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Effect of mild hypothermia on the expression of IL-10 and IL-18 in neonates with hypoxic ischemic encephalopathy

  • Authors:
    • Hongwei Wu
    • Gang Liu
    • Xia Yang
    • Qing Liu
    • Zhenguang Li
  • View Affiliations / Copyright

    Affiliations: Department of Newborn Medicine, Xuzhou Children's Hospital, Xuzhou Medical University, Xuzhou, Jiangsu 221006, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2194-2198
    |
    Published online on: July 12, 2019
       https://doi.org/10.3892/etm.2019.7768
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Abstract

The effect of mild hypothermia on the expression of interleukin (IL)-10 and IL-18 in neonates with hypoxic ischemic encephalopathy was investigated. A retrospective analysis was performed on 97 neonates with hypoxic-ischemic encephalopathy (HIE) admitted to the neonatal intensive care unit of Xuzhou Children's Hospital, Xuzhou Medical University from September 2016 to August 2018. Of these patients, 54 with mild hypothermia were included in the experimental group (moderate + severe), and 43 patients who received conventional therapy were included in the control group (moderate + severe). The effect of mild hypothermia on IL-10 and IL-18 expression levels was analyzed, and the relationship between IL-10, IL-18 and disease severity in children with hypoxic ischemic encephalopathy was analyzed. The concentration of IL-10 in the experimental group was significantly lower than that in the control group at 1, 2, 3 and 5 days (P<0.05). The concentration of IL-18 in the experimental group was significantly lower than that in the control group at the 2, 3 and 5 days (P<0.05). NBNA scores of the experimental group were significantly higher than those of the control group at 14 and 28 days after birth (P<0.05). Before treatment, the expression levels of IL-10 and IL-18 in severe children were significantly higher than those in moderate children (P<0.05). IL-10 was positively correlated with the severity of the disease (r=0.521, P<0.05), and IL-18 was also positively correlated with the severity of the disease (r=0.616 P<0.05). Mild hypothermia treatment can effectively improve the neurological function of children with HIE, reduce the expression of IL-10 and IL-18 in serum, and inhibit the inflammatory response. Therefore, the expression of IL-10 and IL-18 was positively correlated with the severity of disease in children with HIE, and could be used as an indicator to judge the severity of HIE.
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Copy and paste a formatted citation
Spandidos Publications style
Wu H, Liu G, Yang X, Liu Q and Li Z: Effect of mild hypothermia on the expression of IL-10 and IL-18 in neonates with hypoxic ischemic encephalopathy. Exp Ther Med 18: 2194-2198, 2019.
APA
Wu, H., Liu, G., Yang, X., Liu, Q., & Li, Z. (2019). Effect of mild hypothermia on the expression of IL-10 and IL-18 in neonates with hypoxic ischemic encephalopathy. Experimental and Therapeutic Medicine, 18, 2194-2198. https://doi.org/10.3892/etm.2019.7768
MLA
Wu, H., Liu, G., Yang, X., Liu, Q., Li, Z."Effect of mild hypothermia on the expression of IL-10 and IL-18 in neonates with hypoxic ischemic encephalopathy". Experimental and Therapeutic Medicine 18.3 (2019): 2194-2198.
Chicago
Wu, H., Liu, G., Yang, X., Liu, Q., Li, Z."Effect of mild hypothermia on the expression of IL-10 and IL-18 in neonates with hypoxic ischemic encephalopathy". Experimental and Therapeutic Medicine 18, no. 3 (2019): 2194-2198. https://doi.org/10.3892/etm.2019.7768
Copy and paste a formatted citation
x
Spandidos Publications style
Wu H, Liu G, Yang X, Liu Q and Li Z: Effect of mild hypothermia on the expression of IL-10 and IL-18 in neonates with hypoxic ischemic encephalopathy. Exp Ther Med 18: 2194-2198, 2019.
APA
Wu, H., Liu, G., Yang, X., Liu, Q., & Li, Z. (2019). Effect of mild hypothermia on the expression of IL-10 and IL-18 in neonates with hypoxic ischemic encephalopathy. Experimental and Therapeutic Medicine, 18, 2194-2198. https://doi.org/10.3892/etm.2019.7768
MLA
Wu, H., Liu, G., Yang, X., Liu, Q., Li, Z."Effect of mild hypothermia on the expression of IL-10 and IL-18 in neonates with hypoxic ischemic encephalopathy". Experimental and Therapeutic Medicine 18.3 (2019): 2194-2198.
Chicago
Wu, H., Liu, G., Yang, X., Liu, Q., Li, Z."Effect of mild hypothermia on the expression of IL-10 and IL-18 in neonates with hypoxic ischemic encephalopathy". Experimental and Therapeutic Medicine 18, no. 3 (2019): 2194-2198. https://doi.org/10.3892/etm.2019.7768
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