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A preliminary study of associating liver partition and portal vein ligation for staged hepatectomy in a rat model of liver cirrhosis

  • Authors:
    • Xianwei Yang
    • Chuang Yang
    • Yiwen Qiu
    • Shu Shen
    • Junjie Kong
    • Wentao Wang
  • View Affiliations / Copyright

    Affiliations: Department of Liver Surgery and Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1203-1211
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    Published online on: June 18, 2019
       https://doi.org/10.3892/etm.2019.7688
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Abstract

Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in a rat model of liver cirrhosis has not, to the best of our knowledge, been previously investigated. The present study therefore aimed to establish a model of ALPPS in cirrhotic rats and to assess liver regeneration. Rats were randomly divided into an ALPPS group with carbon tetrachloride‑induced cirrhosis (group A) and a normal liver (group B). Rat weight, cytokine levels, biochemical parameters and histopathology were assessed 1, 2, 3, 7 and 14 days after ALPPS. Higher aspartate aminotransferase and alanine aminotransferase levels were detected in group A on the first postoperative day. On the first, second and third days, hepatocyte proliferation rate was higher in group B than in group A. After 3 days, hepatocyte proliferation rate in group B began to decrease, but the rate in group A continued to increase until the 14th day. Higher levels of hepatocyte growth factor, interleukin‑6 and tumor necrosis factor‑α were detected in group A compared with group B, but the differences were not significant. The present study demonstrated that ALPPS promoted liver regeneration in a rat model of cirrhosis, but significantly impaired liver function. Compared with the ALPPS model, group B exhibited a delayed peak of proliferation. The mechanism of liver regeneration induced by ALPPS in cirrhotic rats may be associated with increased cytokine levels.
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Copy and paste a formatted citation
Spandidos Publications style
Yang X, Yang C, Qiu Y, Shen S, Kong J and Wang W: A preliminary study of associating liver partition and portal vein ligation for staged hepatectomy in a rat model of liver cirrhosis. Exp Ther Med 18: 1203-1211, 2019.
APA
Yang, X., Yang, C., Qiu, Y., Shen, S., Kong, J., & Wang, W. (2019). A preliminary study of associating liver partition and portal vein ligation for staged hepatectomy in a rat model of liver cirrhosis. Experimental and Therapeutic Medicine, 18, 1203-1211. https://doi.org/10.3892/etm.2019.7688
MLA
Yang, X., Yang, C., Qiu, Y., Shen, S., Kong, J., Wang, W."A preliminary study of associating liver partition and portal vein ligation for staged hepatectomy in a rat model of liver cirrhosis". Experimental and Therapeutic Medicine 18.2 (2019): 1203-1211.
Chicago
Yang, X., Yang, C., Qiu, Y., Shen, S., Kong, J., Wang, W."A preliminary study of associating liver partition and portal vein ligation for staged hepatectomy in a rat model of liver cirrhosis". Experimental and Therapeutic Medicine 18, no. 2 (2019): 1203-1211. https://doi.org/10.3892/etm.2019.7688
Copy and paste a formatted citation
x
Spandidos Publications style
Yang X, Yang C, Qiu Y, Shen S, Kong J and Wang W: A preliminary study of associating liver partition and portal vein ligation for staged hepatectomy in a rat model of liver cirrhosis. Exp Ther Med 18: 1203-1211, 2019.
APA
Yang, X., Yang, C., Qiu, Y., Shen, S., Kong, J., & Wang, W. (2019). A preliminary study of associating liver partition and portal vein ligation for staged hepatectomy in a rat model of liver cirrhosis. Experimental and Therapeutic Medicine, 18, 1203-1211. https://doi.org/10.3892/etm.2019.7688
MLA
Yang, X., Yang, C., Qiu, Y., Shen, S., Kong, J., Wang, W."A preliminary study of associating liver partition and portal vein ligation for staged hepatectomy in a rat model of liver cirrhosis". Experimental and Therapeutic Medicine 18.2 (2019): 1203-1211.
Chicago
Yang, X., Yang, C., Qiu, Y., Shen, S., Kong, J., Wang, W."A preliminary study of associating liver partition and portal vein ligation for staged hepatectomy in a rat model of liver cirrhosis". Experimental and Therapeutic Medicine 18, no. 2 (2019): 1203-1211. https://doi.org/10.3892/etm.2019.7688
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