36 

Wang CH, Li CH and Kong B: Therapeutic effect of N-acetylcysteine on patients with idiopathic pulmonary fibrosis. Chin J Diffic and Compl Cas. 14:129–136. 2015.(In Chinese).

37 

Yang ZG, Ma XT and Wang SQ: Observation on treating effect of N-acetylcystein on idiopathic pulmonary fibrosis. J Med Forum. 29:18–20. 2008.(In Chinese).

38 

Zhu JY, Zeng YQ, Yuan LJ, Chen G, Wang YL and Hu K: Study on the treatment of idiopathic pulmonary fibrosis with prednisone, N-acetylcysteine combined Captopril. J Yunyang Med Coll. 28:582–584. 2009.(In Chinese).

39 

Noble PW, Barkauskas CE and Jiang D: Pulmonary fibrosis: Patterns and perpetrators. J Clin Invest. 122:2756–2762. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Lancaster LH, de Andrade JA, Zibrak JD, Padilla ML, Albera C, Nathan SD, Wijsenbeek MS, Stauffer JL, Kirchgaessler KU and Costabel U: Pirfenidone safety and adverse event management in idiopathic pulmonary fibrosis. Eur Respir Rev. 26:1700572017. View Article : Google Scholar : PubMed/NCBI

41 

Richeldi L, du Bois RM, Raghu G, Azuma A, Brown KK, Costabel U, Cottin V, Flaherty KR, Hansell DM, Inoue Y, et al: Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis. N Engl J Med. 370:2071–2082. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Duecker R, Baer P, Eickmeier O, Strecker M, Kurz J, Schaible A, Henrich D, Zielen S and Schubert R: Oxidative stress-driven pulmonary inflammation and fibrosis in a mouse model of human ataxia-telangiectasia. Redox Biol. 14:645–655. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Hosseinzadeh A, Javad-Moosavi SA, Reiter RJ, Yarahmadi R, Ghaznavi H and Mehrzadi S: Oxidative/nitrosative stress, autophagy and apoptosis as therapeutic targets of melatonin in idiopathic pulmonary fibrosis. Expert Opin Ther Targets. 22:1049–1061. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Oldham JM, Ma SF, Martinez FJ, Anstrom KJ, Raghu G, Schwartz DA, Valenzi E, Witt L, Lee C, Vij R, et al: TOLLIP, MUC5B, and the response to N-acetylcysteine among individuals with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 192:1475–1482. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Idiopathic Pulmonary Fibrosis Clinical Research Network, ; Raghu G, Anstrom KJ, King TE Jr, Lasky JA and Martinez FJ: Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis. N Engl J Med. 366:1968–1977. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Newton CA, Zhang D, Oldham JM, Kozlitina J, Ma SF, Martinez FJ, Raghu G, Noth I and Garcia CK: Telomere length and use of immunosuppressive medications in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. Dec 19–2018.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fen F, Zhang J, Wang Z, Wu Q and Zhou X: Efficacy and safety of N‑acetylcysteine therapy for idiopathic pulmonary fibrosis: An updated systematic review and meta‑analysis. Exp Ther Med 18: 802-816, 2019.
APA
Fen, F., Zhang, J., Wang, Z., Wu, Q., & Zhou, X. (2019). Efficacy and safety of N‑acetylcysteine therapy for idiopathic pulmonary fibrosis: An updated systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 18, 802-816. https://doi.org/10.3892/etm.2019.7579
MLA
Fen, F., Zhang, J., Wang, Z., Wu, Q., Zhou, X."Efficacy and safety of N‑acetylcysteine therapy for idiopathic pulmonary fibrosis: An updated systematic review and meta‑analysis". Experimental and Therapeutic Medicine 18.1 (2019): 802-816.
Chicago
Fen, F., Zhang, J., Wang, Z., Wu, Q., Zhou, X."Efficacy and safety of N‑acetylcysteine therapy for idiopathic pulmonary fibrosis: An updated systematic review and meta‑analysis". Experimental and Therapeutic Medicine 18, no. 1 (2019): 802-816. https://doi.org/10.3892/etm.2019.7579
Copy and paste a formatted citation
x
Spandidos Publications style
Fen F, Zhang J, Wang Z, Wu Q and Zhou X: Efficacy and safety of N‑acetylcysteine therapy for idiopathic pulmonary fibrosis: An updated systematic review and meta‑analysis. Exp Ther Med 18: 802-816, 2019.
APA
Fen, F., Zhang, J., Wang, Z., Wu, Q., & Zhou, X. (2019). Efficacy and safety of N‑acetylcysteine therapy for idiopathic pulmonary fibrosis: An updated systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 18, 802-816. https://doi.org/10.3892/etm.2019.7579
MLA
Fen, F., Zhang, J., Wang, Z., Wu, Q., Zhou, X."Efficacy and safety of N‑acetylcysteine therapy for idiopathic pulmonary fibrosis: An updated systematic review and meta‑analysis". Experimental and Therapeutic Medicine 18.1 (2019): 802-816.
Chicago
Fen, F., Zhang, J., Wang, Z., Wu, Q., Zhou, X."Efficacy and safety of N‑acetylcysteine therapy for idiopathic pulmonary fibrosis: An updated systematic review and meta‑analysis". Experimental and Therapeutic Medicine 18, no. 1 (2019): 802-816. https://doi.org/10.3892/etm.2019.7579
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