Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats

  • Authors:
    • Jiancheng Xi
    • Xiaobo Luo
    • Yipeng Wang
    • Jinglong Li
    • Lixin Guo
    • Guangseng Wu
    • Qingui Li
  • View Affiliations

  • Published online on: September 5, 2019     https://doi.org/10.3892/etm.2019.7974
  • Pages: 3681-3687
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

It has been reported that tetrahydrocurcumin has hypoglycemic, hypolipidemic, anti‑metastasis, anticancer and anti‑depressant pharmacological effects, and its antioxidative, hypoglycemic and hypolipidemic properties are better than those of curcumin. The present study assessed whether tetrahydrocurcumin exerts a neuroprotective effect against spinal cord injury (SCI) and investigated the underlying mechanisms. In a rat model of SCI, tetrahydrocurcumin enhanced the average Basso‑Beattie‑Bresnahan scores, inhibited water accumulation in the spinal cord and decreased inflammatory factors. Furthermore, oxidative stress and apoptosis (caspase‑3 activity and B‑cell lymphoma 2‑associated X protein levels) were also suppressed in SCI rats treated with tetrahydrocurcumin. Tetrahydrocurcumin effectively decreased the gene expression of matrix metalloproteinase‑3 and ‑13, as well as cyclooxygenase‑2, promoted the phosphorylation of Akt and enhanced the protein expression of forkhead box (FOX)O4 in SCI rats. The present study delineates that tetrahydrocurcumin protects against SCI and inhibits the oxidative stress response by regulating the FOXO4 in SCI model rats.
View Figures
View References

Related Articles

Journal Cover

November-2019
Volume 18 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xi J, Luo X, Wang Y, Li J, Guo L, Wu G and Li Q: Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats. Exp Ther Med 18: 3681-3687, 2019
APA
Xi, J., Luo, X., Wang, Y., Li, J., Guo, L., Wu, G., & Li, Q. (2019). Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats. Experimental and Therapeutic Medicine, 18, 3681-3687. https://doi.org/10.3892/etm.2019.7974
MLA
Xi, J., Luo, X., Wang, Y., Li, J., Guo, L., Wu, G., Li, Q."Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats". Experimental and Therapeutic Medicine 18.5 (2019): 3681-3687.
Chicago
Xi, J., Luo, X., Wang, Y., Li, J., Guo, L., Wu, G., Li, Q."Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3681-3687. https://doi.org/10.3892/etm.2019.7974