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Expression and potential prognostic value of histone family gene signature in breast cancer

  • Authors:
    • Wenting Xie
    • Jiajia Zhang
    • Peng Zhong
    • Shanshan Qin
    • Han Zhang
    • Xin Fan
    • Yuzhen Yin
    • Ruipeng Liang
    • Yali Han
    • Yina Liao
    • Xiaqing Yu
    • Huideng Long
    • Zhongwei Lv
    • Chao Ma
    • Fei Yu
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China, Medical College, Anhui University of Science and Technology, Huainan, Anhui 232001, P.R. China, Shanghai Center of Thyroid Diseases, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4893-4903
    |
    Published online on: October 25, 2019
       https://doi.org/10.3892/etm.2019.8131
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Abstract

Breast cancer (BC) is the most common type of malignancy among females worldwide. Histone modifications, which are the major post-translational modifications, have a significant role in cancer development and prognosis. However, whether histone family genes may serve as potential prognostic biomarkers for BC patients has remained elusive. In the present study, RNA-sequencing data were obtained from The Cancer Genome Atlas (TCGA). Differentially expressed genes were identified and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway functional enrichment analysis was performed. As histone family genes have been reported to be associated with cervical cancer, the present study hypothesized that histone family genes are associated with gynecological tumors. Histone family genes, including histone cluster 1 H1A family member B (HIST1H1B), HIST1H2AJ, HIST1H2AM, HIST1H2BI, HIST1H2BO, HIST1H3B, HIST1H3F, HIST1H3H, HIST1H4C and HIST1H4D, were upregulated and identified as hub genes in the protein-protein interaction network. In addition, Oncomine and the Human Protein Atlas were used to further verify the expression levels of histone gene sets. The PrognoScan database was then used to investigate the association between expression and prognostic value regarding cancer patient survival. The present results indicated that higher expression of histone gene sets was associated with poor overall survival, relapse-free survival and distant metastasis-free survival of BC patients. The differential expression of histone family genes between BC and normal samples was validated by reverse transcription-quantitative PCR. Finally, to determine the clinical role of histone family genes in BC, the correlations between histone family genes expression and clinical characteristics were investigated through data collected from TCGA. Therefore, the present study indicates that histone gene sets may be used as prognostic factors for survival prediction for BC patients.
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1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

DeSantis CE, Ma J, Goding Sauer A, Newman LA and Jemal A: Breast cancer statistics, 2017, racial disparity in mortality by state. CA Cancer J Clin. 67:439–448. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Reed E and Corner J: Defining the illness trajectory of metastatic breast cancer. BMJ Support Palliat Care. 5:358–365. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Redig AJ and McAllister SS: Breast cancer as a systemic disease: A view of metastasis. J Intern Med. 274:113–126. 2013. View Article : Google Scholar : PubMed/NCBI

5 

McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M and Clark GM; Statistics Subcommittee of the NCI-EORTC Working Group on Cancer Diagnostics, : REporting recommendations for tumour MARKer prognostic studies (REMARK). Br J Cancer. 93:387–391. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Costa-Pinheiro P, Montezuma D, Henrique R and Jerónimo C: Diagnostic and prognostic epigenetic biomarkers in cancer. Epigenomics. 7:1003–1015. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Dworkin AM, Huang TH and Toland AE: Epigenetic alterations in the breast: Implications for breast cancer detection, prognosis and treatment. Semin Cancer Biol. 19:165–171. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Karsli-Ceppioglu S, Dagdemir A, Judes G, Ngollo M, Penault-Llorca F, Pajon A, Bignon YJ and Bernard-Gallon D: Epigenetic mechanisms of breast cancer: An update of the current knowledge. Epigenomics. 6:651–664. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Yang HD, Kim PJ, Eun JW, Shen Q, Kim HS, Shin WC, Ahn YM, Park WS, Lee JY and Nam SW: Oncogenic potential of histone-variant H2A.Z.1 and its regulatory role in cell cycle and epithelial-mesenchymal transition in liver cancer. Oncotarget. 7:11412–11423. 2016.PubMed/NCBI

10 

Rangasamy D: Histone variant H2A.Z can serve as a new target for breast cancer therapy. Curr Med Chem. 17:3155–3161. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Chen H, Lorton B, Gupta V and Shechter D: A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression. Oncogene. 36:373–386. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Yokoyama Y, Matsumoto A, Hieda M, Shinchi Y, Ogihara E, Hamada M, Nishioka Y, Kimura H, Yoshidome K, Tsujimoto M, et al: Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity. Breast Cancer Res. 16:R662014. View Article : Google Scholar : PubMed/NCBI

13 

Li X, Tian R, Gao H, Yang Y, Williams BRG, Gantier MP, McMillan NAJ, Xu D, Hu Y and Gao Y: Identification of a histone family gene signature for predicting the prognosis of cervical cancer patients. Sci Rep. 7:164952017. View Article : Google Scholar : PubMed/NCBI

14 

Tomczak K, Czerwińska P and Wiznerowicz M: The Cancer Genome Atlas (TCGA): An immeasurable source of knowledge. Contemp Oncol (Pozn). 19:A68–A77. 2015.PubMed/NCBI

15 

Robinson MD, McCarthy DJ and Smyth GK: edgeR: A Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26:139–140. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Huang W, Sherman BT and Lempicki RA: Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res. 37:1–13. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Huang W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al The Gene Ontology Consortium, : Gene ontology: Tool for the unification of biology. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Gene Ontology Consortium, . Gene Ontology Consortium: Going forward. Nucleic Acids Res. 43:D1049–D1056. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Kanehisa M, Furumichi M, Tanabe M, Sato Y and Morishima K: KEGG: New perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 45:D353–D361. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Szklarczyk D, Morris JH, Cook H, Kuhn M, Wyder S, Simonovic M, Santos A, Doncheva NT, Roth A, Bork P, et al: The STRING database in 2017: Quality-controlled protein-protein association networks, made broadly accessible. Nucleic Acids Res. 45:D362–D368. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Van Parys T, Melckenbeeck I, Houbraken M, Audenaert P, Colle D, Pickavet M, Demeester P and Van de Peer Y: A Cytoscape app for motif enumeration with ISMAGS. Bioinformatics. 33:461–463. 2017.PubMed/NCBI

23 

Rhodes DR, Kalyana-Sundaram S, Mahavisno V, Varambally R, Yu J, Briggs BB, Barrette TR, Anstet MJ, Kincead-Beal C, Kulkarni P, et al: Oncomine 3.0: Genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia. 9:166–180. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Pontén F, Jirström K and Uhlen M: The Human Protein Atlas - a tool for pathology. J Pathol. 216:387–393. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Mizuno H, Kitada K, Nakai K and Sarai A: PrognoScan: A new database for meta-analysis of the prognostic value of genes. BMC Med Genomics. 2:182009. View Article : Google Scholar : PubMed/NCBI

26 

Tang R, Liang L, Luo D, Feng Z, Huang Q, He R, Gan T, Yang L and Chen G: Downregulation of miR-30a is associated with poor prognosis in lung cancer. Med Sci Monit. 21:2514–2520. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Abbasi S, Rasouli M, Nouri M and Kalbasi S: Association of estrogen receptor-α A908G (K303R) mutation with breast cancer risk. Int J Clin Exp Med. 6:39–49. 2013.PubMed/NCBI

28 

Basse C and Arock M: The increasing roles of epigenetics in breast cancer: Implications for pathogenicity, biomarkers, prevention and treatment. Int J Cancer. 137:2785–2794. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Katz TA, Huang Y, Davidson NE and Jankowitz RC: Epigenetic reprogramming in breast cancer: From new targets to new therapies. Ann Med. 46:397–408. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Fidalgo F, Rodrigues TC, Silva AG, Facure L, de Sá BC, Duprat JP, Achatz MI, Rosenberg C, Carraro DM and Krepischi AC: Role of rare germline copy number variation in melanoma-prone patients. Future Oncol. 12:1345–1357. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Ohshima K, Hatakeyama K, Nagashima T, Watanabe Y, Kanto K, Doi Y, Ide T, Shimoda Y, Tanabe T, Ohnami S, et al: Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors. Sci Rep. 7:6412017. View Article : Google Scholar : PubMed/NCBI

32 

Mirisola V, Mora R, Esposito AI, Guastini L, Tabacchiera F, Paleari L, Amaro A, Angelini G, Dellepiane M, Pfeffer U, et al: A prognostic multigene classifier for squamous cell carcinomas of the larynx. Cancer Lett. 307:37–46. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Castel D, Philippe C, Calmon R, Le Dret L, Truffaux N, Boddaert N, Pagès M, Taylor KR, Saulnier P, Lacroix L, et al: Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes. Acta Neuropathol. 130:815–827. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Braunstein M, Liao L, Lyttle N, Lobo N, Taylor KJ, Krzyzanowski PM, Kalatskaya I, Yao CQ, Stein LD, Boutros PC, et al: Downregulation of histone H2A and H2B pathways is associated with anthracycline sensitivity in breast cancer. Breast Cancer Res. 18:162016. View Article : Google Scholar : PubMed/NCBI

35 

Chen X, Hu H, He L, Yu X, Liu X, Zhong R and Shu M: A novel subtype classification and risk of breast cancer by histone modification profiling. Breast Cancer Res Treat. 157:267–279. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Hedrich CM: Epigenetics in SLE. Curr Rheumatol Rep. 19:582017. View Article : Google Scholar : PubMed/NCBI

37 

Hu N, Qiu X, Luo Y, Yuan J, Li Y, Lei W, Zhang G, Zhou Y, Su Y and Lu Q: Abnormal histone modification patterns in lupus CD4+ T cells. J Rheumatol. 35:804–810. 2008.PubMed/NCBI

38 

Alam S, Arif Z and Alam K: Glycated-H2A histone is better bound by serum anti-DNA autoantibodies in SLE patients: Glycated-histones as likely trigger for SLE? Autoimmunity. 48:19–28. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Bernatsky S, Ramsey-Goldman R, Labrecque J, Joseph L, Boivin JF, Petri M, Zoma A, Manzi S, Urowitz MB, Gladman D, et al: Cancer risk in systemic lupus: An updated international multi-centre cohort study. J Autoimmun. 42:130–135. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xie W, Zhang J, Zhong P, Qin S, Zhang H, Fan X, Yin Y, Liang R, Han Y, Liao Y, Liao Y, et al: Expression and potential prognostic value of histone family gene signature in breast cancer. Exp Ther Med 18: 4893-4903, 2019.
APA
Xie, W., Zhang, J., Zhong, P., Qin, S., Zhang, H., Fan, X. ... Yu, F. (2019). Expression and potential prognostic value of histone family gene signature in breast cancer. Experimental and Therapeutic Medicine, 18, 4893-4903. https://doi.org/10.3892/etm.2019.8131
MLA
Xie, W., Zhang, J., Zhong, P., Qin, S., Zhang, H., Fan, X., Yin, Y., Liang, R., Han, Y., Liao, Y., Yu, X., Long, H., Lv, Z., Ma, C., Yu, F."Expression and potential prognostic value of histone family gene signature in breast cancer". Experimental and Therapeutic Medicine 18.6 (2019): 4893-4903.
Chicago
Xie, W., Zhang, J., Zhong, P., Qin, S., Zhang, H., Fan, X., Yin, Y., Liang, R., Han, Y., Liao, Y., Yu, X., Long, H., Lv, Z., Ma, C., Yu, F."Expression and potential prognostic value of histone family gene signature in breast cancer". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4893-4903. https://doi.org/10.3892/etm.2019.8131
Copy and paste a formatted citation
x
Spandidos Publications style
Xie W, Zhang J, Zhong P, Qin S, Zhang H, Fan X, Yin Y, Liang R, Han Y, Liao Y, Liao Y, et al: Expression and potential prognostic value of histone family gene signature in breast cancer. Exp Ther Med 18: 4893-4903, 2019.
APA
Xie, W., Zhang, J., Zhong, P., Qin, S., Zhang, H., Fan, X. ... Yu, F. (2019). Expression and potential prognostic value of histone family gene signature in breast cancer. Experimental and Therapeutic Medicine, 18, 4893-4903. https://doi.org/10.3892/etm.2019.8131
MLA
Xie, W., Zhang, J., Zhong, P., Qin, S., Zhang, H., Fan, X., Yin, Y., Liang, R., Han, Y., Liao, Y., Yu, X., Long, H., Lv, Z., Ma, C., Yu, F."Expression and potential prognostic value of histone family gene signature in breast cancer". Experimental and Therapeutic Medicine 18.6 (2019): 4893-4903.
Chicago
Xie, W., Zhang, J., Zhong, P., Qin, S., Zhang, H., Fan, X., Yin, Y., Liang, R., Han, Y., Liao, Y., Yu, X., Long, H., Lv, Z., Ma, C., Yu, F."Expression and potential prognostic value of histone family gene signature in breast cancer". Experimental and Therapeutic Medicine 18, no. 6 (2019): 4893-4903. https://doi.org/10.3892/etm.2019.8131
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