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Article

Clinical impact of omalizumab in refractory chronic urticaria: One centre experience

  • Authors:
    • Diana Deleanu
    • Irena Nedelea
    • Carina Petricau
    • Poliana Leru
    • Dinu Dumitrascu
    • Adriana Muntean
  • View Affiliations / Copyright

    Affiliations: Allergy Department, Professor Doctor Octavian Fodor Regional Institute of Gastroenterology and Hepatology, 400162 Cluj-Napoca, Romania, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania, Anatomy Discipline, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
  • Pages: 5078-5081
    |
    Published online on: October 24, 2019
       https://doi.org/10.3892/etm.2019.8126
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Abstract

Chronic spontaneous urticaria is a debilitating disorder, which has a major impact on the quality of life of affected individuals, and is a substantial global burden. Refractory, difficult to treat cases pose a difficult challenge to patients and clinicians alike. Advances in the field of immunotherapy have led to novel and effective therapeutic strategies. Omalizumab, an immunomodulatory anti-IgE monoclonal antibody, inaugurated a new era in the treatment of refractory chronic urticaria. Several multicenter clinical trials have proven omalizumab to be a safe and effective option for the treatment of refractory symptoms of chronic spontaneous urticaria, while some small studies have shown its efficacy in chronic inductible urticaria as well. In this study, we bring forth updates in chronic urticaria approach, with a focus on our experience with anti-IgE therapy in different forms of chronic urticaria treated at the Allergy Department of the Professor Doctor Octavian Fodor Regional Institute of Gastroenterology and Hepatology (Cluj-Napoca, Romania).
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1 

Maurer M, Weller K, Bindslev-Jensen C, Giménez-Arnau A, Bousquet PJ, Bousquet J, Canonica GW, Church MK, Godse KV, Grattan CE, et al: Unmet clinical needs in chronic spontaneous urticaria. A GA2LEN task force report. Allergy. 66:317–330. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Zuberbier T, Aberer W, Asero R, Abdul Latiff AH, Baker D, Ballmer-Weber B, Bernstein JA, Bindslev-Jensen C, Brzoza Z, Buense Bedrikow R, et al Endorsed by the following societies, : AAAAI, AAD, AAIITO, ACAAI, AEDV, APAAACI, ASBAI, ASCIA, BAD, BSACI, CDA, CMICA, CSACI, DDG, DDS, DGAKI, DSA, DST, EAACI, EIAS, EDF, EMBRN, ESCD, GA2LEN, IAACI, IADVL, JDA, NVvA, MSAI, ÖGDV, PSA, RAACI, SBD, SFD, SGAI, SGDV, SIAAIC, SIDeMaST, SPDV, TSD, UNBB, UNEV and WAO: The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 73:1393–1414. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Zuberbier T, Balke M, Worm M, Edenharter G and Maurer M: Epidemiology of urticaria: A representative cross-sectional population survey. Clin Exp Dermatol. 35:869–873. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Bernstein JA, Lang DM, Khan DA, Craig T, Dreyfus D, Hsieh F, Sheikh J, Weldon D, Zuraw B, Bernstein DI, et al: The diagnosis and management of acute and chronic urticaria: 2014 update. J Allergy Clin Immunol. 133:1270–1277. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Gaig P, Olona M, Muñoz Lejarazu D, Caballero MT, Domínguez FJ, Echechipia S, García Abujeta JL, Gonzalo MA, Lleonart R, Martínez Cócera C, et al: Epidemiology of urticaria in Spain. J Investig Allergol Clin Immunol. 14:214–220. 2004.PubMed/NCBI

6 

Maurer M, Abuzakouk M, Bérard F, Canonica W, Oude Elberink H, Giménez-Arnau A, Grattan C, Hollis K, Knulst A, Lacour JP, et al: The burden of chronic spontaneous urticaria is substantial: Real-world evidence from ASSURE-CSU. Allergy. 72:2005–2016. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Magerl M, Altrichter S, Borzova E, Giménez-Arnau A, Grattan CE, Lawlor F, Mathelier-Fusade P, Meshkova RY, Zuberbier T, Metz M, et al: The definition, diagnostic testing, and management of chronic inducible urticarias - The EAACI/GA(2) LEN/EDF/UNEV consensus recommendations 2016 update and revision. Allergy. 71:780–802. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Maxim E, Aksut C, Tsoi D and Dellavalle R: Global burden of urticaria: Insights from the 2016 Global Burden of Disease Study. J Am Acad Dermatol. 79:567–569. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Saini S, Rosen KE, Hsieh HJ, Wong DA, Conner E, Kaplan A, Spector S and Maurer M: A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine-refractory chronic idiopathic urticaria. J Allergy Clin Immunol. 128:567–573.e1. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Maurer M, Altrichter S, Bieber T, Biedermann T, Bräutigam M, Seyfried S, Brehler R, Grabbe J, Hunzelmann N, Jakob T, et al: Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase. J Allergy Clin Immunol. 128:202–209.e5. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Saini SS, Bindslev-Jensen C, Maurer M, Grob JJ, Bülbül Baskan E, Bradley MS, Canvin J, Rahmaoui A, Georgiou P, Alpan O, et al: Efficacy and safety of omalizumab in patients with chronic idiopathic/spontaneous urticaria who remain symptomatic on H1 antihistamines: A randomized, placebo-controlled study. J Invest Dermatol. 135:67–75. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Maurer M, Rosén K, Hsieh HJ, Saini S, Grattan C, Gimenéz-Arnau A, Agarwal S, Doyle R, Canvin J, Kaplan A, et al: Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria. N Engl J Med. 368:924–935. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Kaplan A, Ledford D, Ashby M, Canvin J, Zazzali JL, Conner E, Veith J, Kamath N, Staubach P, Jakob T, et al: Omalizumab in patients with symptomatic chronic idiopathic/spontaneous urticaria despite standard combination therapy. J Allergy Clin Immunol. 132:101–109. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Zhao ZT, Ji CM, Yu WJ, Meng L, Hawro T, Wei JF and Maurer M: Omalizumab for the treatment of chronic spontaneous urticaria: A meta-analysis of randomized clinical trials. J Allergy Clin Immunol. 137:1742–1750.e4. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Maurer M, Metz M, Brehler R, Hillen U, Jakob T, Mahler V, Pföhler C, Staubach P, Treudler R, Wedi B, et al: Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence. J Allergy Clin Immunol. 141:638–649. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Metz M, Altrichter S, Ardelean E, Kessler B, Krause K, Magerl M, Siebenhaar F, Weller K, Zuberbier T and Maurer M: Anti-immunoglobulin E treatment of patients with recalcitrant physical urticaria. Int Arch Allergy Immunol. 154:177–180. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Metz M, Bergmann P, Zuberbier T and Maurer M: Successful treatment of cholinergic urticaria with anti-immunoglobulin E therapy. Allergy. 63:247–249. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Metz M, Schütz A, Weller K, Gorczyza M, Zimmer S, Staubach P, Merk HF and Maurer M: Omalizumab is effective in cold urticaria-results of a randomized placebo-controlled trial. J Allergy Clin Immunol. 140:864–867.e5. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Boyce JA: Successful treatment of cold-induced urticaria/anaphylaxis with anti-IgE. J Allergy Clin Immunol. 117:1415–1418. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Güzelbey O, Ardelean E, Magerl M, Zuberbier T, Maurer M and Metz M: Successful treatment of solar urticaria with anti-immunoglobulin E therapy. Allergy. 63:1563–1565. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Bullerkotte U, Wieczorek D, Kapp A and Wedi B: Effective treatment of refractory severe heat urticaria with omalizumab. Allergy. 65:931–932. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Krause K, Ardelean E, Kessler B, Magerl M, Metz M, Siebenhaar F, Weller K, Worm M, Zuberbier T and Maurer M: Antihistamine-resistant urticaria factitia successfully treated with anti-immunoglobulin E therapy. Allergy. 65:1494–1495. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Maurer M, Schütz A, Weller K, Schoepke N, Peveling-Oberhag A, Staubach P, Müller S, Jakob T and Metz M: Omalizumab is effective in symptomatic dermographism - results of a randomized placebo-controlled trial. J Allergy Clin Immunol. 140:870–873.e5. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Bindslev-Jensen C and Skov PS: Efficacy of omalizumab in delayed pressure urticaria: A case report. Allergy. 65:138–139. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Zuberbier T, Aberer W, Asero R, Bindslev-Jensen C, Brzoza Z, Canonica GW, Church MK, Ensina LF, Giménez-Arnau A, Godse K, et al: European Academy of Allergy and Clinical Immunology; Global Allergy and Asthma European Network; European Dermatology Forum; World Allergy Organization: The EAACI/GA(2) LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: The 2013 revision and update. Allergy. 69:868–887. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Weller K, Groffik A, Church MK, Hawro T, Krause K, Metz M, Martus P, Casale TB, Staubach P and Maurer M: Development and validation of the Urticaria Control Test: a patient-reported outcome instrument for assessing urticaria control. J Allergy Clin Immunol. 133:1365–1372.e1-6. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Młynek A, Zalewska-Janowska A, Martus P, Staubach P, Zuberbier T and Maurer M: How to assess disease activity in patients with chronic urticaria? Allergy. 63:777–780. 2008. View Article : Google Scholar : PubMed/NCBI

28 

Syrigos N, Grapsa D, Zande M, Tziotou M and Syrigou E: Treatment response to omalizumab in patients with refractory chronic spontaneous urticaria. Int J Dermatol. 57:417–422. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Rorie A and Gierer S: A case of aquagenic urticaria successfully treated with omalizumab. J Allergy Clin Immunol Pract. 4:547–548. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Sussman G, Hébert J, Barron C, Bian J, Caron-Guay RM, Laflamme S and Stern S: Real-life experiences with omalizumab for the treatment of chronic urticaria. Ann Allergy Asthma Immunol. 112:170–174. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Deleanu D, Nedelea I, Petricau C, Leru P, Dumitrascu D and Muntean A: Clinical impact of omalizumab in refractory chronic urticaria: One centre experience. Exp Ther Med 18: 5078-5081, 2019.
APA
Deleanu, D., Nedelea, I., Petricau, C., Leru, P., Dumitrascu, D., & Muntean, A. (2019). Clinical impact of omalizumab in refractory chronic urticaria: One centre experience. Experimental and Therapeutic Medicine, 18, 5078-5081. https://doi.org/10.3892/etm.2019.8126
MLA
Deleanu, D., Nedelea, I., Petricau, C., Leru, P., Dumitrascu, D., Muntean, A."Clinical impact of omalizumab in refractory chronic urticaria: One centre experience". Experimental and Therapeutic Medicine 18.6 (2019): 5078-5081.
Chicago
Deleanu, D., Nedelea, I., Petricau, C., Leru, P., Dumitrascu, D., Muntean, A."Clinical impact of omalizumab in refractory chronic urticaria: One centre experience". Experimental and Therapeutic Medicine 18, no. 6 (2019): 5078-5081. https://doi.org/10.3892/etm.2019.8126
Copy and paste a formatted citation
x
Spandidos Publications style
Deleanu D, Nedelea I, Petricau C, Leru P, Dumitrascu D and Muntean A: Clinical impact of omalizumab in refractory chronic urticaria: One centre experience. Exp Ther Med 18: 5078-5081, 2019.
APA
Deleanu, D., Nedelea, I., Petricau, C., Leru, P., Dumitrascu, D., & Muntean, A. (2019). Clinical impact of omalizumab in refractory chronic urticaria: One centre experience. Experimental and Therapeutic Medicine, 18, 5078-5081. https://doi.org/10.3892/etm.2019.8126
MLA
Deleanu, D., Nedelea, I., Petricau, C., Leru, P., Dumitrascu, D., Muntean, A."Clinical impact of omalizumab in refractory chronic urticaria: One centre experience". Experimental and Therapeutic Medicine 18.6 (2019): 5078-5081.
Chicago
Deleanu, D., Nedelea, I., Petricau, C., Leru, P., Dumitrascu, D., Muntean, A."Clinical impact of omalizumab in refractory chronic urticaria: One centre experience". Experimental and Therapeutic Medicine 18, no. 6 (2019): 5078-5081. https://doi.org/10.3892/etm.2019.8126
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