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Article Open Access

Poly(lactic‑co‑glycolic acid)‑bioactive glass composites as nanoporous scaffolds for bone tissue engineering: In vitro and in vivo studies

  • Authors:
    • Liuqing Yang
    • Shuying Liu
    • Wei Fang
    • Jun Chen
    • Yu Chen
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Guangzhou Women and Children’s Medical Center, Guangzhou, Guangdong 510623, P.R. China, Department of Periodontics, Stomatological Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China, Department of Oral and Maxillofacial Surgery, Stomatological Hospital, Southern Medical University, Guangzhou, Guangdong 510280, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4874-4880
    |
    Published online on: October 23, 2019
       https://doi.org/10.3892/etm.2019.8121
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Abstract

The aim of the present study was to investigate the feasibility of using composite scaffolds of poly(lactic‑co‑glycolic acid) (PLGA) and bioactive glass (BG) to repair bone defects. PLGA/BG composite scaffolds were prepared by thermally‑induced phase separation. Scanning electron microscopy (SEM) was used to study the morphology, and liquid (absolute ethanol) replacement was used to calculate the porosity of the scaffold. The biocompatibility and degradation of the scaffold were determined using human osteosarcoma cell line MG‑63 and animal experiments. SEM showed that the scaffold had a nanofibrous three‑dimensional network structure with a fiber diameter of 160‑320 nm, a pore size of 1‑7 µm, and a porosity of 93.048±0.121%. The scaffold structure was conducive to cell adhesion and proliferation. It promoted cell osteogenesis and could be stably degraded in vivo.
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Copy and paste a formatted citation
Spandidos Publications style
Yang L, Liu S, Fang W, Chen J and Chen Y: Poly(lactic‑co‑glycolic acid)‑bioactive glass composites as nanoporous scaffolds for bone tissue engineering: In vitro and in vivo studies. Exp Ther Med 18: 4874-4880, 2019.
APA
Yang, L., Liu, S., Fang, W., Chen, J., & Chen, Y. (2019). Poly(lactic‑co‑glycolic acid)‑bioactive glass composites as nanoporous scaffolds for bone tissue engineering: In vitro and in vivo studies. Experimental and Therapeutic Medicine, 18, 4874-4880. https://doi.org/10.3892/etm.2019.8121
MLA
Yang, L., Liu, S., Fang, W., Chen, J., Chen, Y."Poly(lactic‑co‑glycolic acid)‑bioactive glass composites as nanoporous scaffolds for bone tissue engineering: In vitro and in vivo studies". Experimental and Therapeutic Medicine 18.6 (2019): 4874-4880.
Chicago
Yang, L., Liu, S., Fang, W., Chen, J., Chen, Y."Poly(lactic‑co‑glycolic acid)‑bioactive glass composites as nanoporous scaffolds for bone tissue engineering: In vitro and in vivo studies". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4874-4880. https://doi.org/10.3892/etm.2019.8121
Copy and paste a formatted citation
x
Spandidos Publications style
Yang L, Liu S, Fang W, Chen J and Chen Y: Poly(lactic‑co‑glycolic acid)‑bioactive glass composites as nanoporous scaffolds for bone tissue engineering: In vitro and in vivo studies. Exp Ther Med 18: 4874-4880, 2019.
APA
Yang, L., Liu, S., Fang, W., Chen, J., & Chen, Y. (2019). Poly(lactic‑co‑glycolic acid)‑bioactive glass composites as nanoporous scaffolds for bone tissue engineering: In vitro and in vivo studies. Experimental and Therapeutic Medicine, 18, 4874-4880. https://doi.org/10.3892/etm.2019.8121
MLA
Yang, L., Liu, S., Fang, W., Chen, J., Chen, Y."Poly(lactic‑co‑glycolic acid)‑bioactive glass composites as nanoporous scaffolds for bone tissue engineering: In vitro and in vivo studies". Experimental and Therapeutic Medicine 18.6 (2019): 4874-4880.
Chicago
Yang, L., Liu, S., Fang, W., Chen, J., Chen, Y."Poly(lactic‑co‑glycolic acid)‑bioactive glass composites as nanoporous scaffolds for bone tissue engineering: In vitro and in vivo studies". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4874-4880. https://doi.org/10.3892/etm.2019.8121
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