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Article

Comprehensive analysis of competing endogenous RNA networks associated with cholangiocarcinoma

  • Authors:
    • Fangting Xu
    • Yuchong Zhao
    • Gang Qin
    • Ye Huan
    • Longyan Li
    • Wei Gao
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesia, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Gastroenterology and Hepatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4103-4112
    |
    Published online on: September 25, 2019
       https://doi.org/10.3892/etm.2019.8052
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Abstract

Cholangiocarcinoma (CCA) is the second most common type of primary malignancy of the liver. Certain long non‑coding RNAs (lncRNAs) have been demonstrated to have key roles in tumor pathogenesis by binding to microRNAs (miRNAs). However, the competing endogenous RNA (ceRNA) network of CCA remains to be fully determined. In the present study, the RNA expression profiles for CCA were downloaded from The Cancer Genome Atlas and further analyzed. A total of 318 differentially expressed (DE) lncRNAs, 87 DE miRNAs and 3,851 DE mRNAs were identified from 36 CCA samples and 9 adjacent non‑tumor samples (for lncRNAs and miRNAs, fold change ≥2.5 and P<0.01; for mRNAs, fold change ≥2 and P<0.01). Further bioinformatics analyses were performed and the ceRNA network for CCA was constructed, which included 16 lncRNAs, 55 miRNAs and 373 mRNAs. Survival analysis of all genes in the network revealed that high expression of the mRNAs fucosyltransferase 4 (P<0.005) and huntingtin‑interacting protein 1 related (P<0.001) has a positive impact on the overall survival of patients with CAA. Furthermore, the lncRNAs H19 and PVT1, and the miRNAs Homo sapiens (hsa)‑miR‑16‑5p and hsa‑miR‑424‑5p, together with peroxisome proliferator‑activated receptors, may also have important roles in the pathogenesis of CCA. The present study provided data to further the understanding of and research into the molecular mechanisms implicated in CCA.
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Copy and paste a formatted citation
Spandidos Publications style
Xu F, Zhao Y, Qin G, Huan Y, Li L and Gao W: Comprehensive analysis of competing endogenous RNA networks associated with cholangiocarcinoma. Exp Ther Med 18: 4103-4112, 2019.
APA
Xu, F., Zhao, Y., Qin, G., Huan, Y., Li, L., & Gao, W. (2019). Comprehensive analysis of competing endogenous RNA networks associated with cholangiocarcinoma. Experimental and Therapeutic Medicine, 18, 4103-4112. https://doi.org/10.3892/etm.2019.8052
MLA
Xu, F., Zhao, Y., Qin, G., Huan, Y., Li, L., Gao, W."Comprehensive analysis of competing endogenous RNA networks associated with cholangiocarcinoma". Experimental and Therapeutic Medicine 18.5 (2019): 4103-4112.
Chicago
Xu, F., Zhao, Y., Qin, G., Huan, Y., Li, L., Gao, W."Comprehensive analysis of competing endogenous RNA networks associated with cholangiocarcinoma". Experimental and Therapeutic Medicine 18, no. 5 (2019): 4103-4112. https://doi.org/10.3892/etm.2019.8052
Copy and paste a formatted citation
x
Spandidos Publications style
Xu F, Zhao Y, Qin G, Huan Y, Li L and Gao W: Comprehensive analysis of competing endogenous RNA networks associated with cholangiocarcinoma. Exp Ther Med 18: 4103-4112, 2019.
APA
Xu, F., Zhao, Y., Qin, G., Huan, Y., Li, L., & Gao, W. (2019). Comprehensive analysis of competing endogenous RNA networks associated with cholangiocarcinoma. Experimental and Therapeutic Medicine, 18, 4103-4112. https://doi.org/10.3892/etm.2019.8052
MLA
Xu, F., Zhao, Y., Qin, G., Huan, Y., Li, L., Gao, W."Comprehensive analysis of competing endogenous RNA networks associated with cholangiocarcinoma". Experimental and Therapeutic Medicine 18.5 (2019): 4103-4112.
Chicago
Xu, F., Zhao, Y., Qin, G., Huan, Y., Li, L., Gao, W."Comprehensive analysis of competing endogenous RNA networks associated with cholangiocarcinoma". Experimental and Therapeutic Medicine 18, no. 5 (2019): 4103-4112. https://doi.org/10.3892/etm.2019.8052
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