|
1
|
Sun M and Kisseleva T: Reversibility of
liver fibrosis. Clin Res Hepatol Gastroenterol. 39 (Suppl
1):S60–S63. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Albanis E and Friedman SL: Hepatic
fibrosis. Pathogenesis and principles of therapy. Clin Liver Dis.
5:315–334, v-vi. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Duarte S, Baber J, Fujii T and Coito AJ:
Matrix metalloproteinases in liver injury, repair and fibrosis.
Matrix Biol. 44-46:147–156. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Bitto N, Liguori E and La Mura V:
Coagulation, microenvironment and liver fibrosis. Cells. 7:E852018.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Hernandez-Gea V and Friedman SL:
Pathogenesis of liver fibrosis. Annu Rev Pathol. 6:425–456. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Higashi T, Friedman SL and Hoshida Y:
Hepatic stellate cells as key target in liver fibrosis. Adv Drug
Deliv Rev. 121:27–42. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Wong L, Yamasaki G, Johnson RJ and
Friedman SL: Induction of beta-platelet-derived growth factor
receptor in rat hepatic lipocytes during cellular activation in
vivo and in culture. J Clin Invest. 94:1563–1569. 1994. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Krizhanovsky V, Yon M, Dickins RA, Hearn
S, Simon J, Miething C, Yee H, Zender L and Lowe SW: Senescence of
activated stellate cells limits liver fibrosis. Cell. 134:657–667.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Kong X, Feng D, Wang H, Hong F, Bertola A,
Wang FS and Gao B: Interleukin-22 induces hepatic stellate cell
senescence and restricts liver fibrosis in mice. Hepatology.
56:1150–1159. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Zhang Z, Yao Z, Zhao S, Shao J, Chen A,
Zhang F and Zheng S: Interaction between autophagy and senescence
is required for dihydroartemisinin to alleviate liver fibrosis.
Cell Death Dis. 8:e28862017. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Lee BY, Han JA, Im JS, Morrone A, Johung
K, Goodwin EC, Kleijer WJ, DiMaio D and Hwang ES:
Senescence-associated beta-galactosidase is lysosomal
beta-galactosidase. Aging Cell. 5:187–195. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Leontieva OV and Blagosklonny MV:
CDK4/6-inhibiting drug substitutes for p21 and p16 in senescence:
Duration of cell cycle arrest and MTOR activity determine
geroconversion. Cell Cycle. 12:3063–3069. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Narita M, Narita M, Krizhanovsky V, Nuñez
S, Chicas A, Hearn SA, Myers MP and Lowe SW: A novel role for
high-mobility group a proteins in cellular senescence and
heterochromatin formation. Cell. 126:503–514. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Chien Y, Scuoppo C, Wang X, Fang X,
Balgley B, Bolden JE, Premsrirut P, Luo W, Chicas A, Lee CS, et al:
Control of the senescence-associated secretory phenotype by NF-κB
promotes senescence and enhances chemosensitivity. Genes Dev.
25:2125–2136. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Osorio FG, Lopez-Otin C and Freije JM:
NF-κB in premature aging. Aging. 4:726–727. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Duci SB, Arifi HM, Ahmeti HR, Zatriqi VK,
Buja ZA, Hoxha ET and Mekaj AY: Outcomes of older adults with burn
injury: University clinical center of kosovo. World J Plast Surg.
4:153–158. 2015.PubMed/NCBI
|
|
17
|
Elmore S: Apoptosis: A review of
programmed cell death. Toxicol Pathol. 35:495–516. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Arur S, Uche UE, Rezaul K, Fong M,
Scranton V, Cowan AE, Mohler W and Han DK: Annexin I is an
endogenous ligand that mediates apoptotic cell engulfment. Dev
Cell. 4:587–598. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Mallat A and Lotersztajn S: Reversion of
hepatic stellate cell to a quiescent phenotype: From myth to
reality? J Hepatol. 59:383–386. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Sun WY, Wang L, Liu H, Li X and Wei W: A
standardized extract from Paeonia lactiflora and Astragalus
membranaceus attenuates liver fibrosis induced by porcine serum in
rats. Int J Mol Med. 29:491–498. 2012.PubMed/NCBI
|
|
21
|
Liu Y, Liu J, Wu KX, Guo XR and Tang ZH: A
rapid method for sensitive profiling of bioactive triterpene and
flavonoid from Astragalus mongholicus and Astragalus membranaceus
by ultra-pressure liquid chromatography with tandem mass
spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci.
1085:110–118. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Mei M, Tang F, Lu M, He X, Wang H, Hou X,
Hu J, Xu C and Han R: Astragaloside IV attenuates apoptosis of
hypertrophic cardiomyocyte through inhibiting oxidative stress and
calpain-1 activation. Environ Toxicol Pharmacol. 40:764–773. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Hao M, Liu Y, Chen P, Jiang H and Kuang
HY: Astragaloside IV protects RGC-5 cells against oxidative stress.
Neural Regen Res. 13:1081–1086. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Wang S, Mou J, Cui L, Wang X and Zhang Z:
Astragaloside IV inhibits cell proliferation of colorectal cancer
cell lines through down-regulation of B7-H3. Biomed Pharmacother.
102:1037–1044. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Wang PP, Luan JJ, Xu WK, Wang L, Xu DJ,
Yang CY, Zhu YH and Wang YQ: Astragaloside IV downregulates the
expression of MDR1 in Bel7402/FU human hepatic cancer cells by
inhibiting the JNK/cJun/AP1 signaling pathway. Mol Med Rep.
16:2761–2766. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Li LC, Xu L, Hu Y, Cui WJ, Cui WH, Zhou WC
and Kan LD: Astragaloside IV improves bleomycin-induced pulmonary
fibrosis in rats by attenuating extracellular matrix deposition.
Front Pharmacol. 8:5132017. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Qian W, Cai X, Qian Q, Zhang W and Wang D:
Astragaloside IV modulates TGF-β1-dependent epithelial-mesenchymal
transition in bleomycin-induced pulmonary fibrosis. J Cell Mol Med.
22:4354–4364. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Wan Y, Xu L, Wang Y, Tuerdi N, Ye M and Qi
R: Preventive effects of astragaloside IV and its active sapogenin
cycloastragenol on cardiac fibrosis of mice by inhibiting the NLRP3
inflammasome. Eur J Pharmacol. 833:545–554. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Chen P, Xie Y, Shen E, Li GG, Yu Y, Zhang
CB, Yang Y, Zou Y, Ge J, Chen R and Chen H: Astragaloside IV
attenuates myocardial fibrosis by inhibiting TGF-β1 signaling in
coxsackievirus B3-induced cardiomyopathy. Eur J Pharmacol.
658:168–174. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Xu W, Shao X, Tian L, Gu L, Zhang M, Wang
Q, Wu B, Wang L, Yao J, Xu X, et al: Astragaloside IV ameliorates
renal fibrosis via the inhibition of mitogen-activated protein
kinases and antiapoptosis in vivo and in vitro. J Pharmacol Exp
Ther. 350:552–562. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Wang L, Chi YF, Yuan ZT, Zhou WC, Yin PH,
Zhang XM, Peng W and Cai H: Astragaloside IV inhibits renal
tubulointerstitial fibrosis by blocking TGF-β/Smad signaling
pathway in vivo and in vitro. Exp Biol Med (Maywood).
239:1310–1324. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Liu H, Wei W, Sun WY and Li X: Protective
effects of astragaloside IV on porcine-serum-induced hepatic
fibrosis in rats and in vitro effects on hepatic stellate cells. J
Ethnopharmacol. 122:502–508. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Ping J, Li JT, Liao ZX, Shang L and Wang
H: Indole-3-carbinol inhibits hepatic stellate cells proliferation
by blocking NADPH oxidase/reactive oxygen species/p38MAPK pathway.
Eur J Pharmacol. 650:656–662. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Li X, Wang X, Han C, Wang X, Xing G, Zhou
L, Li G and Niu Y: Astragaloside IV suppresses collagen production
of activated hepatic stellate cells via oxidative stress-mediated
p38 MAPK pathway. Free Radic Biol Med. 60:168–176. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Tsuchida T and Friedman SL: Mechanisms of
hepatic stellate cell activation. Nat Rev Gastroenterol Hepatol.
14:397–411. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Huang Y, Deng X and Liang J: Modulation of
hepatic stellate cells and reversibility of hepatic fibrosis. Exp
Cell Res. 352:420–426. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
de Oliveira da Silva B, Ramos LF and
Moraes KCM: Molecular interplays in hepatic stellate cells:
Apoptosis, senescence, and phenotype reversion as cellular
connections that modulate liver fibrosis. Cell Bio Int. 41:946–959.
2017. View Article : Google Scholar
|
|
39
|
Kang C, Xu Q, Martin TD, Li MZ, Demaria M,
Aron L, Lu T, Yankner BA, Campisi J and Elledge SJ: The DNA damage
response induces inflammation and senescence by inhibiting
autophagy of GATA. Science. 349:aaa56122015. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Thirukkumaran C, Shi ZQ, Thirukkumaran P,
Luider J, Kopciuk K, Spurrell J, Elzinga K and Morris D: PUMA and
NF-κB are cell signaling predictors of reovirus oncolysis of breast
cancer. PLoS One. 12:e01682332017. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Zoubek ME, Trautwein C and Strnad P:
Reversal of liver fibrosis: From fiction to reality. Best Pract Res
Clin Gastroenterol. 31:129–141. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Rufini A, Tucci P, Celardo I and Melino G:
Senescence and aging: The critical roles of p53. Oncogene.
32:5129–5143. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Chen J, Pan J, Wang J, Song K, Zhu D,
Huang C and Duan Y: Soluble egg antigens of schistosoma japonicum
induce senescence in activated hepatic stellate cells by activation
of the STAT3/p53/p21 pathway. Sci Rep. 6:309572016. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Campisi J and d'Adda di Fagagna F:
Cellular senescence: When bad things happen to good cells. Nat Rev
Mol Cell Biol. 8:729–740. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Zhao Z, Pan X, Liu L and Liu N: Telomere
length maintenance, shortening, and lengthening. J Cell Physiol.
229:1323–1329. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Duval F, Moreno-Cuevas JE, Gonzalez-Garza
MT, Rodriguez-Montalvo C and Cruz-Vega DE: Liver fibrosis and
protection mechanisms action of medicinal plants targeting
apoptosis of hepatocytes and hepatic stellate cells. Adv Pharmacol
Sci. 2014:3732952014.PubMed/NCBI
|
|
47
|
Meng D, Li Z, Wang G, Ling L, Wu Y and
Zhang C: Carvedilol attenuates liver fibrosis by suppressing
autophagy and promoting apoptosis in hepatic stellate cells. Biomed
Pharmacother. 108:1617–1627. 2018. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Senoo T, Sasaki R, Akazawa Y, Ichikawa T,
Miuma S, Miyaaki H, Taura N and Nakao K: Geranylgeranylacetone
attenuates fibrogenic activity and induces apoptosis in cultured
human hepatic stellate cells and reduces liver fibrosis in carbon
tetrachloride-treated mice. BMC Gastroenterol. 18:342018.
View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Kuo LM, Chen PJ, Sung PJ, Chang YC, Ho CT,
Wu YH and Hwang TL: The bioactive extract of pinnigorgia sp.
induces apoptosis of hepatic stellate cells via
ROS-ERK/JNK-caspase-3 signaling. Mar Drugs. 16:E192018. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Hu T, Fei Z and Wei N: Chemosensitive
effects of astragaloside IV in osteosarcoma cells via induction of
apoptosis and regulation of caspase-dependent Fas/FasL signaling.
Pharmacol Rep. 69:1159–1164. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Yuan W, Zhang Y, Ge Y, Yan M, Kuang R and
Zheng X: Astragaloside IV inhibits proliferation and promotes
apoptosis in rat vascular smooth muscle cells under high glucose
concentration in vitro. Planta Med. 74:1259–1264. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Childs BG, Baker DJ, Kirkland JL, Campisi
J and van Deursen JM: Senescence and apoptosis: Dueling or
complementary cell fates? EMBO Rep. 15:1139–1153. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Xia Y, Shen S and Verma IM: NF-κB, an
active player in human cancers. Cancer Immunol Res. 2:823–830.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Hayden MS and Ghosh S: Regulation of NF-κB
by TNF family cytokines. Semin Immunol. 26:253–266. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Lee JJ, Koh KN, Park CJ, Jang S, Im HJ and
Kim N: The combination of flavokawain B and daunorubicin induces
apoptosis in human myeloid leukemic cells by modifying NF-κB.
Anticancer Res. 38:2771–2778. 2018.PubMed/NCBI
|
|
56
|
Yilmaz B and Karabay AZ: Food additive
sodium benzoate (NaB) activates NFkB and induces apoptosis in
HCT116 cells. Molecules. 23:E7232018. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Kim CS, Choi JS, Joo SY, Bae EH, Ma SK,
Lee J and Kim SW: Nicotine-induced apoptosis in human renal
proximal tubular epithelial cells. PLoS One. 11:e01525912016.
View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Ying HZ, Chen Q, Zhang WY, Zhang HH, Ma Y,
Zhang SZ, Fang J and Yu CH: PDGF signaling pathway in hepatic
fibrosis pathogenesis and therapeutics (Review). Mol Med Rep.
16:7879–7889. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Trappoliere M, Caligiuri A, Schmid M,
Bertolani C, Failli P, Vizzutti F, Novo E, di Manzano C, Marra F,
Loguercio C and Pinzani M: Silybin, a component of sylimarin,
exerts anti-inflammatory and anti-fibrogenic effects on human
hepatic stellate cells. J Hepatol. 50:1102–1111. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Paik YH, Kim JK, Lee JI, Kang SH, Kim DY,
An SH, Lee SJ, Lee DK, Han KH, Chon CY, et al: Celecoxib induces
hepatic stellate cell apoptosis through inhibition of Akt
activation and suppresses hepatic fibrosis in rats. Gut.
58:1517–1527. 2009. View Article : Google Scholar : PubMed/NCBI
|
