lncRNA NEF inhibits glioma by downregulating TGF‑β1

Huang,Qiao; Chen,Hua; Zuo,Bin; Cheng,Chen; Yu,Wei; Yang,Yuenan

doi:10.3892/etm.2019.7602

July-2019 Volume 18 Issue 1

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July-2019 Volume 18 Issue 1

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Article

lncRNA NEF inhibits glioma by downregulating TGF‑β1

Authors:
- Qiao Huang
- Hua Chen
- Bin Zuo
- Chen Cheng
- Wei Yu
- Yuenan Yang
View Affiliations / Copyright

Affiliations: Department of Oncology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei 443003, P.R. China, Department of Neurosurgery, Yichang Second People's Hospital, Yichang, Hubei 443000, P.R. China
Pages: 692-698
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Published online on: May 23, 2019

https://doi.org/10.3892/etm.2019.7602
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Abstract

NEF is a tumor suppressing long non‑coding (lnc)RNA in hepatocellular carcinoma. Based on current literature, the involvement of NEF in other human diseases is still unknown. The current study aimed to investigate the potential involvement of NEF in glioma, which is a type of rare, but aggressive malignancy. It was determined that NEF expression was downregulated in tumor tissues compared with adjacent heathy tissues. A low blood NEF level in patients with glioma effectively distinguished patients from healthy controls who had high blood NEF levels. Blood NEF levels were significantly correlation with distant tumor metastasis, but not tumor growth. Blood NEF levels were negatively correlated with blood transforming growth factor (TGF)‑β1 levels in patients with distant tumor metastasis, but not in patients with non‑metastatic glioma and healthy controls. NEF overexpression inhibited cancer cell migration and invasion. In addition, NEF overexpression downregulated TGF‑β1 expression. The authors of the current study concluded that lncRNA NEF may inhibit glioma cell migration and invasion by downregulating TGF‑β1.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

lncRNA NEF inhibits glioma by downregulating TGF‑β1

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Abstract

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