Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2019 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2019 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Reduced miR‑202 levels enhanced oral cancer development via targeting Sp1

Retraction in: /10.3892/etm.2024.12539
  • Authors:
    • Jia Zhao
    • Deguang Ding
    • Ge Zhao
  • View Affiliations / Copyright

    Affiliations: Special Clinic, Jinan Stomatology Hospital, Jinan, Shandong 250001, P.R. China, Department of Stomatology, Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250001, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 489-496
    |
    Published online on: May 23, 2019
       https://doi.org/10.3892/etm.2019.7603
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The current study aimed to evaluate the possible role of microRNA (miR)‑202 in the development of oral cancer. First, miR‑202 levels were found to be decreased in the serum and tissues of oral cancer patients compared with healthy controls. Receiver operating characteristic analysis was carried out to explore the diagnostic value of serum miR‑202 for oral cancer. Overexpression of miR‑202 significantly decreased the migratory capacity of SCC‑9 cells, while inhibition of miR‑202 markedly increased the migratory capacity of SCC‑9 cells. Moreover, the invasive capacity was decreased in SCC‑9 cells transfected with an miR‑202 mimic. In addition, the invasive capacity was enhanced in SCC‑9 cells transfected with an miR‑202 inhibitor. A dual luciferase reporter assay showed that overexpression of miR‑202 markedly suppressed the relative luciferase activity of the pmirGLO‑SP1‑3'untranslated region. Overexpression of miR‑202 suppressed the protein level of Sp1, but inhibition of miR‑202 markedly enhanced the protein expression of Sp1. Inhibition of miR‑202 enhanced the phosphorylation of protein kinase B. Additionally, the correlations between the expression levels of Sp1 and miR‑202 and the clinicopathological factors of oral cancer were analyzed. The results showed that patients with high expression of Sp1 and miR‑202 progressed to earlier clinical stages, had deeper infiltration depths and were more prone to lymph node metastasis compared with the healthy controls. In conclusion, the current study presented novel data indicating that decreased miR‑202 enhanced the progression of oral cancer via Sp1.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Lin SS, Peng CY, Liao YW, Chou MY, Hsieh PL and Yu CC: miR-1246 targets CCNG2 to enhance cancer stemness and chemoresistance in oral carcinomas. Cancers (Basel). 10:E2722018. View Article : Google Scholar : PubMed/NCBI

2 

Min SK, Jung SY, Kang HK, Park SA, Lee JH, Kim MJ and Min BM: Functional diversity of miR-146a-5p and TRAF6 in normal and oral cancer cells. Int J Oncol. 51:1541–1552. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Fang CY, Chen PY, Ho DC, Tsai LL, Hsieh PL, Lu MY, Yu CC and Yu CH: miR-145 mediates the anti-cancer stemness effect of photodynamic therapy with 5-aminolevulinic acid (ALA) in oral cancer cells. J Formos Med Assoc. 117:738–742. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Cheng CM, Shiah SG, Huang CC, Hsiao JR and Chang JY: Up-regulation of miR-455-5p by the TGF-β-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B. J Pathol. 240:38–49. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Christopher AF, Gupta M and Bansal P: Micronome revealed miR-19a/b as key regulator of SOCS3 during cancer related inflammation of oral squamous cell carcinoma. Gene. 594:30–40. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Dickman CT, Lawson J, Jabalee J, MacLellan SA, LePard NE, Bennewith KL and Garnis C: Selective extracellular vesicle exclusion of miR-142-3p by oral cancer cells promotes both internal and extracellular malignant phenotypes. Oncotarget. 8:15252–15266. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Kuo YZ, Tai YH, Lo HI, Chen YL, Cheng HC, Fang WY, Lin SH, Yang CL, Tsai ST and Wu LW: MiR-99a exerts anti-metastasis through inhibiting myotubularin-related protein 3 expression in oral cancer. Oral Dis. 20:e65–e75. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Li TK, Yin K, Chen Z, Bao Y and Zhang SX: MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5. Genet Mol Res. Mar 8–2017.(Epub ahead of print). doi: 10.4238/gmr16019327. View Article : Google Scholar

9 

Li X, Fan Q, Li J, Song J and Gu Y: MiR-124 down-regulation is critical for cancer associated fibroblasts-enhanced tumor growth of oral carcinoma. Exp Cell Res. 351:100–108. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Ling Z, Liu D, Zhang G, Liang Q, Xiang P, Xu Y, Han C and Tao T: miR-361-5p modulates metabolism and autophagy via the Sp1-mediated regulation of PKM2 in prostate cancer. Oncol Rep. 38:1621–1628. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Mak CS, Yung MM, Hui LM, Leung LL, Liang R, Chen K, Liu SS, Qin Y, Leung TH, Lee KF, et al: MicroRNA-141 enhances anoikis resistance in metastatic progression of ovarian cancer through targeting KLF12/Sp1/survivin axis. Mol Cancer. 16:112017. View Article : Google Scholar : PubMed/NCBI

12 

Meng Q, Wang S, Tang W, Wu S, Gao N, Zhang C, Cao X, Li X, Zhang Z, Aschner M, et al: XRCC1 mediated the development of cervival cancer through a novel Sp1/Krox-20 swich. Oncotarget. 8:86217–86226. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Muramoto K, Tange R, Ishii T, Miyauchi K and Sato T: Downregulation of transcription factor Sp1 suppresses malignant properties of A549 human lung cancer cell line with decreased β4-galactosylation of highly branched N-glycans. Biol Pharm Bull. 40:1282–1288. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Peng M, Hu Y, Song W, Duan S, Xu Q, Ding Y, Geng J and Zhou J: MIER3 suppresses colorectal cancer progression by down-regulating Sp1, inhibiting epithelial-mesenchymal transition. Sci Rep. 7:110002017. View Article : Google Scholar : PubMed/NCBI

15 

Yang CZ, Ma J, Zhu DW, Liu Y, Montgomery B, Wang LZ, Li J, Zhang ZY, Zhang CP and Zhong LP: GDF15 is a potential predictive biomarker for TPF induction chemotherapy and promotes tumorigenesis and progression in oral squamous cell carcinoma. Ann Oncol. 25:1215–1222. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Liborio-Kimura TN, Jung HM and Chan EK: miR-494 represses HOXA10 expression and inhibits cell proliferation in oral cancer. Oral Oncol. 51:151–157. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Liu CM, Peng CY, Liao YW, Lu MY, Tsai ML, Yeh JC, Yu CH and Yu CC: Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction. J Formos Med Assoc. 116:41–48. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Lopes CB, Magalhães LL, Teófilo CR, Alves APNN, Montenegro RC, Negrini M and Ribeiro-Dos-Santos Â: Differential expression of hsa-miR-221, hsa-miR-21, hsa-miR-135b and hsa-miR-29c suggests a field effect in oral cancer. BMC Cancer. 18:7212018. View Article : Google Scholar : PubMed/NCBI

20 

Su F, Geng J, Li X, Qiao C, Luo L, Feng J, Dong X and Lv M: SP1 promotes tumor angiogenesis and invasion by activating VEGF expression in an acquired trastuzumab-resistant ovarian cancer model. Oncol Rep. 38:2677–2684. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Xiao Q, Zheng F, Wu J, Tang Q, Wang W and Hann SS: Activation of ERK and mutual regulation of stat3 and SP1 contribute to inhibition of PDK1 expression by atractylenolide-1 in human lung cancer cells. Cell Physiol Biochem. 43:2353–2366. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Ye Y, Qian XY, Xiao MM, Shao YL, Guo LM, Liao DP, Da J, Zhang LJ and Xu J: Decreased Sp1 expression mediates downregulation of SHIP2 in gastric cancer cells. Int J Mol Sci. 18:E2202017. View Article : Google Scholar : PubMed/NCBI

23 

Wang ZQ, Cai Q, Hu L, He CY, Li JF, Quan ZW, Liu BY, Li C and Zhu ZG: Long noncoding RNA UCA1 induced by SP1 promotes cell proliferation via recruiting EZH2 and activating AKT pathway in gastric cancer. Cell Death Dis. 8:e28392017. View Article : Google Scholar : PubMed/NCBI

24 

Dauer P, Gupta VK, McGinn O, Nomura A, Sharma NS, Arora N, Giri B, Dudeja V, Saluja AK and Banerjee S: Inhibition of Sp1 prevents ER homeostasis and causes cell death by lysosomal membrane permeabilization in pancreatic cancer. Sci Rep. 7:15642017. View Article : Google Scholar : PubMed/NCBI

25 

Han D, Cho JH, Lee RH, Bang W, Park K, Kim MS, Shim JH, Chae JI and Moon SY: Antitumorigenic effect of atmospheric-pressure dielectric barrier discharge on human colorectal cancer cells via regulation of Sp1 transcription factor. Sci Rep. 7:430812017. View Article : Google Scholar : PubMed/NCBI

26 

Huang H, Jin H, Zhao H, Wang J, Li X, Yan H, Wang S, Guo X, Xue L, Li J, et al: RhoGDIβ promotes Sp1/MMP-2 expression and bladder cancer invasion through perturbing miR-200c-targeted JNK2 protein translation. Mol Oncol. 11:1579–1594. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao J, Ding D and Zhao G: Reduced miR‑202 levels enhanced oral cancer development via targeting Sp1 Retraction in /10.3892/etm.2024.12539. Exp Ther Med 18: 489-496, 2019.
APA
Zhao, J., Ding, D., & Zhao, G. (2019). Reduced miR‑202 levels enhanced oral cancer development via targeting Sp1 Retraction in /10.3892/etm.2024.12539. Experimental and Therapeutic Medicine, 18, 489-496. https://doi.org/10.3892/etm.2019.7603
MLA
Zhao, J., Ding, D., Zhao, G."Reduced miR‑202 levels enhanced oral cancer development via targeting Sp1 Retraction in /10.3892/etm.2024.12539". Experimental and Therapeutic Medicine 18.1 (2019): 489-496.
Chicago
Zhao, J., Ding, D., Zhao, G."Reduced miR‑202 levels enhanced oral cancer development via targeting Sp1 Retraction in /10.3892/etm.2024.12539". Experimental and Therapeutic Medicine 18, no. 1 (2019): 489-496. https://doi.org/10.3892/etm.2019.7603
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao J, Ding D and Zhao G: Reduced miR‑202 levels enhanced oral cancer development via targeting Sp1 Retraction in /10.3892/etm.2024.12539. Exp Ther Med 18: 489-496, 2019.
APA
Zhao, J., Ding, D., & Zhao, G. (2019). Reduced miR‑202 levels enhanced oral cancer development via targeting Sp1 Retraction in /10.3892/etm.2024.12539. Experimental and Therapeutic Medicine, 18, 489-496. https://doi.org/10.3892/etm.2019.7603
MLA
Zhao, J., Ding, D., Zhao, G."Reduced miR‑202 levels enhanced oral cancer development via targeting Sp1 Retraction in /10.3892/etm.2024.12539". Experimental and Therapeutic Medicine 18.1 (2019): 489-496.
Chicago
Zhao, J., Ding, D., Zhao, G."Reduced miR‑202 levels enhanced oral cancer development via targeting Sp1 Retraction in /10.3892/etm.2024.12539". Experimental and Therapeutic Medicine 18, no. 1 (2019): 489-496. https://doi.org/10.3892/etm.2019.7603
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team