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Efficacy and safety of combination of magnesium sulfate, phentolamine and nifedipine in treatment of patients with hypertensive disorder complicating pregnancy

  • Authors:
    • Jinggui Zhang
    • Jun Li
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Medicine, Affiliated Hospital of Beihua University, Jilin 132001, P.R. China, Screening Laboratory, Jilin Hospital for Gynecology and Obstetrics, Jilin 132011, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3341-3346
    |
    Published online on: August 30, 2019
       https://doi.org/10.3892/etm.2019.7965
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Abstract

Efficacy and safety of the combination of magnesium sulfate, phentolamine and nifedipine in the treatment of patients with hypertensive disorder complicating pregnancy (HDCP) and its effect on hemodynamics and urinary protein level were investigated. One hundred and six patients with HDCP diagnosed at the Affiliated Hospital of Beihua University from February 5, 2016 to May 9, 2017 were retrospectively analyzed. Patients were divided into the magnesium sulfate group and the combination group, according to the therapeutic schemes. The efficacy 1 week later was observed. The general clinical data of the patients were recorded, and data were acquired with respect to hemodynamic indexes before and after treatment [changes of S/D ratio of umbilical artery flow, and cardiac index and total peripheral resistance (TPR)], the 24‑h urinary protein level, clinical efficacy and safety [adverse drug reactions (ADR) and maternal and neonatal outcomes]. Before treatment, there was no statistically significant difference between the two groups in terms of S/D ratio of umbilical artery flow (P>0.05), while after treatment the S/D ratio was significantly lower than that before treatment in both groups (P<0.05). Before treatment, there was no statistically significant difference between the two groups in terms of cardiac index (P>0.05). TPR after treatment was significantly lower than that before treatment in both groups (P<0.001). Compared with the magnesium sulfate group, patients in the combination group had significantly lower 24‑h urinary protein level after treatment (P<0.001), significantly higher total effective rate (P<0.05), significantly lower incidence rate of ADR (P<0.001), and significantly lower incidence rate of adverse maternal and neonatal outcomes (P<0.001). In conclusion, the combination of magnesium sulfate, phentolamine and nifedipine can significantly improve the hemodynamic indexes, the 24‑h urinary protein level, the clinical efficacy, ADR and maternal and neonatal outcomes of patients with HDCP, therefore it is worthy of use in the clinic.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang J and Li J: Efficacy and safety of combination of magnesium sulfate, phentolamine and nifedipine in treatment of patients with hypertensive disorder complicating pregnancy. Exp Ther Med 18: 3341-3346, 2019.
APA
Zhang, J., & Li, J. (2019). Efficacy and safety of combination of magnesium sulfate, phentolamine and nifedipine in treatment of patients with hypertensive disorder complicating pregnancy. Experimental and Therapeutic Medicine, 18, 3341-3346. https://doi.org/10.3892/etm.2019.7965
MLA
Zhang, J., Li, J."Efficacy and safety of combination of magnesium sulfate, phentolamine and nifedipine in treatment of patients with hypertensive disorder complicating pregnancy". Experimental and Therapeutic Medicine 18.5 (2019): 3341-3346.
Chicago
Zhang, J., Li, J."Efficacy and safety of combination of magnesium sulfate, phentolamine and nifedipine in treatment of patients with hypertensive disorder complicating pregnancy". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3341-3346. https://doi.org/10.3892/etm.2019.7965
Copy and paste a formatted citation
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Spandidos Publications style
Zhang J and Li J: Efficacy and safety of combination of magnesium sulfate, phentolamine and nifedipine in treatment of patients with hypertensive disorder complicating pregnancy. Exp Ther Med 18: 3341-3346, 2019.
APA
Zhang, J., & Li, J. (2019). Efficacy and safety of combination of magnesium sulfate, phentolamine and nifedipine in treatment of patients with hypertensive disorder complicating pregnancy. Experimental and Therapeutic Medicine, 18, 3341-3346. https://doi.org/10.3892/etm.2019.7965
MLA
Zhang, J., Li, J."Efficacy and safety of combination of magnesium sulfate, phentolamine and nifedipine in treatment of patients with hypertensive disorder complicating pregnancy". Experimental and Therapeutic Medicine 18.5 (2019): 3341-3346.
Chicago
Zhang, J., Li, J."Efficacy and safety of combination of magnesium sulfate, phentolamine and nifedipine in treatment of patients with hypertensive disorder complicating pregnancy". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3341-3346. https://doi.org/10.3892/etm.2019.7965
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