Osteoporotic vertebral fracture caused by topical corticosteroid abuse: A case report

Piaserico,Stefano; Linder,Dennis; Messina,Francesco; Alaibac,Mauro

doi:10.3892/etm.2019.7825

October-2019 Volume 18 Issue 4

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October-2019 Volume 18 Issue 4

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Case Report

Osteoporotic vertebral fracture caused by topical corticosteroid abuse: A case report

Authors:
- Stefano Piaserico
- Dennis Linder
- Francesco Messina
- Mauro Alaibac
View Affiliations / Copyright

Affiliations: Dermatology Unit, Department of Medicine, University of Padua, Padua I‑35128, Italy, Department of Dermatology and Venereology, Ben Gurion University of The Negev, Beer‑Sheva 84101, Israel
Pages: 2746-2748
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Published online on: July 30, 2019

https://doi.org/10.3892/etm.2019.7825
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Abstract

In the present case report, a 32‑year‑old man with a 20‑year long history of psoriasis, who presented with severe lower back pain and had no records of previous trauma, is reported. The patient reported the regular use of clobetasol cream, for 8 years, at an average dosage of 100 grams (g) per week. At the time of visit, the patient presented with severe psoriasis, which was associated with a cushingoid appearance. An X‑ray of the spine was performed and the results revealed diffuse vertebral collapse that was caused by osteoporosis. The patient was diagnosed with iatrogenic Cushing's syndrome caused by the long‑term use of clobetasol 17‑propionate cream. The topical clobetasol treatment was stopped and replaced with infliximab infusions. Complete control of the disease was subsequently achieved. Iatrogenic Cushing's syndrome is generally caused by systemic corticosteroid abuse. However, the topical application of potent glucocorticoids, including clobetasol treatment on the skin and mucosae, results in the same syndrome.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Osteoporotic vertebral fracture caused by topical corticosteroid abuse: A case report

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Abstract

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