lncRNA NEF inhibits glioma by downregulating TGF‑β1

Huang,Qiao; Chen,Hua; Zuo,Bin; Cheng,Chen; Yu,Wei; Yang,Yuenan

doi:10.3892/etm.2019.7602

lncRNA NEF inhibits glioma by downregulating TGF‑β1

Authors:
- Qiao Huang
- Hua Chen
- Bin Zuo
- Chen Cheng
- Wei Yu
- Yuenan Yang
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Affiliations: Department of Oncology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei 443003, P.R. China, Department of Neurosurgery, Yichang Second People's Hospital, Yichang, Hubei 443000, P.R. China
Published online on: May 23, 2019 https://doi.org/10.3892/etm.2019.7602
Pages: 692-698

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Abstract

NEF is a tumor suppressing long non‑coding (lnc)RNA in hepatocellular carcinoma. Based on current literature, the involvement of NEF in other human diseases is still unknown. The current study aimed to investigate the potential involvement of NEF in glioma, which is a type of rare, but aggressive malignancy. It was determined that NEF expression was downregulated in tumor tissues compared with adjacent heathy tissues. A low blood NEF level in patients with glioma effectively distinguished patients from healthy controls who had high blood NEF levels. Blood NEF levels were significantly correlation with distant tumor metastasis, but not tumor growth. Blood NEF levels were negatively correlated with blood transforming growth factor (TGF)‑β1 levels in patients with distant tumor metastasis, but not in patients with non‑metastatic glioma and healthy controls. NEF overexpression inhibited cancer cell migration and invasion. In addition, NEF overexpression downregulated TGF‑β1 expression. The authors of the current study concluded that lncRNA NEF may inhibit glioma cell migration and invasion by downregulating TGF‑β1.

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1	Mehlen P and Puisieux A: Metastasis: A question of life or death. Nat Rev Cancer. 6:449–458. 2006. View Article : Google Scholar : PubMed/NCBI
2	Valastyan S and Weinberg RA: Tumor metastasis: Molecular insights and evolving paradigms. Cell. 147:275–292. 2011. View Article : Google Scholar : PubMed/NCBI
3	Omuro A and DeAngelis LM: Glioblastoma and other malignant gliomas: A clinical review. JAMA. 310:1842–1850. 2013. View Article : Google Scholar : PubMed/NCBI
4	Mishra MV, Andrews DW, Glass J, Evans JJ, Dicker AP, Shen X and Lawrence YR: Characterization and outcomes of optic nerve gliomas: A population-based analysis. J Neurooncol. 107:591–597. 2012. View Article : Google Scholar : PubMed/NCBI
5	Stark AM, van de Bergh J, Hedderich J, Mehdorn HM and Nabavi A: Glioblastoma: Clinical characteristics, prognostic factors and survival in 492 patients. Clin Neurol Neurosurg. 114:840–845. 2012. View Article : Google Scholar : PubMed/NCBI
6	Akhurst RJ and Derynck R: TGF-beta signaling in cancer-a double-edged sword. Trends Cell Biol. 11:S44–S51. 2001. View Article : Google Scholar : PubMed/NCBI
7	Han J, Alvarez-Breckenridge CA, Wang QE and Yu J: TGF-β signaling and its targeting for glioma treatment. Am J Cancer Res. 5:945–955. 2015.PubMed/NCBI
8	Yuan J, Yang F, Wang F, Ma JZ, Guo YJ, Tao QF, Liu F, Pan W, Wang TT, Zhou CC, et al: A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma. Cancer Cell. 25:666–681. 2014. View Article : Google Scholar : PubMed/NCBI
9	Fan Y, Shen B, Tan M, Mu X, Qin Y, Zhang F and Liu Y: TGF-β-induced upregulation of malat1 promotes bladder cancer metastasis by associating with suz12. Clin Cancer Res. 20:1531–1541. 2014. View Article : Google Scholar : PubMed/NCBI
10	Prensner JR and Chinnaiyan AM: The emergence of lncRNAs in cancer biology. Cancer Discov. 1:391–407. 2011. View Article : Google Scholar : PubMed/NCBI
11	Liang WC, Ren JL, Wong CW, Chan SO, Waye MM, Fu WM and Zhang JF: LncRNA-NEF antagonized epithelial to mesenchymal transition and cancer metastasis via cis-regulating FOXA2 and inactivating Wnt/β-catenin signaling. Oncogene. 37:1445–1456. 2018. View Article : Google Scholar : PubMed/NCBI
12	Zhang J, Tian XJ and Xing J: Signal transduction pathways of EMT induced by TGF-β, SHH, and WNT and their crosstalks. J Clin Med. 5:E412016. View Article : Google Scholar : PubMed/NCBI
13	Zhang X, Sun S, Pu JK, Tsang AC, Lee D, Man VO, Lui WM, Wong ST and Leung GK: Long non-coding RNA expression profiles predict clinical phenotypes in glioma. Neurobiol Dis. 48:1–8. 2012. View Article : Google Scholar : PubMed/NCBI
14	Ma KX, Wang HJ, Li XR, Li T, Su G, Yang P and Wu JW: Long noncoding RNA MALAT1 associates with the malignant status and poor prognosis in glioma. Tumor Biol. 36:3355–3359. 2015. View Article : Google Scholar
15	Li J, Zhang M, An G and Ma Q: LncRNA TUG1 acts as a tumor suppressor in human glioma by promoting cell apoptosis. Exp Biol Med (Maywood). 241:644–649. 2016. View Article : Google Scholar : PubMed/NCBI
16	Kros JM, Mustafa DM, Dekker LJ, Sillevis Smitt PA, Luider TM and Zheng PP: Circulating glioma biomarkers. Neuro Oncol. 17:343–360. 2015.PubMed/NCBI
17	Pan W, Gu W, Nagpal S, Gephart MH and Quake SR: Brain tumor mutations detected in cerebral spinal fluid. Clin Chem. 61:514–522. 2015. View Article : Google Scholar : PubMed/NCBI
18	Westphal M and Lamszus K: Circulating biomarkers for gliomas. Nat Rev Neurol. 11:556–566. 2015. View Article : Google Scholar : PubMed/NCBI