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Eckol inhibits Reg3A‑induced proliferation of human SW1990 pancreatic cancer cells

  • Authors:
    • Mengya Zhang
    • Weiping Zhou
    • Shuqi Zhao
    • Shulan Li
    • Dan Yan
    • Jun Wang
  • View Affiliations / Copyright

    Affiliations: Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, Hubei 430065, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2825-2832
    |
    Published online on: August 14, 2019
       https://doi.org/10.3892/etm.2019.7889
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Abstract

Pancreatic cancer (PaC) is characterized by a highly inflammatory tumor microenvironment, and inflammatory mediators are implicated in the progression of this cancer. Regenerating gene protein (Reg) 3A is significantly upregulated during pancreatic inflammation, and has been demonstrated to serve an important role during PaC progression, based on its increased expression levels in PaC and potent cell proliferation‑promoting activity. The aim of the present study was to investigate the effect of eckol, a phlorotannin compound with a variety of biological activities including anti‑inflammatory, anti‑tumor and cytoprotective effects, on Reg3A‑induced proliferation of human SW1990 PaC cells. SW1990 cells were pre‑treated with eckol for 48 h at concentrations of 5, 10 and 20 µg/ml. Subsequently, Reg3A protein was added to the culture media at a final concentration of 50 ng/ml in the presence or absence of eckol for 24 h. The cytotoxicity and proliferative capacity of the SW1990 cells was determined using an MTT and flow cytometry analysis. Cell colony formation was also used to determine the effect of eckol on the anchorage‑independent growth and colony‑forming capacity of Reg3A‑treated PaC cells. The expression levels of cyclin D1, STAT3, JAK2, and NF‑κB p65 were measured with reverse transcription‑quantitative PCR and western blotting. Eckol reduced Reg3A‑promoted cell survival, inhibited Reg3A‑induced cell cycle progression and inhibited colony growth of SW1990 cells in soft agar in a concentration‑dependent manner. Additionally, the Reg3A‑mediated upregulation of expression of JAK2, STAT3, NF‑κBp65 and cyclin D1 was reduced when treated with eckol. Reg3A is upregulated during pancreatic inflammation and exhibits a pro‑growth function and may thus serve a critical role during inflammation‑driven PaC malignancies. Eckol may be a potential protective agent against progression of PaC accompanied by pancreatic inflammation.
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View References

1 

Ma Y, Wu Q, Li X, Gu X, Xu J and Yang J: Pancreatic cancer: From bench to bedside. Ann Transl Med. 4:4582016. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Xu Q, Fu R, Yin G, Liu X, Liu Y and Xiang M: Microarray-based gene expression profiling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells. Gene. 578:263–273. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Li Q, Wang H, Zogopoulos G, Shao Q, Dong K, Lv F, Nwilati K, Gui XY, Cuggia A, Liu JL and Gao ZH: Reg proteins promote acinar-to-ductal metaplasia and act as novel diagnostic and prognostic markers in pancreatic ductal adenocarcinoma. Oncotarget. 7:77838–77853. 2016.PubMed/NCBI

5 

Liu X, Wang J, Wang H, Yin G, Liu Y, Lei X and Xiang M: REG3A accelerates pancreatic cancer cell growth under IL-6-associated inflammatory condition: Involvement of a REG3A-JAK2/STAT3 positive feedback loop. Cancer Lett. 362:45–60. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Wang J, Zhou H, Han Y, Liu X, Wang M, Wang X, Yin G, Li X and Xiang M: SOCS3 methylation in synergy with Reg3A overexpression promotes cell growth in pancreatic cancer. J Mol Med (Berl). 92:1257–1269. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Chen ZF, Huang ZM, Xue HB, Lin XQ, Chen RP, Chen MJ and Jin RF: REG3A promotes the proliferation, migration, and invasion of gastric cancer cells. Onco Targets Ther. 10:2017–2023. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Ye Y, Xiao L, Wang SJ, Yue W, Yin QS, Sun MY, Xia W, Shao ZY and Zhang H: Up-regulation of REG3A in colorectal cancer cells confers proliferation and correlates with colorectal cancer risk. Oncotarget. 7:3921–3933. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Fukushima N, Koopmann J, Sato N, Prasad N, Carvalho R, Leach SD, Hruban RH and Goggins M: Gene expression alterations in the non-neoplastic parenchyma adjacent to infiltrating pancreatic ductal adenocarcinoma. Mod Pathol. 18:779–787. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Xie MJ, Motoo Y, Iovanna JL, Su SB, Ohtsubo K, Matsubara F and Sawabu N: Overexpression of pancreatitis-associated protein (PAP) in human pancreatic ductal adenocarcinoma. Digest Dis Sci. 48:459–464. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Yue Q, Gao G, Zou G, Yu H and Zheng X: Natural products as adjunctive treatment for pancreatic cancer: Recent trends and advancements. Biomed Res Int. 2017:84125082017. View Article : Google Scholar : PubMed/NCBI

12 

Marasini B and Sahu RP: Natural anti-cancer agents: Implications in gemcitabine-resistant pancreatic cancer treatment. Mini Rev Med Chem. 17:920–927. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Li Y, Fu X, Duan D, Liu X, Xu J and Gao X: Extraction and identification of phlorotannins from the brown alga, sargassum fusiforme (Harvey) setchell. Mar Drugs. 15(pii): E492017. View Article : Google Scholar : PubMed/NCBI

14 

Kang MC, Cha SH, Wijesinghe WA, Kang SM, Lee SH, Kim EA, Song CB and Jeon YJ: Protective effect of marine algae phlorotannins against AAPH- induced oxidative stress in zebrafish embryo. Food Chem. 138:950–955. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Lee MS, Shin T, Utsuki T, Choi JS, Byun DS and Kim HR: Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and hepatoprotective properties in tacrine-treated HepG2 cells. J Agric Food Chem. 60:5340–5349. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Kim AD, Kang KA, Piao MJ, Kim KC, Zheng J, Yao CW, Cha JW, Hyun CL, Kang HK, Lee NH and Hyun JW: Cytoprotective effect of eckol against oxidative stress-induced mitochondrial dysfunction: Involvement of the FoxO3a/AMPK pathway. J Cell Biochem. 115:1403–1411. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Jung HA, Kim JI, Choung SY and Choi JS: Protective effect of the edible brown alga Ecklonia stolonifera on doxorubicin-induced hepatotoxicity in primary rat hepatocytes. J Pharm Pharmacol. 66:1180–1188. 2014.PubMed/NCBI

18 

Ahn BR, Moon HE, Kim HR, Jung HA and Choi JS: Neuroprotective effect of edible brown alga Eisenia bicyclis on amyloid beta peptide-induced toxicity in PC12 cells. Arch Pharm Res. 35:1989–1998. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Kang SM, Cha SH, Ko JY, Kang MC, Kim D, Heo SJ, Kim JS, Heu MS, Kim YT, Jung WK and Jeon YJ: Neuroprotective effects of phlorotannins isolated from a brown alga, Ecklonia cava, against H2O2-induced oxidative stress in murine hippocampal HT22 cells. Environ Toxicol Pharmacol. 34:96–105. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Jung HA, Roy A, Jung JH and Choi JS: Evaluation of the inhibitory effects of eckol and dieckol isolated from edible brown alga Eisenia bicyclis on human monoamine oxidases A and B. Arch Pharm Res. 40:480–491. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Jung HA, Jung HJ, Jeong HY, Kwon HJ, Ali MY and Choi JS: Phlorotannins isolated from the edible brown alga Ecklonia stolonifera exert anti-adipogenic activity on 3T3-L1 adipocytes by downregulating C/EBPα and PPARγ. Fitoterapia. 92:260–229. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Jung HA, Jin SE, Ahn BR, Lee CM and Choi JS: Anti- inflammatory activity of edible brown alga Eisenia bicyclis and its constituents fucosterol and phlorotannins in LPS-stimulated RAW264. 7 macrophages. Food Chem Toxicol. 59:199–206. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Kang YM, Eom SH and Kim YM: Protective effect of phlorotannins from Eisenia bicyclis against lipopolysaccharide-stimulated inflammation in HepG2 cells. Environ Toxicol Pharmacol. 35:395–401. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Noda H, Amano H, Arashima K, Hashimoto S and Nisizawa K: Studies on the antitumor activity of marine algae. Nippon Suisan Gakk. 55:1259–1264. 1989. View Article : Google Scholar

25 

Hyun KH, Yoon CH, Kim RK, Lim EJ, An S, Park MJ, Hyun JW, Suh Y, Kim MJ and Lee SJ: Eckol suppresses maintenance of stemness and malignancies in glioma stem-like cells. Toxicol Appl Pharmacol. 254:32–40. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Ochoa JJ, Farquharson AJ, Grant I, Moffat LE, Heys SD and Wahle KW: Conjugated linoleic acids (CLAs) decrease prostate cancer cell proliferation: Different molecularmechanisms for cis-9, trans-11 and trans-10, cis-12 isomers. Carcinogenesis. 25:1185–1191. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Pesic M and Greten FR: Inflammation and cancer: Tissue regeneration gone awry. Curr Opin Cell Biol. 43:55–61. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Hamada S, Masamune A and Shimosegawa T: Inflammation and pancreatic cancer: Disease promoter and new therapeutic target. J Gastroenterol. 49:605–617. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Gukovsky I, Li N, Todoric J, Gukovskaya A and Karin M: Inflammation, autophagy, and obesity: Common features in the pathogenesis of pancreatitis and pancreatic cancer. Gastroenterology. 144:1199–1209. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Zambirinis CP, Pushalkar S, Saxena D and Miller G: Pancreatic cancer, inflammation, and microbiome. Cancer J. 20:195–202. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Zhao X, Fan W, Xu Z, Chen H, He Y, Yang G, Hu H, Tang S, Wang P, Zhang Z, et al: Inhibiting tumor necrosis factor-alpha diminishes desmoplasia and inflammation to overcome chemoresistance in pancreatic ductal adenocarcinoma. Oncotarget. 7:81110–81122. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Piao MJ, Lee NH, Chae S and Hyun JW: Eckol inhibits ultraviolet B-induced cell damage in human keratinocytes via a decrease in oxidative stress. Biol Pharm Bull. 35:873–880. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Kang KA, Lee KH, Chae S, Zhang R, Jung MS, Lee Y, Kim SY, Kim HS, Joo HG, Park JW, et al: Eckol isolated from Ecklonia cava attenuates oxidative stress induced cell damage in lung fibroblast cells. FEBS Lett. 579:6295–6304. 2005. View Article : Google Scholar : PubMed/NCBI

35 

Harada D, Takigawa N and Kiura K: The Role of STAT3 in non-small cell lung cancer. Cancers (Basel). 6:708–722. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Karin M: Nuclear factor-kappaB in cancer development and progression. Nature. 441:431–436. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Grivennikov SI and Karin M: Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev. 21:11–19. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Ledoux AC and Perkins ND: NF-κB and the cell cycle. Biochem Soc Trans. 42:76–81. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang M, Zhou W, Zhao S, Li S, Yan D and Wang J: Eckol inhibits Reg3A‑induced proliferation of human SW1990 pancreatic cancer cells. Exp Ther Med 18: 2825-2832, 2019.
APA
Zhang, M., Zhou, W., Zhao, S., Li, S., Yan, D., & Wang, J. (2019). Eckol inhibits Reg3A‑induced proliferation of human SW1990 pancreatic cancer cells. Experimental and Therapeutic Medicine, 18, 2825-2832. https://doi.org/10.3892/etm.2019.7889
MLA
Zhang, M., Zhou, W., Zhao, S., Li, S., Yan, D., Wang, J."Eckol inhibits Reg3A‑induced proliferation of human SW1990 pancreatic cancer cells". Experimental and Therapeutic Medicine 18.4 (2019): 2825-2832.
Chicago
Zhang, M., Zhou, W., Zhao, S., Li, S., Yan, D., Wang, J."Eckol inhibits Reg3A‑induced proliferation of human SW1990 pancreatic cancer cells". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2825-2832. https://doi.org/10.3892/etm.2019.7889
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang M, Zhou W, Zhao S, Li S, Yan D and Wang J: Eckol inhibits Reg3A‑induced proliferation of human SW1990 pancreatic cancer cells. Exp Ther Med 18: 2825-2832, 2019.
APA
Zhang, M., Zhou, W., Zhao, S., Li, S., Yan, D., & Wang, J. (2019). Eckol inhibits Reg3A‑induced proliferation of human SW1990 pancreatic cancer cells. Experimental and Therapeutic Medicine, 18, 2825-2832. https://doi.org/10.3892/etm.2019.7889
MLA
Zhang, M., Zhou, W., Zhao, S., Li, S., Yan, D., Wang, J."Eckol inhibits Reg3A‑induced proliferation of human SW1990 pancreatic cancer cells". Experimental and Therapeutic Medicine 18.4 (2019): 2825-2832.
Chicago
Zhang, M., Zhou, W., Zhao, S., Li, S., Yan, D., Wang, J."Eckol inhibits Reg3A‑induced proliferation of human SW1990 pancreatic cancer cells". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2825-2832. https://doi.org/10.3892/etm.2019.7889
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