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Case Report Open Access

Disseminated mucormycosis with cerebellum involvement due to Rhizomucor pusillus in a patient with multiple myeloma and secondary myelodysplastic syndrome: A case report

  • Authors:
    • Qiong Chen
    • Kuang Chen
    • Shenxian Qian
    • Shenghai Wu
    • Lihui Xu
    • Xilian Huang
    • Pengfei Shi
    • Kaile Wang
    • Minmin Wang
    • Xianjun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, P.R. China, Department of Hematology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4076-4080
    |
    Published online on: September 27, 2019
       https://doi.org/10.3892/etm.2019.8065
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Abstract

Mucormycosis is an angioinvasive fungal infection with a high mortality rate. Patients with hematological malignancies following voriconazole therapy are at high risk from mucormycosis. Here, the present study reports on a 68‑year‑old man diagnosed with multiple myeloma and secondary myelodysplastic syndrome, who was infected with disseminated mucormycosis with cerebellum involvement confirmed by mycological culture and histopathological examination. For patients with hematological malignancies who are receiving antifungal therapy, an opportunistic infection of mucormycosis should be considered if a ‘breakthrough’ infection occurs in the predilection sites (such as the sinuses, lungs, skin, brain and gastrointestinal tract). It is difficult to diagnose mucormycosis because of the limited reliable detection methods, and because mucormycosis often presents with an acute onset and progresses rapidly, particularly in immunocompromised patients. Antifungal therapy with amphotericin B or posaconazole should be started as soon as possible considering the empirical diagnosis.
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1 

Petrikkos G, Skiada A, Lortholary O, Roilides E, Walsh TJ and Kontoyiannis DP: Epidemiology and clinical manifestations of mucormycosis. Clin Infect Dis. 54 (Suppl 1):S23–S34. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Kauffman CA: Zygomycosis: Reemergence of an old pathogen. Clin Infect Dis. 39:588–590. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Vaezi A, Moazeni M, Rahimi MT, de Hoog S and Badali H: Mucormycosis in Iran: A systematic review. Mycoses. 59:402–415. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Jeong W, Keighley C, Wolfe R, Lee WL, Slavin MA, Kong DCM and Chen SC: The epidemiology and clinical manifestations of mucormycosis: A systematic review and meta-analysis of case reports. Clin Microbiol Infect. 25:26–34. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Kursun E, Turunc T, Demiroglu YZ, Aliskan HE and Arslan AH: Evaluation of 28 cases of mucormycosis. Mycoses. 58:82–87. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Serris A, Danion F and Lanternier F: Disease entities in mucormycosis. J Fungi (Basel). 5(pii): E232019. View Article : Google Scholar : PubMed/NCBI

7 

Roden MM, Zaoutis TE, Buchanan WL, Knudsen TA, Sarkisova TA, Schaufele RL, Sein M, Sein T, Chiou CC, Chu JH, et al: Epidemiology and outcome of zygomycosis: A review of 929 reported cases. Clin Infect Dis. 41:634–653. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Andrey DO, Kaiser L, Emonet S, Erard V, Chalandon Y and van Delden C: Cerebral Rhizomucor infection treated by Posaconazole delayed-release tablets in an allogeneic stem cell transplant recipient. Int J Infect Dis. 55:24–26. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Xipell M, Losno RA, Garcia-Vidal C, Rovira M, Alejo-Cancho I, Puig de la Bellacasa J, López M, Cardozo C, Bodro M, Mensa J and Soriano A: Clinical features and outcome in patients with mucormycosis in a tertiary hospital (2012–2016). Rev Iberoam Micol. 35:162–166. 2018.(In Spanish). View Article : Google Scholar : PubMed/NCBI

10 

Posteraro B, Spanu T, Fiori B, De Maio F, De Carolis E, Giaquinto A, Prete V, De Angelis G, Torelli R, D'Inzeo T, et al: Antifungal susceptibility profiles of bloodstream yeast isolates by Sensititre YeastOne over nine years at a large Italian teaching hospital. Antimicrob Agents Chemother. 59:3944–3955. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Clinical and Laboratory Standards Institute (CLSI) M38, . Reference method for broth dilution antifungal susceptibility testing of filamentous Fungi. 3rd. CLSI; Wayne, PA: 2017, https://clsi.org/standards/products/microbiology/documents/m38/November 30–2017

12 

Kennedy KJ, Daveson K, Slavin MA, van Hal SJ, Sorrell TC, Lee A, Marriott DJ, Chapman B, Halliday CL, Hajkowicz K, et al: Mucormycosis in Australia: Contemporary epidemiology and outcomes. Clin Microbiol Infect. 22:775–781. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Long B and Koyfman A: Mucormycosis: What emergency physicians need to know? Am J Emerg Med. 33:1823–1825. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Ville S, Talarmin JP, Gaultier-Lintia A, Bouquié R, Sagan C, Le Pape P, Giral M and Morio F: Disseminated mucormycosis with cerebral involvement owing to rhizopus microsporus in a kidney recipient treated with combined liposomal amphotericin B and posaconazole therapy. Exp Clin Transplant. 14:96–99. 2016.PubMed/NCBI

15 

Chamilos G, Marom EM, Lewis RE, Lionakis MS and Kontoyiannis DP: Predictors of pulmonary zygomycosis versus invasive pulmonary aspergillosis in patients with cancer. Clin Infect Dis. 41:60–66. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Bitar D, Van Cauteren D, Lanternier F, Dannaoui E, Che D, Dromer F, Desenclos JC and Lortholary O: Increasing incidence of zygomycosis (mucormycosis), France, 1997–2006. Emerg Infect Dis. 15:1395–1401. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Cornely OA, Arikan-Akdagli S, Dannaoui E, Groll AH, Lagrou K, Chakrabarti A, Lanternier F, Pagano L, Skiada A, Akova M, et al: ESCMID and ECMM joint clinical guidelines for the diagnosis and management of mucormycosis 2013. Clin Microbiol Infect. 20 (Suppl 3):S5–S26. 2014. View Article : Google Scholar

18 

Lin E, Moua T and Limper AH: Pulmonary mucormycosis: Clinical features and outcomes. Infection. 45:443–448. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Wang Q, Liu B and Yan Y: Disseminated mucormycosis (DM) after pneumonectomy: A case report. BMC Infect Dis. 16:3372016. View Article : Google Scholar : PubMed/NCBI

20 

Walsh TJ, Gamaletsou MN, McGinnis MR, Hayden RT and Kontoyiannis DP: Early clinical and laboratory diagnosis of invasive pulmonary, extrapulmonary and disseminated mucormycosis (zygomycosis). Clin Infect Dis. 54 (Suppl 1):S55–S60. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Paul SR and Gable PS: Mucormycosis as the elusive cause of an aortic thrombus and tissue-obliterating abscess. Case Rep Hematol. 2019:48421502019.PubMed/NCBI

22 

Song Y, Qiao J, Giovanni G, Liu G, Yang H, Wu J and Chen J: Mucormycosis in renal transplant recipients: Review of 174 reported cases. BMC Infect Dis. 17:2832017. View Article : Google Scholar : PubMed/NCBI

23 

Iwen PC, Freifeld AG, Sigler L and Tarantolo SR: Molecular identification of Rhizomucor pusillus as a cause of sinus-orbital zygomycosis in a patient with acute myelogenous leukemia. J Clin Microbiol. 43:5819–5821. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Dannaoui E, Meletiadis J, Mouton JW, Meis JF and Verweij PE; Eurofung Network, : In vitro susceptibilities of zygomycetes to conventional and new antifungals. J Antimicrob Chemother. 51:45–52. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Multani A, Reveron-Thornton R, Garvert DW, Gomez CA, Montoya JG and Lui NS: Cut it out! Thoracic Surgeon's approach to pulmonary mucormycosis and the role of surgical resection in survival. Mycoses. 62:893–907. 2019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen Q, Chen K, Qian S, Wu S, Xu L, Huang X, Shi P, Wang K, Wang M, Wang X, Wang X, et al: Disseminated mucormycosis with cerebellum involvement due to Rhizomucor pusillus in a patient with multiple myeloma and secondary myelodysplastic syndrome: A case report. Exp Ther Med 18: 4076-4080, 2019.
APA
Chen, Q., Chen, K., Qian, S., Wu, S., Xu, L., Huang, X. ... Wang, X. (2019). Disseminated mucormycosis with cerebellum involvement due to Rhizomucor pusillus in a patient with multiple myeloma and secondary myelodysplastic syndrome: A case report. Experimental and Therapeutic Medicine, 18, 4076-4080. https://doi.org/10.3892/etm.2019.8065
MLA
Chen, Q., Chen, K., Qian, S., Wu, S., Xu, L., Huang, X., Shi, P., Wang, K., Wang, M., Wang, X."Disseminated mucormycosis with cerebellum involvement due to Rhizomucor pusillus in a patient with multiple myeloma and secondary myelodysplastic syndrome: A case report". Experimental and Therapeutic Medicine 18.5 (2019): 4076-4080.
Chicago
Chen, Q., Chen, K., Qian, S., Wu, S., Xu, L., Huang, X., Shi, P., Wang, K., Wang, M., Wang, X."Disseminated mucormycosis with cerebellum involvement due to Rhizomucor pusillus in a patient with multiple myeloma and secondary myelodysplastic syndrome: A case report". Experimental and Therapeutic Medicine 18, no. 5 (2019): 4076-4080. https://doi.org/10.3892/etm.2019.8065
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Q, Chen K, Qian S, Wu S, Xu L, Huang X, Shi P, Wang K, Wang M, Wang X, Wang X, et al: Disseminated mucormycosis with cerebellum involvement due to Rhizomucor pusillus in a patient with multiple myeloma and secondary myelodysplastic syndrome: A case report. Exp Ther Med 18: 4076-4080, 2019.
APA
Chen, Q., Chen, K., Qian, S., Wu, S., Xu, L., Huang, X. ... Wang, X. (2019). Disseminated mucormycosis with cerebellum involvement due to Rhizomucor pusillus in a patient with multiple myeloma and secondary myelodysplastic syndrome: A case report. Experimental and Therapeutic Medicine, 18, 4076-4080. https://doi.org/10.3892/etm.2019.8065
MLA
Chen, Q., Chen, K., Qian, S., Wu, S., Xu, L., Huang, X., Shi, P., Wang, K., Wang, M., Wang, X."Disseminated mucormycosis with cerebellum involvement due to Rhizomucor pusillus in a patient with multiple myeloma and secondary myelodysplastic syndrome: A case report". Experimental and Therapeutic Medicine 18.5 (2019): 4076-4080.
Chicago
Chen, Q., Chen, K., Qian, S., Wu, S., Xu, L., Huang, X., Shi, P., Wang, K., Wang, M., Wang, X."Disseminated mucormycosis with cerebellum involvement due to Rhizomucor pusillus in a patient with multiple myeloma and secondary myelodysplastic syndrome: A case report". Experimental and Therapeutic Medicine 18, no. 5 (2019): 4076-4080. https://doi.org/10.3892/etm.2019.8065
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