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Downregulation of microRNA‑3934‑5p induces apoptosis and inhibits the proliferation of neuroblastoma cells by targeting TP53INP1

  • Authors:
    • Wei Ye
    • Fulv Liang
    • Chen Ying
    • Maolin Zhang
    • Dongbo Feng
    • Xinyu Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Jianou Municipal Hospital, Jianou, Fujian 353100, P.R. China, Department of Urology, The Third Hospital of Xiamen, Xiamen, Fujian 361000, P.R. China, Department of Urology, Haicang Hospital of Xiamen, Xiamen, Fujian 361026, P.R. China, Department of Surgery, Xiapu County Hospital, Xiapu County, Ningde, Fujian 355100, P.R. China, Department of Sports Medicine, The Central Hospital of Yongzhou, Yongzhou, Hunan 425000, P.R. China, Department of General Surgery, Xiamen Maternity and Child Health Care Hospital, Xiamen, Fujian 361000, P.R. China
    Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3729-3736
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    Published online on: September 13, 2019
       https://doi.org/10.3892/etm.2019.8007
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Abstract

Neuroblastoma is the most common pediatric extracranial solid tumour in the world. miRNAs are a group of endogenous small non‑coding RNAs that act on target genes to serve critical roles in many biological processes. Presently, the expression and role of miR‑3934‑5p in neuroblastoma remains unclear. Therefore, the aim of the present study was to investigate the expression of miR‑3934‑5p in neuroblastoma tissues and cell lines and to assess the role of miR‑3934‑5p in neuroblastoma. In the current study, the results revealed that miR‑3934‑5p was significantly upregulated in neuroblastoma tissues and cell lines. The data also identified TP53INP1 as a direct target gene of miR‑3934‑5p, which was negatively regulated by miR‑3934‑5p. The present study further demonstrated that TP53INP1 was downregulated in both neuroblastoma tissues and cell lines. Furthermore, the results of the current study indicate that miR‑3934‑5p downregulation may induce apoptosis and inhibit neuroblastoma cell viability. However, these effects were reversed via TP53INP1‑siRNA. Data from the current study indicates that the miR‑3934‑5p/TP53INP1 axis may be a novel therapeutic target for neuroblastoma treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Ye W, Liang F, Ying C, Zhang M, Feng D and Jiang X: Downregulation of microRNA‑3934‑5p induces apoptosis and inhibits the proliferation of neuroblastoma cells by targeting TP53INP1. Exp Ther Med 18: 3729-3736, 2019.
APA
Ye, W., Liang, F., Ying, C., Zhang, M., Feng, D., & Jiang, X. (2019). Downregulation of microRNA‑3934‑5p induces apoptosis and inhibits the proliferation of neuroblastoma cells by targeting TP53INP1. Experimental and Therapeutic Medicine, 18, 3729-3736. https://doi.org/10.3892/etm.2019.8007
MLA
Ye, W., Liang, F., Ying, C., Zhang, M., Feng, D., Jiang, X."Downregulation of microRNA‑3934‑5p induces apoptosis and inhibits the proliferation of neuroblastoma cells by targeting TP53INP1". Experimental and Therapeutic Medicine 18.5 (2019): 3729-3736.
Chicago
Ye, W., Liang, F., Ying, C., Zhang, M., Feng, D., Jiang, X."Downregulation of microRNA‑3934‑5p induces apoptosis and inhibits the proliferation of neuroblastoma cells by targeting TP53INP1". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3729-3736. https://doi.org/10.3892/etm.2019.8007
Copy and paste a formatted citation
x
Spandidos Publications style
Ye W, Liang F, Ying C, Zhang M, Feng D and Jiang X: Downregulation of microRNA‑3934‑5p induces apoptosis and inhibits the proliferation of neuroblastoma cells by targeting TP53INP1. Exp Ther Med 18: 3729-3736, 2019.
APA
Ye, W., Liang, F., Ying, C., Zhang, M., Feng, D., & Jiang, X. (2019). Downregulation of microRNA‑3934‑5p induces apoptosis and inhibits the proliferation of neuroblastoma cells by targeting TP53INP1. Experimental and Therapeutic Medicine, 18, 3729-3736. https://doi.org/10.3892/etm.2019.8007
MLA
Ye, W., Liang, F., Ying, C., Zhang, M., Feng, D., Jiang, X."Downregulation of microRNA‑3934‑5p induces apoptosis and inhibits the proliferation of neuroblastoma cells by targeting TP53INP1". Experimental and Therapeutic Medicine 18.5 (2019): 3729-3736.
Chicago
Ye, W., Liang, F., Ying, C., Zhang, M., Feng, D., Jiang, X."Downregulation of microRNA‑3934‑5p induces apoptosis and inhibits the proliferation of neuroblastoma cells by targeting TP53INP1". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3729-3736. https://doi.org/10.3892/etm.2019.8007
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