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Article

Long non‑coding RNA H19 knockdown inhibits the cell viability and promotes apoptosis of thyroid cancer cells through regulating the PI3K/AKT pathway

  • Authors:
    • Xiaoyu Li
    • Qinghuai Li
    • Xiao Jin
    • Hao Guo
    • Yong Li
  • View Affiliations / Copyright

    Affiliations: Department of Thyroid and Breast Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China, The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China
  • Pages: 1863-1869
    |
    Published online on: July 1, 2019
       https://doi.org/10.3892/etm.2019.7720
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Abstract

Certain long non‑coding (lnc)RNAs have been reported to serve important roles in the genesis and progression of thyroid cancer (TC). Recent studies have demonstrated that the expression of lncRNA H19 is upregulated in TC tissues; however, knowledge of the associated molecular mechanisms is limited. Therefore, the present study aimed to clarify the roles of H19 in TC. The mRNA expression of lncRNA H19 in TC tissues was determined using reverse transcription‑quantitative polymerase chain reaction analysis, and the effects of H19 knockdown on cell viability and apoptosis in vitro were assessed using MTT and flow cytometric assays, respectively. Finally, the signaling pathways involved in the effects of H19 were examined. The results indicated that H19 was upregulated in TC tissues. Silencing of H19 inhibited the cell viability and promoted apoptosis of FTC‑133 and TPC‑1 TC cells, accompanied by an increased expression of B‑cell lymphoma 2 (Bcl‑2)‑associated X protein and caspase 3, and repressed expression of Bcl‑2. The results of western blot analysis suggested that the levels of phosphorylated phosphoinositide‑3 kinase (PI3K) and phosphorylated AKT were attenuated by H19 silencing. These results suggest that lncRNA H19 exerts an oncogenic function in TC, in part through the PI3K/AKT pathway.
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View References

1 

Klubo-Gwiezdzinska J, Yang L, Merkel R, Patel D, Nilubol N, Merino MJ, Skarulis M, Sadowski SM and Kebebew E: Results of screening in familial non-medullary thyroid cancer. Thyroid. 27:1017–1024. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Aschebrook-Kilfoy B, James B, Nagar S, Kaplan S, Seng V, Ahsan H, Angelos P, Kaplan EL, Guerrero MA, Kuo JH, et al: Risk factors for decreased quality of life in thyroid cancer survivors: Initial findings from the North American thyroid cancer survivorship study. Thyroid. 25:1313–1321. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Grogan RH, Kaplan SP, Cao H, Weiss RE, Degroot LJ, Simon CA, Embia OM, Angelos P, Kaplan EL and Schechter RB: A study of recurrence and death from papillary thyroid cancer with 27 years of median follow-up. Surgery. 154:1436–1447. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Gillanders SL and O'Neill JP: Prognostic markers in well differentiated papillary and follicular thyroid cancer (WDTC). Eur J Surg Oncol. 44:286–296. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Jeong S, Lee J, Kim D, Seol MY, Lee WK, Jeong JJ, Nam KH, Jung SG, Shin DY, Lee EJ, et al: Relationship of focally amplified long noncoding on chromosome 1 (FAL1) lncRNA with E2F transcription factors in thyroid cancer. Medicine (Baltimore). 95:e25922016. View Article : Google Scholar : PubMed/NCBI

6 

Mercer TR, Dinger ME and Mattick JS: Long non-coding RNAs: Insights into functions. Nat Rev Genet. 10:155–159. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Hao S, Yao L, Huang J, He H, Yang F, Di Y, Jin C and Fu D: Genome-wide analysis identified a number of dysregulated long noncoding RNA (lncRNA) in human pancreatic ductal adenocarcinoma. Technol Cancer Res Treat. 17:15330346177484292018. View Article : Google Scholar : PubMed/NCBI

8 

Ponzio G, Rezzonico R, Bourget I, Allan R, Nottet N, Popa A, Magnone V, Rios G, Mari B and Barbry P: A new long noncoding RNA (lncRNA) is induced in cutaneous squamous cell carcinoma and down-regulates several anticancer and cell differentiation genes in mouse. J Biol Chem. 292:12483–12495. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Zhao JH, Sun JX, Song YX, Chen XW, Yang YC, Ma B, Wang J, Gao P and Wang ZN: A novel long noncoding RNA-LOWEG is low expressed in gastric cancer and acts as a tumor suppressor by inhibiting cell invasion. J Cancer Res Clin Oncol. 142:601–609. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Chen C, Zhou L, Wang H, Chen J, Li W, Liu W, Shen M, Liu H and Fu X: Long noncoding RNA CNALPTC1 promotes cell proliferation and migration of papillary thyroid cancer via sponging miR-30 family. Am J Cancer Res. 8:192–206. 2018.PubMed/NCBI

11 

Li T, Yang XD, Ye CX, Shen ZL, Yang Y, Wang B, Guo P, Gao ZD, Ye YJ, Jiang KW and Wang S: Long noncoding RNA HIT000218960 promotes papillary thyroid cancer oncogenesis and tumor progression by upregulating the expression of high mobility group AT-hook 2 (HMGA2) gene. Cell Cycle. 16:224–231. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Jendrzejewski J, He H, Radomska HS, Li W, Tomsic J, Liyanarachchi S, Davuluri RV, Nagy R and de la Chapelle A: The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type. Proc Natl Acad Sci USA. 109:8646–8651. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Jendrzejewski J, Thomas A, Liyanarachchi S, Eiterman A, Tomsic J, He H, Radomska HS, Li W, Nagy R, Sworczak K and de la Chapelle A: PTCSC3 is involved in papillary thyroid carcinoma development by modulating S100A4 gene expression. J Clin Endocrinol Metab. 100:E1370–E1377. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Zheng H, Wang M, Jiang L, Chu H, Hu J, Ning J, Li B, Wang D and Xu J: BRAF-activated long noncoding RNA modulates papillary thyroid carcinoma cell proliferation through regulating thyroid stimulating hormone receptor. Cancer Res Treat. 48:698–707. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Wang Y, Guo Q, Zhao Y, Chen J, Wang S, Hu J and Sun Y: BRAF-activated long non-coding RNA contributes to cell proliferation and activates autophagy in papillary thyroid carcinoma. Oncol Lett. 8:1947–1952. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Liu L, Yang J, Zhu X, Li D, Lv Z and Zhang X: Long noncoding RNA H19 competitively binds miR-17-5p to regulate YES1 expression in thyroid cancer. FEBS J. 283:2326–2339. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Mei JM and Niu CS: Effects of CDNF on 6-OHDA-induced apoptosis in PC12 cells via modulation of Bcl-2/Bax and caspase-3 activation. Neurol Sci. 35:1275–1280. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Pal MK, Jaiswar SP, Srivastav AK, Goyal S, Dwivedi A, Verma A, Singh J, Pathak AK, Sankhwar PL and Ray RS: Synergistic effect of piperine and paclitaxel on cell fate via cyt-c, Bax/Bcl-2-caspase-3 pathway in ovarian adenocarcinomas SKOV-3 cells. Eur J Pharmacol. 791:751–762. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Liao YX, Zhang ZP, Zhao J and Liu JP: Effects of fibronectin 1 on cell proliferation, senescence and apoptosis of human glioma cells through the PI3K/AKT signaling pathway. Cell Physiol Biochem. 48:1382–1396. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Zhou Y, Li S, Li J, Wang D and Li Q: Effect of microRNA-135a on cell proliferation, migration, invasion, apoptosis and tumor angiogenesis through the IGF-1/PI3K/Akt signaling pathway in non-small cell lung cancer. Cell Physiol Biochem. 42:1431–1446. 2017. View Article : Google Scholar : PubMed/NCBI

22 

de Oliveira JC, Oliveira LC, Mathias C, Pedroso GA, Lemos DS, Salviano-Silva A, Jucoski TS, Lobo-Alves SC, Zambalde EP, Cipolla GA and Gradia DF: Long non-coding RNAs in cancer: Another layer of complexity. J Gene Med. 21:e30652019.PubMed/NCBI

23 

Tang Y, Soroush F, Tong Z, Kiani MF and Wang B: Targeted multidrug delivery system to overcome chemoresistance in breast cancer. Int J Nanomedicine. 12:671–681. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Yan J, Zhang Y, She Q, Li X, Peng L, Wang X, Liu S, Shen X, Zhang W, Dong Y, et al: Long noncoding RNA H19/miR-675 axis promotes gastric cancer via FADD/Caspase 8/Caspase 3 signaling pathway. Cell Physiol Biochem. 42:2364–2376. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Xu Y, Wang Z, Jiang X and Cui Y: Overexpression of long noncoding RNA H19 indicates a poor prognosis for cholangiocarcinoma and promotes cell migration and invasion by affecting epithelial-mesenchymal transition. Biomed Pharmacother. 92:17–23. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Rothhut B, Ghoneim C, Antonicelli F and Soula-Rothhut M: Epidermal growth factor stimulates matrix metalloproteinase-9 expression and invasion in human follicular thyroid carcinoma cells through focal adhesion kinase. Biochimie. 89:613–624. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Dettmer M, Perren A, Moch H, Komminoth P, Nikiforov YE and Nikiforova MN: Comprehensive MicroRNA expression profiling identifies novel markers in follicular variant of papillary thyroid carcinoma. Thyroidology. 23:1383–1389. 2013. View Article : Google Scholar

28 

Murugan AK, Munirajan AK and Alzahrani AS: Long noncoding RNAs: Emerging players in thyroid cancer pathogenesis. Endocr Relat Cancer. 25:R59–R82. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Wang P, Liu G, Xu W, Liu H, Bu Q and Sun D: Long noncoding RNA H19 inhibits cell viability, migration, and invasion via downregulation of IRS-1 in thyroid cancer cells. Technol Cancer Res Treat. 16:1102–1112. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Mahmoudian-Sani MR, Jalali A, Jamshidi M, Moridi H, Alghasi A, Shojaeian A and Mobini GR: Long non-coding RNAs in thyroid cancer: Implications for pathogenesis, diagnosis, and therapy. Oncol Res Treat. 42:136–142. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Liu N, Zhou Q, Qi YH, Wang H, Yang L and Fan QY: Effects of long non-coding RNA H19 and microRNA let7a expression on thyroid cancer prognosis. Exp Mol Pathol. 103:71–77. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Lee KT, Gopalan V and Lam AK: Roles of long-non-coding RNAs in cancer therapy through the PI3K/Akt signalling pathway. Histol Histopathol. 34:593–609. 2019.PubMed/NCBI

33 

Wang SH, Wu XC, Zhang MD, Weng MZ, Zhou D and Quan ZW: Long noncoding RNA H19 contributes to gallbladder cancer cell proliferation by modulated miR-194-5p targeting AKT2. Tumour Biol. 37:9721–9730. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Liao Z, Zhao J and Yang Y: Downregulation of lncRNA H19 inhibits the migration and invasion of melanoma cells by inactivating the NF-κB and PI3K/Akt signaling pathways. Mol Med Rep. 17:7313–7318. 2018.PubMed/NCBI

35 

Renault TT, Dejean LM and Manon S: A brewing understanding of the regulation of Bax function by Bcl-xL and Bcl-2. Mech Ageing Dev. 161:201–210. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Feng K, Liu Y, Xu LJ, Zhao LF, Jia CW and Xu MY: Long noncoding RNA PVT1 enhances the viability and invasion of papillary thyroid carcinoma cells by functioning as ceRNA of microRNA-30a through mediating expression of insulin like growth factor 1 receptor. Biomed Pharmacother. 104:686–698. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li X, Li Q, Jin X, Guo H and Li Y: Long non‑coding RNA H19 knockdown inhibits the cell viability and promotes apoptosis of thyroid cancer cells through regulating the PI3K/AKT pathway. Exp Ther Med 18: 1863-1869, 2019.
APA
Li, X., Li, Q., Jin, X., Guo, H., & Li, Y. (2019). Long non‑coding RNA H19 knockdown inhibits the cell viability and promotes apoptosis of thyroid cancer cells through regulating the PI3K/AKT pathway. Experimental and Therapeutic Medicine, 18, 1863-1869. https://doi.org/10.3892/etm.2019.7720
MLA
Li, X., Li, Q., Jin, X., Guo, H., Li, Y."Long non‑coding RNA H19 knockdown inhibits the cell viability and promotes apoptosis of thyroid cancer cells through regulating the PI3K/AKT pathway". Experimental and Therapeutic Medicine 18.3 (2019): 1863-1869.
Chicago
Li, X., Li, Q., Jin, X., Guo, H., Li, Y."Long non‑coding RNA H19 knockdown inhibits the cell viability and promotes apoptosis of thyroid cancer cells through regulating the PI3K/AKT pathway". Experimental and Therapeutic Medicine 18, no. 3 (2019): 1863-1869. https://doi.org/10.3892/etm.2019.7720
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Li Q, Jin X, Guo H and Li Y: Long non‑coding RNA H19 knockdown inhibits the cell viability and promotes apoptosis of thyroid cancer cells through regulating the PI3K/AKT pathway. Exp Ther Med 18: 1863-1869, 2019.
APA
Li, X., Li, Q., Jin, X., Guo, H., & Li, Y. (2019). Long non‑coding RNA H19 knockdown inhibits the cell viability and promotes apoptosis of thyroid cancer cells through regulating the PI3K/AKT pathway. Experimental and Therapeutic Medicine, 18, 1863-1869. https://doi.org/10.3892/etm.2019.7720
MLA
Li, X., Li, Q., Jin, X., Guo, H., Li, Y."Long non‑coding RNA H19 knockdown inhibits the cell viability and promotes apoptosis of thyroid cancer cells through regulating the PI3K/AKT pathway". Experimental and Therapeutic Medicine 18.3 (2019): 1863-1869.
Chicago
Li, X., Li, Q., Jin, X., Guo, H., Li, Y."Long non‑coding RNA H19 knockdown inhibits the cell viability and promotes apoptosis of thyroid cancer cells through regulating the PI3K/AKT pathway". Experimental and Therapeutic Medicine 18, no. 3 (2019): 1863-1869. https://doi.org/10.3892/etm.2019.7720
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