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Cerebellar fastigial nucleus is involved in post‑stroke depression through direct cerebellar‑hypothalamic GABAergic and glutamatergic projections

  • Authors:
    • Yuan Li
    • Xin Zhang
    • Lixin Chen
    • Bo Yang
    • Rubo Sui
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China, Department of Pharmacy, General Hospital of Fushun Mining Bureau, Fushun, Liaoning 113008, P.R. China , Nursing College of Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2885-2892
    |
    Published online on: August 16, 2019
       https://doi.org/10.3892/etm.2019.7913
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Abstract

The present study aimed to investigate whether the cerebellar fastigial nucleus (FN) is involved in post‑stroke depression (PSD), and to observe the effect of direct cerebellar‑hypothalamic γ‑aminobutyric acid (GABA)ergic and glutamatergic projections on PSD, in order to understand the mechanisms underlying the cerebellar modulation of mood and emotion. Healthy Sprague‑Dawley rats were randomly divided into five groups: Sham‑operated, Stroke, PSD, FN lesion, and decussation of superior cerebellar peduncle (XSCP) lesion groups. Sham surgery was performed in animals of the Sham group (n=6). The rats in the other four groups (n=6 for each group) underwent middle cerebral artery occlusion. The rats were examined twice a week in an open field test. In addition, the expression of cytokines in hippocampal tissues, and the content of glutamate and GABA in the lateral hypothalamic area (LHA) were measured. The results showed that scores corresponding to the behavioral signs of depression were decreased in the PSD, FN lesion and XSCP lesion groups. In addition, the mRNA levels of tumor necrosis factor‑α, interleukin (IL)‑6, and IL‑1β in the hippocampus of the PSD, FN lesion and XSCP lesion groups were significantly increased. The GABA and glutamate content in the LHA were also decreased significantly in the PSD, FN lesion and XSCP lesion groups. Taken together, the findings of the present study indicated that the cerebellar FN may be involved in PSD through the direct cerebellar‑hypothalamic glutamatergic and GABAergic projections.
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View References

1 

Towfighi A, Ovbiagele B, El Husseini N, Hackett ML, Jorge RE, Kissela BM, Mitchell PH, Skolarus LE, Whooley MA, Williams LS, et al: Poststroke depression: A scientific statement for healthcare professionals from the American heart association/American stroke association. Stroke. 48:e30–e43. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Spalletta G, Bossù P, Ciaramella A, Bria P, Caltagirone C and Robinson RG: The etiology of poststroke depression: A review of the literature and a new hypothesis involving inflammatory cytokines. Mol Psychiatry. 11:984–991. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Jiao JT, Cheng C, Ma YJ, Huang J, Dai MC, Jiang C, Wang C and Shao JF: Association between inflammatory cytokines and the risk of post-stroke depression, and the effect of depression on outcomes of patients with ischemic stroke in a 2-year prospective study. Exp Ther Med. 12:1591–1598. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Schmahmann JD and Sherman JC: The cerebellar cognitive affective syndrome. Brain. 121:561–579. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Bugalho P, Correa B and Viana-Baptista M: Role of the cerebellum in cognitive and behavioural control: Scientific basis and investigation models. Acta Med Port. 19:257–267. 2006.(In Portuguese). PubMed/NCBI

6 

Schmahmann JD, MacMore J and Vangel M: Cerebellar stroke without motor deficit: Clinical evidence for motor and non-motor domains within the human cerebellum. Neuroscience. 162:852–861. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Lei Z, Zhao M and Sui RB: Cerebellar fastigial nucleus electrical stimulation alleviates depressive-like behaviors in post-stroke depression rat model and potential mechanisms. Cell Physiol Biochem. 41:1403–1412. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Su CY, Wuang YP, Lin Y and Su JH: The role of processing speed in post-stroke cognitive dysfunction. Arch Clin Neuropsychol. 30:148–160. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Galea E, Glickstein SB, Feinstein DL, Golanov EV and Reis DJ: Stimulation of cerebellar fastigial nucleus inhibits interleukin-1beta-induced cerebrovascular inflammation. Am J Physiol. 275:H2053–H2063. 1998.PubMed/NCBI

10 

Ni SJ, Qiu YH, Lu JH, Cao BB and Peng YP: Effect of cerebellar fastigial nuclear lesions on differentiation and function of thymocytes. J Neuroimmunol. 222:40–47. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Madden KS: Catecholamines, sympathetic innervation, and immunity. Brain Behav Immun. 17 (Suppl 1):S5–S10. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Nance DM and Sanders VM: Autonomic innervation and regulation of the immune system (1987–2007). Brain Behav Immun. 21:736–745. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Trotter RN, Stornetta RL, Guyenet PG and Roberts MR: Transneuronal mapping of the CNS network controlling sympathetic outflow to the rat thymus. Auton Neurosci. 131:9–20. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Dietrichs E, Haines DE, Røste GK and Røste LS: Hypothalamocerebellar and cerebellohypothalamic projections-circuits for regulating nonsomatic cerebellar activity? Histol Histopathol. 9:603–614. 1994.PubMed/NCBI

15 

Haines DE, Dietrichs E, Mihailoff GA and McDonald EF: The cerebellar-hypothalamic axis: Basic circuits and clinical observations. Int Rev Neurobiol. 41:83–107. 1997. View Article : Google Scholar : PubMed/NCBI

16 

Cao BB, Huang Y, Jiang YY, Qiu YH and Peng YP: Cerebellar fastigial nuclear glutamatergic neurons regulate immune function via hypothalamic and sympathetic pathways. J Neuroimmune Pharmacol. 10:162–178. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Cao BB, Huang Y, Lu JH, Xu FF, Qiu YH and Peng YP: Cerebellar fastigial nuclear GABAergic projections to the hypothalamus modulate immune function. Brain Behav Immun. 27:80–90. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Paxinos G and Watson С: The rat brain in stereotaxic coordinates. New York. Academic1986.

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Willner P, Muscat R and Papp M: Chronic mild stress-induced anhedonia: A realistic animal model of depression. Neurosci Biobehav Rev. 16:525–534. 1992. View Article : Google Scholar : PubMed/NCBI

21 

Roth KA and Katz RJ: Stress, behavioral arousal, and open field activity-a reexamination of emotionality in the rat. Neurosci Biobehav Rev. 3:247–263. 1979. View Article : Google Scholar : PubMed/NCBI

22 

Sapolsky RM, Romero LM and Munck AU: How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev. 21:55–89. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Köhler C and Schwarcz R: Comparison of ibotenate and kainate neurotoxicity in rat brain: A histological study. Neuroscience. 8:819–835. 1983. View Article : Google Scholar : PubMed/NCBI

24 

Liu JL, Li JP and Dong WW: A clinical study of fastigial nucleus electrical stimulation on post stroke depression. J Chin J Clin Rehabilitation. 7:1926–1927. 2003.

25 

Schmahmann JD: The role of the cerebellum in affect and psychosis. J Neurolinguis. 13:189–214. 2000. View Article : Google Scholar

26 

Wang J, Pu Y and Wang T: Influences of cerebellar interpositus nucleus and fastigial nucleus on neuronal activity of lateral hypothalamic area. Sci China C Life Sci. 40:176–183. 1997. View Article : Google Scholar : PubMed/NCBI

27 

Zhang YP, Ma C, Wen YQ and Wang JJ: Convergence of gastric vagal and cerebellar fastigial nuclear inputs on glycemia-sensitive neurons of lateral hypothalamic area in the rat. Neurosci Res. 45:9–16. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Schutter DJ and Van Honk J: The cerebellum on the rise in human emotion. Cerebellum. 4:290–294. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Min BI, Oomura Y and Katafuchi T: Responses of rat lateral hypothalamic neuronal activity to fastigial nucleus stimulation. J Neurophysiol. 61:1178–1184. 1989. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Zhang X, Chen L, Yang B and Sui R: Cerebellar fastigial nucleus is involved in post‑stroke depression through direct cerebellar‑hypothalamic GABAergic and glutamatergic projections. Exp Ther Med 18: 2885-2892, 2019.
APA
Li, Y., Zhang, X., Chen, L., Yang, B., & Sui, R. (2019). Cerebellar fastigial nucleus is involved in post‑stroke depression through direct cerebellar‑hypothalamic GABAergic and glutamatergic projections. Experimental and Therapeutic Medicine, 18, 2885-2892. https://doi.org/10.3892/etm.2019.7913
MLA
Li, Y., Zhang, X., Chen, L., Yang, B., Sui, R."Cerebellar fastigial nucleus is involved in post‑stroke depression through direct cerebellar‑hypothalamic GABAergic and glutamatergic projections". Experimental and Therapeutic Medicine 18.4 (2019): 2885-2892.
Chicago
Li, Y., Zhang, X., Chen, L., Yang, B., Sui, R."Cerebellar fastigial nucleus is involved in post‑stroke depression through direct cerebellar‑hypothalamic GABAergic and glutamatergic projections". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2885-2892. https://doi.org/10.3892/etm.2019.7913
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Zhang X, Chen L, Yang B and Sui R: Cerebellar fastigial nucleus is involved in post‑stroke depression through direct cerebellar‑hypothalamic GABAergic and glutamatergic projections. Exp Ther Med 18: 2885-2892, 2019.
APA
Li, Y., Zhang, X., Chen, L., Yang, B., & Sui, R. (2019). Cerebellar fastigial nucleus is involved in post‑stroke depression through direct cerebellar‑hypothalamic GABAergic and glutamatergic projections. Experimental and Therapeutic Medicine, 18, 2885-2892. https://doi.org/10.3892/etm.2019.7913
MLA
Li, Y., Zhang, X., Chen, L., Yang, B., Sui, R."Cerebellar fastigial nucleus is involved in post‑stroke depression through direct cerebellar‑hypothalamic GABAergic and glutamatergic projections". Experimental and Therapeutic Medicine 18.4 (2019): 2885-2892.
Chicago
Li, Y., Zhang, X., Chen, L., Yang, B., Sui, R."Cerebellar fastigial nucleus is involved in post‑stroke depression through direct cerebellar‑hypothalamic GABAergic and glutamatergic projections". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2885-2892. https://doi.org/10.3892/etm.2019.7913
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