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Sphingosine‑1‑phosphate induces islet β‑cell proliferation and decreases cell apoptosis in high‑fat diet/streptozotocin diabetic mice

  • Authors:
    • Yizhi He
    • Bingyin Shi
    • Xinrui Zhao
    • Jing Sui
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China, Department of Immunology and Rheumatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3415-3424
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    Published online on: September 11, 2019
       https://doi.org/10.3892/etm.2019.7999
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Abstract

Sphingosine‑1‑phosphate (S1P) has been reported to enhance the function of islet β‑cells, providing a potential therapeutic target for diabetes mellitus. In the present study, the effects of S1P on the proliferation and apoptosis of β‑cells in type 2 diabetic mice were investigated. The mice were administered intraperitoneal S1P solution daily at a dose of 20 µg/kg for three weeks. The intraperitoneal glucose tolerance test (IPGTT) and homeostatic model assessment of insulin resistance (HOMA‑IR) index determination were carried out. Immunohistochemical staining was used to detect the protein expression of insulin, antigen Ki‑67 and S1P receptor isoforms (S1PR1/S1PR2/S1PR3) in pancreatic islets. Compared with the diabetic control (DC) group, the IPGTT results and HOMA‑IR index in the S1P treatment group were decreased. The islets in the S1P group exhibited higher insulin immunostaining intensity than the DC group, as well as higher proliferation (P<0.05) and lower apoptosis rates (P<0.05). Positive staining for the S1P receptors S1PR1, S1PR2 and S1PR3 was observed in the cytoplasm and membrane of the islet cells. S1PR1 and S1PR2 proteins showed increased expression in the S1P and DC groups compared with the normal control group (P<0.01 and P<0.05, respectively), whereas no significant difference was observed in the expression of S1PR3 among these groups. In conclusion, extracellular S1P can induce islet β‑cell proliferation and decrease cell apoptosis in diabetic mice. S1P function may be mediated via S1PR1 and S1PR2; therefore, targeting S1P/S1PR signalling pathways may be a novel therapeutic strategy for diabetes mellitus.
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View References

1 

Wang L, Gao P, Zhang M, Huang Z, Zhang D, Deng Q, Li Y, Zhao Z, Qin X, Jin D, et al: Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013. JAMA. 317:2515–2523. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Haass NK, Nassif N and McGowan EM: Switching the sphingolipid rheostat in the treatment of diabetes and cancer comorbidity from a problem to an advantage. Biomed Res Int. 2015:1651052015. View Article : Google Scholar : PubMed/NCBI

3 

Billings LK and Florez JC: The genetics of type 2 diabetes: What have we learned from GWAS? Ann N Y Acad Sci. 1212:59–77. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Fayyaz S, Japtok L and Kleuser B: Divergent role of sphingosine 1-phosphate on insulin resistance. Cell Physiol Biochem. 34:134–147. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Silva VR, Micheletti TO, Pimentel GD, Katashima CK, Lenhare L, Morari J, Mendes MC, Razolli DS, Rocha GZ, de Souza CT, et al: Hypothalamic S1P/S1PR1 axis controls energy homeostasis. Nat Commun. 5:48592014. View Article : Google Scholar : PubMed/NCBI

6 

Spiegel S and Milstien S: Functions of a new family of sphingosine-1-phosphate receptors. Biochim Biophys Acta. 1484:107–116. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Pulkoski-Gross MJ, Donaldson JC and Obeid LM: Sphingosine-1-phosphate metabolism: A structural perspective. Crit Rev Biochem Mol Biol. 50:298–313. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Maceyka M, Harikumar KB, Milstien S and Spiegel S: Sphingosine-1-phosphate signaling and its role in disease. Trends Cell Biol. 22:50–60. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Pyne S and Pyne NJ: New perspectives on the role of sphingosine 1-phosphate in cancer. Handb Exp Pharmacol. 55–71. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Cuvillier O, Pirianov G, Kleuser B, Vanek PG, Coso OA, Gutkind S and Spiegel S: Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature. 381:800–803. 1996. View Article : Google Scholar : PubMed/NCBI

11 

Gómez-Muñoz A, Waggoner DW, O'Brien L and Brindley DN: Interaction of ceramides, sphingosine, and sphingosine 1-phosphate in regulating DNA synthesis and phospholipase D activity. J Biol Chem. 270:26318–26325. 1995. View Article : Google Scholar : PubMed/NCBI

12 

Pyne S and Pyne NJ: The differential regulation of cyclic AMP by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal regulated kinase-2 in airway smooth muscle. Biochem J. 315:917–923. 1996. View Article : Google Scholar : PubMed/NCBI

13 

Hatoum D, Haddadi N, Lin Y, Nassif NT and McGowan EM: Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: Challenges for SphK as an oncotarget. Oncotarget. 8:36898–36929. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Spiegel S and Milstien S: Sphingosine-1-phosphate: Signaling inside and out. FEBS Lett. 476:55–57. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Strub GM, Maceyka M, Hait NC, Milstien S and Spiegel S: Extracellular and intracellular actions of sphingosine-1-phosphate. Adv Exp Med Biol. 688:141–155. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Obinata H and Hla T: Sphingosine 1-phosphate in coagulation and inflammation. Semin Immunopathol. 34:73–91. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Blaho VA and Hla T: An update on the biology of sphingosine 1-phosphate receptors. J Lipid Res. 55:1596–1608. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Kihara Y, Maceyka M, Spiegel S and Chun J: Lysophospholipid receptor nomenclature review: IUPHAR Review 8. Br J Pharmacol. 171:3575–3594. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Wang F, Van Brocklyn JR, Hobson JP, Movafagh S, Zukowska-Grojec Z, Milstien S and Spiegel S: Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis. J Biol Chem. 274:35343–35350. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Ishii I, Fukushima N, Ye X and Chun J: Lysophospholipid receptors: Signaling and biology. Annu Rev Biochem. 73:321–354. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Takuwa Y, Okamoto Y, Yoshioka K and Takuwa N: Sphingosine- 1-phosphate signaling in physiology and diseases. Biofactors. 38:329–337. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Völzke A, Koch A, Meyer ZHD, Huwiler A and Pfeilschifter J: Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. Biochim Biophys Acta. 1841:11–21. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Takuwa Y, Takuwa N and Sugimoto N: The Edg family G protein-coupled receptors for lysophospholipids: Their signaling properties and biological activities. J Biochem. 131:767–771. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Brinkmann V: Sphingosine 1-phosphate receptors in health and disease: Mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol Ther. 115:84–105. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Mandala S, Hajdu R, Bergstrom J, Quackenbush E, Xie J, Milligan J, Thornton R, Shei GJ, Card D, Keohane C, et al: Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science. 296:346–349. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Taha TA, Argraves KM and Obeid LM: Sphingosine-1-phosphate receptors: Receptor specificity versus functional redundancy. Biochim Biophys Acta. 1682:48–55. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Laychock SG, Tian Y and Sessanna SM: Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells. Diabetes. 52:1986–1993. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Serafimidis I, Rodriguez-Aznar E, Lesche M, Yoshioka K, Takuwa Y, Dahl A, Pan D and Gavalas A: Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling. PLoS Biol. 15:e20009492017. View Article : Google Scholar : PubMed/NCBI

29 

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF and Turner RC: Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28:412–419. 1985. View Article : Google Scholar : PubMed/NCBI

30 

Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA and Butler PC: Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes. 52:102–110. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Ashcroft FM and Rorsman P: Diabetes mellitus and the β cell: The last ten years. Cell. 148:1160–1171. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Bonner-Weir S, Li WC, Ouziel-Yahalom L, Guo L, Weir GC and Sharma A: Beta-cell growth and regeneration: Replication is only part of the story. Diabetes. 59:2340–2348. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Mandrup-Poulsen T: beta-cell apoptosis: Stimuli and signaling. Diabetes. 50 (Suppl 1):S58–S63. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Kim RH, Takabe K, Milstien S and Spiegel S: Export and functions of sphingosine-1-phosphate. Biochim Biophys Acta. 1791:692–696. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Wei Q, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X and Zhao L: A mini review of fluoride-induced apoptotic pathways. Environ Sci Pollut Res Int. 25:33926–33935. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Guo H, Chen L, Cui H, Peng X, Fang J, Zuo Z, Deng J, Wang X and Wu B: Research advances on pathways of nickel-induced apoptosis. Int J Mol Sci. 17:E102015. View Article : Google Scholar : PubMed/NCBI

37 

Qi Y, Chen J, Lay A, Don A, Vadas M and Xia P: Loss of sphingosine kinase 1 predisposes to the onset of diabetes via promoting pancreatic beta-cell death in diet-induced obese mice. FASEB J. 27:4294–4304. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Xia P, Wang L, Gamble JR and Vadas MA: Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. J Biol Chem. 274:34499–34505. 1999. View Article : Google Scholar : PubMed/NCBI

39 

Olivera A, Kohama T, Edsall L, Nava V, Cuvillier O, Poulton S and Spiegel S: Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J Cell Biol. 147:545–558. 1999. View Article : Google Scholar : PubMed/NCBI

40 

Sarkar S, Maceyka M, Hait NC, Paugh SW, Sankala H, Milstien S and Spiegel S: Sphingosine kinase 1 is required for migration, proliferation and survival of MCF-7 human breast cancer cells. FEBS Lett. 579:5313–5317. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Sukocheva O, Wadham C, Holmes A, Albanese N, Verrier E, Feng F, Bernal A, Derian CK, Ullrich A, Vadas MA and Xia P: Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: The role of sphingosine kinase-1. J Cell Biol. 173:301–310. 2006. View Article : Google Scholar : PubMed/NCBI

42 

Morales A, Lee H, Goñi FM, Kolesnick R and Fernandez-Checa JC: Sphingolipids and cell death. Apoptosis. 12:923–939. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Laychock SG, Sessanna SM, Lin MH and Mastrandrea LD: Sphingosine 1-phosphate affects cytokine-induced apoptosis in rat pancreatic islet beta-cells. Endocrinology. 147:4705–4712. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Shimizu H, Okajima F, Kimura T, Ohtani K, Tsuchiya T, Takahashi H, Kuwabara A, Tomura H, Sato K and Mori M: Sphingosine 1-phosphate stimulates insulin secretion in HIT-T 15 cells and mouse islets. Endocr J. 47:261–269. 2000. View Article : Google Scholar : PubMed/NCBI

45 

Hasan NM, Longacre MJ, Stoker SW, Kendrick MA, Druckenbrod NR, Laychock SG, Mastrandrea LD and MacDonald MJ: Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line. Arch Biochem Biophys. 518:23–30. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Ng ML, Wadham C and Sukocheva OA: The role of sphingolipid signalling in diabetesassociated pathologies (Review). Int J Mol Med. 39:243–252. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Lee SY, Lee HY, Song JH, Kim GT, Jeon S, Song YJ, Lee JS, Hur JH, Oh HH, Park SY, et al: Adipocyte-specific deficiency of de novo sphingolipid biosynthesis leads to lipodystrophy and insulin resistance. Diabetes. 66:2596–2609. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Kitada Y, Kajita K, Taguchi K, Mori I, Yamauchi M, Ikeda T, Kawashima M, Asano M, Kajita T, Ishizuka T, et al: Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates high-fat diet-induced adipocyte hypertrophy and systemic glucose intolerance in mice. Endocrinology. 157:1839–1851. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Japtok L, Schmitz EI, Fayyaz S, Krämer S, Hsu LJ and Kleuser B: Sphingosine 1-phosphate counteracts insulin signaling in pancreatic beta-cells via the sphingosine 1-phosphate receptor subtype 2. FASEB J. 29:3357–3369. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Imasawa T, Koike K, Ishii I, Chun J and Yatomi Y: Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic beta-cells. Biochem Biophys Res Commun. 392:207–211. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
He Y, Shi B, Zhao X and Sui J: Sphingosine‑1‑phosphate induces islet β‑cell proliferation and decreases cell apoptosis in high‑fat diet/streptozotocin diabetic mice. Exp Ther Med 18: 3415-3424, 2019.
APA
He, Y., Shi, B., Zhao, X., & Sui, J. (2019). Sphingosine‑1‑phosphate induces islet β‑cell proliferation and decreases cell apoptosis in high‑fat diet/streptozotocin diabetic mice. Experimental and Therapeutic Medicine, 18, 3415-3424. https://doi.org/10.3892/etm.2019.7999
MLA
He, Y., Shi, B., Zhao, X., Sui, J."Sphingosine‑1‑phosphate induces islet β‑cell proliferation and decreases cell apoptosis in high‑fat diet/streptozotocin diabetic mice". Experimental and Therapeutic Medicine 18.5 (2019): 3415-3424.
Chicago
He, Y., Shi, B., Zhao, X., Sui, J."Sphingosine‑1‑phosphate induces islet β‑cell proliferation and decreases cell apoptosis in high‑fat diet/streptozotocin diabetic mice". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3415-3424. https://doi.org/10.3892/etm.2019.7999
Copy and paste a formatted citation
x
Spandidos Publications style
He Y, Shi B, Zhao X and Sui J: Sphingosine‑1‑phosphate induces islet β‑cell proliferation and decreases cell apoptosis in high‑fat diet/streptozotocin diabetic mice. Exp Ther Med 18: 3415-3424, 2019.
APA
He, Y., Shi, B., Zhao, X., & Sui, J. (2019). Sphingosine‑1‑phosphate induces islet β‑cell proliferation and decreases cell apoptosis in high‑fat diet/streptozotocin diabetic mice. Experimental and Therapeutic Medicine, 18, 3415-3424. https://doi.org/10.3892/etm.2019.7999
MLA
He, Y., Shi, B., Zhao, X., Sui, J."Sphingosine‑1‑phosphate induces islet β‑cell proliferation and decreases cell apoptosis in high‑fat diet/streptozotocin diabetic mice". Experimental and Therapeutic Medicine 18.5 (2019): 3415-3424.
Chicago
He, Y., Shi, B., Zhao, X., Sui, J."Sphingosine‑1‑phosphate induces islet β‑cell proliferation and decreases cell apoptosis in high‑fat diet/streptozotocin diabetic mice". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3415-3424. https://doi.org/10.3892/etm.2019.7999
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