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Differential expression of miR‑4492 and IL‑10 is involved in chronic rhinosinusitis with nasal polyps

  • Authors:
    • Linge Li
    • Juan Feng
    • Dinghao Zhang
    • Jun Yong
    • Yan Wang
    • Jianfeng Yao
    • Rongfu Huang
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China, Reproductive Medicine Center, Quanzhou Maternal and Child Health Hospital, Fujian Medical University, Quanzhou, Fujian 362000, P.R. China, Clinical Laboratory, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian 362000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3968-3976
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    Published online on: September 18, 2019
       https://doi.org/10.3892/etm.2019.8022
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Abstract

Chronic rhinosinusitis (CRS) is one of the most common types of respiratory disease and affects a large proportion of the population worldwide. The clinical differences between CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP) facilitate studies on the development of polyps. In the present study, next‑generation sequencing was performed to identify differentially expressed microRNAs (miRNAs/miRs) in CRSwNP vs. CRSsNP tissues and subsequently validated the expression of selected genes using reverse transcription‑quantitative polymerase chain reaction analysis. In total, 6 miRNAs were identified to be downregulated in the CRSwNP samples compared with those in the CRSsNP samples. The predicted targets of these miRNAs were determined to be enriched in a number of signaling pathways, including the ErbB, Ras, cyclic adenosine monophosphate and Janus kinase (Jak)/signal transducer and activator of transcription (STAT) pathways. The expression of miR‑4492 and that if its targets predicted by a bioinformatics analysis, tumor necrosis factor α (TNF‑α) and interleukin (IL)‑10, was validated in 96 clinical specimens. miR‑4492 was downregulated and IL‑10 was upregulated in CRSwNP vs. CRSsNP tissues, and an inverse correlation between miR‑4492 and IL‑10 was determined in CRS tissues; however no difference was identified in the expression of TNF‑α between the different groups. The present results indicate that the miR‑4492/IL‑10 interaction in the Jak/STAT signaling pathway may be one of the key mechanisms in CRSwNP.
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Copy and paste a formatted citation
Spandidos Publications style
Li L, Feng J, Zhang D, Yong J, Wang Y, Yao J and Huang R: Differential expression of miR‑4492 and IL‑10 is involved in chronic rhinosinusitis with nasal polyps. Exp Ther Med 18: 3968-3976, 2019.
APA
Li, L., Feng, J., Zhang, D., Yong, J., Wang, Y., Yao, J., & Huang, R. (2019). Differential expression of miR‑4492 and IL‑10 is involved in chronic rhinosinusitis with nasal polyps. Experimental and Therapeutic Medicine, 18, 3968-3976. https://doi.org/10.3892/etm.2019.8022
MLA
Li, L., Feng, J., Zhang, D., Yong, J., Wang, Y., Yao, J., Huang, R."Differential expression of miR‑4492 and IL‑10 is involved in chronic rhinosinusitis with nasal polyps". Experimental and Therapeutic Medicine 18.5 (2019): 3968-3976.
Chicago
Li, L., Feng, J., Zhang, D., Yong, J., Wang, Y., Yao, J., Huang, R."Differential expression of miR‑4492 and IL‑10 is involved in chronic rhinosinusitis with nasal polyps". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3968-3976. https://doi.org/10.3892/etm.2019.8022
Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Feng J, Zhang D, Yong J, Wang Y, Yao J and Huang R: Differential expression of miR‑4492 and IL‑10 is involved in chronic rhinosinusitis with nasal polyps. Exp Ther Med 18: 3968-3976, 2019.
APA
Li, L., Feng, J., Zhang, D., Yong, J., Wang, Y., Yao, J., & Huang, R. (2019). Differential expression of miR‑4492 and IL‑10 is involved in chronic rhinosinusitis with nasal polyps. Experimental and Therapeutic Medicine, 18, 3968-3976. https://doi.org/10.3892/etm.2019.8022
MLA
Li, L., Feng, J., Zhang, D., Yong, J., Wang, Y., Yao, J., Huang, R."Differential expression of miR‑4492 and IL‑10 is involved in chronic rhinosinusitis with nasal polyps". Experimental and Therapeutic Medicine 18.5 (2019): 3968-3976.
Chicago
Li, L., Feng, J., Zhang, D., Yong, J., Wang, Y., Yao, J., Huang, R."Differential expression of miR‑4492 and IL‑10 is involved in chronic rhinosinusitis with nasal polyps". Experimental and Therapeutic Medicine 18, no. 5 (2019): 3968-3976. https://doi.org/10.3892/etm.2019.8022
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