Open Access

Clinical characteristics of patients with premature acute coronary syndrome and adverse cardiovascular events after PCI

  • Authors:
    • Xiao‑Jun Shi
    • Miao‑Nan Li
    • Ling Xuan
    • Hui Li
    • Bin Chen
    • Jun Zhang
    • Hong‑Ju Wang
  • View Affiliations

  • Published online on: May 28, 2019     https://doi.org/10.3892/etm.2019.7618
  • Pages: 793-801
  • Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Few studies have compared the clinical manifestations of patients with premature acute coronary syndrome (ACS) and late‑onset ACS as well as the adverse cardiovascular events following percutaneous coronary intervention (PCI). To investigate the clinicopathological characteristics of patients with premature ACS and adverse cardiovascular events following PCI, a total of 726 patients with ACS undergoing PCI were divided into two groups: A premature ACS group and a late‑onset ACS group. Following discharge, all patients were followed‑up for an average of 23.5±5.3 months. Clinical characteristics, Gensini scores, vascular lesions and adverse cardiovascular events were compared between the two groups. There were no significant differences in smoking, diabetes, ACS composition ratio, baseline treatment of coronary heart disease, high‑density lipoprotein level and C‑reactive protein levels between the two groups. Sex and hypertriglyceridemia were determined to be independent risk factors of premature ACS, while age, hypertension and a high Gensini score were independent risk factors for adverse cardiovascular events in patients with ACS following PCI. Furthermore, the prevalence of premature ACS was significantly higher in females. Although serum levels of fasting blood glucose, total cholesterol, triglycerides and low‑density lipoprotein were also significantly higher in patients with premature ACS compared with patients with late‑onset ACS, patients with premature ACS exhibited fewer vascular lesions compared with patients with late‑onset ACS. Furthermore, the incidence of adverse cardiovascular events in patients with ACS following PCI did not differ significantly between premature and late‑onset ACS groups. Taken together, these results suggest that female patients should be closely observed for early risk factors of premature ACS to prevent and reduce the occurrence of adverse cardiovascular events in patients with ACS following PCI.
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July-2019
Volume 18 Issue 1

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Spandidos Publications style
Shi XJ, Li MN, Xuan L, Li H, Chen B, Zhang J and Wang HJ: Clinical characteristics of patients with premature acute coronary syndrome and adverse cardiovascular events after PCI. Exp Ther Med 18: 793-801, 2019
APA
Shi, X., Li, M., Xuan, L., Li, H., Chen, B., Zhang, J., & Wang, H. (2019). Clinical characteristics of patients with premature acute coronary syndrome and adverse cardiovascular events after PCI. Experimental and Therapeutic Medicine, 18, 793-801. https://doi.org/10.3892/etm.2019.7618
MLA
Shi, X., Li, M., Xuan, L., Li, H., Chen, B., Zhang, J., Wang, H."Clinical characteristics of patients with premature acute coronary syndrome and adverse cardiovascular events after PCI". Experimental and Therapeutic Medicine 18.1 (2019): 793-801.
Chicago
Shi, X., Li, M., Xuan, L., Li, H., Chen, B., Zhang, J., Wang, H."Clinical characteristics of patients with premature acute coronary syndrome and adverse cardiovascular events after PCI". Experimental and Therapeutic Medicine 18, no. 1 (2019): 793-801. https://doi.org/10.3892/etm.2019.7618