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Article

Meta‑analysis of the association between aldose reductase gene (CA)n microsatellite variants and risk of diabetic retinopathy

  • Authors:
    • Wensheng Mi
    • Yan Xia
    • Yanhui Bian
  • View Affiliations / Copyright

    Affiliations: Department of Pathophysiology, School of Basic Medical Science, Changsha Medical University, Changsha, Hunan 410219, P.R. China
  • Pages: 4499-4509
    |
    Published online on: October 8, 2019
       https://doi.org/10.3892/etm.2019.8086
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Abstract

Diabetic retinopathy (DR) is one of the most severe microvascular complications of diabetes mellitus (DM). The (CA)n microsatellite variation of the aldose reductase (ALR) gene has been indicated to be associated with DR in previous studies; however, the results were inconclusive. To provide a more precise evaluation of the association between the (CA)n variations of ALR and the risk for DR, a meta‑analysis was performed in the present study. Relevant articles were retrieved from the PubMed, Embase, Chinese National Knowledge Infrastructure and Cochrane Library databases. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of the associations. The present meta‑analysis included 17 studies comprising 1,575 DM patients with retinopathy and 1,741 DM patients without retinopathy. The results indicated that the Z‑2 allele was a risk factor for DR in Asian (OR=1.82, 95% CI: 1.16‑2.86, P=0.009) and Caucasian (OR=2.08, 95% CI: 1.14‑3.79, P=0.02) populations, as well as in type 1 diabetes (T1D; OR=3.42, 95% CI: 1.46‑8.04, P=0.005) and type 2 diabetes (T2D; OR=1.66, 95% CI: 1.05‑2.63, P=0.03). Furthermore, the Z+2 allele was determined to be a protective factor for DR in Caucasian individuals (OR=0.50, 95% CI: 0.34‑0.73, P=0.0004) and those with T1D (OR=0.39, 95% CI: 0.27‑0.57, P<0.00001). Z+4 was also identified to be a protective factor, reducing the risk of DR in patients with T1D (OR=0.74, 95% CI: 0.57‑0.96, P=0.02). Z‑4 was revealed to be a risk factor for DR in Asian populations (OR=1.57, 95% CI: 1.22‑2.03, P=0.0005) and in individuals with T1D (OR=1.62, 95% CI: 1.27‑2.08, P=0.0001). However, no association was detected between the Z, Z+6 and Z‑6 alleles and the risk of DR (P>0.05). In conclusion, the present results revealed the following: Z+2 may serve as a protective factor for DR in Caucasian individuals and those with T1D; Z+4 may be a protective factor for DR in patients with T2D; Z‑2 may represent a risk factor for DR in all subgroups analyzed; and Z‑4 may be a risk factor for DR in Asian populations and patients with T2D.
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1 

Ola MS, Nawaz MI, Siddiquei MM, Al-Amro S and Abu El-Asrar AM: Recent advances in understanding the biochemical and molecular mechanism of diabetic retinopathy. J Diabetes Complications. 26:56–64. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Chang YC and Wu WC: Dyslipidemia and diabetic retinopathy. Rev Diabet Stud. 10:121–132. 2012. View Article : Google Scholar

3 

Tuuminen R, Haukka J and Loukovaara S: Poor glycemic control associates with high intravitreal angiopoietin-2 levels in patients with diabetic retinopathy. Acta Ophthalmologica. 93:e515–e516. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Grassi MA, Tikhomirov A, Ramalingam S, Below JE, Cox NJ and Nicolae DL: Genome-wide meta-analysis for severe diabetic retinopathy. Hum Mol Genet. 20:2472–2481. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Warpeha KM and Chakravarthy U: Molecular genetics of microvascular disease in diabetic retinopathy. Eye (Lond). 17:305–311. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Gonzalez-Salinas R, Garcia-Gutierrez MC, Garcia-Aguirre G, Morales-Canton V, Velez-Montoya R, Soberon-Ventura VR, Gonzalez V, Lechuga R, Garcia-Solis P, Garcia-Gutierrez DG, et al: Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population. Int J Ophthalmol. 10:135–139. 2017.PubMed/NCBI

7 

Wang W, He M and Huang W: Association of monocyte chemoattractant protein-1 gene 2518A/G polymorphism with diabetic retinopathy in type 2 diabetes mellitus: A meta-analysis. Diabetes Res Clin Pract. 120:40–46. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Zhang Y, Xia W, Lu P and Yuan HJ: The association between VDR gene polymorphisms and diabetic retinopathy susceptibility: A systematic review and meta-analysis. Biomed Res Int. 2016:53052822016. View Article : Google Scholar : PubMed/NCBI

9 

Li GY, Li ZB, Li F, Dong LP, Tang L, Xiang J, Li JM and Bao MH: Meta-analysis on the association of ALDH2 polymorphisms and type 2 diabetic mellitus, diabetic retinopathy. Int J Environ Res Public Health. 14(pii): E1652017. View Article : Google Scholar : PubMed/NCBI

10 

Fujisawa T, Ikegami H, Kawaguchi Y, Shintani M, Kawabata Y, Ono M, Nishino M, Ogihara T, Okamoto N and Fukuda M: Genetic susceptibility to diabetic retinopathy: CA repeat polymorphism of the aldose reductase gene. Folia Jap Ophthalmol Clin. 52:128–130. 2001.

11 

Abhary S, Burdon KP, Laurie KJ, Thorpe S, Landers J, Goold L, Lake S, Petrovsky N and Craig JE: Aldose reductase gene polymorphisms and diabetic retinopathy susceptibility. Diabetes Care. 33:1834–1836. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Crespo I, Giménez-Dejoz J, Porté S, Cousido-Siah A, Mitschler A, Podjarny A, Pratsinis H, Kletsas D, Parés X, Ruiz FX, et al: Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase. Eur J Med Chem. 152:160–174. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Radha V, Rema M and Mohan V: Genes and diabetic retinopathy. Indian J Ophthalmol. 50:5–11. 2002.PubMed/NCBI

14 

Graham A, Brown L, Hedge PJ, Gammack AJ and Markham AF: Structure of the human aldose reductase gene. J Biol Chem. 266:6872–6877. 1991.PubMed/NCBI

15 

Li YY, Wang H, Yang XX, Geng HY, Gong G and Lu XZ: AR C-106T gene polymorphism and diabetic nephropathy in the Eastern Asians with T2DM: A meta-analysis including 2120 subjects. Diabetes Res Clin Pract. 130:244–251. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Gupta B and Singh SK: Association of aldose reductase gene polymorphism (C-106T) in susceptibility of diabetic peripheral neuropathy among north Indian population. J Diabetes Complications. 31:1085–1089. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Abhary S, Hewitt AW, Burdon KP and Craig JE: A systematic meta-analysis of genetic association studies for diabetic retinopathy. Diabetes. 58:2137–2147. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Olmos P, Bastías MJ, Vollrath V, Toro L, Trincado A, Salinas P, Claro JC, López JM, Acosta AM, Miquel JF and Castro J: C(−106)T polymorphism of the aldose reductase gene and the progression rate of diabetic retinopathy. Diabetes Res Clin Pract. 74:175–182. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Zhou M, Zhang P, Xu X and Sun Z: The relationship between aldose reductase C106T polymorphism and diabetic retinopathy: An updated meta-analysis. Invest Ophthalmol Vis Sci. 56:2279–2289. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Song ZD, Tao Y, Han N and Wu YZ: Association of the aldose reductase-106TT genotype with increased risk for diabetic retinopathy in the Chinese han population: An updated meta-analysis. Curr Eye Res. 41:1087–1091. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Ng DP, Conn J, Chung SS and Larkins RG: Aldose reductase (AC)n microsatellite polymorphism and diabetic microvascular complications in Caucasian Type 1 diabtes mellitus. Diabetes Res Clin Pract. 52:21–27. 2001. View Article : Google Scholar : PubMed/NCBI

22 

dos Santos KG, Canani LH, Gross JL, Tschiedel B, Souto KE and Roisenberg I: The-106CC genotype of the aldose reductase gene is associated with an increased risk of proliferative diabetic retinopathy in Caucasian-Brazilians with type 2 diabetes. Mol Genet Metab. 88:280–284. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Heesom AE, Hibberd ML, Millward A and Demaine AG: Polymorphism in the 5′-end of the aldose reductase gene is strongly associated with the development of diabetic nephropathy in type I diabetes. Diabetes. 46:287–291. 1997. View Article : Google Scholar : PubMed/NCBI

24 

Kao YL, Donaghue K, Chan A, Knight J and Silink M: An aldose reductase intragenic polymorphism associated with diabetic retinopathy. Diabetes Res Clin Pract. 46:155–160. 1999. View Article : Google Scholar : PubMed/NCBI

25 

Liu L, Xiang K and Zheng T: A study of association between polymorphism of aldose reductase gene and diabetic microangiopathy. Chin J Endocrinol Metab. 15:263–266. 1999.

26 

Zghal-Mokni I, Arfa I, Elloumi-Zghal H, Abid A, Amrouche-Rached C, Kaabi B, Chakroun S, Blousa-Chabchoub S, Gaïgi S, Ayed S, et al: Association study between diabetic retinopathy and aldose reductase gene polymorphism in Tunisians. J Fr Ophtalmol. 28:386–390. 2005.(In French). View Article : Google Scholar : PubMed/NCBI

27 

Richeti F, Noronha RM, Waetge RT, de Vasconcellos JP, de Souza OF, Kneipp B, Assis N, Rocha MN, Calliari LE, Longui CA, et al: Evaluation of AC(n) and C(−106)T polymorphisms of the aldose reductase gene in Brazilian patients with DM1 and susceptibility to diabetic retinopathy. Mol Vis. 13:740–745. 2007.PubMed/NCBI

28 

Park HK, Ahn CW, Lee GT, Kim SJ, Song YD, Lim SK, Kim KR, Huh KB and Lee HC: (AC)(n) polymorphism of aldose reductase gene and diabetic microvascular complications in type 2 diabetes mellitus. Diabetes Res Clin Pract. 55:151–157. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Ko BC, Lam KS, Wat NM and Chung SS: An (A-C)n dinucleotide repeat polymorphic marker at the 5′ end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients. Diabetes. 44:727–732. 1995. View Article : Google Scholar : PubMed/NCBI

30 

Petrovic MG, Peterlin B, Hawlina M and Petrovic D: Aldose reductase (AC)n gene polymorphism and susceptibility to diabetic retinopathy in type 2 diabetes in Caucasians. J Diabetes Complications. 19:70–73. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Higgins J and Green S: Cochrane handbook for systematic reviews of interventions, version 5.1.0 [updated March 2011]The Cochrane Collaboration. 2011

32 

Boccia S: PRISMA: An attempt to improve standards for reporting systematic review and meta-analysis. Epidemiol Biostatist Public Health. 6:E3822009.

33 

Wells GA, Shea BJ, O'Connell D, Robertson J, Peterson J, Welch V, Losos M and Tugwell P: The newcastle-ottawa scale (NOS) for assessing the quality of nonrandomized studies in meta-analysis. Appl Eng Agric. 18:727–734. 2014.

34 

Li QJ, Xie P, Zeng WM and Song HP: Correlation between (AC)n polymorphism of the aldose reductase gene and retinopathy in type 2 diabetes mellitus. Chin J Endocrinol Metab. 17:367–368. 2001.

35 

Zhang JH, Wang HY and Li SY: Correlation between polymorphism of the aldose reductase gene and retinopathy in type 2 diabetes mellitus. J Shandong Univ. 46:399–406. 2008.

36 

Chen S, Liu CS and Wang XJ: The correlation study between the two gene polymorphism of aldose reductase gene 5′end and diabetic retinopathy. China Mod Med. 20:13–15. 2013.

37 

Zou X and Lu J: Study on the relationship between the polymorphism of (ac)n in the 5′-end of the ar gene and the susceptibility of microangopathy in type 2 diabetes mellitus. Med J Chin Peoples Liberat Army. 25:353–356. 2000.

38 

Wang Y, Ng MC, Lee SC, So WY, Tong PC, Cockram CS, Critchley JA and Chan JC: Phenotypic heterogeneity and associations of two aldose reductase gene polymorphisms with nephropathy and retinopathy in type 2 diabetes. Diabetes Care. 26:2410–2415. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Demaine A, Cross D and Millward A: Polymorphisms of the aldose reductase gene and susceptibility to retinopathy in type 1 diabetes mellitus. Invest Ophthalmol Vis Sci. 41:4064–4068. 2000.PubMed/NCBI

40 

Ichikawa F, Yamada K, Ishiyama-Shigemoto S, Yuan X and Nonaka K: Association of an (A-C)n dinucleotide repeat polymorphic marker at the 5′-region of the aldose reductase gene with retinopathy but not with nephropathy or neuropathy in Japanese patients with Type 2 diabetes mellitus. Diabet Med. 16:744–748. 1999. View Article : Google Scholar : PubMed/NCBI

41 

Ikegishi Y, Tawata M, Aida K and Onaya T: Z-4 allele upstream of the aldose reductase gene is associated with proliferative retinopathy in Japanese patients with NIDDM, and elevated luciferase gene transcription in vitro. Life Sci. 65:2061–2070. 1999. View Article : Google Scholar : PubMed/NCBI

42 

Kumaramanickavel G, Sripriya S, Ramprasad VL, Upadyay NK, Paul PG and Tarun S: Z-aldose reductase allele and diabetic retinopathy in India. Ophthalmic Genet. 24:41–48. 2003. View Article : Google Scholar : PubMed/NCBI

43 

Isermann B, Susanne Schmidt, Bierhaus A, Schiekofer S, Borcea V, Ziegler R, Nawroth PP and Ritz E: (CA)(n) dinucleotide repeat polymorphism at the 5′-end of the aldose reductase gene is not associated with microangiopathy in Caucasians, with long-term diabetes mellitus 1. Nephrol Dial Transplant. 15:918–920. 2000. View Article : Google Scholar : PubMed/NCBI

44 

Kaur N and Vanita V: Association of aldose reductase gene (AKR1B1) polymorphism with diabetic retinopathy. Diabetes Res Clin Pract. 121:41–48. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Petrash JM, Flath M, Sens D and Bylander J: Effects of osmotic stress and hyperglycemia on aldose reductase gene expression in human renal proximal tubule cells. Biochem Biophys Res Commun. 187:201–208. 1992. View Article : Google Scholar : PubMed/NCBI

46 

Nishimura C, Saito T, Ito T, Omori Y and Tanimoto T: High levels of erythrocyte aldose reductase and diabetic retinopathy in NIDDM patients. Diabetologia. 37:328–330. 1994. View Article : Google Scholar : PubMed/NCBI

47 

Lu L, Risch E, Deng Q, Biglia N, Picardo E, Katsaros D and Yu H: An insulin-like growth factor-II intronic variant affects local DNA conformation and ovarian cancer survival. Carcinogenesis. 34:2024–2030. 2013. View Article : Google Scholar : PubMed/NCBI

48 

Lu L, Katsaros D, Mayne ST, Risch HA, Benedetto C, Canuto EM and Yu H: Functional study of risk loci of stem cell-associated gene lin-28B and associations with disease survival outcomes in epithelial ovarian cance. Carcinogenesis. 33:2119–2125. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Shah VO, Scavini M, Nikolic J, Sun Y, Vai S, Griffith JK, Dorin RI, Stidley C, Yacoub M, Vander Jagt DL, et al: Z-2 microsatellite allele is linked to increased expression of the aldose reductase gene in diabetic nephropathy. J Clin Endocrinol Metab. 83:2886–2891. 1998. View Article : Google Scholar : PubMed/NCBI

50 

Donaghue KC, Margan SH, Chan AK, Holloway B, Silink M, Rangel T and Bennetts B: The association of aldose reductase gene (AKR1B1) polymorphisms with diabetic neuropathy in adolescents. Diabet Med. 22:1315–1320. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Liew G, Klein R and Wong TY: The role of genetics in susceptibility to diabetic retinopathy. Int Ophthalmol Clin. 49:35–52. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Cho H and Sobrin L: Genetics of diabetic retinopathy. Curr Diab Rep. 14:5152014. View Article : Google Scholar : PubMed/NCBI

53 

Ju Z, Daichao W, Yan L and Tan SJ: Association of luteinizing hormone/choriogonadotropin receptor gene polymorphisms with polycystic ovary syndrome risk: A meta-analysis. Gynecol Endocrinol. 35:81–85. 2019. View Article : Google Scholar : PubMed/NCBI

54 

Roy MS, Klein R, O'Colmain BJ, Klein BE, Moss SE and Kempen JH: The prevalence of diabetic retinopathy among adult type 1 diabetic persons in the United States. Arch Ophthalmol. 122:546–551. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Mi W, Xia Y and Bian Y: Meta‑analysis of the association between aldose reductase gene (CA)n microsatellite variants and risk of diabetic retinopathy. Exp Ther Med 18: 4499-4509, 2019.
APA
Mi, W., Xia, Y., & Bian, Y. (2019). Meta‑analysis of the association between aldose reductase gene (CA)n microsatellite variants and risk of diabetic retinopathy. Experimental and Therapeutic Medicine, 18, 4499-4509. https://doi.org/10.3892/etm.2019.8086
MLA
Mi, W., Xia, Y., Bian, Y."Meta‑analysis of the association between aldose reductase gene (CA)n microsatellite variants and risk of diabetic retinopathy". Experimental and Therapeutic Medicine 18.6 (2019): 4499-4509.
Chicago
Mi, W., Xia, Y., Bian, Y."Meta‑analysis of the association between aldose reductase gene (CA)n microsatellite variants and risk of diabetic retinopathy". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4499-4509. https://doi.org/10.3892/etm.2019.8086
Copy and paste a formatted citation
x
Spandidos Publications style
Mi W, Xia Y and Bian Y: Meta‑analysis of the association between aldose reductase gene (CA)n microsatellite variants and risk of diabetic retinopathy. Exp Ther Med 18: 4499-4509, 2019.
APA
Mi, W., Xia, Y., & Bian, Y. (2019). Meta‑analysis of the association between aldose reductase gene (CA)n microsatellite variants and risk of diabetic retinopathy. Experimental and Therapeutic Medicine, 18, 4499-4509. https://doi.org/10.3892/etm.2019.8086
MLA
Mi, W., Xia, Y., Bian, Y."Meta‑analysis of the association between aldose reductase gene (CA)n microsatellite variants and risk of diabetic retinopathy". Experimental and Therapeutic Medicine 18.6 (2019): 4499-4509.
Chicago
Mi, W., Xia, Y., Bian, Y."Meta‑analysis of the association between aldose reductase gene (CA)n microsatellite variants and risk of diabetic retinopathy". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4499-4509. https://doi.org/10.3892/etm.2019.8086
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