Correlation between coronary stenosis and Toll‑like receptors 2 and 4 levels in Chinese Zhuang patients with coronary heart disease

Huang,Zhaohe; Liu,Yan; Liang,Limei; Liu,Wenjing; Sooranna,Suren  R.; Mo,Jianjiao; Liu,Li; Li,Zhile; Li,Kela; Guo,Jun

doi:10.3892/etm.2019.7805

Correlation between coronary stenosis and Toll‑like receptors 2 and 4 levels in Chinese Zhuang patients with coronary heart disease

Authors:
- Zhaohe Huang
- Yan Liu
- Limei Liang
- Wenjing Liu
- Suren R. Sooranna
- Jianjiao Mo
- Li Liu
- Zhile Li
- Kela Li
- Jun Guo
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Affiliations: Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510630, P.R. China, Department of Cardiology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, P.R. China, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London SW10 9NH, UK
Published online on: July 24, 2019 https://doi.org/10.3892/etm.2019.7805
Pages: 2346-2352

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Abstract

The present study attempted to determine the correlation of the degree of coronary artery stenosis and Tolllike receptor 2/4 (TLR2/4) levels in Chinese Zhuang patients with coronary heart disease (CHD). A total of 466 Chinese patients from the Zhuang Ethnic population diagnosed with CHD at the Department of Cardiology the Affiliated Hospital of Youjiang Medical University between January 2016 and August 2017, together with 102 control patients, were recruited for the present study. The patients with CHD were divided into three groups depending on the number of diseased arteries. The patients with CHD were also classified according to their Gensini scores. Blood liver and renal function parameters, as well as blood sugar and lipid levels were measured. ELISA was used for TLR2/4 measurements. There were no significant differences with gender, age and body mass index between the CHD and control groups. The levels of TLR2/4 in the peripheral blood of the control and CHD groups were 2.34±0.85/5.08±2.41 and 5.22±3.16/9.33±4.92 ng/ml, respectively, and the differences were significant (P<0.001). Analysis of the three subgroups of vessel disease indicated that the expression of TLR2/4 was progressively higher with the increase in the number of affected vessels (P<0.01). There were also significant differences between the mild, moderate and severe stenosis groups (P<0.01). A positive linear correlation between TLR2/4 and the Gensini coronary artery score was identified (r=0.508 and 0.346, respectively; P<0.0001). In conclusion, the present study determined a positive correlation between the degree of coronary artery stenosis and the expression level of TLR2/4 in the serum of Chinese Zhuang patients with CHD. Serum TLR2/4 may be used to predict the severity of CHD.

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