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Article

miR‑25‑3p promotes glioma cell proliferation and migration by targeting FBXW7 and DKK3

  • Authors:
    • Gang Peng
    • Chenxing Yang
    • Yi Liu
    • Chenfu Shen
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Xiangya Hospital of Central South University, Changsha, Hunan 410008, P.R. China
  • Pages: 769-778
    |
    Published online on: May 15, 2019
       https://doi.org/10.3892/etm.2019.7583
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Abstract

MicroRNAs (miRs) serve important roles in glioma. However, the underlying molecular mechanism of miR‑25 in glioma progression remains largely unknown; therefore, it was investigated in the present study. RT‑qPCR analysis revealed that miR‑25 expression levels were markedly increased in human glioma tissue and glioma cell lines compared with normal brain tissues and normal human astrocytes, respectively. miR‑25 upregulation exhibited an association with glioma progression, and the knockdown of miR‑25 significantly inhibited glioma cell proliferation and migration. F‑box and WD repeat domain containing 7 (FBXW7) and dickkopf WNT signaling pathway inhibitor 3 (DKK3) were identified as target genes of miR‑25. FBXW7 and DKK3 expression levels were significantly downregulated in glioma tissue samples compared with normal brain tissue, and their expression levels were negatively regulated by miR‑25 expression in glioma cells. Furthermore, inhibition of FBXW7 and DKK3 expression suppressed the miR‑25‑induced effects on glioma cell proliferation and migration. The findings of the present study suggest that miR‑25 may promote glioma cell proliferation and migration by inhibiting the expression of FBXW7 and DKK3. Therefore, miR‑25 may serve as a promising molecular target for the treatment of glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Peng G, Yang C, Liu Y and Shen C: miR‑25‑3p promotes glioma cell proliferation and migration by targeting FBXW7 and DKK3. Exp Ther Med 18: 769-778, 2019.
APA
Peng, G., Yang, C., Liu, Y., & Shen, C. (2019). miR‑25‑3p promotes glioma cell proliferation and migration by targeting FBXW7 and DKK3. Experimental and Therapeutic Medicine, 18, 769-778. https://doi.org/10.3892/etm.2019.7583
MLA
Peng, G., Yang, C., Liu, Y., Shen, C."miR‑25‑3p promotes glioma cell proliferation and migration by targeting FBXW7 and DKK3". Experimental and Therapeutic Medicine 18.1 (2019): 769-778.
Chicago
Peng, G., Yang, C., Liu, Y., Shen, C."miR‑25‑3p promotes glioma cell proliferation and migration by targeting FBXW7 and DKK3". Experimental and Therapeutic Medicine 18, no. 1 (2019): 769-778. https://doi.org/10.3892/etm.2019.7583
Copy and paste a formatted citation
x
Spandidos Publications style
Peng G, Yang C, Liu Y and Shen C: miR‑25‑3p promotes glioma cell proliferation and migration by targeting FBXW7 and DKK3. Exp Ther Med 18: 769-778, 2019.
APA
Peng, G., Yang, C., Liu, Y., & Shen, C. (2019). miR‑25‑3p promotes glioma cell proliferation and migration by targeting FBXW7 and DKK3. Experimental and Therapeutic Medicine, 18, 769-778. https://doi.org/10.3892/etm.2019.7583
MLA
Peng, G., Yang, C., Liu, Y., Shen, C."miR‑25‑3p promotes glioma cell proliferation and migration by targeting FBXW7 and DKK3". Experimental and Therapeutic Medicine 18.1 (2019): 769-778.
Chicago
Peng, G., Yang, C., Liu, Y., Shen, C."miR‑25‑3p promotes glioma cell proliferation and migration by targeting FBXW7 and DKK3". Experimental and Therapeutic Medicine 18, no. 1 (2019): 769-778. https://doi.org/10.3892/etm.2019.7583
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