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Review

Psoriasis: Association of interleukin-17 gene polymorphisms with severity and response to treatment (Review)

  • Authors:
    • Alexandra Dana Pușcaș
    • Andreea Cătană
    • Cristian Pușcaș
    • Iulia Ioana Roman
    • Corina Vornicescu
    • Mihaela Șomlea
    • Remus Ioan Orăsan
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, ʻIuliu Hațieganuʼ University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania, Department of Genetics, ʻIuliu Hațieganuʼ University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania, Department of Neuroscience, ʻIuliu Hațieganuʼ University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania, Department of Dermatology, ʻIuliu Hațieganuʼ University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania
  • Pages: 875-880
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    Published online on: May 28, 2019
       https://doi.org/10.3892/etm.2019.7624
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Abstract

Psoriasis is a chronic, inflammatory disease with a complex pathogenesis that is not yet fully understood. Although it is a multifactorial disease, the genetic factor has a major role in the pathogenesis of psoriasis. Genome wide association studies have identified over 50 genetic loci associated with psoriasis risk. Beside TNF-α or IL-23, the IL-17 family is a newer group that has proven implications in the pathogenesis of psoriasis. The most important members of the family, with pro-inflammatory qualities, are IL-17A and IL-17F. These interleukins are produced by a varied number of cells, but by far the most important are Th17 cells. Of the patients 20-30% present moderate-to-severe psoriasis, therefore, systemic medication (phototherapy, methotrexate, cyclosporine, acitretin or biologic agents) is mandatory. The necessity of an individualized treatment plan, for each patient, is imperative in order to establish the best strategy for non-responders to classical treatment or to other biologic treatments. The discovery of Th17 pathway improved the treatment and prognosis of psoriasis. Anti-psoriatic agents against IL-17 or its receptors are a novel group of biologic agents; these include ixekizumab, secukinumab and brodalumab. Polymorphisms of IL-17 family have been correlated with the severity and response to treatment in psoriasis, and also with the risk of inflammatory, infectious, autoimmune or neoplastic pathologies. The significant difference in the presence or absence of susceptibility loci in different population is due to genetic background and environmental factors that have a major impact on disease predisposition. In this study, we reviewed the importance and influence of the IL-17 polymorphisms as predictors of response to treatment and severity of the disease.
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1 

Kim SY, Hur MS, Choi BG, Kim MJ, Lee YW, Choe YB and Ahn KJ: A preliminary study of new single polymorphisms in the T helper type 17 pathway for psoriasis in the Korean population. Clin Exp Immunol. 187:251–258. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Batani A, Brănișteanu DE, Ilie MA, Boda D, Ianosi S, Ianosi G and Caruntu C: Assessment of dermal papillary and microvascular parameters in psoriasis vulgaris using in vivo reflectance confocal microscopy. Exp Ther Med. 15:1241–1246. 2018.PubMed/NCBI

3 

Boda D, Negrei C, Nicolescu F and Balalau C: Assessment of some oxidative stress parameters in methotrexate treated psoriasis patients. Farmacia. 62:704–710. 2014.

4 

Batalla A, Coto E, González-Lara L, González-Fernández D, Gómez J, Aranguren TF, Queiro R, Santos-Juanes J, López-Larrea C and Coto-Segura P: Association between single nucleotide polymorphisms IL17RA rs4819554 and IL17E rs79877597 and psoriasis in a Spanish cohort. J Dermatol Sci. 80:111–115. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Căruntu C: Boda D, Căruntu A, Rotaru M, Baderca F and Zurac S: In vivo imaging techniques for psoriatic lesions. Rom J Morphol Embryol. 55 (Suppl 3):1191–1196. 2014.PubMed/NCBI

6 

Bilal J, Berlinberg A, Bhattacharjee S, Trost J, Riaz IB and Kurtzman DJB: A systematic review and meta-analysis of the efficacy and safety of the interleukin (IL)-12/23 and IL-17 inhibitors ustekinumab, secukinumab, ixekizumab, brodalumab, guselkumab and tildrakizumab for the treatment of moderate to severe plaque psoriasis. J Dermatolog Treat. 29:569–578. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Coto E, Santos-Juanes J, Coto-Segura P and Alvarez V: New psoriasis susceptibility genes: Momentum for skin-barrier disruption. J Invest Dermatol. 131:1003–1005. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, et al Collaborative Association Study of Psoriasis (CASP); Genetic Analysis of Psoriasis Consortium; Psoriasis Association Genetics Extension; Wellcome Trust Case Control Consortium 2, : Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet. 44:1341–1348. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Yin X, Low HQ, Wang L, Li Y, Ellinghaus E, Han J, Estivill X, Sun L, Zuo X, Shen C, et al: Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility. Nat Commun. 6:69162015. View Article : Google Scholar : PubMed/NCBI

10 

Harden JL, Krueger JG and Bowcock AM: The immunogenetics of psoriasis: A comprehensive review. J Autoimmun. 64:66–73. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Strange A, Capon F, Spencer CC, Knight J, Weale ME, Allen MH, Barton A, Band G, Bellenguez C, Bergboer JG, et al Genetic Analysis of Psoriasis Consortium and the Wellcome Trust Case Control Consortium 2, : A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet. 42:985–990. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Anbunathan H and Bowcock AM: The molecular revolution in cutaneous biology: The era of genome-wide association studies and statistical, big data, and computational topics. J Invest Dermatol. 137:e113–e118. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Lønnberg AS, Zachariae C and Skov L: Targeting of interleukin-17 in the treatment of psoriasis. Clin Cosmet Investig Dermatol. 7:251–259. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Malakouti M, Brown GE, Wang E, Koo J and Levin EC: The role of IL-17 in psoriasis. J Dermatolog Treat. 26:41–44. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Nestle FO, Kaplan DH and Barker J: Psoriasis. N Engl J Med. 361:496–509. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Shibata S, Saeki H, Tsunemi Y, Kato T, Nakamura K, Kakinuma T, Kagami S, Fujita H, Tada Y, Sugaya M, et al: IL-17F single nucleotide polymorphism is not associated with psoriasis vulgaris or atopic dermatitis in the Japanese population. J Dermatol Sci. 53:163–165. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Girolomoni G, Mrowietz U and Paul C: Psoriasis: Rationale for targeting interleukin-17. Br J Dermatol. 167:717–724. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Yang L, Anderson DE, Baecher-Allan C, Hastings WD, Bettelli E, Oukka M, Kuchroo VK and Hafler DA: IL-21 and TGF-beta are required for differentiation of human T(H)17 cells. Nature. 454:350–352. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Gaffen SL, Kramer JM, Yu JJ and Shen F: The IL-17 cytokine family. Vitam Horm. 74:255–282. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Miossec P and Kolls JK: Targeting IL-17 and TH17 cells in chronic inflammation. Nat Rev Drug Discov. 11:763–776. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Tesmer LA, Lundy SK, Sarkar S and Fox DA: Th17 cells in human disease. Immunol Rev. 223:87–113. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Patel DD, Lee DM, Kolbinger F and Antoni C: Effect of IL-17A blockade with secukinumab in autoimmune diseases. Ann Rheum Dis. 72 (Suppl 2):ii116–ii123. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Leipe J, Grunke M, Dechant C, Reindl C, Kerzendorf U, Schulze-Koops H and Skapenko A: Role of Th17 cells in human autoimmune arthritis. Arthritis Rheum. 62:2876–2885. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Miossec P, Korn T and Kuchroo VK: Interleukin-17 and type 17 helper T cells. N Engl J Med. 361:888–898. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Gaffen SL: Recent advances in the IL-17 cytokine family. Curr Opin Immunol. 23:613–619. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Gaffen SL: Structure and signalling in the IL-17 receptor family. Nat Rev Immunol. 9:556–567. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Wright JF, Bennett F, Li B, Brooks J, Luxenberg DP, Whitters MJ, Tomkinson KN, Fitz LJ, Wolfman NM, Collins M, et al: The human IL-17F/IL-17A heterodimeric cytokine signals through the IL-17RA/IL-17RC receptor complex. J Immunol. 181:2799–2805. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Chiricozzi A: Pathogenic role of IL-17 in psoriasis and psoriatic arthritis. Actas Dermosifiliogr. 105 (Suppl 1):9–20. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Starnes T, Robertson MJ, Sledge G, Kelich S, Nakshatri H, Broxmeyer HE and Hromas R: Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production. J Immunol. 167:4137–4140. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Arisawa T, Tahara T, Shibata T, Nagasaka M, Nakamura M, Kamiya Y, Fujita H, Nakamura M, Yoshioka D, Arima Y, et al: The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis. J Clin Immunol. 28:44–49. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Kawaguchi M, Adachi M, Oda N, Kokubu F and Huang SK: IL-17 cytokine family. J Allergy Clin Immunol. 114:1265–1274. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Prieto-Pérez R, Solano-López G, Cabaleiro T, Román M, Ochoa D, Talegón M, Baniandrés O, López Estebaranz JL, de la Cueva P, Daudén E, et al: The polymorphism rs763780 in the IL-17F gene is associated with response to biological drugs in patients with psoriasis. Pharmacogenomics. 16:1723–1731. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Chiricozzi A, Guttman-Yassky E, Suárez-Fariñas M, Nograles KE, Tian S, Cardinale I, Chimenti S and Krueger JG: Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis. J Invest Dermatol. 131:677–687. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Batalla A, Coto E, Gómez J, Eirís N, González-Fernández D, Gómez-De Castro C, Daudén E, Llamas-Velasco M, Prieto-Perez R, Abad-Santos F, et al: IL17RA gene variants and anti-TNF response among psoriasis patients. Pharmacogenomics J. 18:76–80. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Martin DA, Towne JE, Kricorian G, Klekotka P, Gudjonsson JE, Krueger JG and Russell CB: The emerging role of IL-17 in the pathogenesis of psoriasis: Preclinical and clinical findings. J Invest Dermatol. 133:17–26. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Harper EG, Guo C, Rizzo H, Lillis JV, Kurtz SE, Skorcheva I, Purdy D, Fitch E, Iordanov M and Blauvelt A: Th17 cytokines stimulate CCL20 expression in keratinocytes in vitro and in vivo: Implications for psoriasis pathogenesis. J Invest Dermatol. 129:2175–2183. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Roostaeyan O, Kivelevitch D and Menter A: A review article on brodalumab in the treatment of moderate-to-severe plaque psoriasis. Immunotherapy. 9:963–978. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Korn T, Bettelli E, Oukka M and Kuchroo VK: IL-17 and Th17 Cells. Annu Rev Immunol. 27:485–517. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Pukelsheim K, Stoeger T, Kutschke D, Ganguly K and Wjst M: Cytokine profiles in asthma families depend on age and phenotype. PLoS One. 5:e142992010. View Article : Google Scholar : PubMed/NCBI

40 

Ramirez-Carrozzi V, Sambandam A, Luis E, Lin Z, Jeet S, Lesch J, Hackney J, Kim J, Zhou M, Lai J, et al: IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat Immunol. 12:1159–1166. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Fujishima S, Watanabe H, Kawaguchi M, Suzuki T, Matsukura S, Homma T, Howell BG, Hizawa N, Mitsuya T, Huang SK, et al: Involvement of IL-17F via the induction of IL-6 in psoriasis. Arch Dermatol Res. 302:499–505. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Wilson NJ, Boniface K, Chan JR, McKenzie BS, Blumenschein WM, Mattson JD, Basham B, Smith K, Chen T, Morel F, et al: Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol. 8:950–957. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Chan JR, Blumenschein W, Murphy E, Diveu C, Wiekowski M, Abbondanzo S, Lucian L, Geissler R, Brodie S, Kimball AB, et al: IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. J Exp Med. 203:2577–2587. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Prieto-Pérez R, Cabaleiro T, Daudén E, Ochoa D, Roman M and Abad-Santos F: Genetics of psoriasis and pharmacogenetics of biological drugs. Autoimmune Dis. 2013:6130862013.PubMed/NCBI

45 

Asarch A, Barak O, Loo DS and Gottlieb AB: Th17 cells: A new therapeutic target in inflammatory dermatoses. J Dermatolog Treat. 19:318–326. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Kagami S, Rizzo HL, Lee JJ, Koguchi Y and Blauvelt A: Circulating Th17, Th22, and Th1 cells are increased in psoriasis. J Invest Dermatol. 130:1373–1383. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Johansen C, Usher PA, Kjellerup RB, Lundsgaard D, Iversen L and Kragballe K: Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin. Br J Dermatol. 160:319–324. 2009. View Article : Google Scholar : PubMed/NCBI

48 

Białecka M, Ostasz R, Kurzawski M, Klimowicz A, Fabiańczyk H, Bojko P, Dziedziejko V, Safranow K, Machoy-Mokrzyńska A and Droździk M: IL17A and IL17F gene polymorphism association with psoriasis risk and response to treatment in a Polish population. Dermatology. 232:592–596. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Raţiu MP, Purcărea I, Popa F, Purcărea VL, Purcărea TV, Lupuleasa D and Boda D: Escaping the economic turn down through performing employees, creative leaders and growth driver capabilities in the Romanian pharmaceutical industry. Farmacia. 59:119–130. 2011.

50 

Caruntu C, Boda D, Dumitrascu G, Constantin C and Neagu M: Proteomics focusing on immune markers in psoriatic arthritis. Biomarkers Med. 9:513–528. 2015. View Article : Google Scholar

51 

Negrei C, Caruntu C, Ginghina O, Dragomiroiu GTAB, Toderescu CD and Boda D: Qualitative and quantitative determination of methotrexate polyglutamates in erythrocytes by high performance liquid chromatography. Rev Chim. 66:607–610. 2015.

52 

Negrei C, Ginghină O, Căruntu C, Burcea Dragomiroiu GTA, Jinescu G and Boda D: Investigation relevance of methotrexate polyglutamates in biological systems by high performance liquid chromatography. Rev Chim. 66:766–768. 2015.

53 

Negrei C, Arsene AL, Toderescu CD, Boda B and Ilie M: Acitretin treatment in psoriazis may influence the cell membrane fluidity. Farmacia. 60:767–771. 2012.

54 

Thomas LW, Lee EB and Wu JJ: Systematic review of anti-drug antibodies of IL-17 inhibitors for psoriasis. J Dermatolog Treat. 18:1–7. 2018.

55 

Liu L, Lu J, Allan BW, Tang Y, Tetreault J, Chow CK, Barmettler B, Nelson J, Bina H, Huang L, et al: Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A. J Inflamm Res. 9:39–50. 2016. View Article : Google Scholar : PubMed/NCBI

56 

Kemény L, Berggren L, Dossenbach M, Dutronc Y and Paul C: Efficacy and safety of ixekizumab in patients with plaque psoriasis across different degrees of disease severity: Results from UNCOVER-2 and UNCOVER-3. J Dermatolog Treat. 4:1–8. 2018.

57 

Gordon KB, Blauvelt A, Papp KA, Langley RG, Luger T, Ohtsuki M, Reich K, Amato D, Ball SG, Braun DK, et al UNCOVER-1 Study Group, : UNCOVER-2 Study Group; UNCOVER-3 Study Group: Phase 3 trials of ixekizumab in moderate-to-severe plaque psoriasis. N Engl J Med. 375:345–356. 2016. View Article : Google Scholar : PubMed/NCBI

58 

Griffiths CE, Reich K, Lebwohl M, van de Kerkhof P, Paul C, Menter A, Cameron GS, Erickson J, Zhang L, Secrest RJ, et al UNCOVER-2 and UNCOVER-3 investigators, : Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): Results from two phase 3 randomised trials. Lancet. 386:541–551. 2015. View Article : Google Scholar : PubMed/NCBI

59 

Olteanu R, Zota A and Constantin M: Biosimilars: An update on clinical trials (review of published and ongoing studies). Acta Dermatovenerol Croat. 25:57–66. 2017.PubMed/NCBI

60 

Nair RP, Stuart PE, Nistor I, Hiremagalore R, Chia NVC, Jenisch S, Weichenthal M, Abecasis GR, Lim HW, Christophers E, et al: Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet. 78:827–851. 2006. View Article : Google Scholar : PubMed/NCBI

61 

Nishikawa R, Nagai H, Bito T, Ikeda T, Horikawa T, Adachi A, Matsubara T and Nishigori C: Genetic prediction of the effectiveness of biologics for psoriasis treatment. J Dermatol. 43:1273–1277. 2016. View Article : Google Scholar : PubMed/NCBI

62 

Park H, Li Z, Yang XO, Chang SH, Nurieva R, Wang YH, Wang Y, Hood L, Zhu Z, Tian Q, et al: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 6:1133–1141. 2005. View Article : Google Scholar : PubMed/NCBI

63 

Olteanu R, Constantin MM, Zota A, Dorobantu DM, Constantin T, Serban ED, Balanescu P, Mihele D and Gheuca-Solovastru L: Original clinical experience and approach to treatment study with interleukin 12/23 inhibitor in moderate-to-severe psoriasis patients. Farmacia. 64:918–921. 2016.

64 

Catanoso MG, Boiardi L, Macchioni P, Garagnani P, Sazzini M, De Fanti S, Farnetti E, Casali B, Chiarolanza I, Nicoli D, et al: IL-23A, IL-23R, IL-17A and IL-17R polymorphisms in different psoriatic arthritis clinical manifestations in the northern Italian population. Rheumatol Int. 33:1165–1176. 2013. View Article : Google Scholar : PubMed/NCBI

65 

Căruntu C, Boda D, Musat S, Căruntu A and Mandache E: Stress-induced mast cell activation in glabrous and hairy skin. Mediators Inflamm. 2014:1–9. 2014. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Pușcaș AD, Cătană A, Pușcaș C, Roman II, Vornicescu C, Șomlea M and Orăsan RI: Psoriasis: Association of interleukin-17 gene polymorphisms with severity and response to treatment (Review). Exp Ther Med 18: 875-880, 2019.
APA
Pușcaș, A.D., Cătană, A., Pușcaș, C., Roman, I.I., Vornicescu, C., Șomlea, M., & Orăsan, R.I. (2019). Psoriasis: Association of interleukin-17 gene polymorphisms with severity and response to treatment (Review). Experimental and Therapeutic Medicine, 18, 875-880. https://doi.org/10.3892/etm.2019.7624
MLA
Pușcaș, A. D., Cătană, A., Pușcaș, C., Roman, I. I., Vornicescu, C., Șomlea, M., Orăsan, R. I."Psoriasis: Association of interleukin-17 gene polymorphisms with severity and response to treatment (Review)". Experimental and Therapeutic Medicine 18.2 (2019): 875-880.
Chicago
Pușcaș, A. D., Cătană, A., Pușcaș, C., Roman, I. I., Vornicescu, C., Șomlea, M., Orăsan, R. I."Psoriasis: Association of interleukin-17 gene polymorphisms with severity and response to treatment (Review)". Experimental and Therapeutic Medicine 18, no. 2 (2019): 875-880. https://doi.org/10.3892/etm.2019.7624
Copy and paste a formatted citation
x
Spandidos Publications style
Pușcaș AD, Cătană A, Pușcaș C, Roman II, Vornicescu C, Șomlea M and Orăsan RI: Psoriasis: Association of interleukin-17 gene polymorphisms with severity and response to treatment (Review). Exp Ther Med 18: 875-880, 2019.
APA
Pușcaș, A.D., Cătană, A., Pușcaș, C., Roman, I.I., Vornicescu, C., Șomlea, M., & Orăsan, R.I. (2019). Psoriasis: Association of interleukin-17 gene polymorphisms with severity and response to treatment (Review). Experimental and Therapeutic Medicine, 18, 875-880. https://doi.org/10.3892/etm.2019.7624
MLA
Pușcaș, A. D., Cătană, A., Pușcaș, C., Roman, I. I., Vornicescu, C., Șomlea, M., Orăsan, R. I."Psoriasis: Association of interleukin-17 gene polymorphisms with severity and response to treatment (Review)". Experimental and Therapeutic Medicine 18.2 (2019): 875-880.
Chicago
Pușcaș, A. D., Cătană, A., Pușcaș, C., Roman, I. I., Vornicescu, C., Șomlea, M., Orăsan, R. I."Psoriasis: Association of interleukin-17 gene polymorphisms with severity and response to treatment (Review)". Experimental and Therapeutic Medicine 18, no. 2 (2019): 875-880. https://doi.org/10.3892/etm.2019.7624
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