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Article Open Access

β‑asarone relieves chronic unpredictable mild stress induced depression by regulating the extracellular signal‑regulated kinase signaling pathway

  • Authors:
    • Haiying Dong
    • Weiliang Cong
    • Xiwen Guo
    • Yuhua Wang
    • Shengju Tong
    • Qiang Li
    • Chengchong Li
  • View Affiliations / Copyright

    Affiliations: Institute of Pathology, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, P.R. China, Department of Anaesthesiology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China, School of Mental Health, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, P.R. China, Department of General Surgery, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China, Department of Cardiology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China
    Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3767-3774
    |
    Published online on: September 18, 2019
       https://doi.org/10.3892/etm.2019.8018
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Abstract

The present study aimed to investigate the effect of β‑asarone treatment in a rat model of depression induced by chronic unpredictable mild stress (CUMS) and to further explore the underlying molecular mechanisms. A rat model of depression was established by subjecting rat to CUMS and treated with various concentrations of β‑asarone (12.5, 25 and 50 mg/kg/day) and fluoxetine (20 mg/kg/day). Next, behavioral tests, including an open field, sucrose preference and forced swimming tests, were performed. In addition, the apoptosis of hippocampal neuronal cells was determined by flow cytometry, gene expression levels were detected by reverse transcription‑quantitative polymerase chain reaction and protein levels were determined by western blot assay. The results revealed that β‑asarone significantly mitigated CUMS‑induced depression‑like behavior, evidenced by the increased sucrose intake, crossing and rearing numbers, and decreased immobility time in the forced swimming test. Furthermore, β‑asarone significantly decreased the apoptosis rate of hippocampal neuronal cells in rats subjected to CUMS. β‑asarone was also found to enhance CREB, BDNF, Trk‑B and Bcl‑2 levels, and reduce Bad level in the hippocampus of CUMS‑treated rats. In addition, the activation of extracellular signal‑regulated kinase pathway inhibited by CUMS was promoted by β‑asarone treatment. In conclusion, the present study findings indicated the antidepressant‑like effects of β‑asarone on CUMS‑induced depression in rats.
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Copy and paste a formatted citation
Spandidos Publications style
Dong H, Cong W, Guo X, Wang Y, Tong S, Li Q and Li C: β‑asarone relieves chronic unpredictable mild stress induced depression by regulating the extracellular signal‑regulated kinase signaling pathway. Exp Ther Med 18: 3767-3774, 2019.
APA
Dong, H., Cong, W., Guo, X., Wang, Y., Tong, S., Li, Q., & Li, C. (2019). β‑asarone relieves chronic unpredictable mild stress induced depression by regulating the extracellular signal‑regulated kinase signaling pathway. Experimental and Therapeutic Medicine, 18, 3767-3774. https://doi.org/10.3892/etm.2019.8018
MLA
Dong, H., Cong, W., Guo, X., Wang, Y., Tong, S., Li, Q., Li, C."β‑asarone relieves chronic unpredictable mild stress induced depression by regulating the extracellular signal‑regulated kinase signaling pathway". Experimental and Therapeutic Medicine 18.5 (2019): 3767-3774.
Chicago
Dong, H., Cong, W., Guo, X., Wang, Y., Tong, S., Li, Q., Li, C."β‑asarone relieves chronic unpredictable mild stress induced depression by regulating the extracellular signal‑regulated kinase signaling pathway". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3767-3774. https://doi.org/10.3892/etm.2019.8018
Copy and paste a formatted citation
x
Spandidos Publications style
Dong H, Cong W, Guo X, Wang Y, Tong S, Li Q and Li C: β‑asarone relieves chronic unpredictable mild stress induced depression by regulating the extracellular signal‑regulated kinase signaling pathway. Exp Ther Med 18: 3767-3774, 2019.
APA
Dong, H., Cong, W., Guo, X., Wang, Y., Tong, S., Li, Q., & Li, C. (2019). β‑asarone relieves chronic unpredictable mild stress induced depression by regulating the extracellular signal‑regulated kinase signaling pathway. Experimental and Therapeutic Medicine, 18, 3767-3774. https://doi.org/10.3892/etm.2019.8018
MLA
Dong, H., Cong, W., Guo, X., Wang, Y., Tong, S., Li, Q., Li, C."β‑asarone relieves chronic unpredictable mild stress induced depression by regulating the extracellular signal‑regulated kinase signaling pathway". Experimental and Therapeutic Medicine 18.5 (2019): 3767-3774.
Chicago
Dong, H., Cong, W., Guo, X., Wang, Y., Tong, S., Li, Q., Li, C."β‑asarone relieves chronic unpredictable mild stress induced depression by regulating the extracellular signal‑regulated kinase signaling pathway". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3767-3774. https://doi.org/10.3892/etm.2019.8018
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