Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2019 Volume 18 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2019 Volume 18 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Aspects concerning patient adherence to anti‑TNFα therapy in psoriasis: A decade of clinical experience

  • Authors:
    • Madalina Mocanu
    • Mihaela‑Paula Toader
    • Elena Rezus
    • Tatiana Taranu
  • View Affiliations / Copyright

    Affiliations: Dermatology Clinic, Railways University Hospital Iasi, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700506 Iasi, Romania, Rheumatology Clinic, University Rehabilitation Hospital, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania
    Copyright: © Mocanu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4987-4992
    |
    Published online on: September 16, 2019
       https://doi.org/10.3892/etm.2019.8008
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Non‑adherence to psoriasis treatment has an important impact in controlling chronic disease evolution and the occurrence of systemic comorbidities. Biologic therapy represents a revolutionary treatment, many of the undesirable psychological and socio‑economical consequences of conventional topical or systemic therapies being avoided. Nevertheless, the discontinuation of biological therapy may occur due to facts related to the patient, to the lack of good communication between the patient and the physician or to the adverse or paradoxical reactions. We studied the non‑adherence reasons to anti‑TNFα agents (Infliximab, Adalimumab, Etanercept) used for treating 84 cases with moderate‑severe psoriasis. The results of our study over the past 10 years showed a 76.2% adherence rate, lowest in patients treated with Etanercept (70.9%). Relative to the anti‑TNF agent used, the highest adherence rate was recorded in Adalimumab (80.8%), followed by Infliximab (76.5%) and Etanercept (70.9%). We have noticed differences between the rates of adhesion to therapy with different anti‑TNFα agents, but with no statistical significance. The main adverse effects that occurred during anti‑TNFα therapy were: local reaction to the drug, mild infectious events, allergic reactions, cardiotoxicity, alopecia areata, pancreatitis, eosinophilia, thrombocytopenia. Anti‑TNF therapy was discontinued in one case of endocarditis, one case with tuberculous laryngitis and another one with polydiscitis (Adalimumab), a case of colon cancer and one of pregnancy (Etanercept) and one paradoxical reaction (Infliximab).
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Schadler ED, Ortel B and Mehlis SL: Biologics for the primary care physician: Review and treatment of psoriasis. Dis Mon. 65:51–90. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Căruntu C, Boda D, Căruntu A, Rotaru M, Baderca F and Zurac S: In vivo imaging techniques for psoriatic lesions. Rom J Morphol Embryol. 55 (Suppl):1191–1196. 2014.PubMed/NCBI

3 

Batani A, Brănișteanu DE, Ilie MA, Boda D, Ianosi S, Ianosi G and Căruntu C: Assessment of dermal papillary and microvascular parameters in psoriasis vulgaris using in vivo reflectance confocal microscopy. Exp Ther Med. 15:1241–1246. 2018.PubMed/NCBI

4 

Negrei C, Ginghină O, Căruntu C, Burcea Dragomiroiu GTA, Jinescu G and Boda D: Investigation relevance of methotrexate polyglutamates in biological systems by high performance liquid chromatography. Rev Chim. 66:766–768. 2015.

5 

Negrei C, Arsene AL, Toderașcu CD, Boda D and Ilie M: Acitretin treatment in psoriasis may influence the cell membrane fluidity. Farmacia. 60:767–771. 2012.

6 

Negrei C, Căruntu C, Ginghina O, Dragomiroiu GTAB, Toderascu CD and Boda D: Qualitative and quantitative determination of methotrexate polyglutamates in erythrocytes by high performance liquid chromatography. Rev Chim. 66:607–610. 2015.

7 

Sbidian E, Chaimani A, Garcia-Doval I, Do G, Hua C, Mazaud C, Droitcourt C, Hughes C, Ingram JR, Naldi L, et al: Systemic pharmacological treatments for chronic plaque psoriasis: A network meta-analysis. Cochrane Database Syst Rev. 12:CD0115352017.PubMed/NCBI

8 

Olteanu R, Zota A and Constantin M: Biosimilars: An update on clinical trials (review of published and ongoing studies. Acta Dermatovenerol Croat. 25:57–66. 2017.PubMed/NCBI

9 

Olteanu R, Constantin MM, Zota A, Dorobantu DM, Constantin T, Serban ED, Balanescu P, Mihele D and Gheuca-Solovastru L: Original clinical experience and approach to treatment study with interleukine 12/23 inhibitor in moderate-to-severe psoriasis patients. Farmacia. 64:918–921. 2016.

10 

Zambrano R, Duitama JF, Posda JI and Flórez JF: Perception of adherence to treatment among patients with cardiovascular risk factors. Rev Fac Nac Salud Publica. 30:163–174. 2012.

11 

Tatu AL and Nwabudike LC: Metoprolol-associated onset of psoriatic arthropathy. Am J Ther. 24:e370–e371. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Sabate E: Adherence to Long-Term Therapies: Evidence for ActionWorld Health Organization; Geneva: 2003, https://www.who.int/chp/knowledge/publications/adherence_report/en/

13 

Boda D, Negrei C, Nicolescu F and Balalau C: Assessment of some oxidative stress parameters in methotrexate treated psoriasis patients. Farmacia. 62:704–710. 2014.

14 

Radtke MA and Augustin M: Economic considerations in psoriasis management. Clin Dermatol. 26:424–431. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Ross C, Marshman G, Grillo M and Stanford T: Biological therapies for psoriasis: Adherence and outcome analysis from a clinical perspective. Australas J Dermatol. 57:137–140. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Raval K, Lofland JH, Waters H and Piech CT: Disease and treatment burden of psoriasis: Examining the impact of biologics. J Drugs Dermatol. 10:189–196. 2011.PubMed/NCBI

17 

Schaarschmidt ML, Kromer C, Herr R, Schmieder A, Goerdt S and Peitsch WK: Treatment satisfaction of patients with psoriasis. Acta Derm Venereol. 95:572–578. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Zschocke I, Ortland C and Reich K: Evaluation of adherence predictors for the treatment of moderate to severe psoriasis with biologics: The importance of physician-patient interaction and communication. J Eur Acad Dermatol Venereol. 31:1014–1020. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Doshi JA, Takeshita J, Pinto L, Li P, Yu X, Rao P, Viswanathan HN and Gelfand JM: Biologic therapy adherence, discontinuation, switching, and restarting among patients with psoriasis in the US Medicare population. J Am Acad Dermatol. 74:1057–1065.e4. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Umezawa Y, Nobeyama Y, Hayashi M, Fukuchi O, Ito T, Saeki H and Nakagawa H: Drug survival rates in patients with psoriasis after treatment with biologics. J Dermatol. 40:1008–1013. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Gniadecki R, Kragballe K, Dam TN and Skov L: Comparison of drug survival rates for adalimumab, etanercept and infliximab in patients with psoriasis vulgaris. Br J Dermatol. 164:1091–1096. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Kim WB, Marinas JE, Qiang J, Shahbaz A, Greaves S and Yeung J: Adverse events resulting in withdrawal of biologic therapy for psoriasis in real-world clinical practice: A Canadian multicenter retrospective study. J Am Acad Dermatol. 73:237–241. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Kaushik SB and Lebwohl MG: Psoriasis: Which therapy for which patient: Focus on special populations and chronic infections. J Am Acad Dermatol. 80:43–53. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Martín B, Sánchez-Carazo JL, Pérez-Ferriols A, Laguna C, Oliver V and Alegre V: Clinical experience with etanercept in the treatment of psoriasis. Actas Dermosifiliogr. 99:540–545. 2008.(In Spanish). View Article : Google Scholar : PubMed/NCBI

25 

Sehgal VN, Pandhi D and Khurana A: Biologics in dermatology: An integrated review. Indian J Dermatol. 59:425–441. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Niculet E, Neculia GV, Tatu AL and Buzia OD: Curcumin-extraction, physical and chemical analysis, formulas and control. Basic methods for further research. Mater Plast. 55:672–675. 2018.

27 

Nwabudike LC and Tatu AL: Using complementary and alternative medicine for the treatment of psoriasis: A step in the right direction. JAMA Dermatol. 155:6362019. View Article : Google Scholar : PubMed/NCBI

28 

Căruntu C, Boda D, Dumitrașcu G, Constantin C and Neagu M: Proteomics focusing on immune markers in psoriatic arthritis. Biomarkers Med. 9:513–528. 2015. View Article : Google Scholar

29 

Ilie MA, Căruntu C, Lixandru D, Tampa M, Georgescu SR, Constantin MM, Constantin C, Neagu M, Zurac SA and Boda D: In vivo confocal laser scanning microscopy imaging of skin inflammation: Clinical applications and research directions. Exp Ther Med. 17:1004–1011. 2019.PubMed/NCBI

30 

Căruntu C, Boda D, Musat S, Căruntu A and Mandache E: Stress-induced mast cell activation in glabrous and hairy skin. Mediators Inflamm. 2014:1059502014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Mocanu M, Toader MP, Rezus E and Taranu T: Aspects concerning patient adherence to anti‑TNFα therapy in psoriasis: A decade of clinical experience. Exp Ther Med 18: 4987-4992, 2019.
APA
Mocanu, M., Toader, M., Rezus, E., & Taranu, T. (2019). Aspects concerning patient adherence to anti‑TNFα therapy in psoriasis: A decade of clinical experience. Experimental and Therapeutic Medicine, 18, 4987-4992. https://doi.org/10.3892/etm.2019.8008
MLA
Mocanu, M., Toader, M., Rezus, E., Taranu, T."Aspects concerning patient adherence to anti‑TNFα therapy in psoriasis: A decade of clinical experience". Experimental and Therapeutic Medicine 18.6 (2019): 4987-4992.
Chicago
Mocanu, M., Toader, M., Rezus, E., Taranu, T."Aspects concerning patient adherence to anti‑TNFα therapy in psoriasis: A decade of clinical experience". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4987-4992. https://doi.org/10.3892/etm.2019.8008
Copy and paste a formatted citation
x
Spandidos Publications style
Mocanu M, Toader MP, Rezus E and Taranu T: Aspects concerning patient adherence to anti‑TNFα therapy in psoriasis: A decade of clinical experience. Exp Ther Med 18: 4987-4992, 2019.
APA
Mocanu, M., Toader, M., Rezus, E., & Taranu, T. (2019). Aspects concerning patient adherence to anti‑TNFα therapy in psoriasis: A decade of clinical experience. Experimental and Therapeutic Medicine, 18, 4987-4992. https://doi.org/10.3892/etm.2019.8008
MLA
Mocanu, M., Toader, M., Rezus, E., Taranu, T."Aspects concerning patient adherence to anti‑TNFα therapy in psoriasis: A decade of clinical experience". Experimental and Therapeutic Medicine 18.6 (2019): 4987-4992.
Chicago
Mocanu, M., Toader, M., Rezus, E., Taranu, T."Aspects concerning patient adherence to anti‑TNFα therapy in psoriasis: A decade of clinical experience". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4987-4992. https://doi.org/10.3892/etm.2019.8008
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team