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Article

miR‑133b is a potential diagnostic biomarker for Alzheimer's disease and has a neuroprotective role

  • Authors:
    • Qin Yang
    • Qiuling Zhao
    • Yanliang Yin
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Dongying People's Hospital, Dongcheng, Shandong 257091, P.R. China, Digestive Endoscopy Center, Dongying People's Hospital, Dongcheng, Shandong 257091, P.R. China, Department of Health Care, Dongying People's Hospital, Dongcheng, Shandong 257091, P.R. China
  • Pages: 2711-2718
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    Published online on: August 5, 2019
       https://doi.org/10.3892/etm.2019.7855
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Abstract

MicroRNAs (miRNAs/miRs) are involved in post‑transcriptional gene regulation and aberrant expression of miRNAs has been widely detected in various human diseases. The aim of the present study was to examine the serum levels of miR‑133b in patients with Alzheimer's disease (AD), and to explore its diagnostic value and neuroprotective role in AD. Reverse transcription‑quantitative PCR was applied to analyze the serum levels of miR‑133b in 105 AD patients and 98 healthy controls. A cell model of AD was established by treating SH‑SY5Y cells with amyloid β (Aβ)25‑35, and the resulting effect on miR‑133b expression was determined. Cell viability and apoptosis were also measured. A dual‑luciferase assay was used to validate a target gene of miR‑133b. Receiver operating characteristic (ROC) curve analysis was also applied to assess the specificity and sensitivity of miR‑133b to diagnose AD. The results indicated that the serum levels of miR‑133b were significantly downregulated in AD patients and SH‑SY5Y cells treated with Aβ25‑35 (all P<0.001). A positive correlation between the serum levels of miR‑133b and the Mini‑Mental State Examination score of AD patients was determined (r=0.8814, P<0.001). The area under the ROC curve for miR‑133b regarding the diagnosis of AD was 0.907, with a sensitivity of 90.8% and specificity of 74.3% at the cutoff value of 1.70. Overexpression of miR‑133b significantly attenuated the Aβ25‑35‑induced inhibition of cell viability (P<0.01) and induction of cell apoptosis (P<0.01). The luciferase reporter assay demonstrated that epidermal growth factor receptor (EGFR) is a target gene of miR‑133b. In conclusion, miR‑133b may serve as a novel diagnostic biomarker for AD and it may have a neuroprotective role in AD and targets EGFR.
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View References

1 

Balin BJ and Hudson AP: Etiology and pathogenesis of late-onset Alzheimer's disease. Curr Allergy Asthma Rep. 14:4172014. View Article : Google Scholar : PubMed/NCBI

2 

Gu QF, Yu JZ, Wu H, Li YH, Liu CY, Feng L, Zhang GX, Xiao BG and Ma CG: Therapeutic effect of Rho kinase inhibitor FSD-C10 in a mouse model of Alzheimer's disease. Exp Ther Med. 16:3929–3938. 2018.PubMed/NCBI

3 

Alzheimer's Association National Plan Milestone Workgroup, Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, et al: 2014 report on the milestones for the US national plan to address Alzheimer's disease. Alzheimers Dement 10 (5 Suppl). S430–S452. 2014.

4 

Mayeux R and Stern Y: Epidemiology of Alzheimer disease. Cold Spring Harb Perspect Med. 2(pii): a0062392012.PubMed/NCBI

5 

Tan MS, Yu JT and Tan L: Bridging integrator 1 (BIN1): Form, function, and Alzheimer's disease. Trends Mol Med. 19:594–603. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Bekris LM, Yu CE, Bird TD and Tsuang DW: Genetics of Alzheimer disease. J Geriatr Psychiatry Neurol. 23:213–227. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Paul S: Integration of miRNA and mRNA expression data for understanding etiology of gynecologic cancers. Methods Mol Biol 1912. 323–338. 2019. View Article : Google Scholar

8 

Huang X, Liang M, Dittmar R and Wang L: Extracellular microRNAs in urologic malignancies: chances and challenges. Int J Mol Sci. 14:14785–14799. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Kumar S, Vijayan M and Reddy PH: MicroRNA-455-3p as a potential peripheral biomarker for Alzheimer's disease. Hum Mol Genet. 26:3808–3822. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Hong H, Li Y and Su B: Identification of circulating miR-125b as a potential biomarker of Alzheimer's disease in APP/PS1 transgenic mouse. J Alzheimers Dis. 59:1449–1458. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Tao J, Wu D, Xu B, Qian W, Li P, Lu Q, Yin C and Zhang W: microRNA-133 inhibits cell proliferation, migration and invasion in prostate cancer cells by targeting the epidermal growth factor receptor. Oncol Rep. 27:1967–1975. 2012.PubMed/NCBI

12 

Kim J, Inoue K, Ishii J, Vanti WB, Voronov SV, Murchison E, Hannon G and Abeliovich A: A MicroRNA feedback circuit in midbrain dopamine neurons. Science. 317:1220–1224. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Goedert M: NEURODEGENERATION. Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein. Science. 349:12555552015. View Article : Google Scholar : PubMed/NCBI

14 

Zhao N, Jin L, Fei G, Zheng Z and Zhong C: Serum microRNA-133b is associated with low ceruloplasmin levels in Parkinson's disease. Parkinsonism Relat Disord. 20:1177–1180. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Zhang X, Yang R, Hu BL, Lu P, Zhou LL, He ZY, Wu HM and Zhu JH: Reduced circulating levels of miR-433 and miR-133b are potential biomarkers for Parkinson's disease. Front Cell Neurosci. 11:1702017. View Article : Google Scholar : PubMed/NCBI

16 

Niu M, Xu R, Wang J, Hou B and Xie A: MiR-133b ameliorates axon degeneration induced by MPP(+) via targeting RhoA. Neuroscience. 325:39–49. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Igawa S, Ryuge S, Ichinoe M, Nakashima H, Otani S, Nakahara Y, Fukui T, Sasaki J, Kubota M, Katagiri M, et al: Impact of EGFR-tyrosine kinase inhibitors on postoperative recurrent non-small-cell lung cancer harboring EGFR mutations. Oncol Res Treat. 40:7–13. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Tanaka T, Kaida T, Yokoi K, Ishii S, Nishizawa N, Kawamata H, Katoh H, Sato T, Nakamura T, Watanabe M and Yamashita K: Critical relevance of genomic gains of PRL-3/EGFR/c-myc pathway genes in liver metastasis of colorectal cancer. Oncol Lett. 17:1257–1266. 2019.PubMed/NCBI

19 

Guo N, Zhao Y, Zhang W, Li S and Yu J: MicroRNA-133a downregulated EGFR expression in human non-small cell lung cancer cells via AKT/ERK signaling. Oncol Lett. 16:6045–6050. 2018.PubMed/NCBI

20 

Bruban J, Voloudakis G, Huang Q, Kajiwara Y, Al Rahim M, Yoon Y, Shioi J, Gama Sosa MA, Shao Z, Georgakopoulos A and Robakis NK: Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms. FASEB J. 29:3702–3712. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Zeng W, Zhu JF, Liu JY, Li YL, Dong X, Huang H and Shan L: miR-133b inhibits cell proliferation, migration and invasion of esophageal squamous cell carcinoma by targeting EGFR. Biomed Pharmacother. 111:476–484. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Lugli G, Cohen AM, Bennett DA, Shah RC, Fields CJ, Hernandez AG and Smalheiser NR: Plasma exosomal miRNAs in persons with and without Alzheimer disease: Altered expression and prospects for biomarkers. PLoS One. 10:e01392332015. View Article : Google Scholar : PubMed/NCBI

23 

Whitworth JA; World Health Organization and International Society of Hypertension Writing Group, : 2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens. 21:1983–1992. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Puavilai G, Chanprasertyotin S and Sriphrapradaeng A: Diagnostic criteria for diabetes mellitus and other categories of glucose intolerance: 1997 criteria by the expert committee on the diagnosis and classification of diabetes mellitus (ADA), 1998 WHO consultation criteria, and 1985 WHO criteria. World Health Organization. Diabetes Res Clin Pract. 44:21–26. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Zhang B, Qiu Q, Yin L, Yao Y, Wang C and Wu X: Measurement of retinal function with flash-electroretinography in Chinese patients with hyperlipidemia. Graefes Arch Clin Exp Ophthalmol. 252:1385–1392. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Wang X, Zhao X, Li L, Yao H, Jiang Y and Zhang J: Effects of Combination of ezetimibe and rosuvastatin on coronary artery plaque in patients with coronary heart disease. Heart Lung Circ. 25:459–465. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Li H, Jia J and Yang Z: Mini-mental state examination in elderly chinese: A population-based normative study. J Alzheimers Dis. 53:487–496. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Hu L, Zhang R, Yuan Q, Gao Y, Yang MQ, Zhang C, Huang J, Sun Y, Yang W, Yang JY, et al: The emerging role of microRNA-4487/6845-3p in Alzheimer's disease pathologies is induced by Aβ25–35 triggered in SH-SY5Y cell. BMC Syst Biol. 12 (Suppl 7):S1192018. View Article : Google Scholar

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Amodio N, Stamato MA, Gullà AM, Morelli E, Romeo E, Raimondi L, Pitari MR, Ferrandino I, Misso G, Caraglia M, et al: Therapeutic targeting of miR-29b/HDAC4 epigenetic loop in multiple myeloma. Mol Cancer Ther. 15:1364–1375. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Tian Y, Yan M, Zheng J, Li R, Lin J, Xu A, Liang Y, Zheng R and Yuan Y: miR-483-5p decreases the radiosensitivity of nasopharyngeal carcinoma cells by targeting DAPK1. Lab Invest. 99:602–611. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Maniati MS, Maniati M, Yousefi T, Ahmadi-Ahangar A and Tehrani SS: New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases. J Cell Biochem. 120:8908–8918. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Díaz NF, Cruz-Reséndiz MS, Flores-Herrera H, García-López G and Molina-Hernández A: MicroRNAs in central nervous system development. Rev Neurosci. 25:675–686. 2014.PubMed/NCBI

34 

Maldonado-Lasuncion I, Atienza M, Sanchez-Espinosa MP and Cantero JL: Aging-related changes in cognition and cortical integrity are associated with serum expression of candidate MicroRNAs for Alzheimer disease. Cereb Cortex. Dec 22–2018.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

35 

Shi Z, Kadeer A, Wang M, Wen B, Li M, Huang J, Gao Y, Liu E, Liu D, Jia D and Liang C: The deregulation of miR-133b is associated with poor prognosis in bladder cancer. Pathol Res Pract. 215:354–357. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Wang QY, Zhou CX, Zhan MN, Tang J, Wang CL, Ma CN, He M, Chen GQ, He JR and Zhao Q: MiR-133b targets Sox9 to control pathogenesis and metastasis of breast cancer. Cell Death Dis. 9:7522018. View Article : Google Scholar : PubMed/NCBI

37 

Zhang Q, Fan X, Xu B, Pang Q and Teng L: miR-133b acts as a tumor suppressor and negatively regulates EMP2 in glioma. Neoplasma. 65:494–504. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Thaker AA, Weinberg BD, Dillon WP, Hess CP, Cabral HJ, Fleischman DA, Leurgans SE, Bennett DA, Hyman BT, Albert MS, et al: Entorhinal cortex: Antemortem cortical thickness and postmortem neurofibrillary tangles and amyloid pathology. AJNR Am J Neuroradiol. 38:961–965. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Arevalo-Rodriguez I, Smailagic N, Roqué I Figuls M, Ciapponi A, Sanchez-Perez E, Giannakou A, Pedraza OL, Bonfill Cosp X and Cullum S: Mini-mental state examination (MMSE) for the detection of Alzheimer's disease and other dementias in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev. CD0107832015.PubMed/NCBI

40 

Li H, Xiang Z, Liu Y, Xu B and Tang J: MicroRNA-133b inhibits proliferation, cellular migration, and invasion via targeting LASP1 in hepatocarcinoma cells. Oncol Res. 25:1269–1282. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Zhen Y, Liu J, Huang Y, Wang Y, Li W and Wu J: miR-133b inhibits cell growth, migration, and invasion by targeting MMP9 in non-small cell lung cancer. Oncol Res. 25:1109–1116. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Appert-Collin A, Hubert P, Crémel G and Bennasroune A: Role of ErbB receptors in cancer cell migration and invasion. Front Pharmacol. 6:2832015. View Article : Google Scholar : PubMed/NCBI

43 

Kim SB, Ly P, Kaisani A, Zhang L, Wright WE and Shay JW: Mitigation of radiation-induced damage by targeting EGFR in noncancerous human epithelial cells. Radiat Res. 180:259–267. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Yarden Y and Sliwkowski MX: Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2:127–137. 2001. View Article : Google Scholar : PubMed/NCBI

45 

Guillot F, Kemppainen S, Lavasseur G, Miettinen PO, Laroche S, Tanila H and Davis S: Brain-specific basal and novelty-induced alternations in PI3K-Akt and MAPK/ERK signaling in a middle-aged AβPP/PS1 mouse model of Alzheimer's disease. J Alzheimers Dis. 51:1157–1173. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Feng MG, Liu CF, Chen L, Feng WB, Liu M, Hai H and Lu JM: MiR-21 attenuates apoptosis-triggered by amyloid-β via modulating PDCD4/PI3K/AKT/GSK-3β pathway in SH-SY5Y cells. Biomed Pharmacother. 101:1003–1007. 2018. View Article : Google Scholar : PubMed/NCBI

47 

Zang G, Fang L, Chen L and Wang C: Ameliorative effect of nicergoline on cognitive function through the PI3K/AKT signaling pathway in mouse models of Alzheimer's disease. Mol Med Rep. 17:7293–7300. 2018.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang Q, Zhao Q and Yin Y: miR‑133b is a potential diagnostic biomarker for Alzheimer's disease and has a neuroprotective role. Exp Ther Med 18: 2711-2718, 2019.
APA
Yang, Q., Zhao, Q., & Yin, Y. (2019). miR‑133b is a potential diagnostic biomarker for Alzheimer's disease and has a neuroprotective role. Experimental and Therapeutic Medicine, 18, 2711-2718. https://doi.org/10.3892/etm.2019.7855
MLA
Yang, Q., Zhao, Q., Yin, Y."miR‑133b is a potential diagnostic biomarker for Alzheimer's disease and has a neuroprotective role". Experimental and Therapeutic Medicine 18.4 (2019): 2711-2718.
Chicago
Yang, Q., Zhao, Q., Yin, Y."miR‑133b is a potential diagnostic biomarker for Alzheimer's disease and has a neuroprotective role". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2711-2718. https://doi.org/10.3892/etm.2019.7855
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Q, Zhao Q and Yin Y: miR‑133b is a potential diagnostic biomarker for Alzheimer's disease and has a neuroprotective role. Exp Ther Med 18: 2711-2718, 2019.
APA
Yang, Q., Zhao, Q., & Yin, Y. (2019). miR‑133b is a potential diagnostic biomarker for Alzheimer's disease and has a neuroprotective role. Experimental and Therapeutic Medicine, 18, 2711-2718. https://doi.org/10.3892/etm.2019.7855
MLA
Yang, Q., Zhao, Q., Yin, Y."miR‑133b is a potential diagnostic biomarker for Alzheimer's disease and has a neuroprotective role". Experimental and Therapeutic Medicine 18.4 (2019): 2711-2718.
Chicago
Yang, Q., Zhao, Q., Yin, Y."miR‑133b is a potential diagnostic biomarker for Alzheimer's disease and has a neuroprotective role". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2711-2718. https://doi.org/10.3892/etm.2019.7855
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