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Puerarin inhibits apoptosis and inflammation in myocardial cells via PPARα expression in rats with chronic heart failure

Retraction in: /10.3892/etm.2025.12916
  • Authors:
    • Le He
    • Tong Wang
    • Bing‑Wei Chen
    • Feng‑Min Lu
    • Jing Xu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Tianjin Chest Hospital, Tianjin 300222, P.R. China, Department of Endocrinology, Tianjin Yellow River Hospital, Tianjin 300110, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3347-3356
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    Published online on: September 6, 2019
       https://doi.org/10.3892/etm.2019.7984
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Abstract

Chronic heart failure affects myocardial energy metabolism and cardiac function. Puerarin has been reported to improve cardiac function through regulation of energy metabolism in mice with myocardial infarction. The aim of the current study was to determine whether puerarin can improve body weight and reduce inflammation and apoptosis in rats with chronic heart failure. Rats were divided into three groups: Puerarin, PBS and sham group. Transverse aortic constriction was performed to induce chronic heart failure in the puerarin an PBS groups. Cardiac function, apoptosis and inflammation were evaluated following a 4‑week treatment in rats with chronic heart failure. The results demonstrated that puerarin significantly increased the survival rate of rats and improved cardiac function compared with the PBS group. In addition, puerarin decreased lactate dehydrogenase and succinate dehydrogenase activity compared with the PBS group. Puerarin treatment increased the expression levels of glucose transporter type 4 and decreased the expression levels of CD36. Additionally, puerarin decreased the levels inflammatory factors, including tumor necrosis factor α, interleukin (IL)‑1β and IL‑6 in serum and myocardial tissue compared with the PBS group. Puerarin upregulated peroxisome proliferator‑activated receptor α (PPARα) and its downstream target genes nuclear respiratory factor 1, FOS proto‑oncogene, YY1 transcription factor, acetyl‑coenzyme A carboxylase a, Fas cell surface death receptor, L‑type pyruvate kinase and acetyl‑coenzyme A dehydrogenase medium chain in myocardial cells from rats with chronic heart failure. These results demonstrated that puerarin inhibited apoptosis and inflammation in myocardial cells via the PPARα pathway. In conclusion, the present study indicated that puerarin may exhibit antiapoptotic and anti‑inflammatory activity through the PPARα pathway in rats with chronic heart failure.
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Copy and paste a formatted citation
Spandidos Publications style
He L, Wang T, Chen BW, Lu FM and Xu J: Puerarin inhibits apoptosis and inflammation in myocardial cells via PPARα expression in rats with chronic heart failure Retraction in /10.3892/etm.2025.12916. Exp Ther Med 18: 3347-3356, 2019.
APA
He, L., Wang, T., Chen, B., Lu, F., & Xu, J. (2019). Puerarin inhibits apoptosis and inflammation in myocardial cells via PPARα expression in rats with chronic heart failure Retraction in /10.3892/etm.2025.12916. Experimental and Therapeutic Medicine, 18, 3347-3356. https://doi.org/10.3892/etm.2019.7984
MLA
He, L., Wang, T., Chen, B., Lu, F., Xu, J."Puerarin inhibits apoptosis and inflammation in myocardial cells via PPARα expression in rats with chronic heart failure Retraction in /10.3892/etm.2025.12916". Experimental and Therapeutic Medicine 18.5 (2019): 3347-3356.
Chicago
He, L., Wang, T., Chen, B., Lu, F., Xu, J."Puerarin inhibits apoptosis and inflammation in myocardial cells via PPARα expression in rats with chronic heart failure Retraction in /10.3892/etm.2025.12916". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3347-3356. https://doi.org/10.3892/etm.2019.7984
Copy and paste a formatted citation
x
Spandidos Publications style
He L, Wang T, Chen BW, Lu FM and Xu J: Puerarin inhibits apoptosis and inflammation in myocardial cells via PPARα expression in rats with chronic heart failure Retraction in /10.3892/etm.2025.12916. Exp Ther Med 18: 3347-3356, 2019.
APA
He, L., Wang, T., Chen, B., Lu, F., & Xu, J. (2019). Puerarin inhibits apoptosis and inflammation in myocardial cells via PPARα expression in rats with chronic heart failure Retraction in /10.3892/etm.2025.12916. Experimental and Therapeutic Medicine, 18, 3347-3356. https://doi.org/10.3892/etm.2019.7984
MLA
He, L., Wang, T., Chen, B., Lu, F., Xu, J."Puerarin inhibits apoptosis and inflammation in myocardial cells via PPARα expression in rats with chronic heart failure Retraction in /10.3892/etm.2025.12916". Experimental and Therapeutic Medicine 18.5 (2019): 3347-3356.
Chicago
He, L., Wang, T., Chen, B., Lu, F., Xu, J."Puerarin inhibits apoptosis and inflammation in myocardial cells via PPARα expression in rats with chronic heart failure Retraction in /10.3892/etm.2025.12916". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3347-3356. https://doi.org/10.3892/etm.2019.7984
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