Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Sijunzi decoction may decrease apoptosis via stabilization of the extracellular matrix following cerebral ischaemia‑reperfusion in rats

  • Authors:
    • Ping Yang
    • Ye‑Mei Tian
    • Wen‑Xiang Deng
    • Xiong Cai
    • Wang‑Hua Liu
    • Liang Li
    • Hui‑Yong Huang
  • View Affiliations / Copyright

    Affiliations: Department of Psychiatry, Brains Hospital of Hunan Province, Clinical Medical School, Hunan University of Chinese Medicine, Changsha, Hunan 410007, P.R. China , Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan 410208, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2805-2812
    |
    Published online on: August 13, 2019
       https://doi.org/10.3892/etm.2019.7878
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Neurons undergo degeneration, apoptosis and death due to ischaemic stroke. The present study investigated the effect of Sijunzi decoction (SJZD), a type of traditional Chinese medicine known as invigorating spleen therapy, on anoikis (a type of apoptosis) in rat brains following cerebral ischaemia‑reperfusion. Rats were randomly divided into sham, model, nimodipine and SJZD low/medium/high dose groups. A middle cerebral artery occlusion model was established. Neurobehavioural scores were evaluated after administration for 14 days using a five‑grade scale. Blood‑brain barrier permeability and apoptotic rate were detected using Evans blue (EB) extravasation and TUNEL staining, respectively. Tissue inhibitor of metalloproteinase 1 (TIMP‑1), matrix metalloproteinase 9 (MMP‑9) and collagen IV (COL IV) were determined using immunohistochemistry. Neurobehavioural scores decreased remarkably in all SJZD and nimodipine groups compared to the model group (P<0.05). Compared with the sham group, EB extravasation was higher in the model group (P<0.01). The amount of EB extravasation decreased in the SJZD high dose and nimodipine groups compared to the model group (P<0.01), and extravasation in the SJZD high dose group was lower than the SJZD low and medium dose groups (P<0.01). TIMP‑1 and MMP‑9 expression and apoptotic rate increased, but COL IV decreased significantly in the hippocampus of the model group compared to the sham group (P<0.01). TIMP‑1 and COL IV expression increased significantly and MMP‑9 and apoptotic rate decreased remarkably in all SJZD and nimodipine groups compared to the model group (P<0.01). TIMP‑1 and COL IV expression decreased, but MMP‑9 expression and apoptotic rate increased in the SJZD low and medium dose groups compared to the SJZD high dose group (P<0.01). SJZD rescued neurons and improved neurobehavioural function in rats following cerebral ischaemia‑reperfusion, especially when used at a high dose. The mechanism may be related to protection of the extracellular matrix followed by anti‑apoptotic effects.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Arnberg F, Grafström J, Lundberg J, Nikkhou-Aski S, Little P, Damberg P, Mitsios N, Mulder J, Lu L, Söderman M, et al: Imaging of a clinically relevant stroke model: Glucose hypermetabolism revisited. Stroke. 46:835–842. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Jickling GC, Liu D, Ander BP, Stamova B, Zhan X and Sharp FR: Targeting neutrophils in ischemic stroke: Translational insights from experimental studies. J Cereb Blood Flow Metab. 35:888–901. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Meschia JF, Bushnell C, Boden-Albala B, Braun LT, Bravata DM, Chaturvedi S, Creager MA, Eckel RH, Elkind MS, Fornage M, et al: Guidelines for the primary prevention of stroke: A statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 45:3754–3832. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Lv Z, Liu C, Zhai M, Zhang Q, Li J, Zheng F and Peng M: LPS Pretreatment attenuates cerebral ischaemia/reperfusion injury by inhibiting inflammation and apoptosis. Cell Physiol Biochem. 45:2246–2256. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Carneiro BR, Pernambuco Filho PC, Mesquita AP, da Silva DS, Pinhal MA, Nader HB and Lopes CC: Acquisition of anoikis resistance up-regulates syndecan-4 expression in endothelial cells. PLoS One. 9:e1160012014. View Article : Google Scholar : PubMed/NCBI

6 

Hill JW, Poddar R, Thompson JF, Rosenberg GA and Yang Y: Intranuclear matrix metalloproteinases promote DNA damage and apoptosis induced by oxygen-glucose deprivation in neurons. Neuroscience. 220:277–290. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Sater AP, Rael LT, Tanner AH, Lieser MJ, Acuna DL, Mains CW and Bar-Or D: Cell death after traumatic brain injury: Detrimental role of anoikis in healing. Clin Chim Acta. 482:149–154. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Guo Z, Sun X, He Z, Jiang Y and Zhang X: Role of matrix metalloproteinase-9 in apoptosis of hippocampal neurons in rats during early brain injury after subarachnoid hemorrhage. Neurol Sci. 31:143–149. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Frisch SM, Schaller M and Cieply B: Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis. J Cell Sci. 126:21–29. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Mazumder MK, Bhattacharya P and Borah A: Inhibition of matrix metalloproteinase-2 and 9 by Piroxicam confer neuroprotection in cerebral ischemia: An in silico evaluation of the hypothesis. Med Hypotheses. 83:697–701. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Cheema ZF, Santillano DR, Wade SB, Newman JM and Miranda RC: The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins. BMC Neurosci. 5:112004. View Article : Google Scholar : PubMed/NCBI

12 

Tian G, Wu C, Li J, Liang B, Zhang F, Fan X, Li Z, Wang Y, Li Z, Liu D, et al: Network pharmacology based investigation into the effect and mechanism of modified sijunzi decoction against the subtypes of chronic atrophic gastritis. Pharmacol Res. 144:158–166. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Li J, Qian J, Jia JG, Jin X, Yu DJ, Xie B, Qian LY, Zhang LG and Guo CX: Effect of Sijunzi decoction on the proliferation of side population cells of human gastric cancer cell line. Zhongguo Zhong Xi Yi Jie He Za Zhi. 34:704–709. 2014.(In Chinese). PubMed/NCBI

14 

Hu KL, Li H, Liu WH, He Q, Zhong YL and Peng ZY: Effect of modified Si Junzitang on expression of ERK1/2, Akt, Bax in rats with cerebral ischemia/reperfusion injury. Chin J Exp Traditional Med Formulae. 24:152–158. 2008.(In Chinese).

15 

Liu S, Zhang YB, Cao WG, Zhang D and Liu L: Comparision of the effects of three Chinese medicinal recipes to cerebral ischemia. Pharmacol Clin Chin Materia Medica. 25:6–7. 2009.(In Chinese).

16 

Liu F and McCullough LD: Middle cerebral artery occlusion model in rodents: Methods and potential pitfalls. J Biomed Biotechnol. 2011:4647012011. View Article : Google Scholar : PubMed/NCBI

17 

Ng YS, Stein J, Ning M and Black-Schaffer RM: Comparison of clinical characteristics and functional outcomes of ischemic stroke in different vascular territories. Stroke. 38:2309–2314. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Chinese Pharmacopoeia Commission, . Pharmacopoeia of the People's Republic of China. 1. 2015th. Chinese Medical Science and Technology Press; Beijing: pp. 8–240. 2015

19 

Longa EZ, Weinstein PR, Carlson S and Cummins R: Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 20:84–91. 1989. View Article : Google Scholar : PubMed/NCBI

20 

Zhang Q, Zhou M, Wu X, Li Z, Liu B, Gao W, Yue J and Liu T: Promoting therapeutic angiogenesis of focal cerebral ischemia using thrombospondin-4 (TSP4) gene-modified bone marrow stromal cells (BMSCs) in a rat model. J Transl Med. 17:1112019. View Article : Google Scholar : PubMed/NCBI

21 

Hao FL, Han XF, Wang XL, Zhao ZR, Guo AH, Lu XJ and Zhao XF: The neurovascular protective effect of alogliptin in murine MCAO model and brain endothelial cells. Biomed Pharmacother. 109:181–187. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Xu JH, Huang YM, Ling W, Li Y, Wang M, Chen XY, Sui Y and Zhao HL: Wen Dan Decoction for hemorrhagic stroke and ischemic stroke. Complement Ther Med. 23:298–308. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Hu HX, Lin RH, Zhu XQ, Li ZF and Chen LD: Anti-inflammatory effects of Gualou Guizhi decoction in transient focal cerebral ischemic brains [Corrected]. Mol Med Rep. 12:1321–1327. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Guo Q, Zhong M, Xu H, Mao X, Zhang Y and Lin N: A systems biology perspective on the molecular mechanisms underlying the therapeutic effects of buyang huanwu decoction on ischemic stroke. Rejuvenation Res. 18:313–325. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Zhang DS, Liu YL, Zhu DQ, Huang XJ and Luo CH: Point application with angong niuhuang sticker protects hippocampal and cortical neurons in rats with cerebral ischemia. Neural Regen Res. 10:286–291. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Zhang C, Wen Y, Fan XN, Tian G, Zhou XY, Deng SZ and Meng ZH: Therapeutic effects of different durations of acupuncture on rats with middle cerebral artery occlusion. Neural Regen Res. 10:159–164. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Zhong YL, Li H, Liu WH and Hu D: The effect of spleen-strengthening therapy on the mRNA and protein expression levels of INTβ3, ILK and FAK in Rats with cerebral ischemia/reperfusion injury. Lishizhen Med Mat Med Res. 28:513–516. 2017.(In Chinese).

28 

Li H, Liu WH, Zhou XQ and He Q: Effects of spleen-strengthening therapy on MMP2 expression in brain tissue and blood brain barrier permeability in rats with cerebral ischemia/reperfusion injury. Hunan J TCM. 29:115–117. 2013.

29 

Li H, Liu WH, Liao LY, Liu BY and Cai GX: Effect of tonifying spleen therapy on the degradation of laminin in rats with cerebral ischemia-reperfusion. Chin J Geriatr Heart Brain Vessel Dis. 12:645–647. 2010.(In Chinese).

30 

Adamczak JM, Schneider G, Nelles M, Que I, Suidgeest E, van der Weerd L, Löwik C and Hoehn M: In vivo bioluminescence imaging of vascular remodeling after stroke. Front Cell Neurosci. 8:2742014. View Article : Google Scholar : PubMed/NCBI

31 

Reinhard J, Renner M, Wiemann S, Shakoor DA, Stute G, Dick HB, Faissner A and Joachim SC: Ischemic injury leads to extracellular matrix alterations in retina and optic nerve. Sci Rep. 7:434702017. View Article : Google Scholar : PubMed/NCBI

32 

Ravi S, Caves JM, Martinez AW, Xiao J, Wen J, Haller CA, Davis ME and Chaikof EL: Effect of bone marrow-derived extracellular matrix on cardiac function after ischemic injury. Biomaterials. 33:7736–7745. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Ma NK, Lim JK, Leong MF, Sandanaraj E, Ang BT, Tang C and Wan AC: Collaboration of 3D context and extracellular matrix in the development of glioma stemness in a 3D model. Biomaterials. 78:62–73. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Klingberg F, Chow ML, Koehler A, Boo S, Buscemi L, Quinn TM, Costell M, Alman BA, Genot E and Hinz B: Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation. J Cell Biol. 207:283–297. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Faissner A and Reinhard J: The extracellular matrix compartment of neural stem and glial progenitor cells. Glia. 63:1330–1349. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Dzyubenko E, Gottschling C and Faissner A: Neuron-glia interactions in neural plasticity: Contributions of neural extracellular matrix and perineuronal nets. Neural Plast. 2016:52149612016. View Article : Google Scholar : PubMed/NCBI

37 

Pandey AK, Bhattacharya P, Shukla SC, Paul S and Patnaik R: Resveratrol inhibits matrix metalloproteinases to attenuate neuronal damage in cerebral ischemia: A molecular docking study exploring possible neuroprotection. Neural Regen Res. 10:568–575. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Neuwelt EA, Bauer B, Fahlke C, Fricker G, Iadecola C, Janigro D, Leybaert L, Molnár Z, O'Donnell ME, Povlishock JT, et al: Engaging neuroscience to advance translational research in brain barrier biology. Nat Rev Neurosci. 12:169–182. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Limmer S, Weiler A, Volkenhoff A, Babatz F and Klämbt C: The Drosophila blood-brain barrier: Development and function of a glial endothelium. Front Neurosci. 8:3652014. View Article : Google Scholar : PubMed/NCBI

40 

Ronaldson PT and Davis TP: Blood-brain barrier integrity and glial support: Mechanisms that can be targeted for novel therapeutic approaches in stroke. Curr Pharm Des. 18:3624–3644. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Wong AD, Ye M, Levy AF, Rothstein JD, Bergles DE and Searson PC: The blood-brain barrier: An engineering perspective. Front Neuroeng. 6:72013. View Article : Google Scholar : PubMed/NCBI

42 

Hladky SB and Barrand MA: Fluid and ion transfer across the blood-brain and blood-cerebrospinal fluid barriers; a comparative account of mechanisms and roles. Fluids Barriers CNS. 13:192016. View Article : Google Scholar : PubMed/NCBI

43 

Sazonova OV, Isenberg BC, Herrmann J, Lee KL, Purwada A, Valentine AD, Buczek-Thomas JA, Wong JY and Nugent MA: Extracellular matrix presentation modulates vascular smooth muscle cell mechanotransduction. Matrix Biol. 41:36–43. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Li S, Jin Z, Koirala S, Bu L, Xu L, Hynes RO, Walsh CA, Corfas G and Piao X: GPR56 regulates pial basement membrane integrity and cortical lamination. J Neurosci. 28:5817–5826. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Johnson KM, Milner R and Crocker SJ: Extracellular matrix composition determines astrocyte responses to mechanical and inflammatory stimuli. Neurosci Lett. 600:104–109. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Moore MC, Pandolfi V and McFetridge PS: Novel human-derived extracellular matrix induces in vitro and in vivo vascularization and inhibits fibrosis. Biomaterials. 49:37–46. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Zhang Z, Wang F, Wang BJ, Chu G, Cao Q, Sun BG and Dai QY: Inhibition of leptin-induced vascular extracellular matrix remodelling by adiponectin. J Mol Endocrinol. 53:145–154. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Xie Y, Mustafa A, Yerzhan A, Merzhakupova D, Yerlan P, N Orakov A, Wang X, Huang Y and Miao L: Nuclear matrix metalloproteinases: Functions resemble the evolution from the intracellular to the extracellular compartment. Cell Death Discov. 3:170362017. View Article : Google Scholar : PubMed/NCBI

49 

Chopra K, Baveja A and Kuhad A: MMPs: A novel drug target for schizophrenia. Expert Opin Ther Targets. 19:77–85. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Fu S, Gu Y, Jiang JQ, Chen X, Xu M, Chen X and Shen J: Calycosin-7-O-β-D-glucoside regulates nitric oxide/caveolin-1/matrix metalloproteinases pathway and protects blood-brain barrier integrity in experimental cerebral ischemia-reperfusion injury. J Ethnopharmacol. 155:692–701. 2014. View Article : Google Scholar : PubMed/NCBI

51 

Wang JJ, Huan SK, Hsieh KH, Chou HC, Hsiao G, Jayakumar T and Sheu JR: Inhibitory effect of midazolam on MMP-9, MMP-1 and MMP-13 expression in PMA-stimulated human chondrocytes via recovery of NF-kB signaling. Arch Med Sci. 9:332–339. 2013. View Article : Google Scholar : PubMed/NCBI

52 

He ZJ, Huang ZT, Chen XT and Zou ZJ: Effects of matrix metalloproteinase 9 inhibition on the blood brain barrier and inflammation in rats following cardiopulmonary resuscitation. Chin Med J (Engl). 122:2346–2351. 2009.PubMed/NCBI

53 

Kwon M, Seo S, Chun H, Chung JM, Chung IK and Hur KC: Dual effect of nerve growth factor on cell death of PC12 cells Induced by serum deprivation. Mol Cells. 13:167–174. 2002.PubMed/NCBI

54 

Kim YS and Joh TH: Matrix metalloproteinases, new insights into the understanding of neurodegenerative disorders. Biomol Ther (Seoul). 20:133–143. 2012. View Article : Google Scholar : PubMed/NCBI

55 

Visse R and Nagase H: Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function, and biochemistry. Circ Res. 92:827–839. 2003. View Article : Google Scholar : PubMed/NCBI

56 

Li JS, Liu K, Liu JX, Wang MH, Zhao YW and Liu ZG: Relationship between the changes in ischemia/reperfusion cerebro-microvessel basement membrane injury and gelatinase system in senile rat. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 20:656–659. 2008.(In Chinese). PubMed/NCBI

57 

Michalski D, Hobohm C, Weise C, Pelz J, Heindl M, Kamprad M, Kacza J and Härtig W: Interrelations between blood-brain barrier permeability and matrix metalloproteinases are differently affected by tissue plasminogen activator and hyperoxia in a rat model of embolic stroke. Med Gas Res. 2:22012. View Article : Google Scholar : PubMed/NCBI

58 

Liu XR, Luo M, Yan F, Zhang CC, Li SJ, Zhao HP, Ji XM and Luo YM: Ischemic postconditioning diminishes matrix metalloproteinase 9 expression and attenuates loss of the extracellular matrix proteins in rats following middle cerebral artery occlusion and reperfusion. CNS Neurosci Ther. 18:855–863. 2012. View Article : Google Scholar : PubMed/NCBI

59 

Gu Y, Dee CM and Shen J: Interaction of free radicals, matrix metalloproteinases and caveolin-1 impacts blood-brain barrier permeability. Front Biosci (Schol Ed). 3:1216–1231. 2011. View Article : Google Scholar : PubMed/NCBI

60 

Zhu M, Xing D, Lu Z, Fan Y, Hou W and Dong H, Xiong L and Dong H: DDR1 may play a key role in destruction of the blood-brain barrier after cerebral ischemia-reperfusion. Neurosci Res. 96:14–19. 2015. View Article : Google Scholar : PubMed/NCBI

61 

Tan F, Fu W, Cheng N, Meng DI and Gu Y: Ligustrazine reduces blood-brain barrier permeability in a rat model of focal cerebral ischemia and reperfusion. Exp Ther Med. 9:1757–1762. 2015. View Article : Google Scholar : PubMed/NCBI

62 

Li DD, Song JN, Huang H, Guo XY, An JY, Zhang M, Li Y, Sun P, Pang HG, Zhao YL and Wang JF: The roles of MMP-9/TIMP-1 in cerebral edema following experimental acute cerebral infarction in rats. Neurosci Lett. 550:168–172. 2013. View Article : Google Scholar : PubMed/NCBI

63 

Lenglet S, Montecucco F, Mach F, Schaller K, Gasche Y and Copin JC: Analysis of the expression of nine secreted matrix metalloproteinases and their endogenous inhibitors in the brain of mice subjected to ischaemic stroke. Thromb Haemost. 112:363–378. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang P, Tian YM, Deng WX, Cai X, Liu WH, Li L and Huang HY: Sijunzi decoction may decrease apoptosis via stabilization of the extracellular matrix following cerebral ischaemia‑reperfusion in rats. Exp Ther Med 18: 2805-2812, 2019.
APA
Yang, P., Tian, Y., Deng, W., Cai, X., Liu, W., Li, L., & Huang, H. (2019). Sijunzi decoction may decrease apoptosis via stabilization of the extracellular matrix following cerebral ischaemia‑reperfusion in rats. Experimental and Therapeutic Medicine, 18, 2805-2812. https://doi.org/10.3892/etm.2019.7878
MLA
Yang, P., Tian, Y., Deng, W., Cai, X., Liu, W., Li, L., Huang, H."Sijunzi decoction may decrease apoptosis via stabilization of the extracellular matrix following cerebral ischaemia‑reperfusion in rats". Experimental and Therapeutic Medicine 18.4 (2019): 2805-2812.
Chicago
Yang, P., Tian, Y., Deng, W., Cai, X., Liu, W., Li, L., Huang, H."Sijunzi decoction may decrease apoptosis via stabilization of the extracellular matrix following cerebral ischaemia‑reperfusion in rats". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2805-2812. https://doi.org/10.3892/etm.2019.7878
Copy and paste a formatted citation
x
Spandidos Publications style
Yang P, Tian YM, Deng WX, Cai X, Liu WH, Li L and Huang HY: Sijunzi decoction may decrease apoptosis via stabilization of the extracellular matrix following cerebral ischaemia‑reperfusion in rats. Exp Ther Med 18: 2805-2812, 2019.
APA
Yang, P., Tian, Y., Deng, W., Cai, X., Liu, W., Li, L., & Huang, H. (2019). Sijunzi decoction may decrease apoptosis via stabilization of the extracellular matrix following cerebral ischaemia‑reperfusion in rats. Experimental and Therapeutic Medicine, 18, 2805-2812. https://doi.org/10.3892/etm.2019.7878
MLA
Yang, P., Tian, Y., Deng, W., Cai, X., Liu, W., Li, L., Huang, H."Sijunzi decoction may decrease apoptosis via stabilization of the extracellular matrix following cerebral ischaemia‑reperfusion in rats". Experimental and Therapeutic Medicine 18.4 (2019): 2805-2812.
Chicago
Yang, P., Tian, Y., Deng, W., Cai, X., Liu, W., Li, L., Huang, H."Sijunzi decoction may decrease apoptosis via stabilization of the extracellular matrix following cerebral ischaemia‑reperfusion in rats". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2805-2812. https://doi.org/10.3892/etm.2019.7878
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team