Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
July-2019 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2019 Volume 18 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

MicroRNA‑146a improves sepsis‑induced cardiomyopathy by regulating the TLR‑4/NF‑κB signaling pathway

  • Authors:
    • Jin Xie
    • Lina Zhang
    • Xiaoyan Fan
    • Xiaoqing Dong
    • Zhe Zhang
    • Wenxing Fan
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Zhangqiu District People's Hospital, Jinan, Shandong 250200, P.R. China, Department of Obstetrics, Zhangqiu District People's Hospital, Jinan, Shandong 250200, P.R. China, Department of Nephrology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 779-785
    |
    Published online on: June 10, 2019
       https://doi.org/10.3892/etm.2019.7657
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the current study was to investigate the regulatory effect of miR‑146a on the toll‑like receptor 4 (TLR‑4)/NF‑κB pathway and therefore inflammation in septic cardiomyopathy. A total of 60 healthy male Sprague Dawley rats were equally divided into a control, LPS, miR‑146a agonist and miR‑146a inhibitor group. Blood samples were collected from rats 24 h after intraperitoneal lipopolysaccharide injection and myocardial tissues were subsequently collected. After hematoxylin and eosin staining of rat myocardial tissues, the degree of inflammatory cell infiltration and myocardial damage was observed. The content of certain myocardial injury markers were also observed, including cardiac troponin I (cTnI), B‑type natriuretic peptide (BNP), creatine kinase myocardial bound (CK‑MB) and myoglobin (Mb). Western blot analysis was performed to detect the expression of NF‑κB/TLR‑4, tumor necrosis factor (TNF‑α) and intercellular adhesion molecule‑1 (ICAM‑1) in myocardial tissues. Reverse transcription‑quantitative (RT‑q) PCR was used to detect the expression of miR‑146a, TNF‑α, interleukin (IL)‑1α and IL‑1β mRNA in myocardial tissues. In the LPS group, myocardial interstitial tissue edema occurred, with enlarged and loosely arranged cardiomyocytes. Compared with the sepsis model group, myocardial interstitial tissue edema was relieved in the miR‑146a agonist group, but was aggravated in the miR‑146a inhibition group. The serum levels of cTnI, BNP, CK‑MB, Mb, NF‑κB, TLR‑4, TNF‑α and ICAM‑1 in the sepsis model group were higher than those in the control group. In the miR‑146a agonist group, levels of myocardial injury markers were lower than those in the sepsis model group, but were higher in the miR‑146a inhibition group. The results of RT‑qPCR demonstrated that the expression of miR‑146a, TNF‑α, IL‑1α and IL‑1β in the sepsis model group were upregulated compared with the control group. In addition, miR‑146a expression in the miR‑146a agonist group and the miR‑146a inhibition group was increased, but TNF‑α, IL‑1α and IL‑1β mRNA was downregulated. miR‑146a may regulate the TLR‑4/NF‑κB signaling pathway via negative feedback mechanisms, leading to the improvement of the inflammatory response and cardiac dysfunction in sepsis‑induced cardiomyopathy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Tønnesen E and Larsen K: Severe sepsis and septic shock. Ugeskr Laeger. 176:V031302002014.(In Danish). PubMed/NCBI

2 

Sharawy N and Lehmann C: New directions for sepsis and septic shock research. J Surg Res. 194:520–527. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Cao Z and Robinson RA: The role of proteomics in understanding biological mechanisms of sepsis. Proteomics Clin Appl. 8:35–52. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Sato R and Nasu M: A review of sepsis-induced cardiomyopathy. J Intensive Care. 3:482015. View Article : Google Scholar : PubMed/NCBI

5 

Sato R, Kuriyama A, Takada T, Nasu M and Luthe SK: Prevalence and risk factors of sepsis-induced cardiomyopathy: A retrospective cohort study. Medicine (Baltimore). 95:e50312016. View Article : Google Scholar : PubMed/NCBI

6 

Hobai IA, Edgecomb J, LaBarge K and Colucci WS: Dysregulation of intracellular calcium transporters in animal models of sepsis-induced cardiomyopathy. Shock. 43:3–15. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Romero-Bermejo FJ, Ruiz-Bailen M, Gil-Cebrian J and Huertos-Ranchal MJ: Sepsis-induced cardiomyopathy. Curr Cardiol Rev. 7:163–183. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Lv X and Wang H: Pathophysiology of sepsis-induced myocardial dysfunction. Mil Med Res. 3:302016. View Article : Google Scholar : PubMed/NCBI

9 

Espín-Pérez A, Krauskopf J, Chadeau-Hyam M, van Veldhoven K, Chung F, Cullinan P, Piepers J, van Herwijnen M, Kubesch N, Carrasco-Turigas G, et al: Short-term transcriptome and microRNAs responses to exposure to different air pollutants in two population studies. Environ Pollut. 242:182–190. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Bernardo BC, Ooi JY, Lin RC and McMullen JR: miRNA therapeutics: A new class of drugs with potential therapeutic applications in the heart. Future Med Chem. 7:1771–1792. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Zhou F, Wang W, Xing Y, Wang T, Xu X and Wang J: NF-κB target microRNAs and their target genes in TNFα-stimulated HeLa cells. Biochim Biophys Acta. 1839:344–354. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Wu ZW, Liu YF, Wang S and Li B: miRNA-146a induces vascular smooth muscle cell apoptosis in a rat model of coronary heart disease via NF-κB pathway. Genet Mol Res. 14:18703–18712. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Wang X, Ha T, Liu L, Zou J, Zhang X, Kalbfleisch J, Gao X, Williams D and Li C: Increased expression of microRNA-164a decreases myocardial ischemia/reperfusion injury. Cardiovasc Res. 97:432–442. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Gao M, Wang X, Zhang X, Ha T, Ma H, Liu L, Kalbfleisch JH, Gao X, Kao RL, Williams DL and Li C: Attenuation of cardiac dysfunction in polymicrobial sepsis by microRNA-146a is mediated via targeting of IRAK1 and TRAF6 expression. J Immunol. 195:672–682. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Taganov KD, Boldin MP, Chang KJ and Baltimore D: NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci USA. 103:12481–12486. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Sun W, Wang Q, Guo Y, Zhao Y, Wang X, Zhang Z, Deng G and Guo M: Selenium suppresses inflammation by inducing microRNA-146a in Staphylococcus aureus-infected mouse mastitis model. Oncotarget. 8:110949–110964. 2017.PubMed/NCBI

17 

Wu ZW, Liu YF, Wang S and Li B: Corrigendum miRNA-146a induces vascular smooth muscle cell apoptosis in a rat model of coronary heart disease via NF-κB pathway-Genet. Mol. Res. 14(4): 18703–18712, Genet Mol Res 15. 2016. View Article : Google Scholar

18 

Li J, Xie C, Zhuang J, Li H, Yao Y, Shao C and Wang H: Resveratrol attenuates inflammation in the rat heart subjected to ischemia-reperfusion: Role of the TLR4/NF-κB signaling pathway. Mol Med Rep. 11:1120–1126. 2015.PubMed/NCBI

19 

Karra R, Knecht AK, Kikuchi K and Poss KD: Myocardial NF-κB activation is essential for zebrafish heart regeneration. Proc Natl Acad Sci USA. 112:13255–13260. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Yang SF, Zhuang TF, Si YM, Qi KY and Zhao J: Coriolus versicolor mushroom polysaccharides exert immunoregulatory effects on mouse B cells via membrane Ig and TLR-4 to activate the MAPK and NF-κB signaling pathways. Mol Immunol. 64:144–151. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Kim E, Kim HC, Lee S, Ryu HG, Park YH, Kim JH, Lim YJ and Park HP: Dexmedetomidine confers neuroprotection against transient global cerebral ischemia/reperfusion injury in rats by inhibiting inflammation through inactivation of the TLR-4/NF-κB pathway. Neurosci Lett. 649:20–27. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Bi W, Zhu L, Jing X, Zeng Z, Liang Y, Xu A, Liu J, Xiao S, Yang L, Shi Q, et al: Rifampicin improves neuronal apoptosis in LPS-stimulated co-cultured BV2 cells through inhibition of the TLR-4 pathway. Mol Med Rep. 10:1793–1799. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Cimolai MC, Alvarez S, Bode C and Bugger H: Mitochondrial mechanisms in septic cardiomyopathy. Int J Mol Sci. 16:17763–17778. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Zhou Q, Pan X, Wang L, Wang X and Xiong D: The protective role of neuregulin-1: A potential therapy for sepsis-induced cardiomyopathy. Eur J Pharmacol. 788:234–240. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Park H, Huang X, Lu C, Cairo MS and Zhou X: MicroRNA-146a and microRNA-146b regulate human dendritic cell apoptosis and cytokine production by targeting TRAF6 and IRAK1 proteins. J Biol Chem. 290:2831–2841. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Wei J, Wang J, Zhou Y, Yan S, Li K and Lin H: MicroRNA-146a contributes to SCI recovery via regulating TRAF6 and IRAK1 expression. Biomed Res Int. 2016:40134872016. View Article : Google Scholar : PubMed/NCBI

28 

Jiang W and Kong L, Ni Q, Lu Y, Ding W, Liu G, Pu L, Tang W and Kong L: miR-146a ameliorates liver ischemia/reperfusion injury by suppressing IRAK1 and TRAF6. PLoS One. 9:e1015302014. View Article : Google Scholar : PubMed/NCBI

29 

Hiram R, Rizcallah E, Sirois C, Sirois M, Morin C, Fortin S and Rousseau E: Resolvin D1 reverses reactivity and Ca2+ sensitivity induced by ET-1, TNF-α, and IL-6 in the human pulmonary artery. Am J Physiol Heart Circ Physiol. 307:H1547–H1558. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Hiram R, Rizcallah E, Marouan S, Sirois C, Sirois M, Morin C, Fortin S and Rousseau E: Resolvin E1 normalizes contractility, Ca2+ sensitivity and smooth muscle cell migration rate in TNF-α- and IL-6-pretreated human pulmonary arteries. Am J Physiol Lung Cell Mol Physiol. 309:L776–L788. 2015.PubMed/NCBI

31 

Dumache R, Rogobete AF, Bedreag OH, Sarandan M, Cradigati AC, Papurica M, Dumbuleu CM, Nartita R and Sandesc D: Use of miRNAs as biomarkers in sepsis. Anal Cell Pathol (Amst). 2015:1867162015.PubMed/NCBI

32 

Landskroner-Eiger S, Moneke I and Sessa WC: miRNAs as modulators of angiogenesis. Cold Spring Harb Perspect Med. 3:a0066432013. View Article : Google Scholar : PubMed/NCBI

33 

Zhou S, Zhang P, Liang P and Huang X: The expression of miR-125b regulates angiogenesis during the recovery of heat-denatured HUVECs. Burns. 41:803–811. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Feng J, Yang Y, Zhang P, Wang F, Ma Y, Qin H and Wang Y: miR-150 functions as a tumour suppressor in human colorectal cancer by targeting c-Myb. J Cell Mol Med. 18:2125–2134. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Slezak-Prochazka I, Kluiver J, de Jong D, Smigielska-Czepiel K, Kortman G, Winkle M, Rutgers B, Koerts J, Visser L, Diepstra A, et al: Inhibition of the miR-155 target NIAM phenocopies the growth promoting effect of miR-155 in B-cell lymphoma. Oncotarget. 7:2391–2400. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Meloche J, Le Guen M, Potus F, Vinck J, Ranchoux B, Johnson I, Antigny F, Tremblay E, Breuils-Bonnet S, Perros F, et al: miR-223 reverses experimental pulmonary arterial hypertension. Am J Physiol Cell Physiol. 309:C363–C372. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Hadar A, Milanesi E, Walczak M, Puzianowska-Kuźnicka M, Kuźnicki J, Squassina A, Niola P, Chillotti C, Attems J, Gozes I and Gurwitz D: SIRT1, miR-132 and miR-212 link human longevity to Alzheimer's Disease. Sci Rep. 8:84652018. View Article : Google Scholar : PubMed/NCBI

38 

Bae SC and Lee YH: MiR-146a levels in rheumatoid arthritis and their correlation with disease activity: A meta-analysis. Int J Rheum Dis. 21:1335–1342. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Hu Q, Song J, Ding B, Cui Y, Liang J and Han S: miR-146a promotes cervical cancer cell viability via targeting IRAK1 and TRAF6. Oncol Rep. 39:3015–3024. 2018.PubMed/NCBI

40 

Zhang QB, Qing YF, Yin CC, Zhou L, Liu XS, Mi QS and Zhou JG: Mice with miR-146a deficiency develop severe gouty arthritis via dysregulation of TRAF 6, IRAK 1 and NALP3 inflammasome. Arthritis Res Ther. 20:452018. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xie J, Zhang L, Fan X, Dong X, Zhang Z and Fan W: MicroRNA‑146a improves sepsis‑induced cardiomyopathy by regulating the TLR‑4/NF‑κB signaling pathway. Exp Ther Med 18: 779-785, 2019.
APA
Xie, J., Zhang, L., Fan, X., Dong, X., Zhang, Z., & Fan, W. (2019). MicroRNA‑146a improves sepsis‑induced cardiomyopathy by regulating the TLR‑4/NF‑κB signaling pathway. Experimental and Therapeutic Medicine, 18, 779-785. https://doi.org/10.3892/etm.2019.7657
MLA
Xie, J., Zhang, L., Fan, X., Dong, X., Zhang, Z., Fan, W."MicroRNA‑146a improves sepsis‑induced cardiomyopathy by regulating the TLR‑4/NF‑κB signaling pathway". Experimental and Therapeutic Medicine 18.1 (2019): 779-785.
Chicago
Xie, J., Zhang, L., Fan, X., Dong, X., Zhang, Z., Fan, W."MicroRNA‑146a improves sepsis‑induced cardiomyopathy by regulating the TLR‑4/NF‑κB signaling pathway". Experimental and Therapeutic Medicine 18, no. 1 (2019): 779-785. https://doi.org/10.3892/etm.2019.7657
Copy and paste a formatted citation
x
Spandidos Publications style
Xie J, Zhang L, Fan X, Dong X, Zhang Z and Fan W: MicroRNA‑146a improves sepsis‑induced cardiomyopathy by regulating the TLR‑4/NF‑κB signaling pathway. Exp Ther Med 18: 779-785, 2019.
APA
Xie, J., Zhang, L., Fan, X., Dong, X., Zhang, Z., & Fan, W. (2019). MicroRNA‑146a improves sepsis‑induced cardiomyopathy by regulating the TLR‑4/NF‑κB signaling pathway. Experimental and Therapeutic Medicine, 18, 779-785. https://doi.org/10.3892/etm.2019.7657
MLA
Xie, J., Zhang, L., Fan, X., Dong, X., Zhang, Z., Fan, W."MicroRNA‑146a improves sepsis‑induced cardiomyopathy by regulating the TLR‑4/NF‑κB signaling pathway". Experimental and Therapeutic Medicine 18.1 (2019): 779-785.
Chicago
Xie, J., Zhang, L., Fan, X., Dong, X., Zhang, Z., Fan, W."MicroRNA‑146a improves sepsis‑induced cardiomyopathy by regulating the TLR‑4/NF‑κB signaling pathway". Experimental and Therapeutic Medicine 18, no. 1 (2019): 779-785. https://doi.org/10.3892/etm.2019.7657
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team