MMP-9 and TIMP-1 in placenta of hypertensive disorder complicating pregnancy

Zhang,Yuyi; Li,Peng; Guo,Yue; Liu,Xiaowan; Zhang,Yubo

doi:10.3892/etm.2019.7591

July-2019 Volume 18 Issue 1

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July-2019 Volume 18 Issue 1

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MMP-9 and TIMP-1 in placenta of hypertensive disorder complicating pregnancy

Authors:
- Yuyi Zhang
- Peng Li
- Yue Guo
- Xiaowan Liu
- Yubo Zhang
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Affiliations: Department of Gynecology and Obstetrics, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China, Department of General Surgery, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China, Department of Gynecology, People's Hospital of Xinjiang Uygur, Urumqi, Xinjiang Uygur Autonomous Region 830001, P.R. China, Department of Stomatology, Quzhou No. 2 People's Hospital, Jinhua, Zhejiang 321000, P.R. China
Pages: 637-641
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Published online on: May 17, 2019

https://doi.org/10.3892/etm.2019.7591
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Abstract

Expression and characteristics of matrix metalloproteinase-9 (MMP-9) and TIMP metallopeptidase inhibitor-1 (TIMP-1) in the placenta of pregnancy induced hypertension (PIH) were detected in Uygur to analyze its correlation with PIH, and to provide a theoretical basis for clinical work. Ninety cases of placental tissue patients who were hospitalized in the Department of Obstetrics of People's Hospital of Xinjiang Uygur from December 2014 to September 2016 were collected, including 30 cases of severe preeclampsia, 30 cases of mild preeclampsia, and 30 cases of normal group. The distribution of MMP-9 and TIMP-1 in placenta was mainly in the cytoplasm of trophoblast cells, vascular endothelial cells and villous mesenchymal cells. The distribution of MMP-9 positive particles in the placenta tissue of the severe group was significantly reduced. The difference of MMP-9 in the three groups was statistically significant. Severe group was statistically significantly different from normal and mild group. With the aggravation of PIH, positive expression of MMP-9 was gradually decreased. TIMP-1 was expressed in each group, and difference was not statistically significant. Positive expression ratio of MMP-9/TIMP-1 in severe group was lower than that in normal pregnancy and mild group, and positive expression ratio of the two groups became smaller as the condition worsened. Positive expression of MMP-9 in placental tissue of patients with PIH decreased significantly with the severity of PIH. TIMP-1 in placental tissue of PIH patients did not change much in each group, and had no significant correlation with PIH.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

MMP-9 and TIMP-1 in placenta of hypertensive disorder complicating pregnancy

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