Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2019 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2019 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Correlation between carotid intima‑media roughness and cardiovascular risk factors

  • Authors:
    • Yu Wu
    • Xuan Lu
    • Li Zhang
    • Xinyao Cheng
    • Li Yuan
    • Mingxing Xie
    • Qing Lv
  • View Affiliations / Copyright

    Affiliations: Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Cardiovascular Division, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 49-56
    |
    Published online on: June 4, 2019
       https://doi.org/10.3892/etm.2019.7646
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Arterial intima‑media roughness (IMR) may indicate an early manifestation of atherosclerosis. To date, few studies have been performed to quantitatively evaluate carotid IMR by ultrasonography (US). The aim of the present study was to analyze the effect of cardiovascular risk factors on carotid IMR. A total of 185 subjects were enrolled for US examination of carotid arteries. Carotid intima‑media thickness (IMT) and IMR were measured in US images by a novel automatic software. According to the number of combined high‑risk factors for coronary heart disease, subjects were assigned to four groups (risk groups 0, 1, 2 and 3+). IMR was lowest in risk group 0 (32.9±2.7 µm), higher in risk group 1 (64.5±6.9 µm; P<0.01 vs. risk group 0) and highest in risk groups 2 and 3+ (89.1±7.4 and 92.0±6.7 µm, respectively; P<0.01 vs. risk groups 0 and 1). According to a multivariate regression analysis, age, systolic blood pressure, smoking status and the triglyceride/high‑density lipoprotein cholesterol ratio were significant predictors of IMR. There was a progressive increase in carotid artery plaque with increasing tertiles of IMR (4.9, 33.9 and 53.2% in tertiles 1, 2 and 3, respectively; P<0.05). Compared with that of subjects in the lowest tertile of IMR, those in the highest tertile had a significantly elevated risk of the presence of plaque in the carotid tree (odds ratio=10.61, 95%CI: 2.15‑52.49, P=0.004). Quantification of carotid IMR from US images with this software is feasible, and carotid IMR, which may help estimate the extent of atherosclerosis, may be used as a complementary factor to stratify patients with cardiovascular risk factors.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

He J, Gu D, Wu X, Reynolds K, Duan X, Yao C, Wang J, Chen CS, Chen J, Wildman RP, et al: Major causes of death among men and women in China. N Engl J Med. 353:1124–1134. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Touboul PJ, Labreuche J, Bruckert E, Schargrodsky H, Prati P, Tosetto A, Hernandez-Hernandez R, Woo KS, Silva H, Vicaut E and Amarenco P: Hdl-c, triglycerides and carotid IMT: A meta-analysis of 21,000 patients with automated edge detection IMT measurement. Atherosclerosis. 232:65–71. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Lethen H, Tries HP, Kersting S, Bramlage P and Lambertz H: Improvement of coronary microvascular function after angiotensin receptor blocker treatment with irbesartan in patients with systemic hypertension. J Clin Hypertens (Greenwich). 13:155–161. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Luijendijk P, Lu H, Heynneman FB, Huijgen R, de Groot EE, Vriend JW, Vliegen HW, Groenink M, Bouma BJ and Mulder BJ: Increased carotid intima-media thickness predicts cardiovascular events in aortic coarctation. Int J Cardiol. 176:776–781. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Schmidt-Trucksass A, Sandrock M, Cheng DC, Müller HM, Baumstark MW, Rauramaa R, Berg A and Huonker M: Quantitative measurement of carotid intima-media roughness-effect of age and manifest coronary artery disease. Atherosclerosis. 166:57–65. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Dalla Pozza R, Pirzer R, Beyerlein A, Weberruß H, Oberhoffer R, Schmidt-Trucksäss A, Netz H and Haas N: Beyond intima-media-thickness: Analysis of the carotid intima-media-roughness in a paediatric population. Atherosclerosis. 251:164–169. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Homma S, Hirose N, Ishida H, Ishii T and Araki G: Carotid plaque and intima-media thickness assessed by b-mode ultrasonography in subjects ranging from young adults to centenarians. Stroke. 32:830–835. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Lind L: Circulating markers of inflammation and atherosclerosis. Atherosclerosis. 169:203–214. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Willerson JT: Systemic and local inflammation in patients with unstable atherosclerotic plaques. Prog Cardiovasc Dis. 44:469–478. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Toutouzas K, Grassos H, Synetos A, Drakopoulou M, Tsiamis E, Moldovan C, Agrogiannis G, Patsouris E, Siores E and Stefanadis C: A new non-invasive method for detection of local inflammation in atherosclerotic plaques: Experimental application of microwave radiometry. Atherosclerosis. 215:82–89. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Belcaro G, Nicolaides AN, Laurora G, Cesarone MR, De Sanctis M, Incandela L and Barsotti A: Ultrasound morphology classification of the arterial wall and cardiovascular events in a 6-year follow-up study. Arterioscler Thromb Vasc Biol. 16:851–856. 1996. View Article : Google Scholar : PubMed/NCBI

12 

Mancia G, Fagard R, Narkiewicz K, Redón J, Zanchetti A, Böhm M, Christiaens T, Cifkova R, De Backer G, Dominiczak A, et al: 2013 ESH/ESC guidelines for the management of arterial hypertension: The task force for the management of arterial hypertension of the european society of hypertension (ESH) and of the european society of cardiology (ESC). J Hypertens. 31:1281–1357. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Gnasso A, Irace C, Mattioli PL and Pujia A: Carotid intima-media thickness and coronary heart disease risk factors. Atherosclerosis. 119:7–15. 1996. View Article : Google Scholar : PubMed/NCBI

14 

American Diabetes Association: Standards of medical care in diabetes-2011. Diabetes Care. 1 (Suppl 34):S11–S61. 2011. View Article : Google Scholar

15 

Zhou B; Coorperative Meta-Analysis Group Of China Obesity Task Force, : Predictive values of body mass index and waist circumference to risk factors of related diseases in Chinese adult population. Zhonghua Liu Xing Bing Xue Za Zhi. 23:5–10. 2002.(In Chinese). PubMed/NCBI

16 

Expert Panel on Detection and Evaluation and Treatment of High Blood Cholesterol in Adults, . Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA. 285:2486–2497. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Touboul PJ, Hennerici M, Meairs S, Adams H, Amarenco P, Bornstein N, Csiba L, Desvarieux M, Ebrahim S, Hernandez Hernandez R, et al: Mannheim carotid intima-media thickness and plaque consensus (2004-2006-2011). An update on behalf of the advisory board of the 3rd, 4th and 5th watching the risk symposia, at the 13th, 15th and 20th European stroke conferences, mannheim, Germany, 2004, Brussels, Belgium, 2006, and hamburg, Germany, 2011. Cerebrovasc Dis. 34:290–296. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Xu X, Zhou Y, Cheng X, Song E and Li G: Ultrasound intima-media segmentation using hough transform and dual snake model. Comput Med Imaging Graph. 36:248–258. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Wendelhag I, Gustavsson T, Suurküla M, Berglund G and Wikstrand J: Ultrasound measurement of wall thickness in the carotid artery: Fundamental principles and description of a computerized analysing system. Clin Physiol. 11:565–577. 1991. View Article : Google Scholar : PubMed/NCBI

20 

Oh J, Wunsch R, Turzer M, Bahner M, Raggi P, Querfeld U, Mehls O and Schaefer F: Advanced coronary and carotid arteriopathy in young adults with childhood-onset chronic renal failure. Circulation. 106:100–105. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Polak JF, Pencina MJ, Pencina KM, O'Donnell CJ, Wolf PA and D'Agostino RB Sr: Carotid-wall intima-media thickness and cardiovascular events. N Engl J Med. 365:213–221. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Gardin JM, Bartz TM, Polak JF, O'Leary DH and Wong ND: What do carotid intima-media thickness and plaque add to the prediction of stroke and cardiovascular disease risk in older adults? The cardiovascular health study. J Am Soc Echocardiogr. 27:998–1005. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Polak JF, Szklo M and O'Leary DH: Associations of coronary heart disease with common carotid artery near and far wall intima-media thickness: The Multi-Ethnic Study of Atherosclerosis. J Am Soc Echocardiogr. 28:1114–1121. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Gigante B, Leander K, Vikström M, Baldassarre D, Veglia F, Strawbridge RJ, McLeod O, Gertow K, Sennblad B, Shah S, et al: Low levels of IgM antibodies against phosphorylcholine are associated with fast carotid intima media thickness progression and cardiovascular risk in men. Atherosclerosis. 236:394–399. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Wu Y, Xie M, Zhang L, Lu X, Cheng X and Lv Q: Carotid intima-media roughness and elasticity in hypertensive patients with normal carotid intima-media thickness. J Ultrasound Med. 2018:(Epub ahead of print).

26 

Raitakari OT, Juonala M, Kähönen M, Taittonen L, Laitinen T, Mäki-Torkko N, Järvisalo MJ, Uhari M, Jokinen E, Rönnemaa T, et al: Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: The Cardiovascular Risk in Young Finns Study. JAMA. 290:2277–2283. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Cheng X, Zhou Y, Jin Y, Li G, Wang H and Song E: Intima-medial thickness homogeneity in the common carotid artery: Measurement method and preliminary clinical study. J Clin Ultrasound. 40:559–565. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Otsuka F, Kramer MC, Woudstra P, Yahagi K, Ladich E, Finn AV, de Winter RJ, Kolodgie FD, Wight TN, Davis HR, et al: Natural progression of atherosclerosis from pathologic intimal thickening to late fibroatheroma in human coronary arteries: A pathology study. Atherosclerosis. 241:772–782. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Bentzon JF, Otsuka F, Virmani R and Falk E: Mechanisms of plaque formation and rupture. Circ Res. 114:1852–1866. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Graf IM, Schreuder FH, Hameleers JM, Mess WH, Reneman RS and Hoeks AP: Wall irregularity rather than intima-media thickness is associated with nearby atherosclerosis. Ultrasound Med Biol. 35:955–961. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Ishizu T, Ishimitsu T, Kamiya H, Seo Y, Moriyama N, Obara K, Watanabe S and Yamaguchi I: The correlation of irregularities in carotid arterial intima-media thickness with coronary artery disease. Heart Vessels. 17:1–6. 2002. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wu Y, Lu X, Zhang L, Cheng X, Yuan L, Xie M and Lv Q: Correlation between carotid intima‑media roughness and cardiovascular risk factors. Exp Ther Med 18: 49-56, 2019.
APA
Wu, Y., Lu, X., Zhang, L., Cheng, X., Yuan, L., Xie, M., & Lv, Q. (2019). Correlation between carotid intima‑media roughness and cardiovascular risk factors. Experimental and Therapeutic Medicine, 18, 49-56. https://doi.org/10.3892/etm.2019.7646
MLA
Wu, Y., Lu, X., Zhang, L., Cheng, X., Yuan, L., Xie, M., Lv, Q."Correlation between carotid intima‑media roughness and cardiovascular risk factors". Experimental and Therapeutic Medicine 18.1 (2019): 49-56.
Chicago
Wu, Y., Lu, X., Zhang, L., Cheng, X., Yuan, L., Xie, M., Lv, Q."Correlation between carotid intima‑media roughness and cardiovascular risk factors". Experimental and Therapeutic Medicine 18, no. 1 (2019): 49-56. https://doi.org/10.3892/etm.2019.7646
Copy and paste a formatted citation
x
Spandidos Publications style
Wu Y, Lu X, Zhang L, Cheng X, Yuan L, Xie M and Lv Q: Correlation between carotid intima‑media roughness and cardiovascular risk factors. Exp Ther Med 18: 49-56, 2019.
APA
Wu, Y., Lu, X., Zhang, L., Cheng, X., Yuan, L., Xie, M., & Lv, Q. (2019). Correlation between carotid intima‑media roughness and cardiovascular risk factors. Experimental and Therapeutic Medicine, 18, 49-56. https://doi.org/10.3892/etm.2019.7646
MLA
Wu, Y., Lu, X., Zhang, L., Cheng, X., Yuan, L., Xie, M., Lv, Q."Correlation between carotid intima‑media roughness and cardiovascular risk factors". Experimental and Therapeutic Medicine 18.1 (2019): 49-56.
Chicago
Wu, Y., Lu, X., Zhang, L., Cheng, X., Yuan, L., Xie, M., Lv, Q."Correlation between carotid intima‑media roughness and cardiovascular risk factors". Experimental and Therapeutic Medicine 18, no. 1 (2019): 49-56. https://doi.org/10.3892/etm.2019.7646
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team