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Article

Immunological consequences following splenectomy in patients with liver cirrhosis

  • Authors:
    • Yusuke Hirakawa
    • Toshiro Ogata
    • Tetsuro Sasada
    • Takuto Yamashita
    • Kyogo Itoh
    • Hiroyuki Tanaka
    • Koji Okuda
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan, Cancer Vaccine Center, Kurume University, Kurume, Fukuoka 839-0863, Japan, Biostatistics Center, Kurume University, Kurume, Fukuoka 830-0011, Japan
  • Pages: 848-856
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    Published online on: June 3, 2019
       https://doi.org/10.3892/etm.2019.7640
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Abstract

The immune status in patients with liver cirrhosis is generally impaired due to concomitant hypersplenism. As the spleen is the largest lymphoid organ, deleterious events resulting from splenectomy are of concern in these patients. However, the immunological consequences after splenectomy have not yet been fully elucidated. In the present study, the immune status after splenectomy was comprehensively examined. Splenectomy was performed in 11 patients with liver cirrhosis and hypersplenism, and the immune status in peripheral blood was examined and compared before and at 1, 3 and 6 months after splenectomy. Splenectomy significantly lowered the neutrophil‑to‑lymphocyte ratio, due to a surge in lymphocytes in the peripheral circulation at 3 and 6 months after splenectomy. The frequency of cluster of differentiation (CD)4+ T cells decreased after splenectomy, whereas the frequency of CD8+ T cells increased. Notably, the frequencies of the naïve and central memory subsets of CD4+ and CD8+ T cells decreased, whereas those of the effector memory subset trended upward. In addition, the frequencies of other immune cells such as γδ T cells, natural killer T cells and natural killer cells transiently increased, while inhibitory cells such as regulatory T cells and myeloid‑derived suppressor cells significantly decreased. T‑cell responses to viral‑ and tumor‑associated antigens increased after splenectomy in five of eight and two of five patients, respectively. To the best of our knowledge, this is the first study to precisely examine the drastic changes of immunological phenotypes in peripheral blood after splenectomy in patients with cirrhosis. Our findings suggested that splenectomy in patients with cirrhosis may ameliorate the impaired immune status, possibly by reducing suppressive cells and enhancing the effector cell population and function, which could, at least in part, explain the mechanisms responsible for the clinical benefits of splenectomy.
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Copy and paste a formatted citation
Spandidos Publications style
Hirakawa Y, Ogata T, Sasada T, Yamashita T, Itoh K, Tanaka H and Okuda K: Immunological consequences following splenectomy in patients with liver cirrhosis. Exp Ther Med 18: 848-856, 2019.
APA
Hirakawa, Y., Ogata, T., Sasada, T., Yamashita, T., Itoh, K., Tanaka, H., & Okuda, K. (2019). Immunological consequences following splenectomy in patients with liver cirrhosis. Experimental and Therapeutic Medicine, 18, 848-856. https://doi.org/10.3892/etm.2019.7640
MLA
Hirakawa, Y., Ogata, T., Sasada, T., Yamashita, T., Itoh, K., Tanaka, H., Okuda, K."Immunological consequences following splenectomy in patients with liver cirrhosis". Experimental and Therapeutic Medicine 18.1 (2019): 848-856.
Chicago
Hirakawa, Y., Ogata, T., Sasada, T., Yamashita, T., Itoh, K., Tanaka, H., Okuda, K."Immunological consequences following splenectomy in patients with liver cirrhosis". Experimental and Therapeutic Medicine 18, no. 1 (2019): 848-856. https://doi.org/10.3892/etm.2019.7640
Copy and paste a formatted citation
x
Spandidos Publications style
Hirakawa Y, Ogata T, Sasada T, Yamashita T, Itoh K, Tanaka H and Okuda K: Immunological consequences following splenectomy in patients with liver cirrhosis. Exp Ther Med 18: 848-856, 2019.
APA
Hirakawa, Y., Ogata, T., Sasada, T., Yamashita, T., Itoh, K., Tanaka, H., & Okuda, K. (2019). Immunological consequences following splenectomy in patients with liver cirrhosis. Experimental and Therapeutic Medicine, 18, 848-856. https://doi.org/10.3892/etm.2019.7640
MLA
Hirakawa, Y., Ogata, T., Sasada, T., Yamashita, T., Itoh, K., Tanaka, H., Okuda, K."Immunological consequences following splenectomy in patients with liver cirrhosis". Experimental and Therapeutic Medicine 18.1 (2019): 848-856.
Chicago
Hirakawa, Y., Ogata, T., Sasada, T., Yamashita, T., Itoh, K., Tanaka, H., Okuda, K."Immunological consequences following splenectomy in patients with liver cirrhosis". Experimental and Therapeutic Medicine 18, no. 1 (2019): 848-856. https://doi.org/10.3892/etm.2019.7640
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