Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2019 Volume 18 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2019 Volume 18 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Clinical relevance of a CD4+ T cell immune function assay in the diagnosis of infection in pediatric living‑donor liver transplantation

  • Authors:
    • Wei Liu
    • Kai Wang
    • Yi‑He Zhao
    • Guang‑Ping Song
    • Wei Gao
    • Dai‑Hong Li
  • View Affiliations / Copyright

    Affiliations: Department of Blood Transfusion, Tianjin First Central Hospital, Tianjin 300192, P.R. China, Department of Transplantation Surgery, Tianjin First Central Hospital, Tianjin 300192, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3823-3828
    |
    Published online on: September 13, 2019
       https://doi.org/10.3892/etm.2019.8003
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the potential of the Immuknow immune cell function assay for the diagnosis of infection after pediatric living‑donor liver transplantation (LDLT). Based on clinical data obtained following liver transplantation, 66 patients were divided into infection (n=28) and non‑infection (n=38) groups. The following factors were considered in the present analysis: Primary disease, lymphocyte count, tacrolimus plasma concentration/dose (C0/D) ratio, CD4+ T lymphocyte ATP levels, at pre‑transplant stage and at weeks 1‑4, and 2 and 3 months post‑transplant. The CD4+ T lymphocyte ATP values were plotted in a receiver operating characteristic (ROC) curve. The CD4+ T lymphocyte ATP value of the infection group was significantly lower compared with that of the non‑infection group (188.6±93.5 vs. 424.4±198.1 ng/ml, respectively; P<0.05). No correlation was observed between the ATP value and tacrolimus plasma C0/D ratio (R2=0.0001484); however, a correlation was reported between the ATP value and lymphocyte count (R2=0.2149). Analysis of the ROC curve indicated that the ATP levels of CD4+ T cells were significantly associated with the diagnostic value of infection (area under the curve=0.866). These findings suggest that low CD4+ T lymphocyte ATP levels may be an independent risk factor for infection following pediatric LDLT, and that the Immuknow assay may be used as a tool to evaluate T lymphocyte function in such patients to predict the risk of infection.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Rawal N and Yazigi N: Pediatric liver transplantation. Pediatr Clin North Am. 64:677–684. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Zhu H and Gao W: Risk factors of bacterial nosocomial infection after pediatric liver transplantation. Zhonghua Er Ke Za Zhi. 55:593–596. 2017.(In Chinese). PubMed/NCBI

3 

Xue F, Zhang J, Han L, Li Q, Xu N, Zhou T, Xi Z, Wu Y and Xia Q: Immune cell functional assay in monitoring of adult liver transplantation recipients with infection. Transplantation. 89:620–626. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Te HS, Dasgupta KA, Cao D, Satoskar R, Mohanty SR, Reau N, Millis JM and Jensen DM: Use of immune function test in monitoring immunosuppression in liver transplant recipients. Clin Transplant. 26:826–832. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Shapiro R: End-stage renal disease in 2010: Innovative approaches to improve outcomes in transplantation. Nat Rev Nephrol. 7:68–70. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Brick C, Atouf O, Benseffaj N and Essakalli M: Rejection of kidney graft: Mechanism and prevention. Nephrol Ther. 7:18–26. 2011.(In French). View Article : Google Scholar : PubMed/NCBI

7 

People's Republic of China Ministry of Health, . Hospital infection diagnostic criteria (trial). Natl Med J China. 81:314–320. 2001.

8 

Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group: KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Transplant. 9 (Suppl 3):S1–S155. 2009. View Article : Google Scholar

9 

Ben-Youssef R, Baron PW, Sahney S, Weissman J, Baqai W, Franco E, Kore A, Trimzi M and Ojogho O: The impact of intercurrent EBV infection on ATP levels in CD4+ T cells of pediatric kidney transplant recipients. Pediatr Transplant. 13:851–855. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Bennett WM, Meyer L, Ridenour J and Batiuk TD: Surveillance and modification of immunosuppression minimizes BK virus nephropathy. Am J Nephrol. 32:10–12. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Kobashigawa JA, Kiyosaki KK, Patel JK, Kittleson MM, Kubak BM, Davis SN, Kawano MA and Ardehali AA: Benefit of immune monitoring in heart transplant patients using ATP production in activated lymphocytes. J Heart Lung Transplant. 29:504–508. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Mandras SA, Crespo J and Patel HM: Innovative application of immunologic principles in heart transplantation. Ochsner J. 10:231–235. 2010.PubMed/NCBI

13 

Naderi H, Pourmand G, Dehghani S, Nikoueinejad H, Jafari M and Tajik N: Monitoring cellular immune function of renal transplant recipients based on adenosine triphosphate (ATP) production by mitogen- induced CD4+ T helper cells. Biomed Pharmacother. 107:1402–1409. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Millán O, Sánchez-Fueyo A, Rimola A, Guillen D, Hidalgo S, Benitez C, Campistol JM and Brunet M: Is the intracellular ATP concentration of CD4+ T-Cells a predictive biomarker of immune status in stable transplant recipients? Transplantation. 88 (Suppl 3):S78–S84. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Chiereghin A, Petrisli E, Ravaioli M, Morelli MC, Turello G, Squarzoni D, Piccirilli G, Ambretti S, Gabrielli L, Pinna AD, et al: Infectious agents after liver transplant: Etiology, timeline and patients' cell-mediated immunity responses. Med Microbiol Immunol. 206:63–71. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Tang B, Liu D, Wu JQ, Zhou JX, Li C and Meng SD: Clinical significance of monitoring CD4+ T lymphocytes in patients with cytomegalovirus pneumonia after renal transplantation. J South Med Univ. 29:1176–1178. 2009.

17 

Xiong HY, Zhang L, Wang LM, Kang YD, Zhou MS, Zhou L, Zhang ZZ, Han S, Fu SX, Yuan Q, et al: Clinical significance of peripheral blood CD4+T-lymphocyte count in patients with severe pulmonary infection after renal transplantation. Chin J Organ Transplant. 6:334–337. 2009.

18 

Oh SH, Kim KM, Kim DY, Lee YJ, Rhee KW, Jang JY, Chang SH, Lee SY, Kim JS, Choi BH, et al: Long-term outcomes of pediatric living donor liver transplantation at a single institution. Pediatr Transplant. 14:870–878. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Venkataramanan R, Shaw LM, Sarkozi L, Mullins R, Pirsch J, MacFarlane G, Scheller D, Ersfele D, Frick M, Fitzsimmons WE, et al: Clinical utility of monitoring tacrolimus blood concentrations in liver transplant patients. J Clin Pharmacol. 41:542–551. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Naderi H, Naiafi A, Khoshroo M and Tajik N: Development of an immune function assay by measuring intracellular adenosine triphosphate (iATP) levels in mitogen-stimulated CD4+ T lymphocytes. J Immunoassay Immunochem. 37:407–420. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Serban G, Whittaker V, Fan J, Liu Z, Manga K, Khan M, Kontogianni K, Padmanabhan A, Cohen D, Suciu-Foca N, et al: Significance of immune cell function monitoring in renal transplantation after Thymoglobulin induction therapy. Hum Immunol. 70:882–890. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Ravaioli M, Neri F, Lazzarotto T, Bertuzzo VR, Di Gioia P, Stacchini G, Morelli MC, Ercolani G, Cescon M, Chiereghin A, et al: Immunosuppression modifications based on an immune response assay: Results of a randomized controlled trial. Transplantation. 99:1625–1632. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Kobayashi S, Soyama A, Takatsuki M, Hidaka M, Adachi T, Kitasato A, Kinoshita A, Hara T, Kanetaka K, Fujita F, et al: Relationship between immune function recovery and infectious complications in patients following living donor liver transplantation. Hepatol Res. 46:908–915. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Luo Y, Ji WB, Duan WD, Shi XJ and Zhao ZM: Delayed introduction of immunosuppressive regimens in critically ill patients after liver transplantation. Hepatobiliary Pancreat Dis Int. 16:487–492. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu W, Wang K, Zhao YH, Song GP, Gao W and Li DH: Clinical relevance of a CD4+ T cell immune function assay in the diagnosis of infection in pediatric living‑donor liver transplantation. Exp Ther Med 18: 3823-3828, 2019.
APA
Liu, W., Wang, K., Zhao, Y., Song, G., Gao, W., & Li, D. (2019). Clinical relevance of a CD4+ T cell immune function assay in the diagnosis of infection in pediatric living‑donor liver transplantation. Experimental and Therapeutic Medicine, 18, 3823-3828. https://doi.org/10.3892/etm.2019.8003
MLA
Liu, W., Wang, K., Zhao, Y., Song, G., Gao, W., Li, D."Clinical relevance of a CD4+ T cell immune function assay in the diagnosis of infection in pediatric living‑donor liver transplantation". Experimental and Therapeutic Medicine 18.5 (2019): 3823-3828.
Chicago
Liu, W., Wang, K., Zhao, Y., Song, G., Gao, W., Li, D."Clinical relevance of a CD4+ T cell immune function assay in the diagnosis of infection in pediatric living‑donor liver transplantation". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3823-3828. https://doi.org/10.3892/etm.2019.8003
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Wang K, Zhao YH, Song GP, Gao W and Li DH: Clinical relevance of a CD4+ T cell immune function assay in the diagnosis of infection in pediatric living‑donor liver transplantation. Exp Ther Med 18: 3823-3828, 2019.
APA
Liu, W., Wang, K., Zhao, Y., Song, G., Gao, W., & Li, D. (2019). Clinical relevance of a CD4+ T cell immune function assay in the diagnosis of infection in pediatric living‑donor liver transplantation. Experimental and Therapeutic Medicine, 18, 3823-3828. https://doi.org/10.3892/etm.2019.8003
MLA
Liu, W., Wang, K., Zhao, Y., Song, G., Gao, W., Li, D."Clinical relevance of a CD4+ T cell immune function assay in the diagnosis of infection in pediatric living‑donor liver transplantation". Experimental and Therapeutic Medicine 18.5 (2019): 3823-3828.
Chicago
Liu, W., Wang, K., Zhao, Y., Song, G., Gao, W., Li, D."Clinical relevance of a CD4+ T cell immune function assay in the diagnosis of infection in pediatric living‑donor liver transplantation". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3823-3828. https://doi.org/10.3892/etm.2019.8003
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team