Integrated bioinformatics analysis reveals novel hub genes closely associated with pathological mechanisms of immunoglobulin A nephropathy
- Authors:
- Dongmei Zhang
- Yiling Cao
- Yongdi Zuo
- Zheng Wang
- Xuhua Mi
- Wanxin Tang
-
Affiliations: Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610000, P.R. China - Published online on: June 18, 2019 https://doi.org/10.3892/etm.2019.7686
- Pages: 1235-1245
-
Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Wyatt RJ and Julian BA: IgA nephropathy. N Engl J Med. 368:2402–2414. 2013. View Article : Google Scholar : PubMed/NCBI | |
Rodrigues JC, Haas M and Reich HN: IgA nephropathy. Clin J Am Soc Nephrol. 12:677–686. 2017. View Article : Google Scholar : PubMed/NCBI | |
Schena FP: A retrospective analysis of the natural history of primary IgA nephropathy worldwide. Am J Med. 89:209–215. 1990. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y, Yan X, Zhao T, Xu Q, Peng Q, Hu R, Quan S, Zhou Y and Xing G: Targeting C3a/C5a receptors inhibits human mesangial cell proliferation and alleviates immunoglobulin A nephropathy in mice. Clin Exp Immunol. 189:60–70. 2017. View Article : Google Scholar : PubMed/NCBI | |
Rops A, Jansen E, van der Schaaf A, Pieterse E, Rother N, Hofstra J, Dijkman HBPM, van de Logt AE, Wetzels J, van der Vlag J and van Spriel AB: Interleukin-6 is essential for glomerular immunoglobulin A deposition and the development of renal pathology in Cd37-deficient mice. Kidney Int. 93:1356–1366. 2018. View Article : Google Scholar : PubMed/NCBI | |
Hennino MF, Buob D, Van der Hauwaert C, Gnemmi V, Jomaa Z, Pottier N, Savary G, Drumez E, Noël C, Cauffiez C and Glowacki F: miR-21-5p renal expression is associated with fibrosis and renal survival in patients with IgA nephropathy. Sci Rep. 6:272092016. View Article : Google Scholar : PubMed/NCBI | |
Tanaka K, Sugiyama H, Yamanari T, Mise K, Morinaga H, Kitagawa M, Onishi A, Ogawa-Akiyama A, Tanabe K, Eguchi J, et al: Renal expression of trefoil factor 3 mRNA in association with tubulointerstitial fibrosis in IgA nephropathy. Nephrology (Carlton). 23:855–862. 2018. View Article : Google Scholar : PubMed/NCBI | |
Liang S, Jin J, Lin B, Gong J, Li Y and He Q: Rapamycin induces autophagy and reduces the apoptosis of podocytes under a stimulated condition of immunoglobulin a nephropathy. Kidney Blood Press Res. 42:177–187. 2017. View Article : Google Scholar : PubMed/NCBI | |
Leung JC, Chan LY, Saleem MA, Mathieson PW, Tang SC and Lai KN: Combined blockade of angiotensin II and prorenin receptors ameliorates podocytic apoptosis induced by IgA-activated mesangial cells. Apoptosis. 20:907–920. 2015. View Article : Google Scholar : PubMed/NCBI | |
Rauen T and Floege J: Inflammation in IgA nephropathy. Pediatr Nephrol. 32:2215–2224. 2017. View Article : Google Scholar : PubMed/NCBI | |
Bao H, Chen H, Zhu X, Zhang M, Yao G, Yu Y, Qin W, Zeng C, Zen K and Liu Z: MiR-223 downregulation promotes glomerular endothelial cell activation by upregulating importin α4 and α5 in IgA nephropathy. Kidney Int. 85:624–635. 2014. View Article : Google Scholar : PubMed/NCBI | |
Hodgin JB, Berthier CC, John R, Grone E, Porubsky S, Gröne HJ, Herzenberg AM, Scholey JW, Hladunewich M, Cattran DC, et al: The molecular phenotype of endocapillary proliferation: Novel therapeutic targets for IgA nephropathy. PLoS One. 9:e1034132014. View Article : Google Scholar : PubMed/NCBI | |
Wang L, Tan RZ, Chen Y, Wang HL, Liu YH, Wen D and Fan JM: CagA promotes proliferation and secretion of extracellular matrix by inhibiting signaling pathway of apoptosis in rat glomerular mesangial cells. Ren Fail. 38:458–464. 2016. View Article : Google Scholar : PubMed/NCBI | |
Cui H, Zhang Y, Zhang Q, Chen W, Zhao H and Liang J: A comprehensive genome-wide analysis of long noncoding RNA expression profile in hepatocellular carcinoma. Cancer Med. 6:2932–2941. 2017. View Article : Google Scholar : PubMed/NCBI | |
Tian W, Liu J, Pei B, Wang X, Guo Y and Yuan L: Identification of miRNAs and differentially expressed genes in early phase non-small cell lung cancer. Oncol Rep. 35:2171–2176. 2016. View Article : Google Scholar : PubMed/NCBI | |
Dong B, Wang G, Yao J, Yuan P, Kang W, Zhi L and He X: Predicting novel genes and pathways associated with osteosarcoma by using bioinformatics analysis. Gene. 628:32–37. 2017. View Article : Google Scholar : PubMed/NCBI | |
Liu D: LYN, a key gene from bioinformatics analysis, contributes to development and progression of esophageal adenocarcinoma. Med Sci Monit Basic Res. 21:253–261. 2015. View Article : Google Scholar : PubMed/NCBI | |
Zhou LT, Qiu S, Lv LL, Li ZL, Liu H, Tang RN, Ma KL and Liu BC: Integrative bioinformatics analysis provides insight into the molecular mechanisms of chronic kidney disease. Kidney Blood Press Res. 43:568–581. 2018. View Article : Google Scholar : PubMed/NCBI | |
Shu B, Fang Y, He W, Yang J and Dai C: Identification of macrophage-related candidate genes in lupus nephritis using bioinformatics analysis. Cell Signal. 46:43–51. 2018. View Article : Google Scholar : PubMed/NCBI | |
Liu P, Lassen E, Nair V, Berthier CC, Suguro M, Sihlbom C, Kretzler M, Betsholtz C, Haraldsson B, Ju W, et al: Transcriptomic and proteomic profiling provides insight into mesangial cell function in IgA nephropathy. J Am Soc Nephrol. 28:2961–2972. 2017. View Article : Google Scholar : PubMed/NCBI | |
Berthier CC, Bethunaickan R, Gonzalez-Rivera T, Nair V, Ramanujam M, Zhang W, Bottinger EP, Segerer S, Lindenmeyer M, Cohen CD, et al: Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis. J Immunol. 189:988–1001. 2012. View Article : Google Scholar : PubMed/NCBI | |
Shved N, Warsow G, Eichinger F, Hoogewijs D, Brandt S, Wild P, Kretzler M, Cohen CD and Lindenmeyer MT: Transcriptome-based network analysis reveals renal cell type-specific dysregulation of hypoxia-associated transcripts. Sci Rep. 7:85762017. View Article : Google Scholar : PubMed/NCBI | |
Gautier L, Cope L, Bolstad BM and Irizarry RA: Affy-analysis of affymetrix GeneChip data at the probe level. Bioinformatics. 20:307–315. 2004. View Article : Google Scholar : PubMed/NCBI | |
Forero DA, Guio-Vega GP and Gonzalez-Giraldo Y: A comprehensive regional analysis of genome-wide expression profiles for major depressive disorder. J Affect Disord. 218:86–92. 2017. View Article : Google Scholar : PubMed/NCBI | |
Leek JT, Johnson WE, Parker HS, Jaffe AE and Storey JD: The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics. 28:882–883. 2012. View Article : Google Scholar : PubMed/NCBI | |
Diboun I, Wernisch L, Orengo CA and Koltzenburg M: Microarray analysis after RNA amplification can detect pronounced differences in gene expression using limma. BMC Genomics. 7:2522006. View Article : Google Scholar : PubMed/NCBI | |
Yu G, Wang LG, Han Y and He QY: ClusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–287. 2012. View Article : Google Scholar : PubMed/NCBI | |
Szklarczyk D, Morris JH, Cook H, Kuhn M, Wyder S, Simonovic M, Santos A, Doncheva NT, Roth A, Bork P, et al: The STRING database in 2017: Quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res. 45:D362–D368. 2017. View Article : Google Scholar : PubMed/NCBI | |
Kohl M, Wiese S and Warscheid B: Cytoscape: Software for visualization and analysis of biological networks. Methods Mol Biol. 696:291–303. 2011. View Article : Google Scholar : PubMed/NCBI | |
Chin CH, Chen SH, Wu HH, Ho CW, Ko MT and Lin CY: cytoHubba: Identifying hub objects and sub-networks from complex interactome. BMC Syst Biol. 8 (Suppl 4):S112014. View Article : Google Scholar : PubMed/NCBI | |
Kawai Y, Masutani K, Torisu K, Katafuchi R, Tanaka S, Tsuchimoto A, Mitsuiki K, Tsuruya K and Kitazono T: Association between serum albumin level and incidence of end-stage renal disease in patients with immunoglobulin A nephropathy: A possible role of albumin as an antioxidant agent. PLoS One. 13:e01966552018. View Article : Google Scholar : PubMed/NCBI | |
Park HJ, Kim JW, Cho BS and Chung JH: Association of FOS-like antigen 1 promoter polymorphism with podocyte foot process effacement in immunoglobulin A nephropathy patients. J Clin Lab Anal. 28:391–397. 2014. View Article : Google Scholar : PubMed/NCBI | |
Qiu LQ, Sinniah R and Hsu SI: Coupled induction of iNOS and p53 upregulation in renal resident cells may be linked with apoptotic activity in the pathogenesis of progressive IgA nephropathy. J Am Soc Nephrol. 15:2066–2078. 2004. View Article : Google Scholar : PubMed/NCBI | |
Boguslawska J, Kedzierska H, Poplawski P, Rybicka B, Tanski Z and Piekielko-Witkowska A: Expression of genes involved in cellular adhesion and extracellular matrix remodeling correlates with poor survival of patients with renal cancer. J Urol. 195:1892–1902. 2016. View Article : Google Scholar : PubMed/NCBI | |
Livingston MJ, Ding HF, Huang S, Hill JA, Yin XM and Dong Z: Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction. Autophagy. 12:976–998. 2016. View Article : Google Scholar : PubMed/NCBI | |
Glasner A, Levi A, Enk J, Isaacson B, Viukov S, Orlanski S, Scope A, Neuman T, Enk CD, Hanna JH, et al: NKp46 receptor-mediated interferon-γ production by natural killer cells increases fibronectin 1 to alter tumor architecture and control metastasis. Immunity. 48:107–119.e4. 2018. View Article : Google Scholar : PubMed/NCBI | |
Jovanovic KK, Escure G, Demonchy J, Willaume A, Van de Wyngaert Z, Farhat M, Chauvet P, Facon T, Quesnel B and Manier S: Deregulation and targeting of TP53 pathway in multiple myeloma. Front Oncol. 8:6652019. View Article : Google Scholar : PubMed/NCBI | |
Yogosawa S and Yoshida K: Tumor suppressive role for kinases phosphorylating p53 in DNA damage-induced apoptosis. Cancer Sci. 109:3376–3382. 2018. View Article : Google Scholar : PubMed/NCBI | |
Zhang SZ, Qiu XJ, Dong SS, Zhou LN, Zhu Y, Wang MD and Jin LW: MicroRNA-770-5p is involved in the development of diabetic nephropathy through regulating podocyte apoptosis by targeting TP53 regulated inhibitor of apoptosis 1. Eur Rev Med Pharmacol Sci. 23:1248–1256. 2019.PubMed/NCBI | |
Chen SN, Lombardi R, Karmouch J, Tsai JY, Czernuszewicz G, Taylor MRG, Mestroni L, Coarfa C, Gurha P and Marian AJ: DNA damage Response/TP53 pathway is activated and contributes to the pathogenesis of dilated cardiomyopathy associated With LMNA (Lamin A/C) mutations. Circ Res. 124:856–873. 2019. View Article : Google Scholar : PubMed/NCBI | |
Liu GC, Zhou YF, Su XC and Zhang J: Interaction between TP53 and XRCC1 increases susceptibility to cervical cancer development: A case control study. BMC Cancer. 19:242019. View Article : Google Scholar : PubMed/NCBI | |
Robin M, Issa AR, Santos CC, Napoletano F, Petitgas C, Chatelain G, Ruby M, Walter L, Birman S, Domingos PM, et al: Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress. Autophagy. 15:771–784. 2019. View Article : Google Scholar : PubMed/NCBI | |
Dai J, Xu LJ, Han GD, Jiang HT, Sun HL, Zhu GT and Tang XM: Down-regulation of long non-coding RNA ITGB2-AS1 inhibits osteosarcoma proliferation and metastasis by repressing Wnt/β-catenin signalling and predicts favourable prognosis. Artif Cells Nanomed Biotechnol. 46 (Suppl 3):S783–S790. 2018. View Article : Google Scholar : PubMed/NCBI | |
Liu H, Dai X, Cao X, Yan H, Ji X, Zhang H, Shen S, Si Y, Zhang H, Chen J, et al: PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin β2 expression. EMBO Rep. 19(pii): e451802018. View Article : Google Scholar : PubMed/NCBI | |
Aziz MH, Cui K, Das M, Brown KE, Ardell CL, Febbraio M, Pluskota E, Han J, Wu H, Ballantyne CM, et al: The upregulation of integrin αDβ2 (CD11d/CD18) on inflammatory macrophages promotes macrophage retention in vascular lesions and development of atherosclerosis. J Immunol. 198:4855–4867. 2017. View Article : Google Scholar : PubMed/NCBI | |
Kijas JM, Bauer TR Jr, Gafvert S, Marklund S, Trowald-Wigh G, Johannisson A, Hedhammar A, Binns M, Juneja RK, Hickstein DD and Andersson L: A missense mutation in the beta-2 integrin gene (ITGB2) causes canine leukocyte adhesion deficiency. Genomics. 61:101–107. 1999. View Article : Google Scholar : PubMed/NCBI | |
Yee NK and Hamerman JA: β(2) integrins inhibit TLR responses by regulating NF-κB pathway and p38 MAPK activation. Eur J Immunol. 43:779–792. 2013. View Article : Google Scholar : PubMed/NCBI | |
Duan J, Zhang X, Zhang S, Hua S and Feng Z: miR-206 inhibits FN1 expression and proliferation and promotes apoptosis of rat type II alveolar epithelial cells. Exp Ther Med. 13:3203–3208. 2017. View Article : Google Scholar : PubMed/NCBI | |
Wang J, Deng L, Huang J, Cai R, Zhu X, Liu F, Wang Q, Zhang J and Zheng Y: High expression of Fibronectin 1 suppresses apoptosis through the NF-κB pathway and is associated with migration in nasopharyngeal carcinoma. Am J Transl Res. 9:4502–4511. 2017.PubMed/NCBI | |
Liu C, Feng Z, Chen T, Lv J, Liu P, Jia L, Zhu J, Chen F, Yang C and Deng Z: Downregulation of NEAT1 reverses the radioactive iodine resistance of papillary thyroid carcinoma cell via miR-101-3p/FN1/PI3K-AKT signaling pathway. Cell Cycle. 18:167–203. 2019. View Article : Google Scholar : PubMed/NCBI | |
Liao YX, Zhang ZP, Zhao J and Liu JP: Effects of Fibronectin 1 on cell proliferation, senescence and apoptosis of human glioma cells through the PI3K/AKT signaling pathway. Cell Physiol Biochem. 48:1382–1396. 2018. View Article : Google Scholar : PubMed/NCBI | |
Bakiri L, Hamacher R, Grana O, Guío-Carrión A, Campos-Olivas R, Martinez L, Dienes HP, Thomsen MK, Hasenfuss SC and Wagner EF: Liver carcinogenesis by FOS-dependent inflammation and cholesterol dysregulation. J Exp Med. 214:1387–1409. 2017. View Article : Google Scholar : PubMed/NCBI | |
Xu X, Kwon OK, Shin IS, Mali JR, Harmalkar DS, Lim Y, Lee G, Lu Q, Oh SR, Ahn KS, et al: Novel benzofuran derivative DK-1014 attenuates lung inflammation via blocking of MAPK/AP-1 and AKT/mTOR signaling in vitro and in vivo. Sci Rep. 9:8622019. View Article : Google Scholar : PubMed/NCBI | |
Chen M, Li X, Shi Q, Zhang Z and Xu S: Hydrogen sulfide exposure triggers chicken trachea inflammatory injury through oxidative stress-mediated FOS/IL8 signaling. J Hazard Mater. 368:243–254. 2019. View Article : Google Scholar : PubMed/NCBI | |
Nagesh R, Kiran Kumar KM, Naveen Kumar M, Patil RH and Sharma SC: Stress activated p38 MAPK regulates cell cycle via AP-1 factors in areca extract exposed human lung epithelial cells. Cytotechnology. 71:507–520. 2019. View Article : Google Scholar : PubMed/NCBI | |
Wu DM, Zhang YT, Lu J and Zheng YL: Effects of microRNA-129 and its target gene c-Fos on proliferation and apoptosis of hippocampal neurons in rats with epilepsy via the MAPK signaling pathway. J Cell Physiol. 233:6632–6643. 2018. View Article : Google Scholar : PubMed/NCBI | |
Liu C, Ding L, Bai L, Chen X, Kang H, Hou L and Wang J: Folate receptor alpha is associated with cervical carcinogenesis and regulates cervical cancer cells growth by activating ERK1/2/c-Fos/c-Jun. Biochem Biophys Res Commun. 491:1083–1091. 2017. View Article : Google Scholar : PubMed/NCBI | |
Hwang MS, Strainic MG, Pohlmann E, Kim H, Pluskota E, Ramirez-Bergeron DL, Plow EF and Medof ME: VEGFR2 survival and mitotic signaling depends on joint-activation of associated C3ar1/C5ar1 and IL-6R-gp130. J Cell Sci. 132(pii): jcs2193522019. View Article : Google Scholar : PubMed/NCBI | |
Mathern DR, K Horwitz J and Heeger PS: Absence of recipient C3aR1 signaling limits expansion and differentiation of alloreactive CD8+ T cell immunity and prolongs murine cardiac allograft survival. Am J Transplant. 198:1628–1640. 2019. View Article : Google Scholar | |
Matsumoto N, Satyam A, Geha M, Lapchak PH, Dalle Lucca JJ, Tsokos MG and Tsokos GC: C3a enhances the formation of intestinal organoids through C3aR1. Front Immunol. 8:10462017. View Article : Google Scholar : PubMed/NCBI | |
Lokman FE, Seman NA, Ismail AA, Yaacob NA, Mustafa N, Khir AS, Hussein Z and Wan Mohamud WN: Gene expression profiling in ethnic Malays with type 2 diabetes mellitus, with and without diabetic nephropathy. J Nephrol. 24:778–789. 2011. View Article : Google Scholar : PubMed/NCBI | |
Wang D, Guan MP, Zheng ZJ, Li WQ, Lyv FP, Pang RY and Xue YM: Transcription factor Egr1 is involved in high glucose-induced proliferation and fibrosis in rat glomerular mesangial cells. Cell Physiol Biochem. 36:2093–2107. 2015. View Article : Google Scholar : PubMed/NCBI | |
Liu F, Zhang ZP, Xin GD, Guo LH, Jiang Q and Wang ZX: miR-192 prevents renal tubulointerstitial fibrosis in diabetic nephropathy by targeting Egr1. Eur Rev Med Pharmacol Sci. 22:4252–4260. 2018.PubMed/NCBI | |
Wu C, Ma X, Zhou Y, Liu Y, Shao Y and Wang Q: Klotho restraining Egr1/TLR4/mTOR axis to reducing the expression of fibrosis and inflammatory cytokines in high glucose cultured rat mesangial cells. Exp Clin Endocrinol Diabetes. Jun 11–2018.(Epub ahead of print). doi: 10.1055/s-0044-101601. | |
Hu F, Xue M, Li Y, Jia YJ, Zheng ZJ, Yang YL, Guan MP, Sun L and Xue YM: Early growth response 1 (Egr1) is a transcriptional activator of NOX4 in oxidative stress of diabetic kidney disease. J Diabetes Res. 2018:34056952018. View Article : Google Scholar : PubMed/NCBI | |
Li Y, Hu F, Xue M, Jia YJ, Zheng ZJ, Wang L, Guan MP and Xue YM: Klotho down-regulates Egr-1 by inhibiting TGF-β1/Smad3 signaling in high glucose treated human mesangial cells. Biochem Biophys Res Commun. 487:216–222. 2017. View Article : Google Scholar : PubMed/NCBI | |
Wu SY, Rupaimoole R, Shen F, Pradeep S, Pecot CV, Ivan C, Nagaraja AS, Gharpure KM, Pham E, Hatakeyama H, et al: A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer. Nat Commun. 7:111692016. View Article : Google Scholar : PubMed/NCBI | |
Sun S, Ning X, Zhai Y, Du R, Lu Y, He L, Li R, Wu W, Sun W and Wang H: Egr-1 mediates chronic hypoxia-induced renal interstitial fibrosis via the PKC/ERK pathway. Am J Nephrol. 39:436–448. 2014. View Article : Google Scholar : PubMed/NCBI | |
Lin CY, Lin TY, Lee MC, Chen SC and Chang JS: Hyperglycemia: GDNF-EGR1 pathway target renal epithelial cell migration and apoptosis in diabetic renal embryopathy. PLoS One. 8:e567312013. View Article : Google Scholar : PubMed/NCBI | |
Singh R, Yadav V, Kumar S and Saini N: MicroRNA-195 inhibits proliferation, invasion and metastasis in breast cancer cells by targeting FASN, HMGCR, ACACA and CYP27B1. Sci Rep. 5:174542015. View Article : Google Scholar : PubMed/NCBI | |
Banks M and Holick MF: Molecular mechanism(s) involved in 25-hydroxyvitamin D's antiproliferative effects in CYP27B1-transfected LNCaP cells. Anticancer Res. 35:3773–3779. 2015.PubMed/NCBI | |
Li G, Wu F, Yang H, Deng X and Yuan Y: MiR-9-5p promotes cell growth and metastasis in non-small cell lung cancer through the repression of TGFBR2. Biomed Pharmacother. 96:1170–1178. 2017. View Article : Google Scholar : PubMed/NCBI | |
Ebefors K, Liu P, Lassén E, Elvin J, Candemark E, Levan K, Haraldsson B and Nyström J: Mesangial cells from patients with IgA nephropathy have increased susceptibility to galactose-deficient IgA1. BMC Nephrol. 17:402016. View Article : Google Scholar : PubMed/NCBI | |
You Z, Xu J, Li B, Ye H, Chen L, Liu Y and Xiong X: The mechanism of ATF3 repression of epithelial-mesenchymal transition and suppression of cell viability in cholangiocarcinoma via p53 signal pathway. J Cell Mol Med. 23:2184–2193. 2019. View Article : Google Scholar : PubMed/NCBI | |
Hsu YJ, Hsu SC, Chang YL, Huang SM, Shih CC, Tsai CS and Lin CY: Indoxyl sulfate upregulates the cannabinoid type 1 receptor gene via an ATF3/c-Jun complex-mediated signaling pathway in the model of uremic cardiomyopathy. Int J Cardiol. 252:128–135. 2018. View Article : Google Scholar : PubMed/NCBI | |
Armstrong HK, Gillis JL, Johnson IRD, Nassar ZD, Moldovan M, Levrier C, Sadowski MC, Chin MY, Tomlinson Guns ES, Tarulli G, et al: Dysregulated fibronectin trafficking by Hsp90 inhibition restricts prostate cancer cell invasion. Sci Rep. 8:20902018. View Article : Google Scholar : PubMed/NCBI | |
Wei X, Zhou D, Wang H, Ding N, Cui XX, Wang H, Verano M, Zhang K, Conney AH, Zheng X and DU ZY: Effects of pyridine analogs of curcumin on growth, apoptosis and NF-κB activity in prostate cancer PC-3 cells. Anticancer Res. 33:1343–1350. 2013.PubMed/NCBI | |
Bork P: The modular architecture of a new family of growth regulators related to connective tissue growth factor. FEBS Lett. 327:125–130. 1993. View Article : Google Scholar : PubMed/NCBI | |
Chen CC and Lau LF: Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol. 41:771–783. 2009. View Article : Google Scholar : PubMed/NCBI | |
Quan T, He T, Shao Y, Lin L, Kang S, Voorhees JJ and Fisher GJ: Elevated cysteine-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skin. Am J Pathol. 169:482–490. 2006. View Article : Google Scholar : PubMed/NCBI | |
Mizwicki MT, Liu G, Fiala M, Magpantay L, Sayre J, Siani A, Mahanian M, Weitzman R, Hayden EY, Rosenthal MJ, et al: 1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients. J Alzheimers Dis. 34:155–170. 2013. View Article : Google Scholar : PubMed/NCBI | |
Carl M, Akagi Y, Weidner S, Isaka Y, Imai E and Rupprecht HD: Specific inhibition of Egr-1 prevents mesangial cell hypercellularity in experimental nephritis. Kidney Int. 63:1302–1312. 2003. View Article : Google Scholar : PubMed/NCBI | |
Mohamad T, Kazim N, Adhikari A and Davie JK: EGR1 interacts with TBX2 and functions as a tumor suppressor in rhabdomyosarcoma. Oncotarget. 9:18084–18098. 2018. View Article : Google Scholar : PubMed/NCBI | |
Carver KA, Smith TL, Gallagher PE and Tallant EA: Angiotensin-(1–7) prevents angiotensin II-induced fibrosis in cremaster microvessels. Microcirculation. 22:19–27. 2015. View Article : Google Scholar : PubMed/NCBI | |
Heider A and Alt R: virtualArray: A R/bioconductor package to merge raw data from different microarray platforms. BMC Bioinformatics. 14:752013. View Article : Google Scholar : PubMed/NCBI | |
Tokunaga K, Uto H, Takami Y, Mera K, Nishida C, Yoshimine Y, Fukumoto M, Oku M, Sogabe A, Nosaki T, et al: Insulin-like growth factor binding protein-1 levels are increased in patients with IgA nephropathy. Biochem Biophys Res Commun. 399:144–149. 2010. View Article : Google Scholar : PubMed/NCBI |