Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2019 Volume 18 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2019 Volume 18 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Lidocaine protects H9c2 cells from hypoxia‑induced injury through regulation of the MAPK/ERK/NF‑κB signaling pathway

  • Authors:
    • Haibin Jin
    • Jin Yu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Tianjin Hospital, Tianjin 300211, P.R. China, Department of Anesthesiology, People's Liberation Army 951 Hospital, Korla, Xinjiang 841000, P.R. China
  • Pages: 4125-4131
    |
    Published online on: September 26, 2019
       https://doi.org/10.3892/etm.2019.8055
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the effect of Lidocaine on hypoxia‑induced injury in cardiomyoblasts whilst exploring the associated molecular mechanism. In the present study, hypoxia was induced in H9c2 cells to establish an in vitro model of myocardial infarction. The cells were treated with lidocaine (0.5, 1, 5, 10 mM) for 48 h under hypoxic conditions. Cell viability and apoptosis levels were determined by MTT assay and flow cytometry, and ELISA was used to measure the levels of inflammatory cytokines released. A creatine kinase isoenzyme/cardiac troponin I detection kit was used to show that lidocaine significantly reduced hypoxia‑induced cardiac troponin 1 and creatine kinase‑muscle/brain release in a dose‑dependent manner. Mitochondrial viability staining suggested that lidocaine significantly enhanced mitochondrial viability under hypoxic conditions. Lidocaine also significantly reduced hypoxia‑induced apoptosis and increased H9c2 viability in a dose‑dependent manner. Additionally, under hypoxic conditions, lidocaine dose‑dependently promoted Bcl‑2 expression, while decreasing Bax and caspase‑3 expression in H9c2 cells. ELISA and reverse transcription quantitative PCR were used to detect the levels of tumor necrosis factor (TNF‑α), interleukin (IL)‑1β and IL‑6 released by H9c2 cells. Results showed that lidocaine markedly reduced the hypoxia‑induced expression levels of IL‑1β, TNF‑α and IL‑6 in a dose‑dependent manner. In addition, protein levels of phosphorylated (p)‑ERK1/2 and NF‑κB p‑p65 were analyzed by western blotting, and results indicated that lidocaine significantly increased the protein levels of p‑ERK1/2 and decreased the protein level of NF‑κB p‑p65 in a dose‑dependent manner under hypoxic conditions. These data suggested that lidocaine might protect cardiomyoblasts from hypoxia‑induced injury via activation of the mitogen activated protein kinase/ERK/NF‑κB signaling pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Moran AE, Forouzanfar MH, Roth GA, Mensah GA, Ezzati M, Flaxman A, Murray CJ and Naghavi M: The global burden of ischemic heart disease in 1990 and 2010: The Global Burden of disease 2010 study. Circulation. 129:1493–1501. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Boateng S and Sanborn T: Acute myocardial infarction. Dis Mon. 59:83–96. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Lu L, Liu M, Sun R, Zheng Y and Zhang P: Myocardial Infarction: Symptoms and treatments. Cell Biochem Biophys. 72:865–867. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Johansson S, Rosengren A, Young K and Jennings E: Mortality and morbidity trends after the first year in survivors of acute myocardial infarction: A systematic review. BMC Cardiovasc Disord. 17:532017. View Article : Google Scholar : PubMed/NCBI

5 

Chen-Scarabelli C, Saravolatz L Jr, Murad Y, Shieh WS, Qureshi W, Di Rezze J, Abrencillo R, Gardin T, Gidwani UK, Saravolatz L, et al: A critical review of the use of carvedilol in ischemic heart disease. Am J Cardiovasc Drugs. 12:391–401. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Gong L, Chang H, Zhang J, Guo G, Shi J and Xu H: Astragaloside IV protects rat cardiomyocytes from hypoxia-induced injury by down-regulation of miR-23a and miR-92a. Cell Physiol Biochem. 49:2240–2253. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Yan L, Yang H, Li Y, Duan H, Wu J, Qian P, Li B and Wang S: Regulator of calcineurin 1-1L protects cardiomyocytes against hypoxia-induced apoptosis via mitophagy. J Cardiovasc Pharmacol. 64:310–317. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC), ; Steg PG, James SK, Atar D, Badano LP, Blömstrom-Lundqvist C, Borger MA, Di Mario C, Dickstein K, Ducrocq G, et al: ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J. 33:2569–2619. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Yuan M, Zhang L, You F, Zhou J, Ma Y, Yang F and Tao L: MiR-145-5p regulates hypoxia-induced inflammatory response and apoptosis in cardiomyocytes by targeting CD40. Mol Cell Biochem. 431:123–131. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Marchant DJ, Boyd JH, Lin DC, Granville DJ, Garmaroudi FS and McManus BM: Infammation in myocardial diseases. Circ Res. 112:126–144. 2012. View Article : Google Scholar

11 

Sun M, Dawood F, Wen WH, Chen M, Dixon I, Kirshenbaum LA and Liu PP: Excessive tumor necrosis factor activation after infarction contributes to susceptibility of myocardial rupture and left ventricular dysfunction. Circulation. 110:3221–3228. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Tare M, Bensley JG, Moss TJ, Lingwood BE, Kim MY, Barton SK, Kluckow M, Gill AW, De Matteo R, Harding R, et al: Exposure to intrauterine inflammation leads to impaired function and altered structure in the preterm heart of fetal sheep. Clin Sci (Lond). 127:559–569. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Mandel I, Podoxenov Y, Suhodolo I, Podoxenov A, Svirko Y, Kamenschikov N, Mikheev S, Sementsov A, Dzuman A and Maslov L: Hypoxic and hyperoxic preconditioning in myocardial protection against ischemia-reperfusion injury: Experimental study. J Cardiothor Vasc Anes. 30 (Suppl 1):S6–S7. 2016. View Article : Google Scholar

14 

Carson IW, Lyons SM and Shanks RG: Anti-arrhythmic drugs. Br J Anaest. 51:659–670. 1979. View Article : Google Scholar

15 

Khan SU, Winnicka L, Saleem MA, Rahman H and Rehman N: Amiodarone, lidocaine, magnesium or placebo in shock refractory ventricular arrhythmia: A Bayesian network meta-analysis. Heart Lung. 46:417–424. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Caracas HC, Maciel JV, Martins PM, de Souza MM and Maia LC: The use of lidocaine as an anti-inflammatory substance: A systematic review. J Dent. 37:93–97. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Fukuda S, Nojima J, Motoki Y, Yamaguti K, Nakatomi Y, Okawa N, Fujiwara K, Watanabe Y and Kuratsune H: A potential biomarker for fatigue: Oxidative stress and anti-oxidative activity. Biol Psych. 118:88–93. 2016. View Article : Google Scholar

18 

Li H, Li C, Zhang H, Zhang L, Cheng R, Li M, Guo Y, Zhang Z, Lu Z, Zhuang Y, et al: Effects of lidocaine on regulatory Tcells in atopic dermatitis. J Allergy Clin Immun. 137:613–617.e5. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Bundscherer AC, Malsy M, Bitzinger DI, Wiese CH, Gruber MA and Graf BM: Effects of Lidocaine on HT-29 and SW480 colon cancer cells in vitro. Anticancer Res. 37:1941–1945. 2017. View Article : Google Scholar : PubMed/NCBI

20 

Ye L, Zhang Y, Chen YJ and Liu Q: Anti-tumor effects of lidocaine on human gastric cancer cells in vitro. Bratisl Lek Listy. 120:212–217. 2019.PubMed/NCBI

21 

Župčić M, Graf Župčić S, Duzel V, Šimurina T, Šakić L, Fudurić J, Peršec J, Milošević M, Stanec Z, Korušić A and Barišin S: A combination of levobupivacaine and lidocaine for paravertebral block in breast cancer patients undergoing quadrantectomy causes greater hemodynamic oscillations than levobupivacaine alone. Croat Med J. 58:270–280. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Maurice JM, Gan Y, Hibner M and Huang Y: Bupivacaine causes cytotoxicity via extracellular signal-regulated kinase (ERK) and Akt pathways in mouse myoblast C2C12 Cells. J Minim Invas Gyn. 16 (Suppl):S11–S12. 2009. View Article : Google Scholar

23 

Müller-Edenborn B, Kania G, Osto E, Jakob P, Krasniqi N, Beck-Schimmer B, Blyszczuk P and Eriksson U: Lidocaine enhances contractile function of ischemic myocardial regions in mouse model of sustained myocardial ischemia. PLoS One. 11:e01546992016. View Article : Google Scholar : PubMed/NCBI

24 

Kaczmarek DJ, Herzog C, Larmann J, Gillmann HJ, Hildebrand R, Schmitz M, Westermann A, Harendza T, Werdehausen R, Osthaus AW, et al: Lidocaine protects from myocardial damage due to ischemia and reperfusion in mice by its antiapoptotic effects. Anesthesiology. 110:1041–1049. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Okamoto A, Sumi C, Tanaka H, Kusunoki M, Iwai T, Nishi K, Matsuo Y, Harada H, Takenaga K, Bono H and Hirota K: HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death. Sci Rep. 7:38162017. View Article : Google Scholar : PubMed/NCBI

26 

Chang YC, Hsu YC, Liu CL, Huang SY, Hu MC and Cheng SP: Local anesthetics induce apoptosis in human thyroid cancer cells through the mitogen-activated protein kinase pathway. PLoS One. 9:e895632014. View Article : Google Scholar : PubMed/NCBI

27 

Fantetti KN, Gray EL, Ganesan P, Kulkarni A and O'Donnell LA: Interferon gamma protects neonatal neural stem/progenitor cells during measles virus infection of the brain. J Neuroinflamm. 13:1072016. View Article : Google Scholar

28 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Choi CW, Hwang JH, Chang YS, Shin SM, Park WS and Lee M: Effects of alpha-phenyl-N-tert-butyl nitrone (PBN)on brain cell membrane function and energy metabolism during transient global cerebral hypoxia-ischemia and reoxygenation-reperfusion in newborn piglets. J Korean Med Sci. 19:413–418. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Vorobieva VV and Shabanov PD: Vibration model for hypoxic type of cell metabolism evaluated on rabbit cardiomyocytes. Bull Exp Biol Med. 147:768–771. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Han F, Chen Q, Su J, Zheng A, Chen K, Sun S, Wu H, Jiang L, Xu X, Yang M, et al: MicroRNA-124 regulates cardiomyocyte apoptosis and myocardial infarction through targeting Dhcr24. J Mol Cell Cardiol. 132:178–188. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Zhang J, Qiu W, Ma J, Wang Y, Hu Z, Long K, Wang X, Jin L, Tang Q, Tang G, et al: miR-27a-5p attenuates hypoxia-induced rat cardiomyocyte injury by inhibiting Atg7. Int J Mol Sci. 20(pii): E24182019. View Article : Google Scholar : PubMed/NCBI

33 

Deng F, Wang S, Zhang L, Xie X, Cai S, Li H, Xie GL, Miao HL, Yang C, Liu X and Xia Z: Propofol through upregulating caveolin-3 attenuates post-hypoxic mitochondrial damage and cell death in H9C2 cardiomyocytes during hyperglycemia. Cell Physiol Biochem. 44:279–292. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Martí-Carvajal AJ, Simancas-Racines D, Anand V and Bangdiwala S: Prophylactic lidocaine for myocardial infarction. Cochrane Database Syst Rev. CD0085532015.PubMed/NCBI

35 

Daido S, Tamiya T, Ono Y, Terada K, Mizumatsu S and Ohmoto T: Expression of Bcl-2, Bcl-x and Bax proteins in astrocytomas in relation to patient survival. Biochem Biophys Res Commun. 18:123–129. 2001.

36 

Tamatani M, Ogawa S, Nuñez G and Tohyama M: Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitric oxide. Cell Death Differ. 5:911–919. 1998. View Article : Google Scholar : PubMed/NCBI

37 

Zhang J, Xia Y, Xu Z and Deng X: Propofol suppressed Hypoxia/Reoxygenation-induced apoptosis in HBVSMC by regulation of the expression of Bcl-2, Bax, Caspase3, Kir6.1, and p-JNK. Oxid Med Cell Longev. 2016:15187382016. View Article : Google Scholar : PubMed/NCBI

38 

Li H, Lv B, Kong L, Xia J, Zhu M, Hu L, Zhen D, Wu Y, Jia X, Zhu S and Cui H: Nova1 mediates resistance of rat pheochromocytoma cells to hypoxia-induced apoptosis via the Bax/Bcl-2/caspase-3 pathway. Int J Mol Med. 40:1125–1133. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Frangogiannis NG: The inflammatory response in myocardial injury, repair, and remodelling. Nat Rev Cardiol. 11:255–265. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Ferdinandy P, Schulz R and Baxter GF: Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. J Pharmacol Rev. 59:418–458. 2007. View Article : Google Scholar

41 

Milano G, Morel S, Bonny C, Samaja M, von Segesser LK, Nicod P and Vassalli G: A Peptide inhibitor of c-Jun NH2-terminal kinase reduces myocardial ischemia-reperfusion injury and infarct size in vivo. Am J Physiol Heart Circ Physiol. 292:H1828–H1835. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Wei H, Li H, Wan SP, Zeng QT, Cheng LX, Jiang LL and Peng YD: Cardioprotective effects of Malvidin against isoproterenol-induced myocardial infarction in rats: A mechanistic study. Med Sci Monit. 23:2007–2016. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Chen Y, Ba L, Huang W, Liu Y, Pan H, Mingyao E, Shi P, Wang Y, Li S, Qi H, et al: Role of carvacrol in cardioprotection against myocardial ischemia/reperfusion injury in rats through activation of MAPK/ERK and Akt/eNOS signaling pathways. Eur J Pharmacol. 796:90–100. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Jin H and Yu J: Lidocaine protects H9c2 cells from hypoxia‑induced injury through regulation of the MAPK/ERK/NF‑κB signaling pathway. Exp Ther Med 18: 4125-4131, 2019.
APA
Jin, H., & Yu, J. (2019). Lidocaine protects H9c2 cells from hypoxia‑induced injury through regulation of the MAPK/ERK/NF‑κB signaling pathway. Experimental and Therapeutic Medicine, 18, 4125-4131. https://doi.org/10.3892/etm.2019.8055
MLA
Jin, H., Yu, J."Lidocaine protects H9c2 cells from hypoxia‑induced injury through regulation of the MAPK/ERK/NF‑κB signaling pathway". Experimental and Therapeutic Medicine 18.5 (2019): 4125-4131.
Chicago
Jin, H., Yu, J."Lidocaine protects H9c2 cells from hypoxia‑induced injury through regulation of the MAPK/ERK/NF‑κB signaling pathway". Experimental and Therapeutic Medicine 18, no. 5 (2019): 4125-4131. https://doi.org/10.3892/etm.2019.8055
Copy and paste a formatted citation
x
Spandidos Publications style
Jin H and Yu J: Lidocaine protects H9c2 cells from hypoxia‑induced injury through regulation of the MAPK/ERK/NF‑κB signaling pathway. Exp Ther Med 18: 4125-4131, 2019.
APA
Jin, H., & Yu, J. (2019). Lidocaine protects H9c2 cells from hypoxia‑induced injury through regulation of the MAPK/ERK/NF‑κB signaling pathway. Experimental and Therapeutic Medicine, 18, 4125-4131. https://doi.org/10.3892/etm.2019.8055
MLA
Jin, H., Yu, J."Lidocaine protects H9c2 cells from hypoxia‑induced injury through regulation of the MAPK/ERK/NF‑κB signaling pathway". Experimental and Therapeutic Medicine 18.5 (2019): 4125-4131.
Chicago
Jin, H., Yu, J."Lidocaine protects H9c2 cells from hypoxia‑induced injury through regulation of the MAPK/ERK/NF‑κB signaling pathway". Experimental and Therapeutic Medicine 18, no. 5 (2019): 4125-4131. https://doi.org/10.3892/etm.2019.8055
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team