Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Protective effects of glucocorticoid on liver injury in a rat sepsis model

  • Authors:
    • Xiaoli Li
    • Meifeng Li
    • Luyi Liu
    • Xinghan Tian
    • Yafeng Liang
  • View Affiliations / Copyright

    Affiliations: Department of Critical Care Medicine, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China
  • Pages: 3153-3160
    |
    Published online on: August 16, 2019
       https://doi.org/10.3892/etm.2019.7899
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Sepsis is one of the leading causes of death with unsatisfactory current treatments. The present study assessed the liver protective effect of glucocorticoids on different levels of inflammation in septic shock rats. A rat septic shock model was established by lipopolysaccharide (LPS) injection. Rats were divided into control (Control), high‑inflammation treated with hydrocortisone (HT), high‑inflammation non‑treatment (HNT), low‑inflammation treated with hydrocortisone (LT) and low‑inflammation non‑treatment (LNT) groups according to the levels of serum C‑reactive protein (CRP), interleukin (IL)‑6 and interferon (IFN)‑γ. The mean arterial pressure and heart rate changes were continuously monitored and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured by an automatic biochemical analyzer. Hematoxylin and eosin (H&E) staining was performed to observe the pathological changes of liver tissue. Western blot analysis was used to detect the expression of p38 mitogen‑activated protein kinase (MAPK) and NF‑κB protein. The results demonstrated that following 7 days of treatment, there were no obvious differences in the serum CRP, IL‑6 and IFN‑γ levels between the HT group and the control group, whilst the HNT group, LT group and LNT group were significantly different compared with the HT and control groups. H&E staining demonstrated that the liver cells in the HT group were homogeneous following 7 days of treatment. Western blot analysis determined that the phosphorylation levels of p38MAPK and NF‑κB in HT group were reduced significantly compared with the LT group, while there was no obvious difference with the control group after 7 days treatment. The present results indicated that glucocorticoids have better therapeutic effect on septic shock rats with high‑inflammation compared with low‑inflammation rats. The present study provides a novel approach for glucocorticoid treatment of septic shock.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Schulte W, Bernhagen J and Bucala R: Cytokines in Sepsis: Potent immunoregulators and potential therapeutic targets-an updated view. Mediators Inflamm. 2013:1659742013. View Article : Google Scholar : PubMed/NCBI

2 

Yan J and Li S and Li S: The role of the liver in sepsis. Int Rev Immunol. 33:498–510. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Ryan T, Coakley JD and Martinloeches I: Defects in innate and adaptive immunity in patients with sepsis and health care associated infection. Ann Transl Med. 5:4472017. View Article : Google Scholar : PubMed/NCBI

4 

Dewitte A, Lepreux S, Villeneuve J, Rigothier C, Combe C, Ouattara A and Ripoche J: Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical [corrected] ill patients? Ann Intensive Care. 7:1152017. View Article : Google Scholar : PubMed/NCBI

5 

Shi LL and Han YQ: Research advance of sepsis related coagulation and inflammation biomarkers. Medical Recapitulate. 5:873–877. 2016.(In Chinese).

6 

Spoto S, Valeriani E and Costantino S: Nosography of systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock and multiple organ dysfunction syndrome in internal medicine patients. Italian J Med. 9:243–251. 2015. View Article : Google Scholar

7 

Michalek J, Svetlikova P, Fedora M, Klimovic M, Klapacova L, Bartosova D, Hrstkova H and Hubacek JA: Interleukin-6 gene variants and the risk of sepsis development in children. Hum Immunol. 68:756–760. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Bozza FA, Salluh JI, Japiassu AM, Soares M, Assis EF, Gomes RN, Bozza MT, Castro-Faria-Neto HC and Bozza PT: Cytokine profiles as markers of disease severity in sepsis: A multiplex analysis. Crit Care. 11:R492007. View Article : Google Scholar : PubMed/NCBI

9 

Alexandrov PN, Kruck TP and Lukiw WJ: Nanomolar aluminum induces expression of the inflammatory systemic biomarker C-reactive protein (CRP) in human brain microvessel endothelial cells (hBMECs). J Inorg Biochem. 152:210–213. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Mayer CM, Gruben HJ, Land EM, Scharnag H and Marz W: W12-P-038 Statin induced inhibition of CRP expression in primary human hepatocytes. Atherosclerosis. 6:70–71. 2005. View Article : Google Scholar

11 

Memiş D, Gursoy O, Tasdogan M, Süt N, Kurt I, Türe M and Karamanlioğlu B: High C-reactive protein and low cholesterol levels are prognostic markers of survival in severe sepsis. J Clin Anesth. 19:186–191. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Ji Y, Zheng MF, Ye SG, Wu XB and Chen JY: Agrocybe aegerita polysaccharide combined with chemotherapy improves tumor necrosis factor-α and interferon-γ levels in rat esophageal carcinoma. Dis Esophagus. 26:859–863. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Valentine L, Potts R and Premenko-Lanier M: CD8+ T cell derived IFN-γ prevents infection by a second heterologous virus. J Immunol. 189:5841–5848. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Lin CF, Lin CM, Lee KY, Wu SY, Feng PH, Chen KY, Chuang HC, Chen CL, Wang YC, Tseng PC and Tsai TT: Escape from IFN-γ-dependent immunosurveillance in tumorigenesis. J Biomed Sci. 24:102017. View Article : Google Scholar : PubMed/NCBI

15 

Conway-Campbell BL, George CL, Pooley JR, Knight DM, Norman MR, Hager GL and Lightman SL: The HSP90 molecular chaperone cycle regulates cyclical transcriptional dynamics of the glucocorticoid receptor and its coregulatory molecules CBP/p300 during ultradian ligand treatment. Mol Endocrinol. 25:944–954. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Oppert M, Schindler R, Husung C, Offermann K, Gräf KJ, Boenisch O, Barckow D, Frei U and Eckardt KU: Low-dose hydrocortisone improves shock reversal and reduces cytokine levels in early hyperdy-namic septic shock. Crit Care Med. 33:2457–2464. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Xiang G, Fan M, Ma Y, Wang M, Gao J, Chen J, Li X, Xue W, Wang Y, Gao H, et al: Anti-inflammatory actions of Caesalpinin M2 in experimental colitis as a selective glucocoricoid receptor modulator. Biochem Pharmacol. 150:150–159. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Annane D, Bellissant E, Bollaert PE, Briegel J, Confalonieri M, De Gaudio R, Keh D, Kupfer Y, Oppert M and Meduri GU: Corticosteroids in thetreatment of severe sepsis and septic shock in adults: A systematic review. JAMA. 301:2362–2375. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Laviolle B, Annane D, Fougerou C and Bellissant E: Gluco- and mineralocorticoid biological effects of a 7-day treatment with low doses of hydrocortisone and fludrocortisone in septic shock. Intensive Care Med. 38:1306–1314. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Shapiro NI, Trzeciak S, Hollander JE, Birkhahn R, Otero R, Osborn TM, Moretti E, Nguyen HB, Gunnerson K, Milzman D, et al: The diagnostic accuracy of plasma neutrophil gelatinase-associated lipocalin in the prediction of acute kidney injury in emergency department patients with suspected sepsis. Ann Emerg Med. 56:52–59.e1. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Cheng B, Xie G, Yao S, Wu X, Guo Q, Gu M, Fang Q, Xu Q, Wang D, Jin Y, et al: Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China. Crit Care Med. 35:2538–2546. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Yu H, Chi D, Wang S and Liu B: Effect of early goal-directed therapy on mortality in patients with severe sepsis or septic shock: A meta-analysis of randomised controlled trials. BMJ Open. 6:e0083302016. View Article : Google Scholar : PubMed/NCBI

23 

Walton E, Oliveros H and Villamor E: Hemoglobin concentration and parasitemia on hospital admission predict risk of multiple organ dysfunction syndrome among adults with malaria. Am J Trop Med Hyg. 91:50–53. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Bone R, Fisher CJ Jr, Clemmer TP, Slotman GJ, Metz CA and Balk RA: A controlled trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med. 317:653–658. 1987. View Article : Google Scholar : PubMed/NCBI

25 

Zhao Y and Ding C: Effects of hydrocortisone on regulating inflammation, hemodynamic stability, and preventing shock in severe sepsis patients. Med Sci Monit. 24:3612–3619. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Greenberg SB and Coursin DB: Timing of corticosteroids in refractory septic shock: A key or wishful thinking? Crit Care Med. 42:1733–1735. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Lu J, Wang X, Chen Q, Chen M, Cheng L, Dai L, Jiang H and Sun Z: The effect of early goal-directed therapy on mortality in patients with severe sepsis and septic shock: A meta-analysis. J Surg Res. 202:389–397. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Yousif NG, Hadi NR, Alamran F and Zigam QA: Cardioprotective effects of irbesartan in polymicrobial sepsis: The role of the p38MAPK/NF-κB signaling pathway. Herz. 43:140–145. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Cuzzocrea S, Crisafulli C, Mazzon E, Esposito E, Muià C, Abdelrahman M, Di Paola R and Thiemermann C: Inhibition of glycogen synthase kinase-3beta attenuates the development of carrageenan-induced lung injury in mice. Br J Pharmacol. 149:687–702. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Eisenhut M: Comment on ‘Duration and intensity of NF-kappa B activity determine the severity of endotoxin-induced acute lung injury’. J Immunol. 177:20382006. View Article : Google Scholar : PubMed/NCBI

31 

Kim SH and Shin TY: Anti-inflammatory effect of leaves of Eriobotrya japonica, correlating with attenuation of p38 MAPK, ERK and NF-kappaB activation in mast cells. Toxicol In Vitro. 23:1215–1219. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Ishibashi Y, Matsui T, Ueda S, Fukami K and Yamagishi SI: Advanced glycation end products potentiate citrated plasma-evoked oxidative and inflammatory reactions in endothelial cells by up-regulating protease-activated receptor-1 expression. Cardiovasc Diabetol. 13:602014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li X, Li M, Liu L, Tian X and Liang Y: Protective effects of glucocorticoid on liver injury in a rat sepsis model. Exp Ther Med 18: 3153-3160, 2019.
APA
Li, X., Li, M., Liu, L., Tian, X., & Liang, Y. (2019). Protective effects of glucocorticoid on liver injury in a rat sepsis model. Experimental and Therapeutic Medicine, 18, 3153-3160. https://doi.org/10.3892/etm.2019.7899
MLA
Li, X., Li, M., Liu, L., Tian, X., Liang, Y."Protective effects of glucocorticoid on liver injury in a rat sepsis model". Experimental and Therapeutic Medicine 18.4 (2019): 3153-3160.
Chicago
Li, X., Li, M., Liu, L., Tian, X., Liang, Y."Protective effects of glucocorticoid on liver injury in a rat sepsis model". Experimental and Therapeutic Medicine 18, no. 4 (2019): 3153-3160. https://doi.org/10.3892/etm.2019.7899
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Li M, Liu L, Tian X and Liang Y: Protective effects of glucocorticoid on liver injury in a rat sepsis model. Exp Ther Med 18: 3153-3160, 2019.
APA
Li, X., Li, M., Liu, L., Tian, X., & Liang, Y. (2019). Protective effects of glucocorticoid on liver injury in a rat sepsis model. Experimental and Therapeutic Medicine, 18, 3153-3160. https://doi.org/10.3892/etm.2019.7899
MLA
Li, X., Li, M., Liu, L., Tian, X., Liang, Y."Protective effects of glucocorticoid on liver injury in a rat sepsis model". Experimental and Therapeutic Medicine 18.4 (2019): 3153-3160.
Chicago
Li, X., Li, M., Liu, L., Tian, X., Liang, Y."Protective effects of glucocorticoid on liver injury in a rat sepsis model". Experimental and Therapeutic Medicine 18, no. 4 (2019): 3153-3160. https://doi.org/10.3892/etm.2019.7899
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team