Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

MicroRNA‑9 inhibits gastric cancer cell proliferation and migration by targeting neuropilin‑1

Retraction in: /10.3892/etm.2024.12687
  • Authors:
    • Cheng Hang
    • Hui‑Shen Yan
    • Chen Gong
    • Hua Gao
    • Qiu‑Hui Mao
    • Jian‑Xin Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Taicang Affiliated Hospital of Soochow University, The First People's Hospital of Taicang, Suzhou, Jiangsu 215400, P.R. China, Department of Traditional Chinese Medicine, Medical College of Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China
    Copyright: © Hang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2524-2530
    |
    Published online on: August 2, 2019
       https://doi.org/10.3892/etm.2019.7841
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Gastric cancer (GC) is a global health problem with poor clinical outcomes. The mechanism of its development and progression remains largely unclear. The present study investigated the role of microRNA‑9 (miR‑9‑5p) in the development and progression of GC. Overexpression of miR‑9‑5p led to reduced expression of neuropilin‑1 (NRP‑1) in GC cells. Dual‑luciferase reporter assay results indicated that miR‑9‑5p directly targeted NRP‑1. Furthermore, overexpression of miR‑9‑5p in GC cells increased the expression of mesenchymal markers, N‑cadherin and vimentin, and decreased the expression of epithelial markers, E‑cadherin and β‑catenin. Overexpression of miR‑9‑5p inhibited GC cell proliferation, migration and invasion, and increased the sensitivity of GC cells to the anti‑cancer drug cisplatin. By contrast, the opposite effects were observed in GC cells following downregulation of miR‑9‑5p. Taken together, the present findings suggested that miR‑9‑5p suppressed NRP‑1 expression and inhibited GC cell proliferation and invasion. In addition, miR‑9‑5p overexpression attenuated GC cell resistance to anti‑cancer drugs, which highlighted the potential of miR‑9‑5p as a target for the treatment of GC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

McGuire S: World Cancer Report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015. Adv Nutr. 7:418–419. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Hartgrink HH, Jansen EP, van Grieken NC and van de Velde CJ: Gastric cancer. Lancet. 374:477–490. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Zheng R, Zeng H, Zhang S and Chen W: Estimates of cancer incidence and mortality in China, 2013. Chin J Cancer. 36:662017. View Article : Google Scholar : PubMed/NCBI

4 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Garzon R, Calin GA and Croce CM: MicroRNAs in cancer. Annu Rev Med. 60:167–179. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Nakamura F and Goshima Y: Structural and functional relation of neuropilins. Adv Exp Med Biol. 515:55–69. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Prud'homme GJ and Glinka Y: Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity. Oncotarget. 3:921–939. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Chu W, Song X, Yang X, Ma L, Zhu J, He M, Wang Z and Wu Y: Neuropilin-1 promotes epithelial-to-mesenchymal transition by stimulating nuclear factor-kappa B and is associated with poor prognosis in human oral squamous cell carcinoma. PLoS One. 9:e1019312014. View Article : Google Scholar : PubMed/NCBI

9 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Han TS, Hur K, Xu G, Choi B, Okugawa Y, Toiyama Y, Oshima H, Oshima M, Lee HJ, Kim VN, et al: MicroRNA-29c mediates initiation of gastric carcinogenesis by directly targeting ITGB1. Gut. 64:203–214. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Bahari F, Emadi-Baygi M and Nikpour P: miR-17-92 host gene, uderexpressed in gastric cancer and its expression was negatively correlated with the metastasis. Indian J Cancer. 52:22–25. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Gwak JM, Kim HJ, Kim EJ, Chung YR, Yun S, Seo AN, Lee HJ and Park SY: MicroRNA-9 is associated with epithelial- mesenchymal transition, breast cancer stem cell phenotype, and tumor progression in breast cancer. Breast Cancer Res Treat. 147:39–49. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Fei D, Li Y, Zhao D, Zhao K, Dai L and Gao Z: Serum miR-9-5p as a prognostic biomarker in patients with osteosarcoma. J Int Med Res. 42:932–937. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Cai L and Cai X: Up-regulation of miR-9 expression predicate advanced clinicopathological features and poor prognosis in patients with hepatocellular carcinoma. Diagn Pathol. 9:10002014. View Article : Google Scholar : PubMed/NCBI

15 

Zheng LD, Qi T, Yang D, Qi M, Li D, Xiang X, Huang K and Tong Q: microRNA-9 suppresses the proliferation, invasion and metastasis of gastric cancer cells through targeting cyclin D1 and Ets1. PLoS One. 8:e557192013. View Article : Google Scholar : PubMed/NCBI

16 

Selcuklu SD, Donoghue MT, Rehmet K, de Souza Gomes M, Fort A, Kovvuru P, Muniyappa MK, Kerin MJ, Enright AJ and Spillane C: MicroRNA-9 inhibition of cell proliferation and identification of novel miR-9-5p targets by transcriptome profiling in breast cancer cells. J Biol Chem. 287:29516–29528. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Xue F, Liang Y, Li Z, Liu Y, Zhang H, Wen Y, Yan L, Tang Q, Xiao E and Zhang D: MicroRNA-9 enhances sensitivity to cetuximab in epithelial phenotype hepatocellular carcinoma cells through regulation of the eukaryotic translation initiation factor 5A-2. Oncol Lett. 15:813–820. 2018.PubMed/NCBI

18 

Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2:442–454. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Harris TJ and Tepass U: Adherens junctions: From molecules to morphogenesis. Nat Rev Mol Cell Biol. 11:502–514. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Christofori G: New signals from the invasive front. Nature. 441:444–450. 2016. View Article : Google Scholar

21 

Huang L, Wu RL and Xu AM: Epithelial-mesenchymal transition in gastric cancer. Am J Transl Res. 7:2141–2158. 2015.PubMed/NCBI

22 

Zheng HX, Li W, Wang Y, Xie T, Cai Y, Wang Z and Jiang B: miR-23a inhibits E-cadherin expression and is regulated by AP-1 and NFAT4 complex during Fas-induced EMT in gastrointestinal cancer. Carcinogenesis. 35:173–183. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Murai T, Yamada S, Fuchs BC, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Tanabe KK and Kodera Y: Epithelial-to-mesenchymal transition predicts prognosis in clinical gastric cancer. J Surg Oncol. 109:684–689. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Yuan D, Xia H, Zhang Y, Chen L, Leng W, Chen T, Chen Q, Tang Q, Mo X, Liu M and Bi F: P-Akt/miR200 signaling regulates epithelial-mesenchymal transition, migration and invasion in circulating gastric tumor cells. Int J Oncol. 45:2430–2438. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Takagi S, Tsuji T, Amagai T, Takamatsu T and Fujisawa H: Specific cell-surface labels in the visual centers of Xenopus laevis tadpole identified using monoclonal antibodies. Dev Biol. 122:90–100. 1987. View Article : Google Scholar : PubMed/NCBI

26 

Soker S, Takashima S, Miao HQ, Neufeld G and Klagsbrun M: Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell. 92:735–745. 1998. View Article : Google Scholar : PubMed/NCBI

27 

Miao HQ, Lee P, Lin H, Soker S and Klagsbrun M: Neuropilin-1 expression by tumor cells promotes tumor angiogenesis and progression. FASEB J. 14:2532–2539. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Pellet-Many C, Frankel P, Jia H and Zachary I: Neuropilins: Structure, function and role in disease. Biochem J. 411:211–226. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hang C, Yan HS, Gong C, Gao H, Mao QH and Zhu JX: MicroRNA‑9 inhibits gastric cancer cell proliferation and migration by targeting neuropilin‑1 Retraction in /10.3892/etm.2024.12687. Exp Ther Med 18: 2524-2530, 2019.
APA
Hang, C., Yan, H., Gong, C., Gao, H., Mao, Q., & Zhu, J. (2019). MicroRNA‑9 inhibits gastric cancer cell proliferation and migration by targeting neuropilin‑1 Retraction in /10.3892/etm.2024.12687. Experimental and Therapeutic Medicine, 18, 2524-2530. https://doi.org/10.3892/etm.2019.7841
MLA
Hang, C., Yan, H., Gong, C., Gao, H., Mao, Q., Zhu, J."MicroRNA‑9 inhibits gastric cancer cell proliferation and migration by targeting neuropilin‑1 Retraction in /10.3892/etm.2024.12687". Experimental and Therapeutic Medicine 18.4 (2019): 2524-2530.
Chicago
Hang, C., Yan, H., Gong, C., Gao, H., Mao, Q., Zhu, J."MicroRNA‑9 inhibits gastric cancer cell proliferation and migration by targeting neuropilin‑1 Retraction in /10.3892/etm.2024.12687". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2524-2530. https://doi.org/10.3892/etm.2019.7841
Copy and paste a formatted citation
x
Spandidos Publications style
Hang C, Yan HS, Gong C, Gao H, Mao QH and Zhu JX: MicroRNA‑9 inhibits gastric cancer cell proliferation and migration by targeting neuropilin‑1 Retraction in /10.3892/etm.2024.12687. Exp Ther Med 18: 2524-2530, 2019.
APA
Hang, C., Yan, H., Gong, C., Gao, H., Mao, Q., & Zhu, J. (2019). MicroRNA‑9 inhibits gastric cancer cell proliferation and migration by targeting neuropilin‑1 Retraction in /10.3892/etm.2024.12687. Experimental and Therapeutic Medicine, 18, 2524-2530. https://doi.org/10.3892/etm.2019.7841
MLA
Hang, C., Yan, H., Gong, C., Gao, H., Mao, Q., Zhu, J."MicroRNA‑9 inhibits gastric cancer cell proliferation and migration by targeting neuropilin‑1 Retraction in /10.3892/etm.2024.12687". Experimental and Therapeutic Medicine 18.4 (2019): 2524-2530.
Chicago
Hang, C., Yan, H., Gong, C., Gao, H., Mao, Q., Zhu, J."MicroRNA‑9 inhibits gastric cancer cell proliferation and migration by targeting neuropilin‑1 Retraction in /10.3892/etm.2024.12687". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2524-2530. https://doi.org/10.3892/etm.2019.7841
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team