Effect of laparoscopic myomectomy on serum levels of IL‑6 and TAC, and ovarian function

Hu,Yanling; Yu,Liyao; Xia,Fen; Liang,Fengqi; Cheng,Chao; Huang,Yuhua; Xiao,Linqi

doi:10.3892/etm.2019.7941

Effect of laparoscopic myomectomy on serum levels of IL‑6 and TAC, and ovarian function

Authors:
- Yanling Hu
- Liyao Yu
- Fen Xia
- Fengqi Liang
- Chao Cheng
- Yuhua Huang
- Linqi Xiao
View Affiliations

Affiliations: Department of Gynaecology and Obstetrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
Published online on: August 26, 2019 https://doi.org/10.3892/etm.2019.7941
Pages: 3588-3594
Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Effect of laparoscopic myomectomy on the serum levels of interleukin‑6 (IL‑6) and total antioxidant capacity (TAC), and the ovarian function of patients with uterine fibroids was studied. Ninety patients with uterine fibroids admitted to The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, from March 2013 to July 2014, were randomly divided into the experimental group (n=45) and the control group (n=45). The experimental group was treated with laparoscopic myomectomy, and the control group was treated with abdominal myomectomy. ELISA was used for detecting IL‑6 and TAC content. Radioimmunoassay (RIA) was used for detecting serum ovarian function indicators, including estradiol (E2), follicle‑stimulating hormone (FSH) and luteinizing hormone (LH). Patients in the experimental group had significantly lower intraoperative blood loss, postoperative exhaust time, number of days to recovery and return to work, number of intraoperative fibroids removed, and length of stay than those in the control group (P<0.05). TAC expression level was significantly higher in the experimental group than that in the control group, on the 1st, 3rd and 5th day after surgery (P<0.05), while IL‑6 expression was significantly lower in the experimental group than that in the control group at the same time points (P<0.05). FSH and LH expression levels were significantly lower in the experimental group than those in the control group (P<0.05) at 1, 3 and 6 months after surgery, while E2 expression level was significantly higher in the experimental group than that in the control group at the same time points (P<0.05). The incidence of postoperative complications of patients in the experimental group was significantly lower than that in the control group (P<0.05). Patients in the experimental group had significantly higher successful pregnancy rate than those in the control group (χ2=6.75, P<0.05). Reducing its effect on ovarian function, serum pain index and oxidative damage index of patients with uterine fibroid, laparoscopic myomectomy also reduces the incidence of postoperative complications and increases the pregnancy rate.

View Figures

View References

1	Thyagarajan MS and Sharif K: Space occupying lesions in liver. Indian J Pediatr. 83:1291–1302. 2016. View Article : Google Scholar : PubMed/NCBI
2	Saccardi C, Gizzo S, Noventa M, Ancona E, Borghero A and Litta PS: Limits and complications of laparoscopic myomectomy: Which are the best predictors? A large cohort single-center experience. Arch Gynecol Obstet. 290:951–956. 2014. View Article : Google Scholar : PubMed/NCBI
3	Evans P and Brunsell S: Uterine fibroid tumors: Diagnosis and treatment. Am Fam Physician. 75:1503–1508. 2007.PubMed/NCBI
4	Sparić R: Uterine myomas in pregnancy, childbirth and puerperium. Srp Arh Celok Lek. 142:118–124. 2014.(In Serbian). View Article : Google Scholar : PubMed/NCBI
5	Ciavattini A, Di Giuseppe J, Stortoni P, Montik N, Giannubilo SR, Litta P, Islam MS, Tranquilli AL, Reis FM and Ciarmela P: Uterine fibroids: Pathogenesis and interactions with endometrium and endomyometrial junction. Obstet Gynecol Int. 2013:1731842013. View Article : Google Scholar : PubMed/NCBI
6	Florio P, Filippeschi M, Imperatore A, Mereu L, Franchini M, Calzolari S, Mencaglia L and Litta P: The practicability and surgeons' subjective experiences with vaginal danazol before an operative hysteroscopy. Steroids. 77:528–533. 2012. View Article : Google Scholar : PubMed/NCBI
7	Arthur R, Kachura J, Liu G, Chan C and Shapiro H: Laparoscopic myomectomy versus uterine artery embolization: Long-term impact on markers of ovarian reserve. J Obstet Gynaecol Can. 36:240–247. 2014. View Article : Google Scholar : PubMed/NCBI
8	Han CM, Lee CL, Su H, Wu PJ, Wang CJ and Yen CF: Single-port laparoscopic myomectomy: Initial operative experience and comparative outcome. Arch Gynecol Obstet. 287:295–300. 2013. View Article : Google Scholar : PubMed/NCBI
9	Li MH, Leng JH, Shi JH, Jia SZ and Lang JH: Comparison of postoperative residue, recurrence and pregnancy outcome between laparoscopic and transabdominal myomectomy. Zhonghua Fu Chan Ke Za Zhi. 46:669–673. 2011.(In Chinese). PubMed/NCBI
10	Dubuisson JB, Fauconnier A, Deffarges JV, Norgaard C, Kreiker G and Chapron C: Pregnancy outcome and deliveries following laparoscopic myomectomy. Hum Reprod. 15:869–873. 2000. View Article : Google Scholar : PubMed/NCBI
11	Dong J: Influence of laparoscopic myomectomy on ovarian function and serum trauma related indexes. J Hainan Med Univ. 20:1103–1104. 2014.(In Chinese).
12	Chen J, Chen W, Zhang L, Li K, Peng S, He M and Hu L: Safety of ultrasound-guided ultrasound ablation for uterine fibroids and adenomyosis: A review of 9988 cases. Ultrason Sonochem. 27:671–676. 2015. View Article : Google Scholar : PubMed/NCBI
13	Cela V, Freschi L, Simi G, Tana R, Russo N, Artini PG and Pluchino N: Fertility and endocrine outcome after robot-assisted laparoscopic myomectomy (RALM). Gynecol Endocrinol. 29:79–82. 2013. View Article : Google Scholar : PubMed/NCBI
14	Wang Q and Luo J: Effect of laparoscopic myomectomy on inflammatory reaction, immune function, stress hormones and ovarian function. J Hainan Med Univ. 24:37–40. 2018.(In Chinese).
15	Yuan G, Zeng CL, Zhu DD and Shi XJ: Influences of RFA combined with TACE on the HIF-1α and EGR level of patients with primary hepatic carcinoma. Eur Rev Med Pharmacol Sci. 21:1738–1745. 2017.PubMed/NCBI
16	Taniguchi F, Koike N, Kikukawa T, Yabuta M, Yamaguchi M, Adachi E and Nakayama T: An evaluation of laparoscopic hysterectomy alone versus in combination with laparoscopic myomectomy for patients with uterine fibroids. Eur J Obstet Gynecol Reprod Biol. 210:132–138. 2017. View Article : Google Scholar : PubMed/NCBI
17	Radosa JC, Radosa CG, Mavrova R, Wagenpfeil S, Hamza A, Joukhadar R, Baum S, Karsten M, Juhasz-Boess I, Solomayer EF, et al: Postoperative quality of life and sexual function in premenopausal women undergoing laparoscopic myomectomy for symptomatic fibroids: A prospective observational cohort study. PLoS One. 11:e01666592016. View Article : Google Scholar : PubMed/NCBI
18	Aktas GE, Sarıkaya A, Can N and Demir SS: Microcalcified hepatic metastases incidentally detected on F-18 NaF PET/CT in a patient with prostate cancer. Nucl Med Mol Imaging. 51:364–367. 2017. View Article : Google Scholar : PubMed/NCBI
19	Abdusattarova K, Mettler L, Alkatout I and Dempfle A: Endoscopic treatment of symptomatic fibroids at reproductive age and beyond. Minim Invasive Ther Allied Technol. 26:355–361. 2017. View Article : Google Scholar : PubMed/NCBI
20	Bean EM, Cutner A, Holland T, Vashisht A, Jurkovic D and Saridogan E: Laparoscopic myomectomy: A single-center retrospective review of 514 patients. J Minim Invasive Gynecol. 24:485–493. 2017. View Article : Google Scholar : PubMed/NCBI
21	Tatsuaki S, Yasuo S, Takehiro O, Yasuhiro H, Yoshihiro N, Michihiko K, Kenta S, Yuji N and Taijiro S: Multidetector CT in detection of troublesome posterior sectoral hepatic duct communicating with cystic duct. Br J Radiol. 90:201702602017. View Article : Google Scholar : PubMed/NCBI
22	Yamaguchi K, Kumakura S, Murakami T, Someya A, Inada E and Nagaoka I: Ketamine suppresses the substance P-induced production of IL-6 and IL-8 by human U373MG glioblastoma/astrocytoma cells. Int J Mol Med. 39:687–692. 2017. View Article : Google Scholar : PubMed/NCBI
23	Kim SY, Koo BN, Shin CS, Ban M, Han K and Kim MD: The effects of single-dose dexamethasone on inflammatory response and pain after uterine artery embolisation for symptomatic fibroids or adenomyosis: A randomised controlled study. BJOG. 123:580–587. 2016. View Article : Google Scholar : PubMed/NCBI
24	Cojocaru IM, Cojocaru M, Sapira V and Ionescu A: Evaluation of oxidative stress in patients with acute ischemic stroke. Rom J Intern Med. 51:97–106. 2013.PubMed/NCBI
25	Jiang X, Zhong P, Huang C, Meng Y, He F and Fan X: Expression and clinical significance of oxidative stress markers in serum of patients with stable chronic obstructive pulmonary disease. Zhongguo Hu Xi Yu Wei Zhong Jian Hu Za Zhi. 15:542–547. 2016.(In Chinese).
26	Hip Fracture Accelerated Surgical Treatment and Care Track (HIP ATTACK) Investigators: Accelerated care versus standard care among patients with hip fracture: The HIP ATTACK pilot trial. CMAJ. 186:E52–E60. 2014. View Article : Google Scholar : PubMed/NCBI
27	Hahn M, Brucker S, Kraemer D, Wallwiener M, Taran FA, Wallwiener CW and Krämer B: Radiofrequency volumetric thermal ablation of fibroids and laparoscopic myomectomy: Long-term follow-up from a randomized trial. Geburtshilfe Frauenheilkd. 75:442–449. 2015. View Article : Google Scholar : PubMed/NCBI
28	Brucker SY, Hahn M, Kraemer D, Taran FA, Isaacson KB and Krämer B: Laparoscopic radiofrequency volumetric thermal ablation of fibroids versus laparoscopic myomectomy. Int J Gynaecol Obstet. 125:261–265. 2014. View Article : Google Scholar : PubMed/NCBI
29	Wang Y, Ji W, Zhang X and Tan J: Laparoscopic liver resection and enucleation of liver hemangioma with selective hepatic vascular occlusion: Technique and indications. J Laparoendosc Adv Surg Tech A. 27:944–950. 2017. View Article : Google Scholar : PubMed/NCBI
30	Song Y, Wang Y and Zhang X: Clinical effectiveness and safety of laparoscopic myomectomy in patients with fibroid. Chin Mod Doc. 56:52–54. 2018.(In Chinese).
31	Liang YZ, Du Z and Chen ZM: Comparison of curative effect of minimally invasive laparoscopic uterine myoma with conventional open surgery for treatment of uterine fibroids. Chin J Clin Oncol Rehabil. 23:209–211. 2016.(In Chinese).
32	Campo S, Campo V and Gambadauro P: Reproductive outcome before and after laparoscopic or abdominal myomectomy for subserous or intramural myomas. Eur J Obstet Gynecol Reprod Biol. 110:215–219. 2003. View Article : Google Scholar : PubMed/NCBI
33	Yuan H, Wang C, Wang D and Wang Y: Comparing the effect of laparoscopic supracervical and total hysterectomy for uterine fibroids on ovarian reserve by assessing serum anti-mullerian hormone levels: A prospective cohort study. J Minim Invasive Gynecol. 22:637–641. 2015. View Article : Google Scholar : PubMed/NCBI