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Investigation of analgesic dose of nalbuphine combined with remifentanil after radical gastrectomy

  • Authors:
    • Yang Zhang
    • Rongfang Zhang
    • Nannan Ding
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Xiangyang No. 1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China, Department of Pharmacy, Xiangyang Central Hospital Affiliated to Hubei University of Arts and Science, Xiangyang, Hubei 441000, P.R. China
  • Pages: 1633-1638
    |
    Published online on: June 28, 2019
       https://doi.org/10.3892/etm.2019.7715
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Abstract

Clinical analgesic effect of different doses of nalbuphine combined with remifentanil on postoperative gastric cancer patients was explored. One hundred cases of gastric cancer patients treated from December 2014 to December 2016 in the Xiangyang No. 1 People's Hospital were selected and separated into group A and group B. The dose in group A was 0.2 mg/kg of nalbuphine plus 0.2 µg/kg of remifentanil, and 0.3 mg/kg of nalbuphine plus 0.1 µg/kg of remifentanil in group B. Analgesia was performed by self‑controlled intravenous injection. The Visual Analogue Scale (VAS) pain scores and the Brinell Comfort Score (BCS) at 2, 6, 12, 24 and 48 h after operation, and the incidence of adverse reactions were compared between the two groups. The VAS scores in group A were higher than those in group B, but the BCS scores in group A were lower (P<0.05). Postoperative patient‑controlled intravenous analgesia (PCIA) press times in group A were lower than those in group B (P<0.05); the incidence of adverse reactions such as nausea and vomiting in group A was higher than that in group B (P<0.05). The analgesic effect of intravenous analgesia scheme of 0.3 mg/kg of nalbuphine and 0.1 µg/kg of remifentanil on gastric cancer patients after operation is better than that of 0.2 mg/kg of nalbuphine and 0.2 µg/kg of remifentanil, which reduces the incidence of adverse reactions, has greater security, and can be promoted.
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1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2018. CA Cancer J Clin. 68:7–30. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Global Burden of Disease Cancer Collaboration, ; Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, Dicker DJ, Chimed-Orchir O, Dandona R, Dandona L, et al: Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: A systematic analysis for the global burden of disease study. JAMA Oncol. 3:524–548. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Xiao H, Xiao Y, Quan H, Liu W, Pan S and Ouyang Y: Intra-abdominal infection after radical gastrectomy for gastric cancer: Incidence, pathogens, risk factors and outcomes. Int J Surg. 48:195–200. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Bencivenga M, Verlato G, Han DS, Marrelli D, Roviello F, Yang HK and de Manzoni G; Italian Research Group for Gastric Cancer (GIRCG), : Validation of two prognostic models for recurrence and survival after radical gastrectomy for gastric cancer. Br J Surg. 104:1235–1243. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Stessel B, Theunissen M, Marcus MA, Joosten EA, van Kuijk SMJ, Fiddelers AAA, Peters ML, Hoofwijk DMN, Buhre WFFA and Gramke HF: Prevalence and predictors of patient nonadherence to pharmacological acute pain therapy at home after day surgery: A prospective cohort study. Pain Pract. 18:194–204. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Daccache G, Caspersen E, Pegoix M, Monthé-Sagan K, Berger L, Fletcher D and Hanouz JL: A targeted remifentanil administration protocol based on the analgesia nociception index during vascular surgery. Anaesth Crit Care Pain Med. 36:229–232. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Eagleman SL, Drover CM, Drover DR, Ouellette NT and MacIver MB: Remifentanil and nitrous oxide anesthesia produces a unique pattern of EEG activity during loss and recovery of response. Front Hum Neurosci. 12:1732018. View Article : Google Scholar : PubMed/NCBI

9 

Maguire DR and France C: Impact of delta-9-tetrahydrocannabinol on the reinforcing effects of remifentanil in rhesus monkeys responding under a food/drug choice procedure. FASEB J. 31 (Suppl 1):lb5912017.

10 

Eleveld DJ, Proost JH, Vereecke H, Absalom AR, Olofsen E, Vuyk J and Struys MMRF: An allometric model of remifentanil pharmacokinetics and pharmacodynamics. Anesthesiology. 126:1005–1018. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Cornelissen JC, Obeng S, Rice KC, Zhang Y, Negus SS and Banks ML: Application of receptor theory to the design and use of fixed-proportion mu-opioid agonist and antagonist mixtures in rhesus monkeys. J Pharmacol Exp Ther. 365:37–47. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Günther T, Dasgupta P, Mann A, Miess E, Kliewer A, Fritzwanker S, Steinborn R and Schulz S: Targeting multiple opioid receptors - improved analgesics with reduced side effects. Br J Pharmacol. 175:2857–2868. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Apfelbaum JL, Horlocker TT, Agarkar M, Connis RT, Hebl JR, Nickinovich DG, Palmer CM, Rathmell JP, Rosenquist RW and Wu CL; American Society of Anesthesiologists Committee on Standards, Practice Parameters, : Practice guidelines for the prevention, detection, and management of respiratory depression associated with neuraxialn opioid administration: An updated report by the American Society of Anesthesiologists Task Force on Neuraxial Opioids and the American Society of Regional Anesthesia and Pain Medicine. Obstet Anesthes Dig. 37:112017. View Article : Google Scholar

14 

Cao X, Yumul R, Elvir Lazo OL, Friedman J, Durra O, Zhang X and White PF: A novel visual facial anxiety scale for assessing preoperative anxiety. PLoS One. 12:e01712332017. View Article : Google Scholar : PubMed/NCBI

15 

Price DD, McGrath PA, Rafii A and Buckingham B: The validation of visual analogue scales as ratio scale measures for chronic and experimental pain. Pain. 17:45–56. 1983. View Article : Google Scholar : PubMed/NCBI

16 

Yao ZY, Jia Z, Xie YH, Zhang LL, Zhang HS, Wu WQ, Zhang CK and Gan LJ: Analgesic effect of dezocine in different doses on elderly patients undergoing abdominal operation under general anesthesia and its influence on stress response to postoperative tracheal extubation. Eur Rev Med Pharmacol Sci. 21:5223–5229. 2017.PubMed/NCBI

17 

Cho JS, Lee MH, Kim SI, Park S, Park HS, Oh E, Lee JH and Koo BN: The Effects of perioperative anesthesia and analgesia on immune function in patients undergoing breast cancer resection: A prospective randomized study. Int J Med Sci. 14:970–976. 2018. View Article : Google Scholar

18 

Sun HL, Dong YC, Wang CQ, Qian YN and Wang ZY: Effects of postoperative analgesia with the combination of tramadol and lornoxicam on serum inflammatory cytokines in patients with gastric cancer. Int J Clin Pharmacol Ther. 52:1023–1029. 2014. View Article : Google Scholar : PubMed/NCBI

19 

McEvoy MD, Scott MJ, Gordon DB, Grant SA, Thacker JKM, Wu CL, Gan TJ, Mythen MG, Shaw AD and Miller TE; Perioperative Quality Initiative (POQI) I Workgroup, : American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative (POQI) joint consensus statement on optimal analgesia within an enhanced recovery pathway for colorectal surgery: Part 1-from the preoperative period to PACU. Perioper Med (Lond). 6:82017. View Article : Google Scholar : PubMed/NCBI

20 

Rose MA and Kam PC: Gabapentin: Pharmacology and its use in pain management. Anaesthesia. 57:451–462. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Viscusi ER, Grond S, Ding L, Danesi H, Jones JB and Sinatra RS: A comparison of opioid-related adverse events with fentanyl iontophoretic transdermal system versus morphine intravenous patient-controlled analgesia in acute postoperative pain. Pain Manag. 6:19–24. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Bijur PE, Mills AM, Chang AK, White D, Restivo A, Persaud S, Schechter CB, Gallagher EJ and Birnbaum AJ: Comparative effectiveness of patient-controlled analgesia for treating acute pain in the emergency department. Ann Emerg Med. 70:809–818.e2. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Loscovich A, Briskin A, Fadeev A, Grisaru-Granovsky S and Halpern S: Emergency cesarean section in a patient with Fontan circulation using an indwelling epidural catheter. J Clin Anesth. 18:631–634. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Yamada K, Abe Y, Satoh S, Yanagibashi Y, Hyakumachi T and Masuda T: Large increase in blood pressure after extubation and high body mass index elevate the risk of spinal epidural hematoma after spinal surgery. Spine. 40:1046–1052. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Britt T, Sturm R, Ricardi R and Labond V: Comparative evaluation of continuous intercostal nerve block or epidural analgesia on the rate of respiratory complications, intensive care unit, and hospital stay following traumatic rib fractures: A retrospective review. Local Reg Anesth. 8:79–84. 2015.PubMed/NCBI

26 

Sprenger C, Eichler IC, Eichler L, Zöllner C and Büchel C: Altered signaling in the descending pain-modulatory system after short-term infusion of the µ-opioid agonist remifentanil. J Neurosci. 38:2454–2470. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Ovari A, Bicker I, Machmueller S, Schuldt T, Sauer M, Soltesz S, Noeldge-Schomburg G, Mlynski R and Mencke T: Sevoflurane at 1.0 MAC together with remifentanil and propofol produces clinically acceptable intubation conditions at the vocal cords: A prospective randomized study. J Int Med Res. 45:1098–1108. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Wang HY, Ting CK, Liou JY, Chen KH, Tsou MY and Chang WK: A previously published propofol-remifentanil response surface model does not predict patient response well in video-assisted thoracic surgery. Medicine (Baltimore). 96:e68952017. View Article : Google Scholar : PubMed/NCBI

29 

de Hoogd S, Ahlers SJGM, van Dongen EP, van de Garde EMW, Daeter EJ, Dahan A, Tibboel D and Knibbe CAJ: Randomized controlled trial on the influence of intraoperative remifentanil versus fentanyl on acute and chronic pain after cardiac surgery. Pain Pract. 18:443–451. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Trescot AM, Datta S, Lee M and Hansen H: Opioid pharmacology. Pain Physician. 11:133–153. 2008.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Zhang R and Ding N: Investigation of analgesic dose of nalbuphine combined with remifentanil after radical gastrectomy. Exp Ther Med 18: 1633-1638, 2019.
APA
Zhang, Y., Zhang, R., & Ding, N. (2019). Investigation of analgesic dose of nalbuphine combined with remifentanil after radical gastrectomy. Experimental and Therapeutic Medicine, 18, 1633-1638. https://doi.org/10.3892/etm.2019.7715
MLA
Zhang, Y., Zhang, R., Ding, N."Investigation of analgesic dose of nalbuphine combined with remifentanil after radical gastrectomy". Experimental and Therapeutic Medicine 18.3 (2019): 1633-1638.
Chicago
Zhang, Y., Zhang, R., Ding, N."Investigation of analgesic dose of nalbuphine combined with remifentanil after radical gastrectomy". Experimental and Therapeutic Medicine 18, no. 3 (2019): 1633-1638. https://doi.org/10.3892/etm.2019.7715
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Zhang R and Ding N: Investigation of analgesic dose of nalbuphine combined with remifentanil after radical gastrectomy. Exp Ther Med 18: 1633-1638, 2019.
APA
Zhang, Y., Zhang, R., & Ding, N. (2019). Investigation of analgesic dose of nalbuphine combined with remifentanil after radical gastrectomy. Experimental and Therapeutic Medicine, 18, 1633-1638. https://doi.org/10.3892/etm.2019.7715
MLA
Zhang, Y., Zhang, R., Ding, N."Investigation of analgesic dose of nalbuphine combined with remifentanil after radical gastrectomy". Experimental and Therapeutic Medicine 18.3 (2019): 1633-1638.
Chicago
Zhang, Y., Zhang, R., Ding, N."Investigation of analgesic dose of nalbuphine combined with remifentanil after radical gastrectomy". Experimental and Therapeutic Medicine 18, no. 3 (2019): 1633-1638. https://doi.org/10.3892/etm.2019.7715
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