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Dexmedetomidine reduces inflammation in traumatic brain injury by regulating the inflammatory responses of macrophages and splenocytes

  • Authors:
    • Mengyao Ding
    • Ying Chen
    • Hengfei Luan
    • Xiaobao Zhang
    • Zhibin Zhao
    • Yong Wu
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu 222002, P.R. China
  • Pages: 2323-2331
    |
    Published online on: July 18, 2019
       https://doi.org/10.3892/etm.2019.7790
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Abstract

Traumatic brain injury (TBI) affects people in all demographics, since it is associated with a variety of chronic degenerative diseases, such as Alzheimer's and Parkinson's disease. In TBI, the central nervous system elicits an immune response involving various immune cells that is necessary for healing and defending the body against pathogens, but can also cause secondary damage to the brain if the response is prolonged. In our clinical practice, it has been identified that administration of dexmedetomidine was associated with reduced production of inflammatory cytokines in patients with TBI, which led to the hypothesis that dexmedetomidine may regulate certain inflammatory responses. To test this hypothesis, the roles of dexmedetomidine in the immune system of mice were investigated. Different biological assays were used to assess the influence of dexmedetomidine on the production of inflammatory cytokines, including tumor necrosis factor (TNF)‑α, interleukin (IL)‑6, IL‑8 and IL‑1β. To understand how dexmedetomidine affects different types of immune cells, the influence of dexmedetomidine on splenocytes was also investigated. Finally, the effects of dexmedetomidine on macrophage activation and inflammatory functions were studied. In the present study, clinical observations and in vivo results using a mouse model of TBI revealed the regulatory functions of dexmedetomidine in TBI‑associated immune response.
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Copy and paste a formatted citation
Spandidos Publications style
Ding M, Chen Y, Luan H, Zhang X, Zhao Z and Wu Y: Dexmedetomidine reduces inflammation in traumatic brain injury by regulating the inflammatory responses of macrophages and splenocytes. Exp Ther Med 18: 2323-2331, 2019.
APA
Ding, M., Chen, Y., Luan, H., Zhang, X., Zhao, Z., & Wu, Y. (2019). Dexmedetomidine reduces inflammation in traumatic brain injury by regulating the inflammatory responses of macrophages and splenocytes. Experimental and Therapeutic Medicine, 18, 2323-2331. https://doi.org/10.3892/etm.2019.7790
MLA
Ding, M., Chen, Y., Luan, H., Zhang, X., Zhao, Z., Wu, Y."Dexmedetomidine reduces inflammation in traumatic brain injury by regulating the inflammatory responses of macrophages and splenocytes". Experimental and Therapeutic Medicine 18.3 (2019): 2323-2331.
Chicago
Ding, M., Chen, Y., Luan, H., Zhang, X., Zhao, Z., Wu, Y."Dexmedetomidine reduces inflammation in traumatic brain injury by regulating the inflammatory responses of macrophages and splenocytes". Experimental and Therapeutic Medicine 18, no. 3 (2019): 2323-2331. https://doi.org/10.3892/etm.2019.7790
Copy and paste a formatted citation
x
Spandidos Publications style
Ding M, Chen Y, Luan H, Zhang X, Zhao Z and Wu Y: Dexmedetomidine reduces inflammation in traumatic brain injury by regulating the inflammatory responses of macrophages and splenocytes. Exp Ther Med 18: 2323-2331, 2019.
APA
Ding, M., Chen, Y., Luan, H., Zhang, X., Zhao, Z., & Wu, Y. (2019). Dexmedetomidine reduces inflammation in traumatic brain injury by regulating the inflammatory responses of macrophages and splenocytes. Experimental and Therapeutic Medicine, 18, 2323-2331. https://doi.org/10.3892/etm.2019.7790
MLA
Ding, M., Chen, Y., Luan, H., Zhang, X., Zhao, Z., Wu, Y."Dexmedetomidine reduces inflammation in traumatic brain injury by regulating the inflammatory responses of macrophages and splenocytes". Experimental and Therapeutic Medicine 18.3 (2019): 2323-2331.
Chicago
Ding, M., Chen, Y., Luan, H., Zhang, X., Zhao, Z., Wu, Y."Dexmedetomidine reduces inflammation in traumatic brain injury by regulating the inflammatory responses of macrophages and splenocytes". Experimental and Therapeutic Medicine 18, no. 3 (2019): 2323-2331. https://doi.org/10.3892/etm.2019.7790
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