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Article

Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats

  • Authors:
    • Jiancheng Xi
    • Xiaobo Luo
    • Yipeng Wang
    • Jinglong Li
    • Lixin Guo
    • Guangseng Wu
    • Qingui Li
  • View Affiliations / Copyright

    Affiliations: Department of Minimally Invasive Spine Surgery, The 309th Hospital of The People's Liberation Army, Beijing 100091, P.R. China
  • Pages: 3681-3687
    |
    Published online on: September 5, 2019
       https://doi.org/10.3892/etm.2019.7974
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Abstract

It has been reported that tetrahydrocurcumin has hypoglycemic, hypolipidemic, anti‑metastasis, anticancer and anti‑depressant pharmacological effects, and its antioxidative, hypoglycemic and hypolipidemic properties are better than those of curcumin. The present study assessed whether tetrahydrocurcumin exerts a neuroprotective effect against spinal cord injury (SCI) and investigated the underlying mechanisms. In a rat model of SCI, tetrahydrocurcumin enhanced the average Basso‑Beattie‑Bresnahan scores, inhibited water accumulation in the spinal cord and decreased inflammatory factors. Furthermore, oxidative stress and apoptosis (caspase‑3 activity and B‑cell lymphoma 2‑associated X protein levels) were also suppressed in SCI rats treated with tetrahydrocurcumin. Tetrahydrocurcumin effectively decreased the gene expression of matrix metalloproteinase‑3 and ‑13, as well as cyclooxygenase‑2, promoted the phosphorylation of Akt and enhanced the protein expression of forkhead box (FOX)O4 in SCI rats. The present study delineates that tetrahydrocurcumin protects against SCI and inhibits the oxidative stress response by regulating the FOXO4 in SCI model rats.
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Copy and paste a formatted citation
Spandidos Publications style
Xi J, Luo X, Wang Y, Li J, Guo L, Wu G and Li Q: Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats. Exp Ther Med 18: 3681-3687, 2019.
APA
Xi, J., Luo, X., Wang, Y., Li, J., Guo, L., Wu, G., & Li, Q. (2019). Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats. Experimental and Therapeutic Medicine, 18, 3681-3687. https://doi.org/10.3892/etm.2019.7974
MLA
Xi, J., Luo, X., Wang, Y., Li, J., Guo, L., Wu, G., Li, Q."Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats". Experimental and Therapeutic Medicine 18.5 (2019): 3681-3687.
Chicago
Xi, J., Luo, X., Wang, Y., Li, J., Guo, L., Wu, G., Li, Q."Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3681-3687. https://doi.org/10.3892/etm.2019.7974
Copy and paste a formatted citation
x
Spandidos Publications style
Xi J, Luo X, Wang Y, Li J, Guo L, Wu G and Li Q: Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats. Exp Ther Med 18: 3681-3687, 2019.
APA
Xi, J., Luo, X., Wang, Y., Li, J., Guo, L., Wu, G., & Li, Q. (2019). Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats. Experimental and Therapeutic Medicine, 18, 3681-3687. https://doi.org/10.3892/etm.2019.7974
MLA
Xi, J., Luo, X., Wang, Y., Li, J., Guo, L., Wu, G., Li, Q."Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats". Experimental and Therapeutic Medicine 18.5 (2019): 3681-3687.
Chicago
Xi, J., Luo, X., Wang, Y., Li, J., Guo, L., Wu, G., Li, Q."Tetrahydrocurcumin protects against spinal cord injury and inhibits the oxidative stress response by regulating FOXO4 in model rats". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3681-3687. https://doi.org/10.3892/etm.2019.7974
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