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Therapeutic effect of vitamin K1 combined with meropenem on the treatment of pertussis syndrome

  • Authors:
    • Wenxin Chen
    • Yufeng Guo
  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Internal Medicine, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252600, P.R. China, Department of Cardiothoracic Surgery, The Second People's Hospital of Liaocheng, Liaocheng, Shandong 252600, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 642-646
    |
    Published online on: May 16, 2019
       https://doi.org/10.3892/etm.2019.7586
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Abstract

Clinical efficacy of vitamin K1 combined with meropenem on the treatment of pertussis syndrome was evaluated. Clinical data of 170 children with pertussis syndrome treated in the Second People's Hospital of Liaocheng from March 2015 to March 2017 were collected. Of these, 87 patients who were treated with vitamin K1 combined with meropenem were regarded as the experiment group. A total of 83 patients who were treated with meropenem alone were regarded as the control group. Both groups were treated with anti‑infective, respiratory support, antispasmodic, expectorant and other basic treatments. The therapeutic effects, duration of spasmodic cough, length of hospitalization, antipyretic time, duration of voice disappearance and healing time were observed between the two groups. The duration of spasmodic cough and length of hospitalization in the experiment were lower than the control group, and the difference was statistically significant between the groups (P<0.05). The explicit efficiency (51.72%) and total effective efficiency (99.55%) in the experiment group were significantly higher than the explicit efficiency (36.14%) and total effective efficiency (78.31%) in the control group. There was a statistically significant difference between the groups (P<0.05). The voice disappearance time and healing time in the experiment group were significantly shorter than the control group, and there was a statistically significant difference between the groups (P<0.05). The antipyretic time in the experiment group was lower than that of the control group, the difference between the groups was not statistically significant (P>0.05). The treatment with vitamin K1 and meropenem has a significant effect in relieving pediatric pertussis syndrome, it can shorten the duration of spasmodic cough, antipyretic time, duration of voice disappearance and length of hospitalization in children with pertussis syndrome, and improve the efficacy clinically.
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Copy and paste a formatted citation
Spandidos Publications style
Chen W and Guo Y: Therapeutic effect of vitamin K1 combined with meropenem on the treatment of pertussis syndrome. Exp Ther Med 18: 642-646, 2019.
APA
Chen, W., & Guo, Y. (2019). Therapeutic effect of vitamin K1 combined with meropenem on the treatment of pertussis syndrome. Experimental and Therapeutic Medicine, 18, 642-646. https://doi.org/10.3892/etm.2019.7586
MLA
Chen, W., Guo, Y."Therapeutic effect of vitamin K1 combined with meropenem on the treatment of pertussis syndrome". Experimental and Therapeutic Medicine 18.1 (2019): 642-646.
Chicago
Chen, W., Guo, Y."Therapeutic effect of vitamin K1 combined with meropenem on the treatment of pertussis syndrome". Experimental and Therapeutic Medicine 18, no. 1 (2019): 642-646. https://doi.org/10.3892/etm.2019.7586
Copy and paste a formatted citation
x
Spandidos Publications style
Chen W and Guo Y: Therapeutic effect of vitamin K1 combined with meropenem on the treatment of pertussis syndrome. Exp Ther Med 18: 642-646, 2019.
APA
Chen, W., & Guo, Y. (2019). Therapeutic effect of vitamin K1 combined with meropenem on the treatment of pertussis syndrome. Experimental and Therapeutic Medicine, 18, 642-646. https://doi.org/10.3892/etm.2019.7586
MLA
Chen, W., Guo, Y."Therapeutic effect of vitamin K1 combined with meropenem on the treatment of pertussis syndrome". Experimental and Therapeutic Medicine 18.1 (2019): 642-646.
Chicago
Chen, W., Guo, Y."Therapeutic effect of vitamin K1 combined with meropenem on the treatment of pertussis syndrome". Experimental and Therapeutic Medicine 18, no. 1 (2019): 642-646. https://doi.org/10.3892/etm.2019.7586
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