Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2019 Volume 18 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Multidrug‑resistant Acinetobacter baumannii strains with NDM‑1: Molecular characterization and in vitro efficacy of meropenem‑based combinations

  • Authors:
    • Jingjing Wang
    • Yongzhong Ning
    • Shu Li
    • Yun Wang
    • Jinhua Liang
    • Chunming Jin
    • Hairun Yan
    • Yongcun Huang
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, The Second Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471000, P.R. China, Department of Laboratory Medicine, Beijing ChuiYangLiu Hospital Αffiliated to Tsinghua University, Beijing 100022, P.R. China, Department of Laboratory Medicine, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China, Department of Laboratory Medicine, The Second Affiliated Hospital of Mudanjiang Medical College, Mudanjiang, Heilongjiang 157001, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2924-2932
    |
    Published online on: August 20, 2019
       https://doi.org/10.3892/etm.2019.7927
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Acinetobacter baumannii is an important cause of hospital‑acquired, multidrug‑resistant (MDR) infections occurring worldwide. Anti‑microbial combination regimens may be the only feasible treatment option for affected patients. In the present study, the efficacy of the combined therapy of meropenem with colistin, ampicillin‑sulbactam, tazobactam and vancomycin against clinical strains of MDR A. baumannii was determined. Anti‑microbial susceptibility testing was performed and resistance genes were characterized by a multiplex polymerase chain reaction (PCR)‑reverse line blot assay. The genetic background of New Delhi metallo‑β‑lactamase 1 (NDM‑1) was analysed by primer walking. The presence of NDM‑1 was detected using the modified Hodge test and the EDTA‑combined disk test. To screen for synergistic drug effects, the fractional inhibitory concentration index was calculated using a checkerboard assay. The results of the PCR as well as the sequence analyses suggested that NDM‑1 was located downstream of the ISAba125 element. In addition, a synergistic effect was determined for meropenem + vancomycin, meropenem + tazobactam and meropenem + ampicillin + sulbactam in two strains each, and in four strains for meropenem + colistin. A total of five A. baumannii strains with resistance to numerous antibiotics and carrying numerous resistance genes were identified. In the strains of A. baumannii, the NDM‑1 gene was integrated in a transposon structure with a copy of the ISAba125 insertion sequence. However, the genetic background was not identical among the different species and strains. The genetic variability of NDM‑1 may facilitate the rapid dissemination of this gene. In conclusion, meropenem may enhance the efficacy of antibiotics in A. baumannii strains with NDM‑1‑associated MDR.
View Figures

Figure 1

Figure 2

View References

1 

Joly-Guillou ML: Clinical impact and pathogenicity of Acinetobacter. Clin Microbiol Infect. 11:868–873. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Wong D, Nielsen TB, Bonomo RA, Pantapalangkoor P, Luna B and Spellberg B: Clinical and pathophysiological overview of acinetobacter infections: A century of challenges. Clin Microbiol Rev. 30:409–447. 2017.PubMed/NCBI

3 

Cai Y, Chai D, Wang R, Liang B and Bai N: Colistin resistance of Acinetobacter baumannii: Clinical reports, mechanisms and antimicrobial strategies. J Antimicrob Chemother. 67:1607–1615. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Novovic K, Mihajlovic S, Vasiljevic Z, Filipic B, Begovic J and Jovcic B: Carbapenem-resistant Acinetobacter baumannii from Serbia: Revision of CarO classification. PLoS One. 10:e01227932015. View Article : Google Scholar : PubMed/NCBI

5 

Boulanger A, Naas T, Fortineau N, Figueiredo S and Nordmann P: NDM-1-producing Acinetobacter baumannii from Algeria. Antimicrob Agents Chemother. 56:2214–2215. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Revathi G, Siu LK, Lu PL and Huang LY: First report of NDM-1-producing Acinetobacter baumannii in East Africa. Int J Infect Dis. 17:e1255–e1258. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Jones LS, Toleman MA, Weeks JL, Howe RA, Walsh TR and Kumarasamy KK: Plasmid carriage of bla NDM-1 in clinical Acinetobacter baumannii isolates from India. Antimicrob Agents Chemother. 58:4211–4213. 2014. View Article : Google Scholar : PubMed/NCBI

8 

El-Gamal MI, Brahim I, Hisham N, Aladdin R, Mohammed H and Bahaaeldin A: Recent updates of carbapenem antibiotics. Eur J Med Chem. 131:185–195. 2017. View Article : Google Scholar : PubMed/NCBI

9 

McGuinness WA, Malachowa N and DeLeo FR: Vancomycin resistance in Staphylococcus aureus. Yale J Biol Med. 90:269–281. 2017.PubMed/NCBI

10 

Acar JF, Goldstein FW and Kitzis MD: Susceptibility survey of piperacillin alone and in the presence of tazobactam. J Antimicrob Chemother. 31 (Suppl A):S23–S28. 1993. View Article : Google Scholar

11 

Sörgel F and Kinzig M: The chemistry, pharmacokinetics and tissue distribution of piperacillin/tazobactam. J Antimicrob Chemother. 31 (Suppl A):S39–S60. 1993. View Article : Google Scholar

12 

Joly-Guillou ML, Decré D, Herrman JL, Bourdelier E and Bergogne-Bérézin E: Bactericidal in-vitro activity of beta-lactams and beta-lactamase inhibitors, alone or associated, against clinical strains of Acinetobacter baumannii: Effect of combination with aminoglycosides. J Antimicrob Chemother. 36:619–629. 1995. View Article : Google Scholar : PubMed/NCBI

13 

Li J, Nation RL, Turnidge JD, Milne RW, Coulthard K, Rayner CR and Paterson DL: Colistin: The re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections. Lancet Infect Dis. 6:589–601. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Arroyo LA, Herrera CM, Fernandez L, Hankins JV, Trent MS and Hancock RE: The pmrCAB operon mediates polymyxin resistance in Acinetobacter baumannii ATCC 17978 and clinical isolates through phosphoethanolamine modification of lipid A. Antimicrob Agents Chemother. 55:3743–3751. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Moffatt JH, Harper M, Harrison P, Hale JD, Vinogradov E, Seemann T, Henry R, Crane B, St Michael F, Cox AD, et al: Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production. Antimicrob Agents Chemother. 54:4971–4977. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Kimberly CC, Anna DF and Michael JR: A review of novel combinations of colistin and lipopeptide or glycopeptide antibiotics for the treatment of multidrug-resistant Acinetobacter baumannii. Infect Dis Ther. 3:69–81. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Patel J, Cockerill F, Bradford P, Eliopoulos G, Hindler J, Jenkins S, Lewis J, Limbago B, Miller L, Nicolau D, et al: Performance standards for antimicrobial susceptibility testing: Twenty-fifth informational supplement; M100-S25Wayne, PA: CLSI; 35. 2015

18 

Clinical and Laboratory Standards Institute, . Performance standards for antimicrobial susceptibility testing; twenty-fifth informational supplement (M100-S25)Wayne (PA): The Institute; 2015

19 

Shoma S, Kamruzzaman M, Ginn AN, Iredell JR and Partridge SR: Characterization of multidrug-resistant Klebsiella pneumoniae from Australia carrying blaNDM-1. Diagn Microbiol Infect Dis. 78:93–97. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Rodriguez-Martinez JM, Nordmann P, Fortineau N and Poirel L: VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae. Antimicrob Agents Chemother. 54:471–476. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Qin S, Fu Y, Zhang Q, Qi H, Wen JG, Xu H, Xu L, Zeng L, Tian H, Rong L, et al: High incidence and endemic spread of NDM-1-positive Enterobacteriaceae in Henan Province, China. Antimicrob Agents Chemother. 58:4275–4282. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Guo H and Xiong J: A specific and versatile genome walking technique. Gene. 381:18–23. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Li P, Yang C, Xie J, Liu N, Wang H, Zhang L, Wang X, Wang Y, Qiu S and Song H: Acinetobacter calcoaceticus from a fatal case of pneumonia harboring bla(NDM-1) on a widely distributed plasmid. BMC Infect Dis. 15:1312015. View Article : Google Scholar : PubMed/NCBI

24 

Pfeifer Y, Wilharm G, Zander E, Wichelhaus TA, Göttig S, Hunfeld KP, Seifert H, Witte W and Higgins PG: Molecular characterization of blaNDM-1 in an Acinetobacter baumannii strain isolated in Germany in 2007. J Antimicrob Chemother. 66:1998–2001. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Bartual SG, Seifert H, Hippler C, Luzon MA, Wisplinghoff H and Rodriguez-Valera F: Development of a multilocus sequence typing scheme for characterization of clinical isolates of Acinetobacter baumannii. J Clin Microbiol. 43:4382–4390. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Memish ZA, Assiri A, Almasri M, Roshdy H, Hathout H, Kaase M, Gatermann SG and Yezli S: Molecular characterization of carbapenemase production among gram-negative bacteria in saudi arabia. Microb Drug Resist. 21:307–314. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Poirel L, Héritier C, Tolün V and Nordmann P: Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae. Antimicrob Agents Chemother. 48:15–22. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Chatterjee S, Datta S, Roy S, Ramanan L, Saha A, Viswanathan R, Som T and Basu S: Carbapenem resistance in Acinetobacter baumannii and other acinetobacter spp. causing neonatal sepsis: Focus on NDM-1 and its linkage to ISAba125. Front Microbiol. 7:11262016. View Article : Google Scholar : PubMed/NCBI

29 

Aaron SD, Ferris W, Henry DA, Speert DP and Macdonald NE: Multiple combination bactericidal antibiotic testing for patients with cystic fibrosis infected with Burkholderia cepacia. Am J Respir Crit Care Med. 161:1206–1212. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Aaron SD, Ferris W, Ramotar K, Vandemheen K, Chan F and Saginur R: Single and combination antibiotic susceptibilities of planktonic, adherent, and biofilm-grown Pseudomonas aeruginosa isolates cultured from sputa of adults with cystic fibrosis. J Clin Microbiol. 40:4172–4179. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Percin D, Akyol S and Kalin G: In vitro synergism of combinations of colistin with selected antibiotics against colistin-resistant Acinetobacter baumannii. GMS Hyg Infect Control. 9:Doc142014.PubMed/NCBI

32 

Ko WC, Lee HC, Chiang SR, Yan JJ, Wu JJ, Lu CL and Chuang YC: In vitro and in vivo activity of meropenem and sulbactam against a multidrug-resistant Acinetobacter baumannii strain. J Antimicrob Chemother. 53:393–395. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Abbo A, Navon-Venezia S, Hammer-Muntz O, Krichali T, Siegman-Igra Y and Carmeli Y: Multidrug-resistant Acinetobacter baumannii. Emerg Infect Dis. 11:22–29. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Nordmann P, Poirel L, Toleman MA and Walsh TR: Does broad-spectrum beta-lactam resistance due to NDM-1 herald the end of the antibiotic era for treatment of infections caused by Gram-negative bacteria? J Antimicrob Chemother. 66:689–692. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Chen Y, Zhou Z, Jiang Y and Yu Y: Emergence of NDM-1-producing Acinetobacter baumannii in China. J Antimicrob Chemother. 66:1255–1259. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Zhou Z, Guan R, Yang Y, Chen L, Fu J, Deng Q, Xie Y, Huang Y, Wang J, Wang D, et al: Identification of New Delhi metallo-β-lactamase gene (NDM-1) from a clinical isolate of Acinetobacter junii in China. Can J Microbiol. 58:112–115. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Tran DN, Tran HH, Matsui M, Suzuki M, Suzuki S, Shibayama K, Pham TD, Van Phuong TT, Dang DA, Trinh HS, et al: Emergence of New Delhi metallo-beta-lactamase 1 and other carbapenemase-producing Acinetobacter calcoaceticus-baumannii complex among patients in hospitals in Ha Noi, Viet Nam. Eur J Clin Microbiol Infect Dis. 36:219–225. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Poirel L, Bonnin RA, Boulanger A, Schrenzel J, Kaase M and Nordmann P: Tn125-related acquisition of blaNDM-like genes in Acinetobacter baumannii. Antimicrob Agents Chemother. 56:1087–1089. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Karaiskos I and Giamarellou H: Multidrug-resistant and extensively drug-resistant Gram-negative pathogens: Current and emerging therapeutic approaches. Expert Opin Pharmacother. 15:1351–1370. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Tamma PD, Cosgrove SE and Maragakis LL: Combination therapy for treatment of infections with gram-negative bacteria. Clin Microbiol Rev. 25:450–470. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Marques MB, Brookings ES, Moser SA, Sonke PB and Waites KB: Comparative in vitro antimicrobial susceptibilities of nosocomial isolates of Acinetobacter baumannii and synergistic activities of nine antimicrobial combinations. Antimicrob Agents Chemother. 41:881–885. 1997. View Article : Google Scholar : PubMed/NCBI

42 

Rodríguez-Hernández MJ, Pachón J, Pichardo C, Cuberos L, Ibáñez-Martínez J, García-Curiel A, Caballero FJ, Moreno I and Jiménez-Mejías ME: Imipenem, doxycycline and amikacin in monotherapy and in combination in Acinetobacter baumannii experimental pneumonia. J Antimicrob Chemother. 45:493–501. 2000. View Article : Google Scholar : PubMed/NCBI

43 

Wolff M, Joly-Guillou ML, Farinotti R and Carbon C: In vivo efficacies of combinations of beta-lactams, beta-lactamase inhibitors, and rifampin against Acinetobacter baumannii in a mouse pneumonia model. Antimicrob Agents Chemother. 44:1406–1411. 1999. View Article : Google Scholar

44 

Gordon NC, Png K and Wareham DW: Potent synergy and sustained bactericidal activity of a vancomycin-colistin combination versus multidrug-resistant strains of Acinetobacter baumannii. Antimicrob Agents Chemother. 54:5316–5322. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Levin AS: Multiresistant Acinetobacter infections: A role for sulbactam combinations in overcoming an emerging worldwide problem. Clin Microbiol Infect. 8:144–153. 2002. View Article : Google Scholar : PubMed/NCBI

46 

Kempf M, Djouhri-Bouktab L, Brunel JM, Raoult D and Rolain JM: Synergistic activity of sulbactam combined with colistin against colistin-resistant Acinetobacter baumannii. Int J Antimicrob Agents. 39:180–181. 2012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang J, Ning Y, Li S, Wang Y, Liang J, Jin C, Yan H and Huang Y: Multidrug‑resistant Acinetobacter baumannii strains with NDM‑1: Molecular characterization and in vitro efficacy of meropenem‑based combinations. Exp Ther Med 18: 2924-2932, 2019.
APA
Wang, J., Ning, Y., Li, S., Wang, Y., Liang, J., Jin, C. ... Huang, Y. (2019). Multidrug‑resistant Acinetobacter baumannii strains with NDM‑1: Molecular characterization and in vitro efficacy of meropenem‑based combinations. Experimental and Therapeutic Medicine, 18, 2924-2932. https://doi.org/10.3892/etm.2019.7927
MLA
Wang, J., Ning, Y., Li, S., Wang, Y., Liang, J., Jin, C., Yan, H., Huang, Y."Multidrug‑resistant Acinetobacter baumannii strains with NDM‑1: Molecular characterization and in vitro efficacy of meropenem‑based combinations". Experimental and Therapeutic Medicine 18.4 (2019): 2924-2932.
Chicago
Wang, J., Ning, Y., Li, S., Wang, Y., Liang, J., Jin, C., Yan, H., Huang, Y."Multidrug‑resistant Acinetobacter baumannii strains with NDM‑1: Molecular characterization and in vitro efficacy of meropenem‑based combinations". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2924-2932. https://doi.org/10.3892/etm.2019.7927
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Ning Y, Li S, Wang Y, Liang J, Jin C, Yan H and Huang Y: Multidrug‑resistant Acinetobacter baumannii strains with NDM‑1: Molecular characterization and in vitro efficacy of meropenem‑based combinations. Exp Ther Med 18: 2924-2932, 2019.
APA
Wang, J., Ning, Y., Li, S., Wang, Y., Liang, J., Jin, C. ... Huang, Y. (2019). Multidrug‑resistant Acinetobacter baumannii strains with NDM‑1: Molecular characterization and in vitro efficacy of meropenem‑based combinations. Experimental and Therapeutic Medicine, 18, 2924-2932. https://doi.org/10.3892/etm.2019.7927
MLA
Wang, J., Ning, Y., Li, S., Wang, Y., Liang, J., Jin, C., Yan, H., Huang, Y."Multidrug‑resistant Acinetobacter baumannii strains with NDM‑1: Molecular characterization and in vitro efficacy of meropenem‑based combinations". Experimental and Therapeutic Medicine 18.4 (2019): 2924-2932.
Chicago
Wang, J., Ning, Y., Li, S., Wang, Y., Liang, J., Jin, C., Yan, H., Huang, Y."Multidrug‑resistant Acinetobacter baumannii strains with NDM‑1: Molecular characterization and in vitro efficacy of meropenem‑based combinations". Experimental and Therapeutic Medicine 18, no. 4 (2019): 2924-2932. https://doi.org/10.3892/etm.2019.7927
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team