Open Access

A preliminary study of associating liver partition and portal vein ligation for staged hepatectomy in a rat model of liver cirrhosis

  • Authors:
    • Xianwei Yang
    • Chuang Yang
    • Yiwen Qiu
    • Shu Shen
    • Junjie Kong
    • Wentao Wang
  • View Affiliations

  • Published online on: June 18, 2019     https://doi.org/10.3892/etm.2019.7688
  • Pages: 1203-1211
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in a rat model of liver cirrhosis has not, to the best of our knowledge, been previously investigated. The present study therefore aimed to establish a model of ALPPS in cirrhotic rats and to assess liver regeneration. Rats were randomly divided into an ALPPS group with carbon tetrachloride‑induced cirrhosis (group A) and a normal liver (group B). Rat weight, cytokine levels, biochemical parameters and histopathology were assessed 1, 2, 3, 7 and 14 days after ALPPS. Higher aspartate aminotransferase and alanine aminotransferase levels were detected in group A on the first postoperative day. On the first, second and third days, hepatocyte proliferation rate was higher in group B than in group A. After 3 days, hepatocyte proliferation rate in group B began to decrease, but the rate in group A continued to increase until the 14th day. Higher levels of hepatocyte growth factor, interleukin‑6 and tumor necrosis factor‑α were detected in group A compared with group B, but the differences were not significant. The present study demonstrated that ALPPS promoted liver regeneration in a rat model of cirrhosis, but significantly impaired liver function. Compared with the ALPPS model, group B exhibited a delayed peak of proliferation. The mechanism of liver regeneration induced by ALPPS in cirrhotic rats may be associated with increased cytokine levels.
View Figures
View References

Related Articles

Journal Cover

August-2019
Volume 18 Issue 2

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yang X, Yang C, Qiu Y, Shen S, Kong J and Wang W: A preliminary study of associating liver partition and portal vein ligation for staged hepatectomy in a rat model of liver cirrhosis. Exp Ther Med 18: 1203-1211, 2019
APA
Yang, X., Yang, C., Qiu, Y., Shen, S., Kong, J., & Wang, W. (2019). A preliminary study of associating liver partition and portal vein ligation for staged hepatectomy in a rat model of liver cirrhosis. Experimental and Therapeutic Medicine, 18, 1203-1211. https://doi.org/10.3892/etm.2019.7688
MLA
Yang, X., Yang, C., Qiu, Y., Shen, S., Kong, J., Wang, W."A preliminary study of associating liver partition and portal vein ligation for staged hepatectomy in a rat model of liver cirrhosis". Experimental and Therapeutic Medicine 18.2 (2019): 1203-1211.
Chicago
Yang, X., Yang, C., Qiu, Y., Shen, S., Kong, J., Wang, W."A preliminary study of associating liver partition and portal vein ligation for staged hepatectomy in a rat model of liver cirrhosis". Experimental and Therapeutic Medicine 18, no. 2 (2019): 1203-1211. https://doi.org/10.3892/etm.2019.7688