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Edaravone attenuates traumatic brain injury through anti‑inflammatory and anti‑oxidative modulation

  • Authors:
    • Man Zhang
    • Chen‑Huai Teng
    • Fang‑Fang Wu
    • Li‑Yun Ge
    • Jian Xiao
    • Hong‑Yu Zhang
    • Da‑Qing Chen
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China, Molecular Pharmacology Research Center, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 467-474
    |
    Published online on: May 30, 2019
       https://doi.org/10.3892/etm.2019.7632
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Abstract

Traumatic brain injury (TBI) is among the leading causes of irreversible neurological damage and death worldwide. The aim of the present study was to investigate whether edaravone (EDA) had a neuroprotective effect on TBI as well as to identify the potential mechanism. Results demonstrated that EDA suppressed inflammatory and oxidative responses in mice following TBI. This was evidenced by a reduction in glutathione peroxidase, interleukin 6, tumor necrosis factor‑α and hydrogen peroxide levels, in addition to an increase in hemeoxygenase‑1, quinone oxidoreductase 1 and superoxide dismutase levels, thereby mitigating neurofunctional deficits, cell apoptosis and structural damage. EDA prevented the transfer of NF‑κB protein from the cytoplasm to the nucleus, whilst promoting the expression of nuclear factor erythroid 2‑related factor 2 (Nrf2) protein in mice following TBI. These results indicated that EDA exerted neuroprotective effects, including impeding neurofunctional deficits, cell apoptosis and structural damage, in mice with TBI, potentially via suppression of NF‑κB‑mediated inflammatory activation and promotion of the Nrf2 antioxidant pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang M, Teng CH, Wu FF, Ge LY, Xiao J, Zhang HY and Chen DQ: Edaravone attenuates traumatic brain injury through anti‑inflammatory and anti‑oxidative modulation. Exp Ther Med 18: 467-474, 2019.
APA
Zhang, M., Teng, C., Wu, F., Ge, L., Xiao, J., Zhang, H., & Chen, D. (2019). Edaravone attenuates traumatic brain injury through anti‑inflammatory and anti‑oxidative modulation. Experimental and Therapeutic Medicine, 18, 467-474. https://doi.org/10.3892/etm.2019.7632
MLA
Zhang, M., Teng, C., Wu, F., Ge, L., Xiao, J., Zhang, H., Chen, D."Edaravone attenuates traumatic brain injury through anti‑inflammatory and anti‑oxidative modulation". Experimental and Therapeutic Medicine 18.1 (2019): 467-474.
Chicago
Zhang, M., Teng, C., Wu, F., Ge, L., Xiao, J., Zhang, H., Chen, D."Edaravone attenuates traumatic brain injury through anti‑inflammatory and anti‑oxidative modulation". Experimental and Therapeutic Medicine 18, no. 1 (2019): 467-474. https://doi.org/10.3892/etm.2019.7632
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang M, Teng CH, Wu FF, Ge LY, Xiao J, Zhang HY and Chen DQ: Edaravone attenuates traumatic brain injury through anti‑inflammatory and anti‑oxidative modulation. Exp Ther Med 18: 467-474, 2019.
APA
Zhang, M., Teng, C., Wu, F., Ge, L., Xiao, J., Zhang, H., & Chen, D. (2019). Edaravone attenuates traumatic brain injury through anti‑inflammatory and anti‑oxidative modulation. Experimental and Therapeutic Medicine, 18, 467-474. https://doi.org/10.3892/etm.2019.7632
MLA
Zhang, M., Teng, C., Wu, F., Ge, L., Xiao, J., Zhang, H., Chen, D."Edaravone attenuates traumatic brain injury through anti‑inflammatory and anti‑oxidative modulation". Experimental and Therapeutic Medicine 18.1 (2019): 467-474.
Chicago
Zhang, M., Teng, C., Wu, F., Ge, L., Xiao, J., Zhang, H., Chen, D."Edaravone attenuates traumatic brain injury through anti‑inflammatory and anti‑oxidative modulation". Experimental and Therapeutic Medicine 18, no. 1 (2019): 467-474. https://doi.org/10.3892/etm.2019.7632
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